oxidative stress https://greenmedinfo.com/category/keywords/oxidative-stress en A leaf extract of Dandelion and its main compound activated nuclear factor erythroid 2-related factor 2 and induced heme oxygenase 1. https://greenmedinfo.com/article/leaf-extract-dandelion-and-its-main-compound-activated-nuclear-factor-erythroi n/a PMID:  J Med Food. 2016 Dec 27. Epub 2016 Dec 27. PMID: 28026992 Abstract Title:  Sesquiterpene Lactone Composition and Cellular Nrf2 Induction of Taraxacum officinale Leaves and Roots and Taraxinic Acidβ-d-Glucopyranosyl Ester. Abstract:  Taraxacum officinale, the common dandelion, is a plant of the Asteraceae family, which is used as a food and medical herb. Various secondary plant metabolites such as sesquiterpene lactones, triterpenoids, flavonoids, phenolic acids, coumarins, and steroids have been described to be present in T. officinale. Dandelion may exhibit various health benefits, including antioxidant, anti-inflammatory, and anticarcinogenic properties. We analyzed the leaves and roots of the common dandelion (T. officinale) using high-performance liquid chromatography/mass spectrometry to determine its sesquiterpene lactone composition. The main compound of the leaf extract taraxinic acidβ-d-glucopyranosyl ester (1), a sesquiterpene lactone, was isolated and the structure elucidation was conducted by nuclear magnetic resonance spectrometry. The leaf extract and its main compound 1 activated the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in human hepatocytes more significantly than the root extract. Furthermore, the leaf extract induced the Nrf2 target gene heme oxygenase 1. Overall, present data suggest that compound 1 may be one of the active principles of T. officinale. https://greenmedinfo.com/article/leaf-extract-dandelion-and-its-main-compound-activated-nuclear-factor-erythroi#comments Dandelion Oxidative Stress Antioxidants Heme oxygenase-1 inducer Nrf2 activation Antioxidants Dandelion Heme oxygenase-1 inducer Nrf2 activation oxidative stress Plant Extracts In Vitro Study Tue, 03 Jan 2017 00:16:53 +0000 greenmedinfo 141323 at https://greenmedinfo.com A review of the antioxidant activity of celery. https://greenmedinfo.com/article/review-antioxidant-activity-celery n/a PMID:  J Evid Based Complementary Altern Med. 2017 Jan 1:2156587217717415. Epub 2017 Jan 1. PMID: 28701046 Abstract Title:  A Review of the Antioxidant Activity of Celery ( Apium graveolens L). Abstract:  Plants are an important source of natural active products that are different, based on mechanism and biological properties. Celery ( Apium graveolens L) is a plant from the apiaceae family and phenolic and antioxidant compounds of this plant have been studied by several scientists. The aim of this study was to review systematically the antioxidant activity of celery. Required articles were searched from databases such as Science Direct, PubMed, Scopus, and Springer. Keywords used in this study were Apium graveolens L, celery, antioxidant, free radical, leaf, and seed. Out of 980 collected articles (published in the period 1997-2015), 9 studies finally met the inclusion criteria and were considered. Celery, because of compounds such as caffeic acid, p-coumaric acid, ferulic acid, apigenin, luteolin, tannin, saponin, and kaempferol, has powerful antioxidant characteristics, to remove free radicals. It is clear that celery, with different compounds and diverse concentration can have varied healing effects. It is suggested that the next studies concentrate on other therapeutic and industrial attributes of celery. https://greenmedinfo.com/article/review-antioxidant-activity-celery#comments Celery Oxidative Stress Antioxidants Antioxidants celery oxidative stress Review Wed, 19 Jul 2017 22:26:39 +0000 greenmedinfo 150694 at https://greenmedinfo.com Acute exposure to sunscreen containing titanium induces an adaptive response and oxidative stress in Mytillus galloprovincialis. https://greenmedinfo.com/article/acute-exposure-sunscreen-containing-titanium-induces-adaptive-response-and-oxi n/a PMID:  Ecotoxicol Environ Saf. 2018 Mar ;149:58-63. Epub 2017 Nov 15. PMID: 29154135 Abstract Title:  Acute exposure to sunscreen containing titanium induces an adaptive response and oxidative stress in Mytillus galloprovincialis. Abstract:  The use of sunscreens to protect against ultraviolet radiation exposure progressively increases as result of a greater awareness