Star Anise (Illicium anisatum) https://greenmedinfo.com/category/substance/star-anise-illicium-anisatum en Anti-glycation properties of Illicium verum Hook. https://greenmedinfo.com/article/anti-glycation-properties-illicium-verum-hook PMID:  BMC Complement Med Ther. 2022 Mar 19 ;22(1):79. Epub 2022 Mar 19. PMID: 35305622 Abstract Title:  Anti-glycation properties of Illicium verum Hook. f. fruit in-vitro and in a diabetic rat model. Abstract:  BACKGROUND: Chronic hyperglycemic triggers the non-enzymatic glycation of biomolecules, resulting in the production of advanced glycation endproducts, that lead to several micro- and macrovascular complications. Therefore, the discovery of new, effective, and safe anti-glycation agents is an important need. One of the best choices for the management of diabetes is to use complementary and alternative medicinal therapies. Therefore, the present study was designed to evaluate the anti-glycation activity of ethanolic extract of Illicium verum Hook. f. (Star anise, a frequently used spice and medicinally important herb).METHODS: The anti-glycation activity of ethanolic extract of Illicium verum Hook. f. was determined by using both in-vitro and in-vivo assays. HSA-fructose glycation model was employed to assess the in-vitro inhibition of protein glycation, additionally cross-linked AGEs (formed by incubating lysozyme with fructose) were assessed by SDS polyacrylamide gel electrophoresis. Dual inhibitory mechanisms, i.e., antioxidant and metal chelating activities, were also evaluated by using DPPH, ABTS, and Fe (II)-chelation assays. Acute toxicity of I. verum extract was also performed (by administrating different doses i.e. 2,000, 1,500, 1,000, and 500 mg/kg of body weight). Finally, in-vivo anti-glycation potential was evaluated by 7 weeks of administration of I. verum extract in streptozotocin-induced diabetic rats.RESULTS: In HSA-fructose glycation model, extract of I. verum showed a good inhibitory activity with ICvalue of 0.11±0.001 mg/mL, as compared to the standard inhibitor, rutin (IC= 0.02±0.01 mg/mL). Extract of I. verum showed inhibitory activity in DPPH, and ABTS radical scavenging assays with ICvalues of 130±1.0, and 57±2.0 μg/mL, respectively, while it was found to be inactive in the Fe-chelation assay. The extract was found to be non-toxic, and reduce the elevated blood glucose, urea, lipid, liver function parameters, and renal AGEs levels in streptozotocin-induced diabetic rats.CONCLUSIONS: These results suggest that I. verum supplementation might help to reduce the burden of AGEs, and may have potential in preventing diabetes-associated complications. <p><a href="https://greenmedinfo.com/article/anti-glycation-properties-illicium-verum-hook" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-glycation-properties-illicium-verum-hook#comments Advanced Glycation End products (AGE) Star Anise (Illicium anisatum) Anti-Glycation Agents Animal Study In Vitro Study Mon, 21 Mar 2022 20:56:51 +0000 greenmedinfo 255111 at https://greenmedinfo.com Antioxidant, anti-obesity, and hypolipidemic effects of polyphenol rich star anise. https://greenmedinfo.com/article/antioxidant-anti-obesity-and-hypolipidemic-effects-polyphenol-rich-star-anise PMID:  Antioxidants (Basel). 2022 Nov 14 ;11(11). Epub 2022 Nov 14. PMID: 36421427 Abstract Title:  Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise () Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model. Abstract:  Star anise (Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (&gt;5 mg/100 mL) phenolic acids in SAT were-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses. <p><a href="https://greenmedinfo.com/article/antioxidant-anti-obesity-and-hypolipidemic-effects-polyphenol-rich-star-anise" target="_blank">read more</a></p> https://greenmedinfo.com/article/antioxidant-anti-obesity-and-hypolipidemic-effects-polyphenol-rich-star-anise#comments High Fat Diet High Sugar Diet Obesity Star Anise (Illicium anisatum) Antioxidants Hypolipidemic Anti-Obesity Agents Animal Study Sat, 26 Nov 2022 06:57:47 +0000 greenmedinfo 267029 at https://greenmedinfo.com Antiviral and Antioxidant Components from the Fruits of Illicium verum Hook.f https://greenmedinfo.com/article/antiviral-and-antioxidant-components-fruits-illicium-verum-hookf PMID:  J Agric Food Chem. 2022 Mar 16. Epub 2022 Mar 16. PMID: 35293738 Abstract Title:  Antiviral and Antioxidant Components from the Fruits ofHook.f. (Chinese Star Anise). Abstract:  Hook.f. (Chinese star anise), a known Chinese traditional spice, is commonly applied in Chinese cuisine and cooking in Southeast Asia. As a kind of medicinal and edible resource, the fruit ofhas attracted great attention for its chemical constituents and physiological activities. In this work, the phytochemical study of the fruits ofled to the isolation and identification of 20 compounds, including 