Xanthones

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63 Diseases Researched for Xanthones
NameACCKFocus
Breast Cancer66Locked
Cancers: All44Locked
Lipopolysaccharide-Induced Toxicity44Locked
Myocardial Fibrosis 24Locked
Prostate Cancer24Locked
Alzheimer's Disease33Locked
Breast Cancer: Triple Negative 33Locked
Cerebral Ischemia13Locked
Diabetes Mellitus: Type 233Locked
Glioma13Locked
Hyperglycemia23Locked
Inflammation33Locked
Oxidative Stress23Locked
Acrylamide-induced toxicity12Locked
Bacterial Infections22Locked
Cholangiocarcinoma22Locked
Chronic Kidney Disease (CKD)12Locked
Coronavirus Disease (Covid-19)22Locked
Dermatitis: Contact12Locked
Diabetic Complications12Locked
Drug Toxicity: Isoprenaline12Locked
Gastric Ulcers12Locked
Hepatitis: Lectin-Induced (concanavalin)12Locked
Hypertension12Locked
Kidney Damage12Locked
Lead Poisoning12Locked
Liver Cancer22Locked
Liver Damage12Locked
Liver Fibrosis12Locked
Lung Cancer22Locked
Melanoma22Locked
Neurodegenerative Diseases12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Parkinson's Disease22Locked
Acute T cell Leukemias11Locked
Advanced Glycation End products (AGE)11Locked
Cancer Stem Cells11Locked
Cancers: Multi-Drug Resistant11Locked
Candida Albicans11Locked
Cardiovascular Diseases11Locked
Cervical Cancer11Locked
Chemotherapy-Induced Toxicity: Cisplatin11Locked
Colon Cancer11Locked
Colorectal Cancer11Locked
Coronavirus Infection11Locked
Depression11Locked
Dermatitis11Locked
Enterococcus Infections11Locked
Gastric Cancer11Locked
Gastrointestinal Inflammation11Locked
Human Papillomavirus (HPV)11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Leukemia: Acute myelogenous leukemia (AML) 11Locked
Metabolic Diseases11Locked
Myocardial Ischemia11Locked
Nasopharyngeal Cancer11Locked
Obesity11Locked
Oral Cancer11Locked
Ovarian Cancer11Locked
Pneumonia11Locked
Prostate Cancer Stem Cells11Locked
Rheumatoid Arthritis11Locked
Staphylococcal Infections11Locked
45 Pharmacological Actions Researched for Xanthones
NameACCKFocus
Antiproliferative 1719Locked
Antioxidants914Locked
Apoptotic1414Locked
Anti-Inflammatory Agents1011Locked
Neuroprotective Agents69Locked
Hepatoprotective48Locked
Anti-Apoptotic47Locked
Anti-Fibrotic36Locked
Cardioprotective35Locked
Chemotherapeutic24Locked
NF-kappaB Inhibitor34Locked
Renoprotective24Locked
Anti-Bacterial Agents33Locked
Anti-metastatic33Locked
Cell cycle arrest33Locked
Chemopreventive33Locked
Gastroprotective23Locked
Interleukin-6 Downregulation23Locked
Nrf2 activation23Locked
Alpha-amylase inhibitor22Locked
Anti-Ulcer Agents12Locked
Antihypertensive Agents12Locked
Antimicrobial22Locked
Antiviral Agents22Locked
Cyclooxygenase 2 Inhibitors22Locked
Cytotoxic22Locked
Cytotoxicity22Locked
Immunomodulatory22Locked
Interleukin-1 beta downregulation12Locked
Interleukin-8 downregulation12Locked
Nitric Oxide Inhibitor22Locked
Transforming growth factor beta (TGF-β) inhibitor12Locked
Alpha-glucosidase inhibitor 11Locked
Anti-Glycation Agents11Locked
Anticarcinogenic Agents11Locked
Antidepressive Agents11Locked
Antinoceceptive 11Locked
Chemosensitizer11Locked
Enzyme Inhibitors: Pancreatic Lipase11Locked
Heme oxygenase-1 inducer11Locked
Hypolipidemic11Locked
Oncogene Suppressor 11Locked
Prostaglandin PGE2 downregulation11Locked
Radiosensitizer11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
66 Abstracts with Xanthones Research

[+]

Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Control Release. 2023 Jan ;353:216-228. Epub 2022 Nov 25. PMID: 36410615
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

