Neurodegenerative diseases https://greenmedinfo.com/category/keywords/neurodegenerative-diseases en Aluminium has been demonstrated to impact the CNS at every level, including by changing gene expression. https://greenmedinfo.com/article/aluminium-has-been-demonstrated-impact-cns-every-level-including-changing-gene n/a PMID:  Immunotherapy. 2014 ;6(10):1055-71. PMID: 25428645 Abstract Title:  Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy? Abstract:  In spite of a common view that aluminum (Al) salts are inert and therefore harmless as vaccine adjuvants or in immunotherapy, the reality is quite different. In the following article we briefly review the literature on Al neurotoxicity and the use of Al salts as vaccine adjuvants and consider not only direct toxic actions on the nervous system, but also the potential impact for triggering autoimmunity. Autoimmune and inflammatory responses affecting the CNS appear to underlie some forms of neurological disease, including developmental disorders. Al has been demonstrated to impact the CNS at every level, including by changing gene expression. These outcomes should raise concerns about the increasing use of Al salts as vaccine adjuvants and for the application as more general immune stimulants. https://greenmedinfo.com/article/aluminium-has-been-demonstrated-impact-cns-every-level-including-changing-gene#comments Aluminum Toxicity Autoimmune Diseases Neurodegenerative Diseases Aluminum Vaccination: All Vaccine Adjuvants aluminum aluminum toxicity Autoimmune Diseases Gene Expression Neurodegenerative diseases Vaccine Adjuvants Review Wed, 15 Feb 2017 03:54:25 +0000 greenmedinfo 143572 at https://greenmedinfo.com Ancient Medical Miracle Rediscovered by Modern Science - Laurus Nobilis https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2013<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;"><img alt="Ancient Medical Miracle Rediscovered by Modern Science - Laurus Nobilis" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/ken@sinfullywholesome.com/images/Laurus%20Nobilis%20research.jpg" style="width: 800px; height: 400px;" /></p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p><p><a href="https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis" target="_blank">read more</a></p> https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis#comments Acne Alzheimer's Arthritis Athlete's foot Bay Laurel Bay Leaves Cardiovascular Disease Cholesterol Alternatives to Blood Pressure Medication Cholesterol Ratio: ldl/hdl Cradle Cap Diabetes Eczema Gastric Ulcers Jock Itch Laurus Nobilis. True Laurel Leukemia Melanoma MRSA Neurodegenerative Diseases Parkinson&#039;s Pityriasis Versicolor Psoriasis Ringworm Rosacea SARS Scalp ringworm Skin Cancer Tinea Versicolor ACE inhibitory effects Anti-catarrhal Anti-fungal effects Anti-leukemia Effects Anti-melanoma effectsAntibacterial effects Anticonvulsive effects Antioxidant Effects Arthritis Bactericidal Blood Sugar Problems Cancer Cicatrizing agent Cold and Flu Ethanol absorption effects Expectorant For Goodness Sake Fungicidal Health Guide: Aging Health Guide: Alzheimer's Health Guide: Herbs and Traditional Knowledge Health Guide: HIV/AIDS Research Health Guide: Medicinal Spices Health Guide: Mental Health Health Guide: Statin Drugs Health Guide: Viruses Health Guides: Healing Foods Heart Health Infant and Children's Heatlh Men's Health Neuromuscular effects Potent analgesic Sedative effects Sympathetic and parasympathic regulator Virucidal Women's Health Wound Healing Effects Aleppo Soap Antioxidant Bay Laurel Bay Leaves Cardiovascular Disease Cholesterol Alternatives to Blood Pressure Medication Cholesterol Ratio: ldl/hdl Diabetes Gastric Ulcers Laurel Laurel Berry Oil Laurel Essential Oil Laurel Oil Laurel Soap Laurus Nobilis leukemia melanoma Neurodegenerative diseases Pityriasis versicolor Ringworm Scalp ringworm skin cancer Skin diesases Tinea versicolor True Laurel Sat, 07 Sep 2013 18:10:44 +0000 sinfullywholesome 109672 at https://greenmedinfo.com Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model. https://greenmedinfo.com/article/black-pepper-significantly-improved-memory-aluminum-chloride-induced-neurotoxi n/a PMID:  Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401 Abstract Title:  Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine. Abstract:  UNLABELLED: Black pepper (Piper nigrum Linn.) has vital pharmacological properties with profound effects on central nervous system. Neurotoxic agents like Aluminum Chloride (AlCl3) cause the oxidative stress and result in improper processing of amyloid proteins leading to accumulation of amyloidβ plaques. AIM: The study aimed to explore the neuroprotective potential of black pepper (BP) extract (12.5mg/kg/day) on memory enhancement and its effect on expression of amyloid precursor protein (APP) isoforms (APP770 and APP695) in AlCl3 induced neurotoxicity (250mg/kg) mouse model. The study included the isolation and identification of pure compound from BP (chavicine) which was found pharmacologically active. METHODS: Morris