of the people and the greater arrival of tourists. The components of these creams can end up in the waters affecting coastal species. Mediterranean mussels (Mytillus galloprovincialis) were subjected to an acute exposure of a sunscreen with TiOin their composition during 24h. The low and medium concentrations used in the assays contained a concentration of TiOin the range of values found in coastal waters of the Balearic Islands. Titanium and metallothionein concentrations were progressively increasing in gills with the sunscreen concentration in a dose-dependent manner. The activities of the antioxidant enzymes and the detoxification glutathione s-transferase evidenced a hormetic shape response with increased activities at lower sunscreen concentrations, a response that was abolished at the highest concentration. In accordance with these enzyme activities, the levels of malondialdehyde, as a marker of lipid peroxidation, were significantly elevated by the higher sunscreen concentrations. Acetylcholinesterase activity maintained control activities except for the highest sunscreen concentration, where a significant decrease was evidenced. In conclusion, the treatment of mussels with a sunscreen containing TiOin the range of Balearic coastal waters induces an adaptive response that is overcome by the highest concentration. Follow-up biomonitoring studies are necessary to control the concentration of sunscreen compound in coastal waters such as titanium since they can induce oxidative stress to affected organisms. https://greenmedinfo.com/article/acute-exposure-sunscreen-containing-titanium-induces-adaptive-response-and-oxi#comments Lipid Peroxidation Oxidative Stress Sunscreen Titanium Dioxide Environmental Pollution Lipid Peroxidation oxidative stress Sunscreen Titanium Dioxide Animal Study Tue, 05 Jun 2018 23:43:52 +0000 greenmedinfo 165310 at https://greenmedinfo.com Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress https://greenmedinfo.com/article/adaptogenic-potential-royal-jelly-liver-rats-exposed-chronic-stress n/a PMID:  PLoS One. 2018 ;13(1):e0191889. Epub 2018 Jan 29. PMID: 29377921 Abstract Title:  Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress. Abstract:  Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ. https://greenmedinfo.com/article/adaptogenic-potential-royal-jelly-liver-rats-exposed-chronic-stress#comments Oxidative Stress Royal Jelly Antioxidants Hepatoprotective Antioxidants Hepatoprotective oxidative stress Royal Jelly Animal Study Thu, 08 Feb 2018 02:52:05 +0000 greenmedinfo 159477 at https://greenmedinfo.com Allicin attenuates liver oxidative stress and inflammation. https://greenmedinfo.com/article/allicin-attenuates-liver-oxidative-stress-and-inflammation n/a PMID:  J Agric Food Chem. 2016 Sep 28 ;64(38):7104-13. Epub 2016 Sep 19. PMID: 27584700 Abstract Title:  Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions. Abstract:  This study investigated the liver-protective effects of allicin, an active compound in fresh garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were investigated in an AFLD model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Allicin (5 and 20 mg/kg bw/day) was orally administered daily in the AFLD mice for 4 weeks. The results indicate that allicin promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels (p&lt;0.05) in the plasma, which are key indicators of liver damage. Allicin reduced fat accumulation, increased glutathione and catalase levels, and decreased microsomal protein cytochrome P450 2E1 (CYP2E1) expression (p&lt;0.05) in the livers of the AFLD mice. Furthermore, allicin supplementation significantly decreased the levels of proinflammatory tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 and suppressed the expression of sterol regulatory element-binding protein-1 (SREBP-1) (p&lt;0.05). Additionally, it improved the hepatic alcohol dehydrogenase (ADH) activity (p&lt;0.05). Collectively, these findings demonstrate that allicin attenuates liver oxidative stress and inflammation. https://greenmedinfo.com/article/allicin-attenuates-liver-oxidative-stress-and-inflammation#comments Alcohol Toxicity Allicin Fatty Liver Inflammation Oxidative Stress Anti-Inflammatory Agents Antioxidants Interleukin-1 beta downregulation Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Alcohol Toxicity Allicin Anti-Inflammatory Agents Fatty Liver Inflammation oxidative stress Animal