RESVERATROL https://greenmedinfo.com/category/keywords/resveratrol en A Primer on Chronic Fatigue Syndrome https://greenmedinfo.com/blog/primer-chronic-fatigue-syndrome <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2015<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="A Primer on Chronic Fatigue Syndrome" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/chronic_fatigue_syndrome1.jpg" style="width: 450px; height: 434px;" /></p> <p class="rtecenter"><span style="font-size:18px;"><em><strong><span style="color: rgb(20, 24, 35); font-family: Helvetica, Arial, 'lucida grande', tahoma, verdana, arial, sans-serif; line-height: 20px;">With over a million Americans diagnosed Chronic Fatigue Syndrome it is important to identify natural solutions to alleviate suffering....</span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/primer-chronic-fatigue-syndrome" target="_blank">read more</a></p> https://greenmedinfo.com/blog/primer-chronic-fatigue-syndrome#comments Alcohol Autoimmune Diseases Cancer Cardiovascular Diseases Chronic Fatigue Syndrome CoQ10 Curcumin Depression Multiple Sclerosis Resveratrol Vitamin D Gluten Alcohol Autoimmune Diseases Cancer Cardiovascular Diseases Chronic Fatigue Syndrome CoQ10 CURCUMIN Depression Gluten Multiple Sclerosis Myalgic Encephalomyelitis RESVERATROL VITAMIN D Mon, 12 Jan 2015 21:15:40 +0000 courtneycraig 115975 at https://greenmedinfo.com Cancer as a Curable Metabolic Disease https://greenmedinfo.com/blog/cancer-curable-metabolic-disease <p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><strong><span style="color: rgb(34, 34, 34); background-color: rgb(255, 255, 255);">This article is copyrighted by Jeffrey Dach MD, 2013</span><br style="color: rgb(34, 34, 34); font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-size: 13px; background-color: rgb(255, 255, 255);" /> <span style="color: rgb(34, 34, 34); background-color: rgb(255, 255, 255);">Republished with permission from <a href="https://jeffreydachmd.com/2015/01/cancer-metabolic-disease-jeffrey-dach-md/" rel="dofollow" target="_blank">JeffreyDachMD.com</a></span></strong></span></span></p> <p class="rtecenter"><img alt="Cancer as a Metabolic Disease" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/cancer_metabolic_disease.jpg" /></p><p><a href="https://greenmedinfo.com/blog/cancer-curable-metabolic-disease" target="_blank">read more</a></p> https://greenmedinfo.com/blog/cancer-curable-metabolic-disease#comments Berberine Betulinic acid Breast Cancer Cancer Curcumin Glioblastoma Grapes Lung Cancer Prostate Cancer Pterostilbene Resveratrol Vitamin K Chemotherapy Berberine Betulinic acid Breast Cancer Cancer Chemotherapy CURCUMIN Glioblastoma Grapes lung cancer prostate cancer Pterostilbene RESVERATROL Vitamin K Wed, 14 Jan 2015 20:23:49 +0000 drdach 115995 at https://greenmedinfo.com Flaxseed May Be a Potent Ovarian Cancer KILLER https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Flaxseed: Ovarian Cancer KILLER? " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/ovarian.png" style="width: 600px; height: 400px;" title="Flaxseed May Be A Potent Ovarian Cancer KILLER" /></p> <p><span style="font-size:18px;"><em><strong>Effective and safe treatments for ovarian cancer simply do not exist today within conventional medical practice. However, promising research indicates that flaxseed and at least 30 other natural substances do have potent anti-ovarian cancer properties</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer" target="_blank">read more</a></p> https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer#comments Curcumin Flaxseed Genistein Ovarian Cancer Ovarian Cancer Stem Cell Ovarian Cancer: Estrogen Induced Resveratrol Turmeric Bisphenol A Cancer Cow Milk anti-tumor cure Ovarian cancer flaxseed kill cancer kill Ovarian cancer ovarian cancer Overdiagnosis RESVERATROL Thu, 11 Sep 2014 16:14:48 +0000 Sayer Ji 114733 at https://greenmedinfo.com French “Paradox” Solved: It’s Not The Red Wine https://greenmedinfo.com/blog/french-%E2%80%9Cparadox%E2%80%9D-solved-it%E2%80%99s-not-red-wine <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="French " not="" red="" s="" solved:="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/RedWine.jpg" style="width: 460px; height: 288px;" the="" /></p> <p>In 1993 French researcher Serge Renaud coined the phrase "the French paradox." &nbsp;He was referring to the mysterious heart health enjoyed by the French despite their high saturated fat diet. &nbsp;Ever since then, people all over the world have been guzzling red <strong><a href="/substance/wine-0">wine</a></strong> and popping <strong><a href="/substance/resveratrol">resveratrol</a></strong> pills in an effort to duplicate the effect.