α-mangostin promotes in vitro and in vivo degradation of androgen receptor and AR-V7 splice variant in prostate cancer cells.Mar 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2023 Apr 1 ;15(7). Epub 2023 Apr 1. PMID: 37046780
Article Published Date : Mar 31, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Prostate Cancer
Pharmacological Actions : Chemotherapeutic
[+]

β-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization.Jul 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2024 Aug ;177:117074. Epub 2024 Jul 6. PMID: 38972149
Article Published Date : Jul 31, 2024
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Glioma
Pharmacological Actions : Antiproliferative
[+]

Alpha-mangostin as a new therapeutic candidate for concanavalin A-induced autoimmune hepatitis.Sep 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2022 Sep 19 ;11(18). Epub 2022 Sep 19. PMID: 36145841
Article Published Date : Sep 18, 2022
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Hepatoprotective
[+]

Alpha-mangostin protects endothelial cells against metabolic memory-induced senescence.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Oct ;23(10):1261-1267. PMID: 33149857
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants
Additional Keywords : Natural Substances Versus Drugs
[+]

Bellidifolin ameliorates isoprenaline-induced myocardial fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:644886. Epub 2021 Apr 30. PMID: 33995055
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Bellidifolin ameliorates myocardial fibrosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:6841276. Epub 2022 May 9. PMID: 35586685
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Evaluating the effect of alpha-mangostin on neural toxicity induced by acrylamide.Aug 31, 2023

Pubmed Data : Environ Sci Pollut Res Int. 2023 Sep ;30(42):95789-95800. Epub 2023 Aug 9. PMID: 37556057
Article Published Date : Aug 31, 2023
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Acrylamide-induced toxicity, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Problem Substances : Acrylamide
[+]

Isolation and biological evaluation of alpha-mangostin as potential therapeutic Agents against liver fibrosis.Sep 10, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineering (Basel). 2023 Sep 11 ;10(9). Epub 2023 Sep 11. PMID: 37760177
Article Published Date : Sep 10, 2023
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Mangiferin improves hepatic lipid metabolism.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:201. Epub 2018 Mar 7. PMID: 29563875
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Xanthones
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

These results demonstrate the anti-ulcer efficacy of xanthones isolated from G. achachairuOct 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Oct 25 ;258:30-9. Epub 2016 Aug 18. PMID: 27545833
Article Published Date : Oct 24, 2016
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Gastric Ulcers
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Natural Substances Versus Drugs
[+]

Xanthone could be a dietary supplement for the patient with diabetic complications.Dec 16, 2019

Pubmed Data : J Am Coll Nutr. 2019 Dec 17:1-10. Epub 2019 Dec 17. PMID: 31846399
Article Published Date : Dec 16, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetic Complications, Kidney Damage, Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
[+]

Xanthone suppresses allergic contact dermatitis in vitro and in vivo.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2020 Jan ;78:106061. Epub 2019 Dec 9. PMID: 31821937
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Dermatitis: Contact
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Xanthones protects lead-induced chronic kidney disease.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2020 Mar ;21:100718. Epub 2019 Dec 10. PMID: 31886417
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Chronic Kidney Disease (CKD), Lead Poisoning
Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
Problem Substances : Lead
[+]

α-Mangostin reduces hypertension in spontaneously hypertensive rats.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2024 ;21(9):1681-1688. Epub 2024 Jun 17. PMID: 39006850
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Xanthones
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Transforming growth factor beta (TGF-β) inhibitor
[+]

The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones.Dec 08, 2021

Pubmed Data : Pharmacol Res. 2021 Dec 9:106032. Epub 2021 Dec 9. PMID: 34896543
Article Published Date : Dec 08, 2021
Study Type : Review
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
[+]

A comprehensive update on the medicinal properties of mangosteen.Oct 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):102-122. Epub 2017 Aug 24. PMID: 28842267
Article Published Date : Oct 31, 2017
Study Type : Review
Additional Links
Substances : Garcinia Mangostana, Xanthones
Diseases : Cancers: All, Diabetes Mellitus: Type 2, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants, Antiproliferative , Apoptotic, Hypolipidemic, Neuroprotective Agents
[+]

A review of the xanthones found in lichens. Mar 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Mar 2 ;21(3):294. Epub 2016 Mar 2. PMID: 26950106
Article Published Date : Mar 01, 2016
Study Type : Review
Additional Links
Substances : Lichens, Xanthones
[+]

Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants.Jun 14, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2024 Jun 15 ;10(11):e31987. Epub 2024 May 27. PMID: 38867992
Article Published Date : Jun 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Coronavirus Disease (Covid-19)
Pharmacological Actions : Antiviral Agents
[+]

Alpha mangostin and cisplatin as modulators of exosomal interaction of ovarian cancer cell with fibroblasts.Aug 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Aug 10 ;23(16). Epub 2022 Aug 10. PMID: 36012171
Article Published Date : Aug 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Ovarian Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Alpha-mangostin could be beneficial to the treatment of rheumatoid arthritis.Dec 04, 2017

Pubmed Data : Curr Mol Med. 2017 Dec 5. Epub 2017 Dec 5. PMID: 29210647
Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana, Xanthones
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Apoptotic
[+]

Alpha-mangostin: A potent inhibitor of TRPV3 and pro-inflammatory cytokine secretion in keratinocytes.Aug 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Aug 18 ;24(16). Epub 2023 Aug 18. PMID: 37629111
Article Published Date : Aug 17, 2023
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Antimicrobial activity of α-mangostin against Staphylococcus species.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2023 ;13:1203663. Epub 2023 May 25. PMID: 37305406
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Staphylococcal Infections
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents
[+]

Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana.Jun 30, 2016

Pubmed Data : Pak J Pharm Sci. 2016 Jul ;29(4 Suppl):1353-7. PMID: 27592485
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Bacterial Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Plant Extracts
[+]

Bellidifolin inhibits proliferation of A549 cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oncol. 2020 ;2020:1723791. Epub 2020 Nov 21. PMID: 33299414
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lung Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
[+]

Bellidifolin protects H9c2 cells from hydrogen peroxide-induced injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2022 ;9:1655-1665. Epub 2022 Aug 17. PMID: 36518482
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants
[+]

Cytotoxicity enhancement in MCF-7 breast cancer cells with depolymerized chitosan delivery of α-mangostin.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Polymers (Basel). 2022 Aug 1 ;14(15). Epub 2022 Aug 1. PMID: 35956654
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer
Pharmacological Actions : Cytotoxicity
[+]

Cytotoxicity enhancement of α-mangostin with folate-conjugated chitosan nanoparticles in MCF-7 breast cancer cells.Nov 13, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Nov 14 ;28(22). Epub 2023 Nov 14. PMID: 38005306
Article Published Date : Nov 13, 2023
Study Type : In Vitro Study
Additional Links
Substances : Folate, Xanthones
Diseases : Breast Cancer
Pharmacological Actions : Cytotoxicity
[+]

Dietary γ-mangostin triggers immunogenic cell death and activates cGAS signaling in acute myeloid leukemia.Oct 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2023 Nov ;197:106973. Epub 2023 Oct 28. PMID: 37898441
Article Published Date : Oct 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemopreventive, Immunomodulatory
[+]

Efficacy of alpha-mangostin for antimicrobial activity against endodontopathogenic microorganisms.Dec 31, 2021

Pubmed Data : Arch Oral Biol. 2022 Jan ;133:105304. Epub 2021 Nov 5. PMID: 34775269
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Candida Albicans, Enterococcus Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells.Sep 30, 2020

Pubmed Data : Oncol Rep. 2020 Oct ;44(4):1747-1757. Epub 2020 Aug 11. PMID: 32945501
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Garcinia hanburyi, Xanthones
Diseases : Acute T cell Leukemias
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Gambogic acid inhibits Wnt/β-catenin signaling and induces ER stress-mediated apoptosis in human cholangiocarcinoma.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2021 Jun 1 ;22(6):1913-1920. Epub 2021 Jun 1. PMID: 34181351
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Wnt/β-catenin signaling pathway modulation
[+]

Gambogic acid protects LPS-induced apoptosis and inflammation.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2021 05 11 ;22(1):28. Epub 2021 May 11. PMID: 33971977
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity, Pneumonia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2018 Mar ;39(3):1485-1493. Epub 2018 Jan 16. PMID: 29344638
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway.Nov 30, 2020

Pubmed Data : Phytomedicine. 2020 Dec ;79:153334. Epub 2020 Sep 3. PMID: 32920288
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Garcinoxanthones B and C significantly inhibited nitric oxide production, which were comparable with the positive control indomethacin.Oct 31, 2016

Pubmed Data : Phytochemistry. 2016 Nov ;131:115-123. Epub 2016 Aug 22. PMID: 27561254
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Lipopolysaccharide-Induced Toxicity, Mangosteen, Natural Substances Versus Drugs, Nitric Oxide Inhibitor, Xanthones
[+]