6 new lignans and phenylpropanoids (-) and 14 known ones (-). Their structures were characterized by extensive analysis of spectroscopic data (IR, UV, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), one-dimensional (1D) and two-dimensional (1D) NMR), electronic circular dichroism (ECD) calculation, and by comparison with literature data. Meanwhile, all compounds (-) were evaluated for their antiviral and antioxidant activities. Especially, compound[(-)-bornyl-coumarate] showed strong antiviral activities against influenza virus A/Puerto Rico/8/34 H1N1 (PR8) with an ICvalue of 1.74± 0.47 μM, which is much better than those of Tamiflu (IC= 10.01± 0.92 μM) and ribavirin (IC= 10.76± 1.60 μM). The antiviral activity against PR8 of compoundwas reported for the first time, which was sufficiently confirmed by cell counting kit 8 (CCK-8), cytopathic effect (CPE) reduction, and immunofluorescence assays. In this study, the discovery of antiviral and antioxidant components from the fruits ofcould benefit the further development and utilization of this plant. <p><a href="https://greenmedinfo.com/article/antiviral-and-antioxidant-components-fruits-illicium-verum-hookf" target="_blank">read more</a></p> https://greenmedinfo.com/article/antiviral-and-antioxidant-components-fruits-illicium-verum-hookf#comments Influenza Oxidative Stress Star Anise (Illicium anisatum) Antioxidants Antiviral Agents In Vitro Study Mon, 21 Mar 2022 21:07:16 +0000 greenmedinfo 255114 at https://greenmedinfo.com I. verum extracts have potential as an eco-friendly biopesticide in integrated pest management against M. persicae. https://greenmedinfo.com/article/i-verum-extracts-have-potential-eco-friendly-biopesticide-integrated-pest-mana PMID:  J Insect Sci. 2016 ;16. Epub 2016 Jan 30. PMID: 26826651 Abstract Title:  Aphicidal Activity of Illicium verum Fruit Extracts and Their Effects on the Acetylcholinesterase and Glutathione S-transferases Activities in Myzus persicae (Hemiptera: Aphididae). Abstract:  This study aims to explore the aphicidal activity and underlying mechanism of Illicium verum Hook. f. that is used as both food and medicine. The contact toxicity of the extracts from I. verum fruit with methyl alcohol (MA), ethyl acetate (EA), and petroleum ether (PE) against Myzus persicae (Sulzer), and the activities of acetylcholinesterase (AChE) and glutathione S-transferases (GSTs) of M. persicae after contact treatment were tested. The results showed that MA, EA, and PE extracts of 1.000 mg/l caused, respectively, M. persicae mortalities of 68.93%, 89.95% and 74.46%, and the LC50 of MA, EA, and PE extracts were 0.31, 0.14 and 0.27 mg/l at 72 h after treatment, respectively; the activities of AChE and GSTs in M. persicae were obviously inhibited by the three extracts, as compared with the control, with strong dose and time-dependent effects, the inhibition rates on the whole reached more than 50.00% at the concentration of 1.000 mg/l at 72 h after treatment. The inhibition of the extracts on AChE and GSTs activities (EA extract&gt;PE extract&gt;MA extract) were correlated with theirs contact toxic effects, so it is inferred that the decline of the metabolic enzymes activities may be one of important reasons of M. persicae death. The study results suggested that I. verum extracts have potential as a eco-friendly biopesticide in integrated pest management against M. persicae. <p><a href="https://greenmedinfo.com/article/i-verum-extracts-have-potential-eco-friendly-biopesticide-integrated-pest-mana" target="_blank">read more</a></p> https://greenmedinfo.com/article/i-verum-extracts-have-potential-eco-friendly-biopesticide-integrated-pest-mana#comments Star Anise (Illicium anisatum) Insecticidal Plant Extracts Insect Study Tue, 11 Apr 2017 16:47:16 +0000 greenmedinfo 146145 at https://greenmedinfo.com Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance. https://greenmedinfo.com/article/star-anise-illicium-verum-chemical-compounds-antiviral-properties-and-clinical PMID:  Phytother Res. 2020 Jun ;34(6):1248-1267. Epub 2020 Jan 29. PMID: 31997473 Abstract Title:  Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance. Abstract:  Medicinal herbs are one of the imperative sources of drugs all over the world. Star anise (Illicium verum), an evergreen, medium-sized tree with star-shaped fruit, is an important herb with wide distribution throughout southwestern parts of the Asian continent. Besides its use as spice in culinary, star anise is one of the vital ingredients of the Chinese medicinal herbs and is widely known for its antiviral effects. It is also the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, anti-inflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects. This review aimed to integrate the information on the customary attributes of the plant star anisewith a specific prominence on its