water maze test, elevated plus maze, fear conditioning, context and cue dependent test and social preference tests were performed to investigate the learning and memory. Gene expression (APP isoforms) and in-vitro and ex-vivo DPPH free radical scavenging activity were performed to evaluate the role of BP. RESULTS: BP significantly improved memory in AlCl3 induced neurotoxicity mouse model along with effectively decreasing the expression of APP770 (amyloidogenic) isoform and improved level of APP695 (non-amyloidogenic) in hippocampus, amygdala and cortex. Fear extinction learning was considerably improved in BP treated group (7.83±2.03) than AlCl3 induced neurotoxicity group (39.75±4.25). In the hippocampus, BP significantly reduced the expression of APP770 (0.37±0.05) as compared to AlCl3 induced neurotoxicity group (0.72±0.06), and effectively increased (34.80±1.39) the percentage inhibition of DPPH free radicals as compared to AlCl3 induced neurotoxicity group (14±2.68). CONCLUSION: The study revealed that BP improves memory and chavicine is a lead compound producing pharmacological effects of BP. https://greenmedinfo.com/article/black-pepper-significantly-improved-memory-aluminum-chloride-induced-neurotoxi#comments Aluminum Toxicity Black Pepper Neurodegenerative Diseases Oxidative Stress Aluminum Chloride Neuroprotective Agents aluminum toxicity Black Pepper Neurodegenerative diseases Neuroprotective Agents oxidative stress Plant Extracts Animal Study Tue, 23 May 2017 15:29:48 +0000 greenmedinfo 148134 at https://greenmedinfo.com Chlorpyrifos can decrease the viability of adipose tissue-derived stem cells-derived neurons and dysregulate the expression of some neuronal markers. https://greenmedinfo.com/article/chlorpyrifos-can-decrease-viability-adipose-tissue-derived-stem-cells-derived- n/a PMID:  Environ Toxicol. 2016 Nov ;31(11):1510-1519. Epub 2015 May 27. PMID: 26018426 Abstract Title:  Study of the chlorpyrifos neurotoxicity using neural differentiation of adipose tissue-derived stem cells. Abstract:  Chlorpyrifos (CPF) is the most commonly used organophosphorus insecticide which causes neurodevelopmental toxicity. So far, animals have been used as ideal models for neurotoxicity studies, but working with animals is very expensive, laborious, and ethically challenging. This has encouraged researchers to seek alternatives. During recent years, several studies have reported successful differentiation of embryonic and adult stem cells to neurons. This has provided an excellent model for neurotoxicologic studies. In this study, neural differentiation of mouse adipose tissue-derived stem cells (ADSCs) was used as an in vitro model for investigation of CPF neurotoxicity. For this purpose, mouse ADSCs were cultured in a medium containing knockout serum replacement and were treated with different concentrations of CPF at several stages of differentiation. Cytotoxic effect of CPF and the expression of neuron-specific genes and proteins were studied in the differentiating ADSCs. Furthermore, the activity of acetylcholinesterase was assessed by Ellman assay at different stages of differentiation. This study showed that up to 500μM CPF did not alter viability of the undifferentiated ADSCs, whereas viability of the differentiating cells decreased with 500 μM CPF. CPF upregulated the expression of some neuron-specific genes and seemed to decrease the number of β-tubulin III and MAP2 proteins-expressing cells. There was nodetectable acetylcholine esterase activity in differentiated ADSCs. In summary, it was shown that CPF treatment can decrease the viability of ADSC-derived neurons and dysregulate the expression of some neuronal markers through acetylcholinesterase-independent mechanisms. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1510-1519, 2016. https://greenmedinfo.com/article/chlorpyrifos-can-decrease-viability-adipose-tissue-derived-stem-cells-derived-#comments Neurodegenerative Diseases Pesticide Toxicity Chlorpyrifos Chlorpyrifos Neurodegenerative diseases Pesticide Toxicity In Vitro Study Fri, 18 Aug 2017 14:35:32 +0000 greenmedinfo 151856 at https://greenmedinfo.com Chronic exposure to electromagnetic waves results in neuronal degeneration of the auditory system. https://greenmedinfo.com/article/chronic-exposure-electromagnetic-waves-results-neuronal-degeneration-auditory- PMID:  Acta Otolaryngol. 