</p> <p>Some 20 years later, researchers are now suggesting that rather than red wine, the secret to the French paradox may be the protective effect of their aged cheeses.</p><p><a href="https://greenmedinfo.com/blog/french-%E2%80%9Cparadox%E2%80%9D-solved-it%E2%80%99s-not-red-wine" target="_blank">read more</a></p> https://greenmedinfo.com/blog/french-%E2%80%9Cparadox%E2%80%9D-solved-it%E2%80%99s-not-red-wine#comments Cardiovascular Disease Cheese Red Wine Mediterranean diet Cardiovascular Disease cheese Mediterranean diet Red Wine RESVERATROL wine Sun, 17 Nov 2013 20:43:26 +0000 mmking 110392 at https://greenmedinfo.com Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. https://greenmedinfo.com/article/resveratrol-ameliorates-muscular-pathology-dystrophic-mdx-mouse-model-duchenne n/a PMID:  J Pharmacol Exp Ther. 2011 Sep ;338(3):784-94. Epub 2011 Jun 7. PMID: 21652783 Abstract Title:  Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. Abstract:  Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. We previously showed that resveratrol (3,5,4&#039;-trihydroxy-trans-stilbene), an antioxidant and activator of the NAD(+)-dependent protein deacetylase SIRT1, delays the progression of heart failure and prolongs the lifespan ofδ-sarcoglycan-deficient hamsters. Because a defect of dystroglycan complex causes muscular dystrophies, and δ-sarcoglycan is a component of this complex, we hypothesized that resveratrol might be a new therapeutic tool for muscular dystrophies. Here, we examined resveratrol&#039;s effect in mdx mice, an animal model of Duchenne muscular dystrophy. mdx mice that received resveratrol in the diet for 32 weeks (4 g/kg diet) showed significantly less muscle mass loss and nonmuscle interstitial tissue in the biceps femoris compared with mdx mice fed a control diet. In the muscles of these mice, resveratrol significantly decreased oxidative damage shown by the immunostaining of nitrotyrosine and 8-hydroxy-2&#039;-deoxyguanosine and suppressed the up-regulation of NADPH oxidase subunits Nox4, Duox1, and p47(phox). Resveratrol also reduced the number of α-smooth muscle actin (α-SMA)(+) myofibroblast cells and endomysial fibrosis in the biceps femoris, although the infiltration of CD45(+) inflammatory cells and increase in transforming growth factor-β1 (TGF-β1) were still observed. In C2C12 myoblast cells, resveratrol pretreatment suppressed the TGF-β1-induced increase in reactive oxygen species, fibronectin production, and expression of α-SMA, and SIRT1 knockdown blocked these inhibitory effects. SIRT1 small interfering RNA also increased the expression of Nox4, p47(phox), and α-SMA in C2C12 cells. Taken together, these findings indicate that SIRT1 activation may be a useful strategy for treating muscular dystrophies. https://greenmedinfo.com/article/resveratrol-ameliorates-muscular-pathology-dystrophic-mdx-mouse-model-duchenne#comments Duchenne's Muscular Dystrophy Resveratrol Stilbenes Antioxidants Duchenne's Muscular Dystrophy RESVERATROL Stilbenes Animal Study Sun, 12 Feb 2017 22:16:19 +0000 greenmedinfo 143390 at https://greenmedinfo.com Resveratrol exerts neuroprotective effects on spinal cord injury by regulating autophagy and apoptosis. https://greenmedinfo.com/article/resveratrol-exerts-neuroprotective-effects-spinal-cord-injury-regulating-autop n/a PMID:  Neuroscience. 2017 Feb 23. Epub 2017 Feb 23. PMID: 28238848 Abstract Title:  Resveratrol Protects Against Spinal Cord Injury by Activating Autophagy and Inhibiting Apoptosis Mediated by the SIRT1/AMPK Signaling Pathway. Abstract:  Spinal cord injury (SCI) is a devastating condition with few effective treatments. Resveratrol, a polyphenolic compound, has exhibited neuroprotective effects in many neurodegenerative diseases. However, the explicit effect and mechanism of resveratrol on SCI is still unclear. Adenosine 5&#039; monophosphate-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1),the downstream protein, play key roles in metabolizing of energy, resisting of resistance, and cellularprotein homeostasis. In this study, we determined the effects of resveratrol on SCI and their potential relationship with