Haritaki (Terminalia chebula) https://greenmedinfo.com/category/substance/haritaki-terminalia-chebula en A herbal formulation is a safe and effective intervention for management of joint discomfort. https://greenmedinfo.com/article/herbal-formulation-safe-and-effective-intervention-management-joint-discomfort PMID:  J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID: 29708818 Abstract Title:  A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee. Abstract:  LI73014F2 is a novel composition prepared from extracts of Terminalia chebula fruit, Curcuma longa rhizome, and Boswellia serrata gum resin with synergistic benefit in 5-Lipoxygenase (5-LOX) inhibition. This herbal composition with strong anti-5-LOX activity exhibited significant pain relief as indicated through improvements in weight-bearing capacity in a monosodium iodoacetate-induced osteoarthritis (OA) model of Sprague-Dawley rats. A 90-day randomized, placebo-controlled double-blind study evaluates the clinical efficacy and tolerability of LI73014F2 in the management of symptoms of OA of the knee (Clinical Trial Registration No. CTRI/2014/01/004338). Subjects, (n = 105), were randomized into three groups: placebo (n = 35), 200 mg/day of LI73014F2 (n = 35), and 400 mg/day of LI73014F2 (n = 35). All study participants were evaluated for pain and physical function by using standard tools, that is, Visual Analog Scale, Lequesne&#039;s FunctionalIndex, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at the baseline (day 0) and on day 14 ± 3, 30 ± 3, 60 ± 3, and at the end of the study (day 90 ± 3). In addition, routine examinations on biochemical parameters in serum, urine, and hematological parameters were conducted on each visit to assess the safety of the study material. At the end of the trial period, LI73014F2 conferred significant pain relief, improved physical function, and quality of life in OA patients. In conclusion, preclinical and clinical data together strongly suggest that the herbal formulation LI73014F2 is a safe and effective intervention for management of joint discomfort, demonstrating efficacy as early as 14 days. <p><a href="https://greenmedinfo.com/article/herbal-formulation-safe-and-effective-intervention-management-joint-discomfort" target="_blank">read more</a></p> https://greenmedinfo.com/article/herbal-formulation-safe-and-effective-intervention-management-joint-discomfort#comments Frankincense Haritaki (Terminalia chebula) Osteoarthritis: Knee Turmeric Anti-Inflammatory Agents Natural Substance Synergy Plant Extracts Human Study Sun, 28 Apr 2019 23:46:52 +0000 greenmedinfo 186454 at https://greenmedinfo.com Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation. https://greenmedinfo.com/article/chebulanin-exerts-its-anti-inflammatory-and-anti-arthritic-effects-inhibiting- PMID:  Int Immunopharmacol. 2020 Aug 11 ;88:106823. Epub 2020 Aug 11. PMID: 32795901 Abstract Title:  Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. Abstract:  Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and progressive joint destruction. Chebulanin is a natural polyphenol acid isolated from the traditional Tibetan medicine Terminalia chebula Retz that has previously been reported to possess anti-inflammatory properties. The present study aimed to investigate the anti-inflammatory and anti-arthritic effects of chebulanin and explore its underlying mechanisms in vivo and in vitro using a collagen-induced arthritis (CIA) mouse model and lipopolysaccharide (LPS) stimulated RAW264.7 cell inflammation model. Arthritis severity scores were assessed twice weekly; the levels of cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum were detected using enzyme-linked immunosorbent assay kits; histopathological assessment was performed using micro computed tomography and hematoxylin and eosin staining. Activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathwayswere assessed using western blotting. The inhibition of translocation of cytosolic p38 and p65 into the nucleus was observed using immunofluorescence staining and western blotting in vitro. Chebulanin significantly suppressed the progression and development of RA in CIA mice by decreasing the arthritis severity scores, attenuating paw swelling and joint destruction, and reducing the levels of