Study Thu, 07 Sep 2017 22:51:53 +0000 greenmedinfo 152922 at https://greenmedinfo.com Allicin could be used in protection in traumatic spinal cord injury. https://greenmedinfo.com/article/allicin-could-be-used-protection-traumatic-spinal-cord-injury n/a PMID:  Mol Med Rep. 2016 Oct ;14(4):3086-92. Epub 2016 Aug 19. PMID: 27573340 Abstract Title:  Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in mice. Abstract:  Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P&lt;0.01) and reduced the spinal cord water content (P&lt;0.01). This protective effect was associated with the inhibition of oxidative stress and inflammatory responses in TSCI mice. Western blot analysis demonstrated that allicin increased the protein levels of HSP70, increased the phosphorylation of Akt and reduced the iNOS protein expression levels in TSCI mice. Additionally, treatment with allicin significantly reduced the levels of ROS and enhanced the NADH levels in TSCI mice. Collectively, these data demonstrate that the effects of allicin on TSCI are mediated via regulation of the HSP70, Akt and iNOS pathways in mice. https://greenmedinfo.com/article/allicin-could-be-used-protection-traumatic-spinal-cord-injury#comments Allicin Oxidative Stress Spinal Cord Injuries Antioxidants Heat Shock Protein Inducer Neuroprotective Agents Allicin Antioxidants Heat Shock Protein Inducer Neuroprotective Agents oxidative stress Spinal Cord Injuries Animal Study Thu, 07 Sep 2017 22:56:01 +0000 greenmedinfo 152925 at https://greenmedinfo.com Allicin provides protection against arsenic trioxide induced liver injury. https://greenmedinfo.com/article/allicin-provides-protection-against-arsenic-trioxide-induced-liver-injury n/a PMID:  Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292 Abstract Title:  Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats. Abstract:  Arsenic trioxide (As2O3) is both the most prevalent, naturally occurring inorganic arsenical threatening human health and an efficient therapeutic for acute promyelocytic leukemia. Regretfully, As2O3-treated cancer patients often suffer from hepatotoxicity. While effective antioxidant and anticarcinogenic actions of allicin have previously been demonstrated, studies indicating how allicin affects As2O3-induced hepatotoxicity and arsenic accumulation are lacking. Our study, for the first time, elaborates potential details of the hepatoprotective mechanisms of allicin against As2O3-induced liver injury. Wistar rats were administrated allicin (30 mg/kg) 1 h before As2O3 (3 mg/kg) by daily gavage for 2 weeks. Our results indicate that allicin ameliorated As2O3-induced liver dysfunction, oxidative stress, and arsenic accumulation in the liver. Meanwhile, allicin decreased NF-κB level and upregulated expression of proteins reduced by As2O3 including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, and Krüppel-like factor 9 (KLF9). In addition, allicin promoted B cell lymphoma-extra large expression and suppressed B cell lymphoma-2-associatedX protein levels regulated by As2O3. However, neither allicin nor As2O3 affected cytochrome P450 2E1 mRNA expression. In conclusion, allicin attenuated As2O3-induced hepatotoxicity by activating the Nrf2 signaling pathway involving KLF9 to inhibit oxidative stress and apoptosis. Our findings elucidate a detailed mechanism by which allicin provides protection against As2O3-induced liver injury and support its potential role as an adjunctive therapy for patients suffering from chronic arsenic exposure. https://greenmedinfo.com/article/allicin-provides-protection-against-arsenic-trioxide-induced-liver-injury#comments Allicin Arsenic Poisoning Oxidative Stress Antioxidants Arsenic Trioxide NF-kappaB Inhibitor Nrf2 activation Allicin Antioxidants Arsenic Poisoning NF-kappaB Inhibitor Nrf2 activation oxidative stress Animal Study Thu, 07 Sep 2017 23:00:33 +0000 greenmedinfo 152926 at https://greenmedinfo.com Apocynin is as effective as α-methyl prednisolone in an animal model of Duchenne's Muscular Dystrophy. https://greenmedinfo.com/article/apocynin-effective-methyl-prednisolone-animal-model-duchennes-muscular-dystrop n/a PMID:  Pharmacol Res. 2016 Apr ;106:101-13. Epub 2016 Feb 27. PMID: 26930420 Abstract Title:  Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard,α-methyl prednisolone. Abstract:  Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of the amino acid taurine, in comparison with