Water: Deuterium Depleted

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36 Diseases Researched for Water: Deuterium Depleted
NameACCKFocus
Lung Cancer625Locked
Lung Cancer: Metastatic220Locked
Cancers: All911Locked
Carcinoma: Non-Small-Cell Lung110Locked
Carcinoma: Small Cell Lung110Locked
Pancreatic Cancer110Locked
Oxidative Stress35Locked
Sepsis24Locked
Aging23Locked
Breast Cancer23Locked
Memory Disorders23Locked
Metabolic Syndrome X23Locked
Obesity23Locked
Chemotherapy and Radiation Toxicity12Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide12Locked
Cognitive Decline/Dysfunction12Locked
Colon Cancer22Locked
Depression12Locked
Depressive Disorder12Locked
Ehrlich carcinoma12Locked
Endotoxemia12Locked
High Fructose Diet12Locked
Hypothermia12Locked
Liver Cancer12Locked
Liver Damage12Locked
Stress12Locked
Alzheimer's Disease11Locked
Brain: Oxidative Stress11Locked
Breast Cancer: Triple Negative 11Locked
DNA damage11Locked
Heavy Metal Toxicity11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Insulin Resistance11Locked
Nasopharyngeal Cancer11Locked
Neurodegenerative Diseases11Locked
Parkinson's Disease11Locked
33 Pharmacological Actions Researched for Water: Deuterium Depleted
NameACCKFocus
Antiproliferative 1545Locked
Chemotherapeutic1030Locked
Cell cycle arrest717Locked
Chemopreventive617Locked
Apoptotic515Locked
Antioxidants914Locked
Anti-Tumor212Locked
Anti-Inflammatory Agents36Locked
Neuroprotective Agents46Locked
Anticarcinogenic Agents35Locked
Cyclooxygenase 2 Inhibitors35Locked
Insulin Sensitizers23Locked
Anti-Apoptotic12Locked
Anticholesteremic Agents12Locked
Antidepressive Agents12Locked
Cytoprotective12Locked
Hepatoprotective12Locked
Hypoglycemic Agents12Locked
Hypolipidemic12Locked
Immunostimulatory12Locked
Interferon Gamma Reducer12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-10 upregulation12Locked
Interleukin-4 upregulation12Locked
Interleukin-6 Downregulation12Locked
Radioprotective12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-metastatic11Locked
Antineoplastic Agents11Locked
Detoxifier11Locked
Genoprotective11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Nrf2 activation11Locked
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View the Evidence:
37 Abstracts with Water: Deuterium Depleted Research

[+]

DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis.Aug 31, 2008

Pubmed Data : Integr Cancer Ther. 2008 Sep ;7(3):172-81. PMID: 18815148
Article Published Date : Aug 31, 2008
Study Type : Human Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-Tumor, Antiproliferative , Chemopreventive, Chemotherapeutic
Additional Keywords : Significant Treatment Outcome
[+]

Deuterium depletion inhibits cell proliferation, RNA and nuclear membrane turnover to enhance survival in pancreatic cancer.Dec 31, 2020

Pubmed Data : Cancer Control. 2021 Jan-Dec;28:1073274821999655. PMID: 33760674
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative
[+]

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Cancer. 2013 ;65(2):240-6. PMID: 23441611
Article Published Date : Dec 31, 2012
Study Type : Animal Study, Human Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Carcinoma: Non-Small-Cell Lung, Carcinoma: Small Cell Lung, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Gene Expression Regulation, Proto-oncogene
[+]

Anti-inflammatory effects of deuterium-depleted water plus Rosa damascena essential oil via cyclooxygenase-2 pathway.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Pharm Sci. 2020 Feb ;17(1):99-107. Epub 2020 Feb 19. PMID: 32454767
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Rose , Water: Deuterium Depleted
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Essential Oils
[+]

Correction of metabolic processes in rats during chronic endotoxicosis.Dec 31, 2014

Pubmed Data : Izv Akad Nauk Ser Biol. 2015(5):518-27. PMID: 26638240
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Endotoxemia
Pharmacological Actions : Antioxidants
[+]

DDW in mice counteracted the behavioral, transcriptional and proliferative changes typical of the depressive-like states, which was comparable to the effects of citalopram.Jan 14, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Brain Res. 2015 Jan 15 ;277:237-44. Epub 2014 Aug 1. PMID: 25092571
Article Published Date : Jan 14, 2015
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Depression, Depressive Disorder, Stress
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Deuterium Content Of Water, Natural Substances Versus Drugs, Risk Factors, Superiority of Natural Substances versus Drugs
[+]

