Xanthones

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33 Diseases Researched for Xanthones
NameACCKFocus
Drug Toxicity: Isoprenaline13Locked
Hyperglycemia23Locked
Myocardial Fibrosis 13Locked
Alzheimer's Disease22Locked
Breast Cancer22Locked
Cancers: All22Locked
Chronic Kidney Disease (CKD)12Locked
Dermatitis: Contact12Locked
Diabetes Mellitus: Type 222Locked
Diabetic Complications12Locked
Gastric Ulcers12Locked
Kidney Damage12Locked
Lead Poisoning12Locked
Liver Cancer22Locked
Liver Damage12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Advanced Glycation End products (AGE)11Locked
Bacterial Infections11Locked
Cancer Stem Cells11Locked
Cancers: Multi-Drug Resistant11Locked
Colon Cancer11Locked
Colorectal Cancer11Locked
Coronavirus Disease11Locked
Coronavirus Infection11Locked
Depression11Locked
Inflammation11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Nasopharyngeal Cancer11Locked
Obesity11Locked
Parkinson's Disease11Locked
Prostate Cancer11Locked
Prostate Cancer Stem Cells11Locked
Rheumatoid Arthritis11Locked
30 Pharmacological Actions Researched for Xanthones
NameACCKFocus
Antioxidants58Locked
Antiproliferative 66Locked
Apoptotic44Locked
Hepatoprotective24Locked
Renoprotective24Locked
Anti-Fibrotic13Locked
Anti-Inflammatory Agents23Locked
Cardioprotective13Locked
Neuroprotective Agents33Locked
Anti-Ulcer Agents12Locked
Cytotoxic22Locked
Gastroprotective12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-6 Downregulation12Locked
Interleukin-8 downregulation12Locked
NF-kappaB Inhibitor12Locked
Nrf2 activation12Locked
Alpha-amylase inhibitor11Locked
Anti-Bacterial Agents11Locked
Anti-Glycation Agents11Locked
Anticarcinogenic Agents11Locked
Antidepressive Agents11Locked
Antimicrobial11Locked
Antinoceceptive 11Locked
Antiviral Agents11Locked
Cell cycle arrest11Locked
Chemopreventive11Locked
Heme oxygenase-1 inducer11Locked
Hypolipidemic11Locked
Nitric Oxide Inhibitor11Locked

View the Evidence:
39 Abstracts with Xanthones Research

[+]

Alpha-mangostin protects endothelial cells against metabolic memory-induced senescence.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Oct ;23(10):1261-1267. PMID: 33149857
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants
Additional Keywords : Natural Substances Versus Drugs
[+]

Bellidifolin ameliorates isoprenaline-induced myocardial fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:644886. Epub 2021 Apr 30. PMID: 33995055
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Mangiferin improves hepatic lipid metabolism.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:201. Epub 2018 Mar 7. PMID: 29563875
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Xanthones
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

These results demonstrate the anti-ulcer efficacy of xanthones isolated from G. achachairuOct 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Oct 25 ;258:30-9. Epub 2016 Aug 18. PMID: 27545833
Article Published Date : Oct 24, 2016
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Gastric Ulcers
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Natural Substances Versus Drugs
[+]

Xanthone could be a dietary supplement for the patient with diabetic complications.Dec 16, 2019

Pubmed Data : J Am Coll Nutr. 2019 Dec 17:1-10. Epub 2019 Dec 17. PMID: 31846399
Article Published Date : Dec 16, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetic Complications, Kidney Damage, Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
[+]

Xanthone suppresses allergic contact dermatitis in vitro and in vivo.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2020 Jan ;78:106061. Epub 2019 Dec 9. PMID: 31821937
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Dermatitis: Contact
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Xanthones protects lead-induced chronic kidney disease.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2020 Mar ;21:100718. Epub 2019 Dec 10. PMID: 31886417
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Chronic Kidney Disease (CKD), Lead Poisoning
Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
Problem Substances : Lead
[+]

The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones.Dec 08, 2021

Pubmed Data : Pharmacol Res. 2021 Dec 9:106032. Epub 2021 Dec 9. PMID: 34896543
Article Published Date : Dec 08, 2021
Study Type : Review
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
[+]