the gold standardα-methyl prednisolone (PDN). The rationale was to target the overproduction of reactive oxygen species (ROS) via disease-related pathways that are worsened by mechanical-metabolic impairment such as inflammation and over-activity of NADPH oxidase (NOX) (taurine and apocynin, respectively) or the failing ROS detoxification mechanisms via sirtuin-1 (SIRT1)-peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) (resveratrol). Resveratrol (100mg/kg i.p. 5days/week), apocynin (38mg/kg/day per os), taurine (1g/kg/day per os), and PDN (1mg/kg i.p., 5days/week) were administered for4-5 weeks to mdx mice in parallel with a standard protocol of treadmill exercise and the outcome was evaluated with a multidisciplinary approach in vivo and ex vivo on pathology-related end-points and biomarkers of oxidative stress. Resveratrol≥taurine&gt;apocynin enhanced in vivo mouse force similarly to PDN. All the compounds reduced the production of superoxide anion, assessed by dihydroethidium staining, with apocynin being as effective as PDN, and ameliorated electrophysiological biomarkers of oxidative stress. Resveratrol also significantly reduced plasma levels of creatine kinase and lactate dehydrogenase. Force of isolated muscles was little ameliorated. However, the three compounds improved histopathology of gastrocnemius muscle more than PDN. Taurine&gt;apocynin&gt;PDN significantly decreased activated NF-kB positive myofibers. Thus, compounds targeting NOX-ROS or SIRT1/PGC-1α pathways differently modulate clinically relevant DMD-related endpoints according to their mechanism of action. With the caution needed in translational research, the results show that the parallel assessment can help the identification of best adjuvant therapies. https://greenmedinfo.com/article/apocynin-effective-methyl-prednisolone-animal-model-duchennes-muscular-dystrop#comments Apocynin Duchenne's Muscular Dystrophy Oxidative Stress Antioxidants Corticosteroid NF-kappaB Inhibitor Apocynin Corticosteroid Duchenne's Muscular Dystrophy Natural Versus Synthetics oxidative stress Animal Study Sun, 12 Feb 2017 22:21:36 +0000 greenmedinfo 143394 at https://greenmedinfo.com Baicalein protects against UVB-induced oxidative stress via scavenging ROS, inhibiting apoptosis, and absorbing UV photons. https://greenmedinfo.com/article/baicalein-protects-against-uvb-induced-oxidative-stress-scavenging-ros-inhibit n/a PMID:  Biomol Ther (Seoul). 2016 Nov 1 ;24(6):616-622. PMID: 27257012 Abstract Title:  Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress. Abstract:  Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS. https://greenmedinfo.com/article/baicalein-protects-against-uvb-induced-oxidative-stress-scavenging-ros-inhibit#comments Baicalein Oxidative Stress Ultraviolet Radiation Induced Damage Anti-Apoptotic Photoprotective Baicalein oxidative stress Ultraviolet Radiation Induced Damage In Vitro Study Mon, 21 Nov 2016 20:30:41 +0000 greenmedinfo 139219 at https://greenmedinfo.com Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model. https://greenmedinfo.com/article/black-pepper-significantly-improved-memory-aluminum-chloride-induced-neurotoxi n/a PMID:  Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401 Abstract Title:  Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine. Abstract:  UNLABELLED: Black pepper (Piper nigrum Linn.) has vital pharmacological properties with profound effects on central nervous system. Neurotoxic agents like Aluminum Chloride (AlCl3) cause the oxidative stress and result in improper processing of amyloid proteins leading to accumulation of amyloidβ plaques. AIM: The study aimed to explore the neuroprotective potential of black pepper (BP) extract (12.5mg/kg/day) on memory enhancement and its effect on expression of amyloid precursor protein (APP) isoforms (APP770 and APP695) in AlCl3 induced neurotoxicity (250mg/kg) mouse model. The study included the isolation and identification of pure compound from BP (chavicine) which was found pharmacologically active. METHODS: Morris water maze test, elevated plus maze, fear conditioning, context and cue dependent test and social preference tests were performed to investigate the learning and memory. Gene expression (APP isoforms) and in-vitro and ex-vivo DPPH free radical scavenging activity were performed to evaluate the role of BP. RESULTS: BP significantly improved memory in AlCl3 induced neurotoxicity