SIRT1/AMPK signaling pathway, autophagy and apoptosis. To determine theeffect of resveratrol on SCI recovery, a spinal cord contusion model was employed. Rats received treatment with resveratrol or DMSO immediately following contusion. We determined that Basso, Beattie, and Bresnahan (BBB) scores were significantly higher for injured rats treated with resveratrol. Nissl and HE staining revealed that resveratrol treatment significantly reduced the loss of motor neurons and lesion size in the spinal cord of injured rats when compared to vehicle-treated animals. Spinal cord tissue was assessed by Western blot, reverse transcriotion-polymerase chain reaction (RT-PCR)and immunohistochemical analyses 7 days after injury for changes in expression of SIRT1/AMPK signaling pathway, autophagy and apoptosis proteins. Expression of SIRT1, p-AMPK, Beclin-1, LC3-B, and Bcl-2 was elevated in resveratrol-treated animals, whereas expression of p62, Cleaved Caspase-3, Caspase-9, and Bcl-2 associated X protein (Bax) was inhibited. Immunofluorescence analysis of primary neurons treated with resveratrol alone or in combination with Compound C (AMPK inhibitor) or EX527 (SIRT1 inhibitor) revealed that treatment with the inhibitors blocks the increase LC3-B expression in cells and increases the portion of TUNEL positive cells. Taken together, these results suggest that resveratrol exerts neuroprotective effects on SCI by regulating autophagy and apoptosis mediated by the SIRT1-AMPK signaling pathway. https://greenmedinfo.com/article/resveratrol-exerts-neuroprotective-effects-spinal-cord-injury-regulating-autop#comments Resveratrol Spinal Cord Injuries Neuroprotective Agents Neuroprotective Agents RESVERATROL Spinal Cord Injuries Animal Study Sat, 04 Mar 2017 00:53:33 +0000 greenmedinfo 144397 at https://greenmedinfo.com Resveratrol might be a promising therapeutic treatment for obesity-related osteoarthritis. https://greenmedinfo.com/article/resveratrol-might-be-promising-therapeutic-treatment-obesity-related-osteoarth n/a PMID:  Mediators Inflamm. 2017 ;2017:7659023. Epub 2017 Jan 29. PMID: 28250578 Abstract Title:  Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet. Abstract:  Obesity has been associated with osteoarthritis (OA) due to increased mass and metabolic factors which are independent of the biomechanical contribution to joint load. Resveratrol, a natural polyphenolic compound, exerts protective effects on OA through its anti-inflammatory property. However, the mechanism of resveratrol on obesity-related OA is unclear. To investigate the effect and possible mechanism of oral resveratrol on obesity-related OA, we fed C57BL/6J mice with a high-fat diet (HFD) for 16 weeks to establish obesity-related OA model; then two doses (22.5 mg/kg and 45 mg/kg) of resveratrol were given by gavage for additional 12 weeks. Mice with HFD significantly increased body weights compared to the control mice, while resveratrol treatment did not cause obvious weight loss. Histological assessments showed that resveratrol at 45 mg/kg significantly improved OA symptoms. Levels of serum IL-1β and leptin were decreased by resveratrol treatment and positively correlated with Mankin scores. Moreover, resveratrol significantly inhibited the expression of TLR4 and TRAF6 in cartilage. These results suggest that HFD induced obesity can lead tothe occurrence of OA, and resveratrol may alleviate OA pathology by decreasing the levels of systematic inflammation and/or inhibiting TLR4 signaling pathway in cartilage. Thus, resveratrol might be a promising therapeutic treatment for obesity-related OA. https://greenmedinfo.com/article/resveratrol-might-be-promising-therapeutic-treatment-obesity-related-osteoarth#comments High Fat Diet Osteoarthritis Resveratrol Anti-Inflammatory Agents Interleukin-1 beta downregulation Anti-Inflammatory Agents high fat diet Interleukin-1 beta downregulation osteoarthritis RESVERATROL Animal Study Sat, 04 Mar 2017 00:08:06 +0000 greenmedinfo 144387 at https://greenmedinfo.com Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma. https://greenmedinfo.com/article/resveratrol-prevents-endothelial-cells-injury-high-dose-interleukin-2-therapy- n/a PMID:  PLoS One. 2012 ;7(4):e35650. Epub 2012 Apr 20. PMID: 22532866 Abstract Title:  Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma. Abstract:  Immunotherapy with high-dose interleukin-2 (HDIL-2) is an effective treatment for patients with