White Mulberry

Name	AC	CK
Obesity	12	30
Oxidative Stress	11	29
Diabetes Mellitus: Type 2	10	21
Hypoglycemia	1	20
Chronic Obstructive Pulmonary Disease	2	14
Hyperglycemia	3	13
Aging Skin	2	11
Inflammation	8	11
Polycystic Ovary Syndrome	1	10
Prediabetes	1	10
Wrinkles	1	10
Insulin Resistance	5	9
High Fat Diet	3	6
Osteoarthritis	3	6
Colon Cancer	1	5
Dyslipidemias	2	5
Alcoholic Liver Disease	2	4
Cancers: All	3	4
Cognitive Decline/Dysfunction	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Complications	2	4
Liver Fibrosis	2	4
Atherosclerosis	1	3
Lipopolysaccharide-Induced Toxicity	3	3
Liver Damage	2	3
Melanoma	1	3
Alzheimer's Disease	2	2
Arthritis	1	2
Breast Cancer	2	2
Cardiomyopathy	1	2
Cardiovascular Diseases	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Colorectal Cancer	1	2
Depression	1	2
Diabetic Nephropathy	1	2
Diabetic Retinopathy	1	2
Endothelial Damage	1	2
Experimental Lung Inflammation	1	2
Glyphosate Toxicity	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Hypertension: Arterial	1	2
Hyperuricemia	1	2
Influenza	2	2
Iron Overload	1	2
Kidney Damage: Chemically-Induced	1	2
Liver Cancer	1	2
Liver Cancer: Prevention	1	2
Lung Cancer	2	2
Memory Disorders	1	2
Menopausal Syndrome	1	2
Myocardial Ischemia	1	2
Neurodegenerative Diseases	1	2
Ovarian Failure	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Coronavirus Infection	1	1
Coxsackievirus Infections	1	1
Ehrlich carcinoma	1	1
Escherichia coli Infections	1	1
Fatty Liver	1	1
Gastric Cancer	1	1
Hepatitis C	1	1
Kidney Damage	1	1
Norovirus	1	1
Osteosarcoma	1	1
Periodontal Diseases	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Skin Diseases	1	1

Name	AC	CK
Hypoglycemic Agents	13	60
Antioxidants	19	52
Anti-Inflammatory Agents	19	43
Hypolipidemic	7	32
Apoptotic	8	23
Interleukin-6 Downregulation	7	21
Interleukin-1 beta downregulation	5	20
Cyclooxygenase 2 Inhibitors	4	17
Malondialdehyde Down-regulation	3	17
Superoxide Dismutase Up-regulation	3	17
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	17
Neuroprotective Agents	9	16
Interleukin-10 upregulation	2	13
Gastrointestinal Agents	6	12
Alpha-glucosidase inhibitor	2	11
Anti-Adipogenic	1	10
Anti-collagenase	1	10
Hepatoprotective	6	10
Chemosensitizer	3	8
Insulin Sensitizers	4	7
NF-kappaB Inhibitor	4	7
Anti-Apoptotic	4	6
Chemoprotective Agents	4	6
Nrf2 activation	3	6
Renoprotective	4	6
Antiviral Agents	5	5
Cardioprotective	3	5
Immunomodulatory	3	5
Analgesics	2	4
Anti-Bacterial Agents	4	4
Anti-Fibrotic	2	4
Anti-metastatic	4	4
Antiproliferative	3	4
Chemotherapeutic	2	4
Heme oxygenase-1 up-regulation	2	4
Neuritogenic	2	4
Antinoceceptive	2	3
Interleukin-8 downregulation	2	3
Anticarcinogenic Agents	1	2
Antidepressive Agents	1	2
Antihypertensive Agents	1	2
Antimutagenic Agents	1	2
Appetite Suppresant	1	2
Cell cycle arrest	2	2
Chemopreventive	1	2
Cyclooxygenase Inhibitors	1	2
Cytoprotective	1	2
Enzyme Inhibitors: Pancreatic Lipase	2	2
Lipolytic	1	2
Lipoxygenase Inhibitors	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Transforming growth factor beta (TGF-β) inhibitor	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vasodilator Agents	1	2
Vasoprotective	1	2
Xanthine oxidase inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Angiogenic	1	1
Antineoplastic Agents	1	1
Bcl-2 protein down-regulation	1	1
Bcl-xL down-regulation	1	1
Caspase-9 Activation	1	1
Cytotoxic	1	1
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1

[+]