Garmoxanthone exhibited strong antibacterial activity .Nov 12, 2017

Pubmed Data : Nat Prod Res. 2017 Nov 13:1-6. Epub 2017 Nov 13. PMID: 29132213
Article Published Date : Nov 12, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana, Xanthones
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Xanthones
[+]

Gerontoxanthone I and macluraxanthone induce mitophagy and attenuate ischemia/reperfusion injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:452. Epub 2020 Apr 15. PMID: 32351391
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function.Nov 30, 2021

Pubmed Data : Nat Prod Res. 2021 Dec ;35(23):5409-5414. Epub 2020 Jun 8. PMID: 32508145
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Immunomodulatory
[+]

Isolated xanthones to inhibit protein oxidation, as indicated by the decreases in dityrosine and N'-formylkynurenine formation.Dec 31, 2016

Pubmed Data : J Nat Med. 2017 Jan ;71(1):216-226. Epub 2016 Oct 13. PMID: 27738860
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Advanced Glycation End products (AGE), Hyperglycemia
Pharmacological Actions : Anti-Glycation Agents
Additional Keywords : Dose Response
[+]

Low-dose gambogic acid may be a potential radionuclide sensitizer.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2021 Aug ;22(2):588. Epub 2021 Jun 4. PMID: 34149899
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lung Cancer
Pharmacological Actions : Radiosensitizer
[+]

Macluraxanthone B inhibits LPS-induced inflammatory responses in RAW264.7 and BV2 cells.Jan 31, 2022

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Feb ;44(1):67-75. Epub 2021 Nov 25. PMID: 34821534
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Xanthones
[+]

Mangosteen is a functional food that could help in lowering the postprandial glucose absorption.Apr 30, 2019

Pubmed Data : J Food Biochem. 2019 May ;43(5):e12844. Epub 2019 Mar 21. PMID: 31353530
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-amylase inhibitor
[+]

Mangosteen pericarp and its bioactive xanthones: Potential therapeutic value in Alzheimer's disease, Parkinson's disease, and depression.Aug 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Aug 27 ;21(17). Epub 2020 Aug 27. PMID: 32867357
Article Published Date : Aug 26, 2020
Study Type : Review
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Alzheimer's Disease, Depression, Parkinson's Disease
Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment.Jan 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Oral Health. 2021 10 10 ;21(1):512. Epub 2021 Oct 10. PMID: 34629065
Article Published Date : Jan 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Oral Cancer
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Multitarget action of xanthones from Garcinia mangostana against α-amylase, α-glucosidase and pancreatic lipase.May 19, 2022

Pubmed Data : Molecules. 2022 May 20 ;27(10). Epub 2022 May 20. PMID: 35630761
Article Published Date : May 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Enzyme Inhibitors: Pancreatic Lipase
Additional Keywords : Xanthones
[+]

Natural prenylated xanthones as potential inhibitors of PI3k/Akt/mTOR pathway in triple negative breast cancer cells.Dec 27, 2021

Pubmed Data : Planta Med. 2021 Dec 28. Epub 2021 Dec 28. PMID: 34963183
Article Published Date : Dec 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents.Feb 18, 2024

Pubmed Data : Phytother Res. 2024 Feb 19. Epub 2024 Feb 19. PMID: 38372084
Article Published Date : Feb 18, 2024
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Gastrointestinal Inflammation
Pharmacological Actions : Antioxidants, Gastroprotective, Nrf2 activation
[+]

Natural xanthones have multifunctional activities against Alzheimer's disease. Jun 30, 2016

Pubmed Data : Neurochem Res. 2016 Jul ;41(7):1806-17. Epub 2016 Apr 2. PMID: 27038926
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
[+]

Potential antitumor effect of α-mangostin against rat mammary gland tumors induced by LA7 cells.Jun 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Jun 17 ;24(12). Epub 2023 Jun 17. PMID: 37373429
Article Published Date : Jun 16, 2023
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Potential of alpha-mangostin-loaded PLGA nanoparticles for cholangiocarcinoma treatment.Oct 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Polymers (Basel). 2022 Oct 20 ;14(20). Epub 2022 Oct 20. PMID: 36298022
Article Published Date : Oct 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Prenylated xanthones from mangosteen (Garcinia mangostana) target oxidative mitochondrial respiration in cancer cells.Aug 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2024 Aug 31 ;179:117365. Epub 2024 Aug 31. PMID: 39217837
Article Published Date : Aug 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Review xanthones and cancer: from natural sources to mechanisms of action.Dec 02, 2019