metastatic melanoma and renal cell carcinoma. However, it is accompanied by severe toxicity involving endothelial cell injury and induction of vascular leak syndrome (VLS). In this study, we found that resveratrol, a plant polyphenol with anti-inflammatory and anti-cancer properties, was able to prevent the endothelial cell injury and inhibit the development of VLS while improving the efficacy of HDIL-2 therapy in the killing of metastasized melanoma. Specifically, C57BL/6 mice were injected with B16F10 cells followed by resveratrol by gavage the next day and continued treatment with resveratrol once a day. On day 9, mice received HDIL-2. On day 12, mice were evaluated for VLS and tumor metastasis. We found that resveratrol significantly inhibited the development of VLS in lung and liver by protecting endothelial cell integrity and preventing endothelial cells from undergoing apoptosis. The metastasis and growth of the tumor in lung were significantly inhibited by HDIL-2 and HDIL-2 + resveratrol treatment. Notably, HDIL-2 + resveratrol co-treatment was more effective in inhibiting tumor metastasis and growth than HDIL-2 treatment alone. We also analyzed the immune status of Gr-1(+)CD11b(+) myeloid-derived suppressor cells (MDSC) and FoxP3(+)CD4(+) regulatory T cells (Treg). We found that resveratrol induced expansion and suppressive function of MDSC which inhibited the development of VLS after adoptive transfer. However, resveratrol suppressed the HDIL-2-induced expansion of Treg cells. We also found that resveratrol enhanced the susceptibility of melanoma to the cytotoxicity of IL-2-activated killer cells, and induced the expression of the tumor suppressor gene FoxO1. Our results suggested the potential use of resveratrol in HDIL-2 treatment against melanoma. We also demonstrated, for the first time, that MDSC is the dominant suppressor cell than regulatory T cell in the development of VLS. https://greenmedinfo.com/article/resveratrol-prevents-endothelial-cells-injury-high-dose-interleukin-2-therapy-#comments Lung Cancer Melanoma Resveratrol Anti-metastatic Chemoprotective Agents Chemosensitizer Anti-metastatic Chemoprotective Agents Chemosensitizer lung cancer melanoma RESVERATROL In Vitro Study Thu, 20 Jul 2017 00:40:59 +0000 greenmedinfo 150717 at https://greenmedinfo.com Resveratrol significantly improves survival in the hamster model of Duchenne's Muscular Dystrophy https://greenmedinfo.com/article/resveratrol-significantly-improves-survival-hamster-model-duchennes-muscular-d n/a PMID:  Ann N Y Acad Sci. 2015 Aug ;1348(1):46-54. Epub 2015 Jun 24. PMID: 26109180 Abstract Title:  The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy. Abstract:  The muscular dystrophies, which cause progressive weakening of the skeletal muscles, are frequently associated with cardiomyopathy. In fact, the leading cause of mortality in patients with Duchenne muscular dystrophy, the most common and most severe type of muscular dystrophy, is heart failure due to cardiomyopathy. Therefore, more effective methods for treating cardiomyopathy are expected to improve long-term outcomes for patients with Duchenne muscular dystrophy. Our recent preclinical data show that treatment with the SIRT1 activator resveratrol is beneficial for dystrophic cardiomyopathy. We examined the effects of resveratrol treatment in two different models of muscular dystrophy: dystrophin-deficient mdx mice andδ-sarcoglycan-deficient TO-2 hamsters. In both models, resveratrol suppressed cardiac hypertrophy, preserved cardiac function, and reduced tissue fibrosis in the diseased heart. Importantly, resveratrol significantly improved survival in TO-2 hamsters. Resveratrol also attenuated skeletal muscle pathology in mdx mice. These promising results indicate resveratrol&#039;s potential for clinical translation to treat cardiomyopathy in patients with muscular dystrophies. https://greenmedinfo.com/article/resveratrol-significantly-improves-survival-hamster-model-duchennes-muscular-d#comments Duchenne's Muscular Dystrophy Resveratrol Stilbenes Duchenne's Muscular Dystrophy RESVERATROL Stilbenes Animal Study Sun, 12 Feb 2017 22:15:21 +0000 greenmedinfo 143389 at https://greenmedinfo.com Resveratrol supplementation increased PTX3 and TAS levels in a dose-dependent manner in T2DM patients. https://greenmedinfo.com/article/resveratrol-supplementation-increased-ptx3-and-tas-levels-dose-dependent-manne n/a PMID:  Acta Diabetol. 