mouse model along with effectively decreasing the expression of APP770 (amyloidogenic) isoform and improved level of APP695 (non-amyloidogenic) in hippocampus, amygdala and cortex. Fear extinction learning was considerably improved in BP treated group (7.83±2.03) than AlCl3 induced neurotoxicity group (39.75±4.25). In the hippocampus, BP significantly reduced the expression of APP770 (0.37±0.05) as compared to AlCl3 induced neurotoxicity group (0.72±0.06), and effectively increased (34.80±1.39) the percentage inhibition of DPPH free radicals as compared to AlCl3 induced neurotoxicity group (14±2.68). CONCLUSION: The study revealed that BP improves memory and chavicine is a lead compound producing pharmacological effects of BP. https://greenmedinfo.com/article/black-pepper-significantly-improved-memory-aluminum-chloride-induced-neurotoxi#comments Aluminum Toxicity Black Pepper Neurodegenerative Diseases Oxidative Stress Aluminum Chloride Neuroprotective Agents aluminum toxicity Black Pepper Neurodegenerative diseases Neuroprotective Agents oxidative stress Plant Extracts Animal Study Tue, 23 May 2017 15:29:48 +0000 greenmedinfo 148134 at https://greenmedinfo.com Chlorpyrifos may affect neurodevelopment in a manner similar to that of several known and suspected neurotoxicants. https://greenmedinfo.com/article/chlorpyrifos-may-affect-neurodevelopment-manner-similar-several-known-and-susp n/a PMID:  Neurotoxicology. 2014 May ;42:58-70. Epub 2014 Apr 12. PMID: 24727577 Abstract Title:  Nuclear NF-κB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells. Abstract:  Chlorpyrifos (CPF) is one of the most widely used organophosphate insecticides with several harmful effects, including neurotoxicity. Although many studies have addressed the neurotoxicity induced by CPF, most data on neurodevelopmental damage was obtained from animal models. We are the first group to use human neural precursor cells (hNPCs) derived from human embryonic stem cells (hESCs) as a developing neuron model to evaluate the mechanisms involved in CPF-induced neurotoxicity. CPF was cytotoxic to these cells in a concentration-dependent manner, as shown by decreased cell viability and increased lactate dehydrogenase release. Furthermore, CPF reduced the expression of AKT and ERK proteins which are involved in intracellular survival pathways. Exposure of hNPCs to CPF led to the production of reactive oxygen species (ROS), and the antioxidant N-acetyl-cystein (NAC) attenuated ROS production induced by CPF. In addition, CPF increased cytochrome c release into the cytosol and activated caspase-9 and -3, indicating that cell death induced by CPF was due to apoptosis in hNPCs. Consistent with these findings, CPF treatment reduced the level of Bcl-2 protein and increased the level of Bax protein. Especially, CPF increased the translocation of BAX into the mitochondria. CPF also induced nuclear accumulation of NF-κB and p53 proteins in a concentration-dependent manner, and their inhibitors attenuated CPF-induced cytotoxicity. In addition, an inhibitor of NF-κB nuclear translocation blocked the increase of p53 in CPF-treated hNPCs. These findings show that CPF induced hNPCs death in part through NF-κB activation via ROS generation, enabling the interaction of p53 with Bcl-2 and Bax and subsequent release of cytochrome c. Collectively, these results represent a unique molecular characterization of CPF-induced cytotoxicity in hNPCs. These data suggest that CPF may affect neurodevelopment in a manner similar to that of several known and suspected neurotoxicants. https://greenmedinfo.com/article/chlorpyrifos-may-affect-neurodevelopment-manner-similar-several-known-and-susp#comments Oxidative Stress Pesticide Toxicity Chlorpyrifos Chlorpyrifos oxidative stress Pesticide Toxicity In Vitro Study Fri, 18 Aug 2017 15:13:21 +0000 greenmedinfo 151860 at https://greenmedinfo.com Cistus incanus extracts are a source of antioxidant compounds with potential uses in pharmaceutical preparations. https://greenmedinfo.com/article/cistus-incanus-extracts-are-source-antioxidant-compounds-potential-uses-pharma n/a PMID:  Int J Mol Sci. 2016 Aug 17 ;17(8). Epub 2016 Aug 17. PMID: 27548139 Abstract Title:  Characterisation and Antioxidant Activity of Crude Extract and Polyphenolic Rich Fractions from C. incanus Leaves. Abstract:  Cistus incanus (Cistaceae) is a Mediterranean evergreen shrub. Cistus incanus herbal teas have been