IL-6 and TNF-α significantly (p <p><a href="https://greenmedinfo.com/article/chebulanin-exerts-its-anti-inflammatory-and-anti-arthritic-effects-inhibiting-" target="_blank">read more</a></p> https://greenmedinfo.com/article/chebulanin-exerts-its-anti-inflammatory-and-anti-arthritic-effects-inhibiting-#comments Haritaki (Terminalia chebula) Rheumatoid Arthritis Anti-Inflammatory Agents Interleukin-6 Downregulation NF-kappaB Inhibitor Tumor Necrosis Factor (TNF) Alpha Inhibitor In Vitro Study Thu, 01 Oct 2020 15:09:46 +0000 greenmedinfo 227489 at https://greenmedinfo.com Chebulic acid has cytoprotective effect on tert-butyl hydroperoxide-induced hepatotoxicity in HepG2 cells. https://greenmedinfo.com/article/chebulic-acid-has-cytoprotective-effect-tert-butyl-hydroperoxide-induced-hepat PMID:  Food Sci Biotechnol. 2019 Apr ;28(2):555-562. Epub 2018 Sep 27. PMID: 30956868 Abstract Title:  Protective effects of chebulic acid fromRetz. against-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. Abstract:  Although chebulic acid isolated fromhas diverse biological effects, its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and the expression of downstream genes have not been elucidated. The purpose of this research is to investigate the hepatoprotective mechanism of chebulic acid against oxidative stress produced by-butyl hydroperoxide (-BHP) in liver cells. The treatment with chebulic acid attenuated cell death in-BHP-induced HepG2 liver cells and increased intracellular glutathione content, upregulated the activity of heme oxygenase-1, and also increased the translocation of Nrf2 into the nucleus and Nrf2 target gene expression in a dose-dependent manner. The exposure of chebulic acid activated the phosphorylation of mitogen-activated protein kinases. The overall result is that chebulic acid has cytoprotective effect on-BHP-induced hepatotoxicity in HepG2 cells through Nrf2-mediated antioxidant enzymes. <p><a href="https://greenmedinfo.com/article/chebulic-acid-has-cytoprotective-effect-tert-butyl-hydroperoxide-induced-hepat" target="_blank">read more</a></p> https://greenmedinfo.com/article/chebulic-acid-has-cytoprotective-effect-tert-butyl-hydroperoxide-induced-hepat#comments Chemically-Induced Liver Damage Haritaki (Terminalia chebula) Antioxidants Hepatoprotective Nrf2 activation Tertiary butyl hydroperoxide In Vitro Study Mon, 29 Apr 2019 14:49:40 +0000 greenmedinfo 186466 at https://greenmedinfo.com Methyl gallate from Terminalia chebula has potential in the treatment of severe secretory and inflammatory diarrheal disease caused by MDR V. cholerae. https://greenmedinfo.com/article/methyl-gallate-terminalia-chebula-has-potential-treatment-severe-secretory-and PMID:  Microb Pathog. 2019 Mar ;128:41-46. Epub 2018 Dec 19. PMID: 30578837 Abstract Title:  In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae. Abstract:  Acute Vibrio cholerae infection triggers significant inflammatory response and immense fluid secretion in the intestine. In the present study, methyl gallate (MG) isolated from Terminalia chebula was evaluated to determine the in vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities against multi-drug resistant (MDR) V. cholerae. Bacterial membrane-damaging and biofilm-inhibitory activities were determined by membrane perturbation and transmission electron microscopy (TEM); and microdilution assays, respectively. Fluid accumulation-inhibitory and anticolonization activities of MG (23.80-95.23 mg/kg body weight) were determined in 4-5 days old BALB/c mice with an incubation time of 18 h. The effect of MG (1, 50 and 500 mg/kg body weight) on intestinal inflammatory reaction induced by V. cholerae was studied by performing histology in Swiss albino mice. MIC and MBC of MG against thetest strains were 32-64 and 64-256 μg/ml, respectively. MG showed the fluid accumulation-inhibitory activity with inhibition values of 42.86-89.08% at doses between 23.80 and 95.23 mg/kg body weight and significant anticolonization activity (p <p><a href="https://greenmedinfo.com/article/methyl-gallate-terminalia-chebula-has-potential-treatment-severe-secretory-and" target="_blank">read more</a></p> https://greenmedinfo.com/article/methyl-gallate-terminalia-chebula-has-potential-treatment-severe-secretory-and#comments Cholera Haritaki (Terminalia chebula) Infection: Antibiotic Resistant Anti-Bacterial Agents Anti-Inflammatory Agents Bacterial Infections: Resistance/Biofilm Formation Plant Extracts Animal Study In Vitro Study Mon, 29 Apr 2019 16:10:57 +0000 greenmedinfo 186467 at https://greenmedinfo.com Tannins from Terminalia chebula fruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters. https://greenmedinfo.com/article/tannins-terminalia-chebula-fruits-attenuates-gaba-antagonist-induced-anxiety-b PMID:  J Pharm Pharmacol. 