Deuterium content of the organic compounds in food has an impact on tumor growth in mice.Dec 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2022 Dec 21 ;45(1):66-77. Epub 2022 Dec 21. PMID: 36661491
Article Published Date : Dec 20, 2022
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Deuterium depleted water is a promising new anticancer agent with potential for future clinical application.Jan 02, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2010 3 ;1(2):277-283. Epub 2010 Mar 1. PMID: 22993540
Article Published Date : Jan 02, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Lung Cancer
Pharmacological Actions : Anti-Tumor, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic
[+]

Deuterium-depleted water as adjuvant therapeutic agent for treatment of diet-induced obesity.Dec 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Dec 19 ;25(1). Epub 2019 Dec 19. PMID: 31861678
Article Published Date : Dec 18, 2019
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Deuterium-depleted water decreased total cholesterol and triglyceride levels along with increased plasma insulin in Wistar-Kyoto rats.Oct 23, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2016 Oct 24 ;65(Supplementum 3):S401-S407. PMID: 27775425
Article Published Date : Oct 23, 2016
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : High Fructose Diet
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
[+]

Deuterium-depleted water has stimulating effects on long-term memory in rats.Nov 06, 2014

Pubmed Data : Neurosci Lett. 2014 Nov 7 ;583:154-8. Epub 2014 Sep 28. PMID: 25263786
Article Published Date : Nov 06, 2014
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration.Sep 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cell Biochem. 2021 Sep 12. Epub 2021 Sep 12. PMID: 34510301
Article Published Date : Sep 11, 2021
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Metabolic Syndrome X
Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers
[+]

Impact of reduced deuterium intake on thermoregulation. Aug 31, 2021

Pubmed Data : Bull Exp Biol Med. 2021 Sep ;171(5):572-575. Epub 2021 Oct 7. PMID: 34617175
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Hypothermia
[+]

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Pubmed Data : Rom J Physiol. 1999 Jul-Dec;36(3-4):205-18. PMID: 11797936
Article Published Date : Jun 30, 1999
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemotherapeutic, Immunostimulatory, Radioprotective
Problem Substances : Cyclophosphamide
[+]

It is suggested that genes playing a key role in the cell cycle regulation and tumour development are sensitive to deuterium depletion.Apr 30, 2000

Pubmed Data : In Vivo. 2000 May-Jun;14(3):437-9. PMID: 10904878
Article Published Date : Apr 30, 2000
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Gene Expression Regulation, Proto-oncogene
[+]

Naturally occurring deuterium is essential for the normal growth rate of cells.Feb 07, 1993

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Lett. 1993 Feb 8 ;317(1-2):1-4. PMID: 8428617
Article Published Date : Feb 07, 1993
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
[+]

Reduction of deuterium level supports resistance of neurons to glucose deprivation and hypoxia.Dec 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Dec 31 ;27(1). Epub 2021 Dec 31. PMID: 35011474
Article Published Date : Dec 30, 2021
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Short term deuterium depletion in drinking water reduced tumor induced oxidative stress in mice liver.Oct 25, 2022

Pubmed Data : Pathol Res Pract. 2022 Oct 26 ;240:154186. Epub 2022 Oct 26. PMID: 36327814
Article Published Date : Oct 25, 2022
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Ehrlich carcinoma, Liver Cancer, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive
[+]

Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries.Nov 30, 2019

Pubmed Data : Pharm Biol. 2019 Dec ;57(1):125-132. PMID: 30961427
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Mint, Water: Deuterium Depleted
Diseases : Liver Damage, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective
Additional Keywords : Essential Oils, Natural Substance Synergy
[+]

Treatment of manganese exposed worms with deuterium-depleted water (90 ppm) restored life-span, DAF-16 and SOD-3 levels to control levels.Jun 19, 2012

Pubmed Data : Toxicol Lett. 2012 Jun 20 ;211(3):319-24. Epub 2012 Apr 26. PMID: 22561170
Article Published Date : Jun 19, 2012
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Aging
Pharmacological Actions : Anti-Apoptotic, Cytoprotective
[+]

A miRNAs profile evolution of triple negative breast cancer cells in the presence of a possible adjuvant therapy and senescence inducer.Apr 30, 2018

Pubmed Data : J BUON. 2018 May-Jun;23(3):692-705. PMID: 30003739
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Exosomes
[+]

Anticancer effect of deuterium depleted water - redox disbalance leads to oxidative stress.Sep 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cell Proteomics. 2019 Sep 13. Epub 2019 Sep 13. PMID: 31519768
Article Published Date : Sep 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Blocking the increase of intracellular deuterium concentration prevents the expression of cancer-related genes, tumor development, and tumor recurrence.Dec 31, 2021