used as a general remedy in traditional medicine since ancient times. Recent studies on the antioxidant properties of its aqueous extracts have indicated polyphenols to be the most active compounds. However, a whole chemical characterisation of polyphenolic compounds in leaves of Cistus incanus (C. incanus) is still lacking. Moreover, limited data is available on the contribution of different polyphenolic compounds towards the total antioxidant capacity of its extracts. The purpose of this study was to characterise the major polyphenolic compounds present in a crude ethanolic leaf extract (CEE) of C. incanus and develop a method for their fractionation. Superoxide anion, hydroxyl and DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assays were also performed to evaluate the antioxidant properties of the obtained fractions. Three different polyphenolic enriched extracts, namely EAC (Ethyl Acetate Fraction), AF1 and AF2 (Aqueos Fractions), were obtained from CEE. Our results indicated that the EAC, enriched in flavonols, exhibited a higher antiradical activity compared to the tannin enriched fractions (AF1 and AF2). These findings provide new perspectives for the use of the EAC as a source of antioxidant compounds with potential uses in pharmaceutical preparations. https://greenmedinfo.com/article/cistus-incanus-extracts-are-source-antioxidant-compounds-potential-uses-pharma#comments Oxidative Stress Rock-rose Antioxidants Antioxidants oxidative stress Plant Extracts Rock-rose In Vitro Study Wed, 07 Jun 2017 18:42:11 +0000 greenmedinfo 148783 at https://greenmedinfo.com Cleanse, Flush, Sweat, Mobilize, Chelate, Detox...and Heal https://greenmedinfo.com/blog/cleanse-flush-sweat-mobilize-chelate-detoxand-heal <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><br /> <img alt="Cleanse, Flush, Sweat, Mobilize, Chelate, Detox...and Heal" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/sayerji/images/cleanse_detox_healing.jpg" /></p><p><a href="https://greenmedinfo.com/blog/cleanse-flush-sweat-mobilize-chelate-detoxand-heal" target="_blank">read more</a></p> https://greenmedinfo.com/blog/cleanse-flush-sweat-mobilize-chelate-detoxand-heal#comments Chlorella (Algae) Heavy Metal Toxicity MSM (Methylsulfonylmethane) Organosulfur Compounds Petroleum Exposure And Toxicity Radiation Disaster Associated Toxicity Vitamin C Chelation Therapy: EDTA Chemical and Drug Toxicity Cytotoxic Detoxifier Oxidative Damage Chelation chlorella Clay Detoxification Hypoxia Inflammation Magnesium oxidative stress potassium sulfur Vitamin C Fri, 15 Sep 2023 14:58:23 +0000 forbiddenhealing 92297 at https://greenmedinfo.com Coffee, Tea, Turmeric and Beyond: Zero-In on Essential Polyphenols https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall-0 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/turmeric_coffee_benefits.jpg" style="width: 564px; height: 315px;" /></p><p><a href="https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall-0" target="_blank">read more</a></p> https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall-0#comments Chocolate Curcumin Polyphenols Resveratrol Turmeric Antioxidants Cannabinoid Medicine electrons Hydroxyl Radicals oxidative stress POLYPHENOLS Tue, 23 Sep 2014 14:08:13 +0000 forbiddenhealing 110337 at https://greenmedinfo.com Coffee, Tea, Turmeric and Beyond: Zero-In on Essential Polyphenols by Capt. Randall https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2013<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><span>Articles appear daily touting the benefits of blueberries, chocolate, red wine, olives, grape seeds/skin and thousands of other herbs, oils, extracts, spices and ferments.&nbsp;These are usually accompanied by strange words like quercetin, anthocyanins, flavonoids and tongue twisters like epigallocatechin that fly over the head of average people just trying to improve their health. Few look any further, much less review the actual chemistry involved.<br /> <p><a href="https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall" target="_blank">read more</a></p> https://greenmedinfo.com/blog/coffee-tea-turmeric-and-beyond-zero-essential-polyphenols-capt-randall#comments anti-cancer anti-inflammatory membrane protective neuro-protective Antioxidants Cannabinoid Medicine electrons Hydroxyl Radicals oxidative stress POLYPHENOLS Sat, 16 Nov 2013 01:46:32 +0000 forbiddenhealing 110336 at https://greenmedinfo.com