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex.Nov 26, 2022

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Pubmed Data : J Obes. 2016 ;2016:4670818. Epub 2016 Aug 6. PMID: 27699065

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Pubmed Data : Neurosci Lett. 2017 Jan 10 ;637:136-141. Epub 2016 Nov 18. PMID: 27871994

Article Published Date : Jan 09, 2017

Study Type : Animal Study

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Substances : White Mulberry

Diseases : Depression, Diabetic Complications

Pharmacological Actions : Antidepressive Agents

[+]

An extract of turmeric and white mulberry could potentially be considered as a dietary supplement product for the management of arthritis.Mar 31, 2016

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Pubmed Data : Pharmacognosy Res. 2016 Apr-Jun;8(2):112-7. PMID: 27034601

Article Published Date : Mar 31, 2016

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Pubmed Data : Mol Med Rep. 2020 Jan ;21(1):320-328. Epub 2019 Nov 21. PMID: 31939614

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : White Mulberry

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Hypoglycemic Agents, Neuritogenic, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Cortex Mori Radicis[Morus Alba L. (Moraceae)] extract alleviates senescence via PI3K/Akt signaling in COPD fibroblasts.Nov 30, 2024

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Pubmed Data : Pharmacogn Mag. 2016 Apr-Jun;12(46):128-33. PMID: 27076749

Article Published Date : Mar 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Hydrogen Peroxide Induced Toxicity, oxidative stress, Plant Extracts, White Mulberry

[+]

Flavonoids extracted from mulberry leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.Oct 18, 2019

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Pubmed Data : J Ethnopharmacol. 2019 Oct 19:112326. Epub 2019 Oct 19. PMID: 31639486

Article Published Date : Oct 18, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids, White Mulberry

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Pharmacological Actions : Hypoglycemic Agents

[+]

Folium mori treatment may aid in the recovery from the central nervous system complications of diabetes mellitus.Mar 31, 2003

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Pubmed Data : Mol Nutr Food Res. 2016 Oct ;60(10):2304-2311. Epub 2016 Jun 27. PMID: 27234065

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Pubmed Data : J Agric Food Chem. 2018 Aug 1 ;66(30):7923-7934. Epub 2018 Jul 17. PMID: 29969905

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Pubmed Data : Molecules. 2021 Feb 26 ;26(5). Epub 2021 Feb 26. PMID: 33652778

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Pubmed Data : Life (Basel). 2022 Oct 18 ;12(10). Epub 2022 Oct 18. PMID: 36295064

Article Published Date : Oct 17, 2022

Study Type : Animal Study

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Substances : White Mulberry

Diseases : Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

[+]

Mulberry leaf extract is a potent protector against glyphosate-induced toxicityFeb 27, 2017

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Pubmed Data : Environ Sci Pollut Res Int. 2017 Feb 28. Epub 2017 Feb 28. PMID: 28247273

Article Published Date : Feb 27, 2017

Study Type : Animal Study

Additional Links

Substances : White Mulberry

Diseases : Glyphosate Toxicity

Pharmacological Actions : Antioxidants, Cytoprotective, Neuroprotective Agents

Additional Keywords : Plant Extracts

Problem Substances : Glyphosate

[+]

Neuroprotective effects of Morus alba ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.Jan 31, 2026

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Pubmed Data : J Asian Nat Prod Res. 2026 Feb ;28(2):250-268. Epub 2025 May 15. PMID: 40372353

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Pubmed Data : Int Immunopharmacol. 2021 Aug ;97:107521. Epub 2021 May 1. PMID: 33940322

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : White Mulberry

Diseases : Alcoholic Liver Disease

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Additional Keywords : Polysaccharides

[+]

White mulberry could be a promising candidate for preventing and controlling cardiovascular diseases linked with endothelial dysfunction.Dec 31, 2017

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Pubmed Data : J Agric Food Chem. 2019 Sep 11 ;67(36):10222-10234. Epub 2019 Sep 3. PMID: 31385700

Article Published Date : Sep 10, 2019

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

[+]

Guangsangon E triggers mitochondria dysfunction and mitophagy in triple-negative breast cancer and leads to non-apoptotic cell death.Nov 30, 2022

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Pubmed Data : Mol Carcinog. 2022 Dec ;61(12):1128-1142. Epub 2022 Sep 19. PMID: 36121321

Article Published Date : Nov 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic

[+]

Identification of renoprotective phytosterols from mulberry fruit against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells.Nov 16, 2021