A comprehensive update on the medicinal properties of mangosteen.Oct 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):102-122. Epub 2017 Aug 24. PMID: 28842267
Article Published Date : Oct 31, 2017
Study Type : Review
Additional Links
Substances : Garcinia Mangostana, Xanthones
Diseases : Cancers: All, Diabetes Mellitus: Type 2, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants, Antiproliferative , Apoptotic, Hypolipidemic, Neuroprotective Agents
[+]

A review of the xanthones found in lichens. Mar 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Mar 2 ;21(3):294. Epub 2016 Mar 2. PMID: 26950106
Article Published Date : Mar 01, 2016
Study Type : Review
Additional Links
Substances : Lichens, Xanthones
[+]

Alpha-mangostin could be beneficial to the treatment of rheumatoid arthritis.Dec 04, 2017

Pubmed Data : Curr Mol Med. 2017 Dec 5. Epub 2017 Dec 5. PMID: 29210647
Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana, Xanthones
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Apoptotic
[+]

Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana.Jun 30, 2016

Pubmed Data : Pak J Pharm Sci. 2016 Jul ;29(4 Suppl):1353-7. PMID: 27592485
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Bacterial Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Plant Extracts
[+]

Bellidifolin inhibits proliferation of A549 cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oncol. 2020 ;2020:1723791. Epub 2020 Nov 21. PMID: 33299414
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lung Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
[+]

Efficacy of alpha-mangostin for antimicrobial activity against endodontopathogenic microorganisms.Dec 31, 2021

Pubmed Data : Arch Oral Biol. 2022 Jan ;133:105304. Epub 2021 Nov 5. PMID: 34775269
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Candida Albicans, Enterococcus Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells.Sep 30, 2020

Pubmed Data : Oncol Rep. 2020 Oct ;44(4):1747-1757. Epub 2020 Aug 11. PMID: 32945501
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Garcinia hanburyi, Xanthones
Diseases : Acute T cell Leukemias
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Gambogic acid inhibits Wnt/β-catenin signaling and induces ER stress-mediated apoptosis in human cholangiocarcinoma.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2021 Jun 1 ;22(6):1913-1920. Epub 2021 Jun 1. PMID: 34181351
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Wnt/β-catenin signaling pathway modulation
[+]

Gambogic acid protects LPS-induced apoptosis and inflammation.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2021 05 11 ;22(1):28. Epub 2021 May 11. PMID: 33971977
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity, Pneumonia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2018 Mar ;39(3):1485-1493. Epub 2018 Jan 16. PMID: 29344638
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway.Nov 30, 2020

Pubmed Data : Phytomedicine. 2020 Dec ;79:153334. Epub 2020 Sep 3. PMID: 32920288
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Garcinoxanthones B and C significantly inhibited nitric oxide production, which were comparable with the positive control indomethacin.Oct 31, 2016

Pubmed Data : Phytochemistry. 2016 Nov ;131:115-123. Epub 2016 Aug 22. PMID: 27561254
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Lipopolysaccharide-Induced Toxicity, Mangosteen, Natural Substances Versus Drugs, Nitric Oxide Inhibitor, Xanthones
[+]

Garmoxanthone exhibited strong antibacterial activity .Nov 12, 2017

Pubmed Data : Nat Prod Res. 2017 Nov 13:1-6. Epub 2017 Nov 13. PMID: 29132213
Article Published Date : Nov 12, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana, Xanthones
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Xanthones
[+]

Isolated xanthones to inhibit protein oxidation, as indicated by the decreases in dityrosine and N'-formylkynurenine formation.Dec 31, 2016

Pubmed Data : J Nat Med. 2017 Jan ;71(1):216-226. Epub 2016 Oct 13. PMID: 27738860
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Advanced Glycation End products (AGE), Hyperglycemia
Pharmacological Actions : Anti-Glycation Agents
Additional Keywords : Dose Response
[+]

Low-dose gambogic acid may be a potential radionuclide sensitizer.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2021 Aug ;22(2):588. Epub 2021 Jun 4. PMID: 34149899
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lung Cancer
Pharmacological Actions : Radiosensitizer
[+]

Mangosteen is a functional food that could help in lowering the postprandial glucose absorption.Apr 30, 2019

Pubmed Data : J Food Biochem. 2019 May ;43(5):e12844. Epub 2019 Mar 21. PMID: 31353530
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-amylase inhibitor
[+]