2018 Dec ;70(12):1662-1674. Epub 2018 Sep 10. PMID: 30198561 Abstract Title:  Tannins from Terminalia chebula fruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters. Abstract:  OBJECTIVES: This article investigates the anxiolytic activity of Terminalia chebula tannin-rich extract against picrotoxin (PTX; GABA antagonist)-induced anxiety in mice model.METHODS: Anxiolytic activity was studied by elevated plus maze (EPM), open field test (OFT), light/dark box test (LDT) and Vogel&#039;s conflict test (VCT). Electroencephalogram (EEG) was performed to know the changes in brain activity instigated by GABA antagonist. 5-hydroxytryptamine (5-HT), dopamine and norepinephrine levels in brain tissues were estimated by HPLC. The mRNA (CREB, BDNF, GABA, and 5-HT) and protein expression (CREB, p-CREB, BDNF, ERK½, p-ERK ½, GABARα1, 5-HTand GAPDH) levels in brain tissue were determined by RT-PCR and Western blot analysis, respectively.KEY FINDINGS: Terminalia chebula tannin-rich extract (TCHE) supplementation increased locomotion in mice towards open arm (EPM), time spent in illuminated area (LDT), rearing frequency (OFT) and number of shocks (VCT) compared to PTX (P <p><a href="https://greenmedinfo.com/article/tannins-terminalia-chebula-fruits-attenuates-gaba-antagonist-induced-anxiety-b" target="_blank">read more</a></p> https://greenmedinfo.com/article/tannins-terminalia-chebula-fruits-attenuates-gaba-antagonist-induced-anxiety-b#comments Anxiety Haritaki (Terminalia chebula) Anti-Anxiety Agents Plant Extracts Animal Study Mon, 29 Apr 2019 18:30:30 +0000 greenmedinfo 186485 at https://greenmedinfo.com Terminalia chebula fruit extracts inhibit bacterial triggers of some autoimmune diseases and potentiate the activity of tetracycline. https://greenmedinfo.com/article/terminalia-chebula-fruit-extracts-inhibit-bacterial-triggers-some-autoimmune-d PMID:  Indian J Microbiol. 2018 Dec ;58(4):496-506. Epub 2018 Jul 12. PMID: 30262960 Abstract Title:  Retz. Fruit Extracts Inhibit Bacterial Triggers of Some Autoimmune Diseases and Potentiate the Activity of Tetracycline. Abstract:  Retz. is a northern Indian plant species known for its anti-inflammatory and antimicrobial properties.fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantified by both liquid dilution and disc diffusion techniques. To screen for combinatorial effects, thefruit extracts were combined with a range of conventional antibiotics and tested against each bacteria using a liquid dilution assay. Where synergy was detected, the optimal ratios were determined using isobologram analysis. Toxicity was examined usingnauplii and HDF bioassays.fruit methanolic, aqueous and ethyl acetate extracts displayed strong antimicrobial activity against the bacterial triggers of all autoimmune inflammatory diseases except, for which only moderate inhibition was observed. Indeed, MIC values as low as 195 μg/mL were measured for the aqueous extract against a resistant strain of. Of further note, both the aqueous and ethyl acetate extracts interacted synergistically in combination with tetracycline against(Σ FIC 0.38 and 0.25 respectively). All extracts were nontoxic in theand HDF toxicity assays, further indicating their potential for medicinal use. <p><a href="https://greenmedinfo.com/article/terminalia-chebula-fruit-extracts-inhibit-bacterial-triggers-some-autoimmune-d" target="_blank">read more</a></p> https://greenmedinfo.com/article/terminalia-chebula-fruit-extracts-inhibit-bacterial-triggers-some-autoimmune-d#comments Autoimmune Diseases Bacterial Infections Haritaki (Terminalia chebula) Multiple Sclerosis Rheumatoid Arthritis Spondylitis: Ankylosing Natural Substance/Drug Synergy In Vitro Study Mon, 29 Apr 2019 18:23:43 +0000 greenmedinfo 186484 at https://greenmedinfo.com