antiviral properties and the phytochemical constituents along with its clinical aptness. <p><a href="https://greenmedinfo.com/article/star-anise-illicium-verum-chemical-compounds-antiviral-properties-and-clinical" target="_blank">read more</a></p> https://greenmedinfo.com/article/star-anise-illicium-verum-chemical-compounds-antiviral-properties-and-clinical#comments Influenza Star Anise (Illicium anisatum) Antiviral Agents Review Tue, 03 Nov 2020 15:18:43 +0000 greenmedinfo 229019 at https://greenmedinfo.com Star anise enhanced the antioxidant capacity which protects birds against E. coli challenge. https://greenmedinfo.com/article/star-anise-enhanced-antioxidant-capacity-which-protects-birds-against-e-coli-c PMID:  Poult Sci. 2020 Jun ;99(6):3092-3101. Epub 2020 May 5. PMID: 32475446 Abstract Title:  Effects of star anise (Illicium verum Hook.f) oil on the nuclear factor E2-related factor 2 signaling pathway of chickens during subclinical Escherichia coli challenge. Abstract:  We characterized the mechanism underlying star anise (Illicium verum Hook.f) oil (SAO)-mediated antioxidant status during subclinical Escherichia coli (E. coli) challenge. A total of 512 male birds (White Leghorn) at 30 wk of age with similar body weight (2.14 ± 0.02 kg) were randomly divided into 2 groups with 1 group being orally challenged with E. coli (every other day from day 15 to day 27) during the experiment. Each group of birds was then randomly allocated to dietary treatment of SAO supplementation at 0, 200, 400, or 600 mg/kg of basal diet (8 replicate cages during each treatment). The treatments were arranged a 4 × 2 factorial arrangement. The experiment comprised 1 wk of adaptation and 3 wks of data collection. There was no interaction (P&gt;0.05) between SAO supplementation and E. coli challenge for final body weight and average daily feed intake of birds. However, E. coli challenge resulted in a significant decrease (P<p><a href="https://greenmedinfo.com/article/star-anise-enhanced-antioxidant-capacity-which-protects-birds-against-e-coli-c" target="_blank">read more</a></p> https://greenmedinfo.com/article/star-anise-enhanced-antioxidant-capacity-which-protects-birds-against-e-coli-c#comments Escherichia coli Infections Star Anise (Illicium anisatum) Antioxidants Nrf2 activation In Vitro Study Tue, 03 Nov 2020 17:29:30 +0000 greenmedinfo 229021 at https://greenmedinfo.com Star anise extract could be used as a potential quorum sensing and biofilm inhibitor. https://greenmedinfo.com/article/star-anise-extract-could-be-used-potential-quorum-sensing-and-biofilm-inhibito PMID:  J Food Prot. 2017 Apr ;80(4):645-653. PMID: 28294685 Abstract Title:  Star Anise (Illicium verum Hook. f.) as Quorum Sensing and Biofilm Formation Inhibitor on Foodborne Bacteria: Study in Milk. Abstract:  Bacteria use quorum sensing (QS) systems to communicate with each other and regulate microbial group behavior, such as the secretion of virulence factors, including biofilm formation. In order to explore safe, edible agents, the potential of star anise (SA) as an anti-QS and antibiofilm agent and its possible application in milk safety were investigated. Staphylococcus aureus , Salmonella Typhimurium, Pseudomonas aeruginosa , and biosensor strain Chromobacterium violaceum were selected as test strains for QS, biofilm, and exopolysaccharide assays. The percent acidities and total plate counts were determined to evaluate the quality of biofilm-inoculated and noninoculated milk. The yield of SA extraction was 25.90%± 0.2% (w/w). At sub-MIC, SA extract did not show any effect on bacterial growth. The production of violacein was inhibited by 89% by SA extract. The extract also inhibited the formation of biofilm by up to 87% in a dose-dependent manner. Inhibition rates of 70.45%, 42.82%, and 35.66% were found for exopolysaccharide production. The swarming motility of S. aureus was reduced by about 95.9% by SA extract. Confocal laser scanning microscopy analysis confirmed that the development of biofilm architecture was hampered. It was found that SA extract could delay the spoilage of milk. In the endeavorto avoid drug resistance, pathogenesis, and resistance to biocides while improving food safety and avoiding health hazard issues arising from synthetic chemicals, SA extract could be used as a potential QS and biofilm inhibitor. <p><a href="https://greenmedinfo.com/article/star-anise-extract-could-be-used-potential-quorum-sensing-and-biofilm-inhibito" target="_blank">read more</a></p> https://greenmedinfo.com/article/star-anise-extract-could-be-used-potential-quorum-sensing-and-biofilm-inhibito#comments Pseudomonas aeruginosa Salmonella Infections Staphylococcus aureus infection Star Anise (Illicium anisatum) Antimicrobial Biofilm Dose Response In Vitro Study Mon, 10 Apr 2017 20:01:49 +0000 greenmedinfo 146126 at https://greenmedinfo.com