2017 Feb 25. Epub 2017 Feb 25. PMID: 28238190 Abstract Title:  Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial. Abstract:  AIMS: The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40 mg/day) has an impact on PTX3 values in T2DM patients from a double-blind randomized placebo-controlled trial. Variations in total antioxidant status (TAS) were evaluated too. METHODS: A total of 192 T2DM patients were randomized to receive resveratrol 500 mg/day (Resv 500 arm), resveratrol 40 mg/day (Resv 40 arm) or placebo for 6 months. At baseline and at the trial end, PTX3 and TAS values were determined. RESULTS: A dose-dependent increase in PTX3 concentrations of 4.7% (Resv 40 arm) and 26.3% (Resv 500 arm), and 8.0% reduction after placebo were found. Adjusted mean differences of change versus placebo were 0.16 (95% CI 0.01-0.32) and 0.25 (0.09-0.42) in the Resv 40 and Resv 500 arms, respectively. At subgroup analyses, lower diabetes duration, aspirin, alcohol use, younger age, female gender, smoking (Resv 500 arm) and female gender and aspirin use (Resv 40 arm) were associated with higher PTX3 increments. A dose-dependent increment in TAS values in the resveratrol arms (1.4 and 6.4% for Resv 40 and Resv 500, respectively), and a reduction in placebo arm (-8.9%) were observed. Adjusted mean differences of change were 28.5 (95% CI 10.1-46.8) and 44.8 (25.4-64.1) in the Resv 40 and Resv 500 arms, respectively. CONCLUSION: Resveratrol supplementation increased PTX3 and TAS levels in a dose-dependent manner in T2DM patients. At present, potential clinical implications of these results remain unclear. CLINICALTRIALS. GOV IDENTIFIER: NCT02244879. https://greenmedinfo.com/article/resveratrol-supplementation-increased-ptx3-and-tas-levels-dose-dependent-manne#comments Diabetes Mellitus: Type 2 Resveratrol Diabetes mellitus: Type 2 Dose Response RESVERATROL Human Study Sat, 04 Mar 2017 00:57:11 +0000 greenmedinfo 144400 at https://greenmedinfo.com These findings add new experimental data for potential therapeutic effects of resveratrol in the brain in a model of subacute systemic inflammation. https://greenmedinfo.com/article/these-findings-add-new-experimental-data-potential-therapeutic-effects-resvera n/a PMID:  Ann Clin Lab Sci. 2017 Jan ;47(1):17-24. PMID: 28249911 Abstract Title:  Resveratrol Attenuates Subacute Systemic Inflammation-Induced Spatial Memory Impairment via Inhibition of Astrocyte Activation and Enhancement of Synaptophysin Expression in the Hippocampus. Abstract:  The aim of this study was to investigate the role of resveratrol on subacute systemic inflammation-induced dysfunction of cognitive memory in mice and its underlying mechanism. Male ICR mice were trained in a water maze for four days of acquisition training and one day of probe trial. Subacute treatment with lipopolysaccharide (LPS) (1 mg/kg) by intraperitoneal injection for 5 days was used to establish a systemic inflammatory model. All mice were sacrificed after probe testing, then the expression of glial fibrillary acidic protein (GFAP), synaptophysin, and sirtuin1 (SIRT1) in hippocampi were determined using immunohistochemistry or western blot analysis. Morris water maze tests indicated that hippocampus-dependent spatial learning and memory were impaired in LPS-treated group. Resveratrol attenuated LPS-induced memory deficit in dose-dependent manner. Immunohistochemistry and western blot analysis revealed that LPS increased hippocampal GFAP expression and inhibited synaptophysin expression, which were prevented by resveratrol treatment. Treatment with LPS declined the SIRT1 protein expression in the hippocampus, which could be prevented by resveratrol. The protective effect of resveratrol could be abolished by a specific SIRT1 inhibitor. Our findings add new experimental data for potential therapeutic effects of resveratrol in the brain in a model of subacute systemic inflammation-induced astrocyte activation, synaptic alteration and cognitive decline. https://greenmedinfo.com/article/these-findings-add-new-experimental-data-potential-therapeutic-effects-resvera#comments Brain Inflammation Cognitive Decline/Dysfunction Resveratrol Anti-Inflammatory Agents Neuroprotective Agents Anti-Inflammatory Agents Brain Inflammation Cognitive Decline/Dysfunction Dose Response Neuroprotective Agents RESVERATROL Animal Study In Vitro Study Sat, 04 Mar 2017 00:47:43 +0000 greenmedinfo 144395 at https://greenmedinfo.com