Pubmed Data : Cancer Control. 2022 Jan-Dec;29:10732748211068963. PMID: 35043700
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
Additional Keywords : Gene Expression Regulation
[+]

Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cells.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2018 May ;21(5):508-516. PMID: 29922432
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors
[+]

Deuterium depleted water considerably suppressed cancer cell lines amoeboid movement in vitro.May 13, 2018

Pubmed Data : J Trace Elem Med Biol. 2018 May 14. Epub 2018 May 14. PMID: 29773469
Article Published Date : May 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All, Colon Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Deuterium depleted water inhibits the proliferation of human MCF7 breast cancer cell lines by inducing cell cycle arrest.Dec 31, 2018

Pubmed Data : Nutr Cancer. 2019 ;71(6):1019-1029. Epub 2019 May 2. PMID: 31045450
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Deuterium depletion in water offers a new adjuvant and protective cancer therapy.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Hypotheses. 2016 Feb ;87:69-74. Epub 2015 Nov 26. PMID: 26826644
Article Published Date : Jan 31, 2016
Study Type : Commentary
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic
[+]

Deuterium-depleted water may protect differentiated PC12 cells against H2O2-induced oxidative stress.Feb 02, 2020

Pubmed Data : Neurochem Res. 2020 Feb 3. Epub 2020 Feb 3. PMID: 32016793
Article Published Date : Feb 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Deuterium-depleted water reduces the number of single-stranded DNA breaks and modifies the miRNA profile.Aug 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Aug 15 ;11(8). Epub 2019 Aug 15. PMID: 31443167
Article Published Date : Aug 14, 2019
Study Type : Review
Additional Links
Substances : Water: Deuterium Depleted
Diseases : DNA damage
Pharmacological Actions : Antioxidants, Genoprotective
[+]

Research progress of the inhibitory effect of deuterium-depleted water on cancers.Sep 30, 2012

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2012 Oct ;32(10):1454-6. PMID: 23076183
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive
[+]

Study of the effects of deuterium-depleted water on the expression of GLUT4 and insulin resistance in the muscle cell line C2C12.Aug 05, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2024 Aug 6 ;12(8). Epub 2024 Aug 6. PMID: 39200235
Article Published Date : Aug 05, 2024
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Synergistic anticancer effects of crocin combined with deuterium-depleted water on HT-29 cells.Feb 23, 2023

Pubmed Data : Anticancer Drugs. 2023 Feb 24. Epub 2023 Feb 24. PMID: 36847076
Article Published Date : Feb 23, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Water: Deuterium Depleted
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance Synergy
[+]

The biological impact of deuterium and therapeutic potential of deuterium-depleted water.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2024 ;15:1431204. Epub 2024 Jul 22. PMID: 39104389
Article Published Date : Dec 31, 2023
Study Type : Review
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Aging, Cancers: All, Heavy Metal Toxicity, Memory Disorders, Metabolic Syndrome X, Obesity, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Detoxifier, Neuroprotective Agents
Additional Keywords : Anti-Obesity Agents
[+]

The results showed that deuterium-depleted water alone or in combination with chemotherapy effectively inhibited cancer progression in most experiments.May 05, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 May 6 ;16(9). Epub 2024 May 6. PMID: 38732643
Article Published Date : May 05, 2024
Study Type : Review
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Chemotherapeutic, Nrf2 activation
Additional Keywords : Natural Substance/Drug Synergy
[+]

The review summarizes reported data on the proliferation and apoptosis of normal and neoplastic cells in different modes of deuteration and deuterium depletion in vivo and in vitro.Feb 03, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Feb 4 ;24(4). Epub 2023 Feb 4. PMID: 36834518
Article Published Date : Feb 03, 2023
Study Type : Review
Additional Links
Substances : Deuterium (heavy water) , Water: Deuterium Depleted
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

These findings suggest that deuterium-depleted water may serve as an adjuvant treatment.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1241-1249. Epub 2018 Jun 19. PMID: 30116375
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Colon Cancer
Pharmacological Actions : Chemotherapeutic
[+]

These results demonstrated that DDW is a novel, non-toxic adjuvant therapeutic agent that suppresses NPC cell proliferation, migration, and invasion.Jun 30, 2013

Pubmed Data : Biomed Pharmacother. 2013 Jul ;67(6):489-96. Epub 2013 Feb 27. PMID: 23773852
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-9 (MMP-9) inhibitor

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