Pubmed Data : Chem Biodivers. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31794156
Article Published Date : Dec 02, 2019
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

The diverse bioactivity of α-mangostin and its therapeutic implications.Aug 18, 2021

Pubmed Data : Future Med Chem. 2021 Aug 19. Epub 2021 Aug 19. PMID: 34410182
Article Published Date : Aug 18, 2021
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Bacterial Infections, Cancers: All, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic
[+]

The effects and mechanism of α-mangostin on chemosensitivity of gastric cancer cells.May 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2021 May 18. Epub 2021 May 18. PMID: 34003591
Article Published Date : May 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
[+]

The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2022 Sep ;50(3). Epub 2022 Jul 29. PMID: 35904170
Article Published Date : Aug 31, 2022
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Cardiovascular Diseases, Metabolic Diseases
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
[+]

The neuro-healing frontier: Alpha-mangostin's potential in Alzheimer's and Parkinson's treatment.Jul 08, 2024

Pubmed Data : Comb Chem High Throughput Screen. 2024 Jul 9. Epub 2024 Jul 9. PMID: 38984574
Article Published Date : Jul 08, 2024
Study Type : Review
Additional Links
Substances : Xanthones
Diseases : Alzheimer's Disease, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The Phytochemical α-mangostin inhibits cervical cancer cell proliferation and tumor growth.Feb 02, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Feb 3 ;24(3). Epub 2023 Feb 3. PMID: 36769377
Article Published Date : Feb 02, 2023
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Cervical Cancer, Human Papillomavirus (HPV)
Pharmacological Actions : Antiproliferative , Oncogene Suppressor
[+]

The stem bark of Garcinia xanthochymus contain compounds (xanthones) with antiproliferative effects on prostate cancer cells. Jan 01, 2012

Pubmed Data : Nat Prod Commun. 2012 Jan ;7(1):53-6. PMID: 22428244
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Garcinia xanthochymus, Xanthones
Diseases : Cancer Stem Cells, Prostate Cancer, Prostate Cancer Stem Cells
Pharmacological Actions : Antiproliferative
[+]

Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma.Aug 11, 2021

Pubmed Data : Eur J Pharm Sci. 2021 Aug 12 ;166:105975. Epub 2021 Aug 12. PMID: 34391880
Article Published Date : Aug 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
[+]

Xanthones could be useful in the treatment of multidrug resistant cancers. Jan 31, 2017

Pubmed Data : Bioorg Med Chem Lett. 2017 Feb 1 ;27(3):447-449. Epub 2016 Dec 20. PMID: 28065566
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Cytotoxic
Additional Keywords : Breast Cancer, Cancers: Multi-Drug Resistant, Cytotoxic, liver cancer, Superiority of Natural Substances versus Drugs, Xanthones
[+]

Xanthones from Garcinia mangostana fruit hulls were cytotoxic against cancer cell lines.Jan 16, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 17. Epub 2017 Jan 17. PMID: 28108382
Article Published Date : Jan 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen, Xanthones
Diseases : Breast Cancer, Colorectal Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Antiproliferative, Apoptotic, Breast Cancer, Cell cycle arrest, COLORECTAL CANCER, liver cancer, Mangosteen, Xanthones
[+]

Xanthones from the roots of Calophyllum blancoi exhibit significant anti-coronavirus activity.Feb 01, 2005

Pubmed Data : Chem Pharm Bull (Tokyo). 2005 Feb ;53(2):244-7. PMID: 15684529
Article Published Date : Feb 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : Xanthones
[+]

α-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model.Jul 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2023 Aug ;37(8):3394-3407. Epub 2023 Apr 3. PMID: 37012651
Article Published Date : Jul 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

α-mangostin nanoparticles cytotoxicity and cell death modalities in breast cancer cell lines.Aug 23, 2021

Pubmed Data : Molecules. 2021 Aug 24 ;26(17). Epub 2021 Aug 24. PMID: 34500560
Article Published Date : Aug 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Xanthones
[+]

α-Mangostin suppresses melanoma growth, migration, and invasion and potentiates the anti-tumor effect of chemotherapy.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2023 ;20(9):1220-1234. Epub 2023 Aug 6. PMID: 37575275
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

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