Mulberry component kuwanon C exerts potent therapeutic efficacy in vitro against COVID-19.Oct 18, 2022

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Pubmed Data : Front Nutr. 2023 ;10:1125831. Epub 2023 Apr 6. PMID: 37090772

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Hyperglycemia

Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Antioxidants, Hypoglycemic Agents

Additional Keywords : Polysaccharides

[+]

The root bark of M. alba and its active compounds might be promising candidates for preventive and therapeutic agents for Alzheimer's disease.Jan 15, 2017

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Pubmed Data : Arch Pharm Res. 2017 Jan 16. Epub 2017 Jan 16. PMID: 28093699

Article Published Date : Jan 15, 2017

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

The root bark of Morus alba L. suppressed the migration of human non-small-cell lung cancer.May 06, 2019

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Pubmed Data : Int J Mol Sci. 2019 May 7 ;20(9). Epub 2019 May 7. PMID: 31067694

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View the Evidence: 103 Abstracts with White Mulberry Research

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M. alba can effectively contribute to the reduction in postprandial glucose levels.Mar 13, 2016

Mulberry (Morus alba l.) leaf improves arachidonic acid metabolism disorder in chronic obstructive pulmonary disease.Nov 24, 2025

Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes. May 31, 2020

M. alba can be used as a nutraceutical agent to ameliorate hyperglycemia.Dec 31, 2015

Morus alba L. (Sangzhi) alkaloids reduce polycystic ovary syndrome by improving hypothalamic-pituitary-ovarian axis function.Apr 24, 2026

The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.Dec 31, 2014

White mulberry supplementation as adjuvant treatment of obesity.Dec 31, 2013

Morus alba flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line.Mar 30, 2016

Cortex Mori extracts induce apoptosis and inhibit tumor invasion via blockage of the PI3K/AKT signaling in melanoma cells.Dec 31, 2021

Hypoglycemic effects of a Fructus Mori polysaccharide in vitro and in vivo.Jul 18, 2017

Mori fructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs.Sep 30, 2025

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex.Nov 26, 2022

Antiobesity effect of ethanolic extract of Ramulus mori in differentiated 3T3-L1 adipocytes and high-fat diet-induced obese mice.Apr 05, 2020

A botanical composition from Morus alba, Yerba mate and Magnolia officinalis could potentially be used for achieving healthy weight loss and maintenance.Feb 15, 2017

A botanical composition from Morus alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression.Dec 31, 2015

A botanical extract of turmeric and white mulberry acted as a bradykinin receptor B1 and B2 antagonist.Dec 31, 2015

Ameliorating effects of white mulberry on iron-overload-induced oxidative stress and liver fibrosis.Aug 27, 2021

An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent.May 18, 2019

An extract of root bark of Morus alba could improve the depressive-like behaviors induced by diabetes.Jan 09, 2017

An extract of turmeric and white mulberry could potentially be considered as a dietary supplement product for the management of arthritis.Mar 31, 2016

Combined treatment of Mori folium and Mori Cortex ameliorate obesity.Aug 23, 2023

Cortex Mori Radicis extract attenuates myocardial damages in diabetic rats by regulating ERS.May 31, 2017

Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats.Dec 31, 2019

Cortex Mori Radicis[Morus Alba L. (Moraceae)] extract alleviates senescence via PI3K/Akt signaling in COPD fibroblasts.Nov 30, 2024

Cyanidin-3-rutinoside from Mori Fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway.Feb 28, 2025

Extracts from mulberry leaves fermented with Cordyceps militaris have lipolytic effects and could be used to treat obesity. Aug 31, 2017

Flavonoid extracted from mulberry fruit possesses a strong antioxidant activity both in vivo and in vitro.Mar 31, 2016

Flavonoids extracted from mulberry leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.Oct 18, 2019

Folium mori treatment may aid in the recovery from the central nervous system complications of diabetes mellitus.Mar 31, 2003

Fructus mori polysaccharide alleviates diabetic symptoms by regulating intestinal microbiota and intestinal barrier against TLR4/NF-κB pathway.Sep 29, 2023

Fructus Mori polysaccharides modulate the axial distribution of gut microbiota and fecal metabolites to improve symptoms of hyperglycemia in type 2 diabetic mice.Apr 30, 2025

In vivo therapeutic exploring for Mori folium extract against type 2 diabetes mellitus.Dec 21, 2021