Mangosteen pericarp and its bioactive xanthones: Potential therapeutic value in Alzheimer's disease, Parkinson's disease, and depression.Aug 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Aug 27 ;21(17). Epub 2020 Aug 27. PMID: 32867357
Article Published Date : Aug 26, 2020
Study Type : Review
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Alzheimer's Disease, Depression, Parkinson's Disease
Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment.Jan 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Oral Health. 2021 10 10 ;21(1):512. Epub 2021 Oct 10. PMID: 34629065
Article Published Date : Jan 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Oral Cancer
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Multitarget action of xanthones from Garcinia mangostana against α-amylase, α-glucosidase and pancreatic lipase.May 19, 2022

Pubmed Data : Molecules. 2022 May 20 ;27(10). Epub 2022 May 20. PMID: 35630761
Article Published Date : May 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Enzyme Inhibitors: Pancreatic Lipase
Additional Keywords : Xanthones
[+]

Natural prenylated xanthones as potential inhibitors of PI3k/Akt/mTOR pathway in triple negative breast cancer cells.Dec 27, 2021

Pubmed Data : Planta Med. 2021 Dec 28. Epub 2021 Dec 28. PMID: 34963183
Article Published Date : Dec 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Natural xanthones have multifunctional activities against Alzheimer's disease. Jun 30, 2016

Pubmed Data : Neurochem Res. 2016 Jul ;41(7):1806-17. Epub 2016 Apr 2. PMID: 27038926
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
[+]

Review xanthones and cancer: from natural sources to mechanisms of action.Dec 02, 2019

Pubmed Data : Chem Biodivers. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31794156
Article Published Date : Dec 02, 2019
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

The diverse bioactivity of α-mangostin and its therapeutic implications.Aug 18, 2021

Pubmed Data : Future Med Chem. 2021 Aug 19. Epub 2021 Aug 19. PMID: 34410182
Article Published Date : Aug 18, 2021
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Bacterial Infections, Cancers: All, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic
[+]

The effects and mechanism of α-mangostin on chemosensitivity of gastric cancer cells.May 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2021 May 18. Epub 2021 May 18. PMID: 34003591
Article Published Date : May 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
[+]

The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2022 Sep ;50(3). Epub 2022 Jul 29. PMID: 35904170
Article Published Date : Aug 31, 2022
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Cardiovascular Diseases, Metabolic Diseases
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
[+]

The stem bark of Garcinia xanthochymus contain compounds (xanthones) with antiproliferative effects on prostate cancer cells. Jan 01, 2012

Pubmed Data : Nat Prod Commun. 2012 Jan ;7(1):53-6. PMID: 22428244
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Garcinia xanthochymus, Xanthones
Diseases : Cancer Stem Cells, Prostate Cancer, Prostate Cancer Stem Cells
Pharmacological Actions : Antiproliferative
[+]

Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma.Aug 11, 2021

Pubmed Data : Eur J Pharm Sci. 2021 Aug 12 ;166:105975. Epub 2021 Aug 12. PMID: 34391880
Article Published Date : Aug 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
[+]

Xanthones could be useful in the treatment of multidrug resistant cancers. Jan 31, 2017

Pubmed Data : Bioorg Med Chem Lett. 2017 Feb 1 ;27(3):447-449. Epub 2016 Dec 20. PMID: 28065566
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Cytotoxic
Additional Keywords : Breast Cancer, Cancers: Multi-Drug Resistant, Cytotoxic, liver cancer, Superiority of Natural Substances versus Drugs, Xanthones
[+]

Xanthones from Garcinia mangostana fruit hulls were cytotoxic against cancer cell lines.Jan 16, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 17. Epub 2017 Jan 17. PMID: 28108382
Article Published Date : Jan 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Breast Cancer, Colorectal Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Antiproliferative, Apoptotic, Breast Cancer, Cell cycle arrest, COLORECTAL CANCER, liver cancer, Mangosteen, Xanthones
[+]

Xanthones from the roots of Calophyllum blancoi exhibit significant anti-coronavirus activity.Feb 01, 2005

Pubmed Data : Chem Pharm Bull (Tokyo). 2005 Feb ;53(2):244-7. PMID: 15684529
Article Published Date : Feb 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Coronavirus Disease, Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : Xanthones
[+]

α-mangostin nanoparticles cytotoxicity and cell death modalities in breast cancer cell lines.Aug 23, 2021

Pubmed Data : Molecules. 2021 Aug 24 ;26(17). Epub 2021 Aug 24. PMID: 34500560
Article Published Date : Aug 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Xanthones

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