bladder cancer https://greenmedinfo.com/category/keywords/bladder-cancer en Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin. https://greenmedinfo.com/article/inhibition-pyruvate-kinase-m2-markedly-reduces-chemoresistance-advanced-bladde n/a PMID:  Sci Rep. 2017 Apr 5 ;7:45983. Epub 2017 Apr 5. PMID: 28378811 Abstract Title:  Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin. Abstract:  Chemoresistance to cisplatin is a principal cause of treatment failure and mortality of advanced bladder cancer (BC). The underlying mechanisms remain unclear, which hinders the development of preventive strategies. Recent data indicate that pyruvate kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregulated in BC. This study explores the role of PKM2 in chemoresistance and whether inhibiting PKM2 augments the chemosensitivity to cisplatin and reduces BC growth and progression. We found that Shikonin binds PKM2 and inhibits BC cell survival in a dose-dependent but pyruvate kinase activity-independent manner. Down-regulation of PKM2 by shRNA blunts cellular responses to shikonin but enhances the responses to cisplatin. Shikonin and cisplatin together exhibit significantly greater inhibition of proliferation and apoptosis than when used alone. Induced cisplatin-resistance is strongly associated with PKM2 overexpression, and cisplatin-resistant cells respond sensitively to shikonin. In syngeneic mice, shikonin and cisplatin together, but not as single-agents, markedly reduces BC growth and metastasis. Based on these data, we conclude that PKM2 overexpression is a key mechanism of chemoresistance of advanced BC to cisplatin. Inhibition of PKM2 via RNAi or chemical inhibitors may be a highly effective approach to overcome chemoresistance and improve the outcome of advanced BC. https://greenmedinfo.com/article/inhibition-pyruvate-kinase-m2-markedly-reduces-chemoresistance-advanced-bladde#comments Bladder Cancer Shikonin Antiproliferative Apoptotic Chemosensitizer Antiproliferative Apoptotic bladder cancer Chemosensitizer Chemotherapeutic Synergy: Cisplatin Dose Response Shikonin In Vitro Study Wed, 03 May 2017 15:21:01 +0000 greenmedinfo 147160 at https://greenmedinfo.com Is Cancer Just a Crapshoot? https://greenmedinfo.com/blog/cancer-just-crapshoot <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2015<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Is Cancer Just a Crapshoot?" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/cancer_crapshoot.jpg" style="width: 600px; height: 399px;" /></p> <p class="rtecenter">Written by Jon Barron or staff member at <strong><a href="http://jonbarron.org/cancer-alternative-cancer-therapies/cancer-just-crapshoot#" target="_blank">The Baseline of Health Foundation</a></strong>.</p><p><a href="https://greenmedinfo.com/blog/cancer-just-crapshoot" target="_blank">read more</a></p> https://greenmedinfo.com/blog/cancer-just-crapshoot#comments Bladder Cancer Breast Cancer Cancer Cervical Cancer Cirrhosis Colorectal Cancer Endometrial Cancer Hepatitis B Hepatitis C Kidney Cancer Liver Cancer Lung Cancer Osteosarcoma Pancreatic Cancer Prostate Cancer Skin Cancer Smoking Thyroid Cancer bladder cancer Breast Cancer Cancer Cervical Cancer Cirrhosis COLORECTAL CANCER Endometrial Cancer Hepatitis B hepatitis C Kidney Cancer liver cancer lung cancer Osteosarcoma Pancreatic Cancer prostate cancer skin cancer Smoking Thyroid Cancer Tue, 20 Jan 2015 17:34:44 +0000 jonbarron 116083 at https://greenmedinfo.com Kimchi Packs Proven Health Benefits https://greenmedinfo.com/blog/kimchi-packs-proven-health-benefits <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><br /> <span style="font-size:22px;"><em><strong><img alt="Kimchi Packs Proven Health Benefits" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/kimchi.jpg" style="width: 460px; height: 276px;" title="Kimchi Packs Proven Health Benefits" /></strong></em></span></p> <p><span style="font-size:22px;"><em><strong>Koreans have been enjoying salted and fermented vegetables known as <a href="/substance/kimchi" rel="dofollow" target="_blank" title="Kimchi Packs Proven Health Benefits">kimchi</a> for about 2000 years. It's typically served with steamed rice at every Korean meal. But this spicy dish is much more than a condiment&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/kimchi-packs-proven-health-benefits" target="_blank">read more</a></p> https://greenmedinfo.com/blog/kimchi-packs-proven-health-benefits#comments Apples beta-Carotene Bladder Cancer Cabbage Cancer Carotenoids Collagen Colon Cancer Diarrhea Fermented Foods and Beverages Fish Garlic Ginger Kimchi Obesity Pear Pine Nut Potassium Probiotics Stress Vitamin C Watercress Antibiotics antibiotics beta-carotene bladder cancer CAROTENOIDS Collagen COLON CANCER Diarrhea Garlic Ginger Kimchi potassium probiotics Tooth Decay Vitamin C Sun, 08 Apr 2018 13:51:25 +0000 GMI Research Group 113250 at https://greenmedinfo.com This meta-analysis suggests that processed meat may be associated with bladder cancer risk. https://greenmedinfo.com/article/meta-analysis-suggests-processed-meat-may-be-associated-bladder-cancer-risk n/a PMID:  Eur J Nutr. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28070638 Abstract Title:  Red and processed meat consumption and risk of bladder cancer: a dose-response meta-analysis of epidemiological studies. Abstract:  BACKGROUND/OBJECTIVES: Several epidemiological studies have analyzed the associations between red and processed meat and bladder cancer risk but the shape and strength of the associations are still unclear. Therefore, we conducted a dose-response meta-analysis to quantify the potential association between red and processed meat and bladder cancer risk. METHODS: Relevant studies were identified by searching the PubMed database through January 2016 and reviewing the reference lists of the retrieved articles. Results were combined using random-effects models. RESULTS: Five cohort studies with 3262 cases and 1,038,787 participants and 8 cases-control studies with 7009 cases and 27,240 participants met the inclusion criteria. Red meat was linearly associated with bladder cancer risk in case-control studies, with a pooled RR of 1.51 (95% confidence interval (CI) 1.13, 2.02) for every 100 g increase per day, while no association was observed among cohort studies (P heterogeneity across study design = 0.02). Based on both case-control and cohort studies, the pooled relative risk (RR) for every 50 g increase of processed meat per day was 1.20 (95% CI 1.06, 1.37) (P heterogeneity across study design = 0.22). CONCLUSIONS: This meta-analysis suggests that processed meat may be positively associated with bladder cancer risk. A positive association between red meat and risk of bladder cancer was observed only in case-control studies, while no association was observe in prospective studies. https://greenmedinfo.com/article/meta-analysis-suggests-processed-meat-may-be-associated-bladder-cancer-risk#comments Bladder Cancer Meat bladder cancer Cancer Dose Response Meat Meta Analysis red meat Risk Factors Tue, 17 Jan 2017 21:53:04 +0000 greenmedinfo 142102 at https://greenmedinfo.com Vitamin K2 induces apoptosis in bladder cancer cells. https://greenmedinfo.com/article/vitamin-k2-induces-apoptosis-bladder-cancer-cells n/a PMID:  PLoS One. 2016 ;11(8):e0161886. Epub 2016 Aug 29. PMID: 27570977 Abstract Title:  Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways. Abstract:  The effects of vitamin K2 on apoptosis in a variety of cancer cells have been well established in previous studies. However, the apoptotic effect of vitamin K2 on bladder cancer cells has not been evaluated. The aim of this study is to examine the apoptotic activity of Vitamin K2 in bladder cancer cells and investigate the underlying mechanism. In this study, Vitamin K2 induced apoptosis in bladder cancer cells through mitochondria pathway including loss of mitochondria membrane potential, cytochrome C release and caspase-3 cascade. Furthermore, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAPK was detected in Vitamin K2-treated cells and both SP600125 (an inhibitor of JNK) and SB203580 (an inhibitor of p38 MAPK) completely abolished the Vitamin K2-induced apoptosis and loss of mitochondria membrane potential. Moreover, the generation of reactive oxygen species (ROS) was detected in bladder cancer cells, upon treatment of vitamin K2 and the anti-oxidant N-acetyl cysteine (NAC) almost blocked the Vitamin K2-triggered apoptosis, loss of mitochondria membrane potential and activation of JNK and p38 MAPK. Taken together, these findings revealed that Vitamin K2 induces apoptosis in bladder cancer cells via ROS-mediated JNK/p38 MAPK and Mitochondrial pathways. https://greenmedinfo.com/article/vitamin-k2-induces-apoptosis-bladder-cancer-cells#comments Bladder Cancer Vitamin K2 Apoptotic Apoptotic bladder cancer Cancer Vitamin K Vitamin K2 In Vitro Study Sun, 08 Jan 2017 20:33:20 +0000 greenmedinfo 141643 at https://greenmedinfo.com