M. alba fruit polysaccharides have markedly antihyperglycemic and antihyperlipidemic effects.Feb 01, 2017

M. alba has protective effect on diabetic retinopathy.Apr 07, 2016

M. alba L. fruit extract might be a potential anti-tumor immunomodulatory candidate chemotherapy agent.Dec 31, 2014

M. alba leaves supplementation could attenuate adiposity, insulin resistance behavioral deficits.Dec 11, 2018

M. alba stem extract exhibited an anti-nociceptive effect as well as cartilage protection.Dec 31, 2015

Memory-enhancing effect of Mori Fructus via induction of nerve growth factor.Jul 13, 2013

Moracin M inhibited airway inflammation in vitro and in vivo, and it has therapeutic potential for treating lung inflammatory disorders.Jul 14, 2016

Mori cortex attenuates high fat diet-induced cognitive impairment.Jun 20, 2020

Mori folium and mori fructus mixture attenuates high-fat diet-induced cognitive deficits in mice.Dec 31, 2014

Mori folium is a potential therapeutic choice for chondroprotection against the collagen matrix breakdown in the cartilage of diseased tissues.Jan 31, 2016

Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate‑induced osteoarthritis.Sep 30, 2017

Mori fructus aqueous extracts attenuate carbon tetrachloride-induced renal injury via the Nrf2 pathway and intestinal flora.Oct 14, 2022

Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway.Apr 09, 2023

Mori fructus polysaccharides attenuate alcohol-induced liver damage.Dec 31, 2020

Morus alba extract exerts antihypertensive action in an experimental model of arterial hypertension.Sep 30, 2016

Morus alba fruit extract and its fractions ameliorate streptozotocin induced cognitive deficit.Aug 18, 2023

Morus alba L. fruit extract may improve hyperglycemia and insulin sensitivity.Jul 31, 2016

Morus alba L. improves diabetic nephropathy.Dec 31, 2022

Morus alba leaf bioactives modulate peroxisome proliferator activated receptor γ in the kidney of diabetic rat and imparts beneficial effects.Jul 31, 2018

Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes.Jan 27, 2021

Morus alba leaves flavonoid extract and Morus alba leaves powder treatment could be useful agents in diabetes improvement.May 29, 2016

Morus alba prevented the cyclophosphamide induced somatic and germinal cell damage.Feb 25, 2021

Morusin attenuates myocardial ischemia/reperfusion injury.Feb 28, 2026

Morusin targets DNA methyltransferase 1 to trigger senescence and sensitizes colorectal cancer to senolytic therapy.Jan 31, 2026

Mulberry (Fructus mori) extract alleviates hyperuricemia by regulating urate transporters and modulating the gut microbiota.Dec 08, 2024

Mulberry leaf extract and 1-deoxynojirimycin improve skeletal muscle insulin resistance.Oct 17, 2022

Mulberry leaf extract is a potent protector against glyphosate-induced toxicityFeb 27, 2017

Neuroprotective effects of Morus alba ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.Jan 31, 2026

Pectin from Fructus Mori relieve oxidative stress and regulates gut microbiota in premature ovarian failure.May 31, 2025

The co-administration of M. alba with gentamicin prevented renal functioning alterations expected with the use of gentamicin alone.Feb 29, 2016

The flavonoid glycoside astragalin may be a new therapeutic agent for the management of menopausal symptoms.May 20, 2016

These findings highlight M. alba root bark as a promising source of lead compounds for the development of functional food ingredients or nutraceuticals targeting inflammation-related disorders.Jan 12, 2026

Treatment with mulberry leaf extract partially protected the livers of rats from NDEA-induced hepatocarcinogenesis.Jan 10, 2016

Untargeted lipidomics analysis of Mori Fructus polysaccharide on acute alcoholic liver injury.Jul 31, 2021

White mulberry could be a promising candidate for preventing and controlling cardiovascular diseases linked with endothelial dysfunction.Dec 31, 2017

A review of the potency of mulberry as natural potent anti-obesity agent in management of obesity.Jul 31, 2019

A water-soluble polysaccharide is able to reduce the number of fat cells and the mass of adipose tissue.Jul 31, 2016

An antioxidant rich fraction of white mulberry stem bark inhibits the growth of Ehrlich ascites carcinoma cells.Dec 31, 2015

Antibacterial and proteomic profiling of Morus alba extract against methicillin-resistant Staphylococcus aureus.Dec 31, 2025

Antioxidant and anti-inflammatory activity on LPS-stimulated RAW 264.7 macrophage cells of white mulberry.May 27, 2023

White Mulberry

View the Evidence:
103 Abstracts with White Mulberry Research