2015 Aug ;135(8):765-70. Epub 2015 Apr 2. PMID: 25836770 Abstract Title:  Effects of chronic exposure to electromagnetic waves on the auditory system. Abstract:  CONCLUSION: The results support that chronic electromagnetic field exposure may cause damage by leading to neuronal degeneration of the auditory system.OBJECTIVES: Numerous researches have been done about the risks of exposure to the electromagnetic fields that occur during the use of these devices, especially the effects on hearing. The aim of this study is to evaluate the effects of the electromagnetic waves emitted by the mobile phones through the electrophysiological and histological methods.METHODS: Twelve adult Wistar albino rats were included in the study. The rats were divided into two groups of six rats. The study group was exposed to the electromagnetic waves over a period of 30 days. The control group was not given any exposure to the electromagnetic fields. After the completion of the electromagnetic wave application, the auditory brainstem responses of both groups were recorded under anesthesia. The degeneration of cochlear nuclei was graded by two different histologists, both of whom were blinded to group information.RESULTS: The histopathologic and immunohistochemical analysis showed neuronal degeneration signs, such as increased vacuolization in the cochlear nucleus, pyknotic cell appearance, and edema in the group exposed to the electromagnetic fields compared to the control group. The average latency of wave in the ABR was similar in both groups (p&gt;0.05). <p><a href="https://greenmedinfo.com/article/chronic-exposure-electromagnetic-waves-results-neuronal-degeneration-auditory-" target="_blank">read more</a></p> https://greenmedinfo.com/article/chronic-exposure-electromagnetic-waves-results-neuronal-degeneration-auditory-#comments Electromagnetic Field Harms Electromagnetic Radiation Neurotoxic electromagnetic fields electromagnetic radiation EMF Neurodegenerative diseases Animal Study Tue, 30 Jul 2019 20:52:59 +0000 greenmedinfo 192370 at https://greenmedinfo.com Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis. https://greenmedinfo.com/article/eugenol-prevents-amyloid-formation-proteins-and-inhibits-amyloid-induced-hemol n/a PMID:  Sci Rep. 2017 Feb 1 ;7:40744. Epub 2017 Feb 1. PMID: 28145454 Abstract Title:  Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis. Abstract:  Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here, we have investigated the effect of eugenol on amyloid formation of selected globular proteins. We find that both spontaneous and seed-induced aggregation processes of insulin and serum albumin (BSA) are significantly suppressed in the presence of eugenol. Isothermal titration calorimetric data predict a single binding site for eugenol-insulin complex confirming the affinity of eugenol for native soluble insulin species. We also find that eugenol suppresses amyloid-induced hemolysis. Our findings reveal the inherent ability of eugenol to stabilize native proteins and to delay the conversion of protein species of native conformation intoβ-sheet assembled mature fibrils, which seems to be crucial for its inhibitory effect. https://greenmedinfo.com/article/eugenol-prevents-amyloid-formation-proteins-and-inhibits-amyloid-induced-hemol#comments Alzheimer's Disease Eugenol Neurodegenerative Diseases Neuroprotective Agents Alzheimer's disease eugenol Neurodegenerative diseases Neuroprotective Agents In Vitro Study Mon, 10 Apr 2017 16:31:44 +0000 greenmedinfo 146110 at https://greenmedinfo.com In Defense of Coconut Oil: Rebuttal to USA Today https://greenmedinfo.com/blog/defense-coconut-oil-rebuttal-usa-today <p class="rtecenter" dir="ltr"><img alt="In Defense of Coconut Oil: Rebuttal to USA Today" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/lrossi/images/coconut_oil_usa_today_greenmedinfo.jpg" style="width: 700px; height: 465px;" title="In Defense of Coconut Oil: Rebuttal to USA Today" /></p> <p dir="ltr"><span style="font-size:18px;"><em><strong><span id="docs-internal-guid-0aee871e-c5ad-6dd4-66cd-6cb142446f08">By now, I'm sure you've seen the</span> USA Today article entitled, "<a href="https://www.usatoday.com/story/news/nation-now/2017/06/16/coconut-oil-isnt-healthy-its-never-been-healthy/402719001/" rel="nofollow" target="_blank" title="In Defense of Coconut Oil: Rebuttal to USA Today">Coconut oil isn't healthy. It's never been healthy</a>". Fear-mongering, attention-grabbing headlines certainly sell copy, but do not make for evidence-informed, high quality science reporting. </strong></em></span></p> <p dir="ltr">As I expressed in my recent post on social media,</p><p><a href="https://greenmedinfo.com/blog/defense-coconut-oil-rebuttal-usa-today" target="_blank">read more</a></p> https://greenmedinfo.com/blog/defense-coconut-oil-rebuttal-usa-today#comments Alzheimer's Disease Autoimmune Diseases Coconut Oil Neurodegenerative Diseases Omega-3 Fatty Acids anti microbial Health Guide: Alzheimer's Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Autoimmune Diseases coconut oil In Defense of Coconut Oil: Rebuttal to USA Today Neurodegenerative diseases omega-3 fatty acids saturated fats Tue, 20 Jun 2017 13:28:50 +0000 AliLeVere 149345 at https://greenmedinfo.com Intake of fisetin during pregnancy in rats ameliorated in utero mercury exposure induced neurotoxicity outcomes. https://greenmedinfo.com/article/intake-fisetin-during-pregnancy-rats-ameliorated-utero-mercury-exposure-induce n/a PMID:  Biol Trace Elem Res. 2017 Jun ;177(2):297-315. Epub 2016 Nov 4. PMID: 27815688 Abstract Title:  Effect of Gestational Intake of Fisetin (3,3&#039;,4&#039;,7-Tetrahydroxyflavone) on Developmental Methyl Mercury Neurotoxicity in F1 Generation Rats. Abstract:  Methyl mercury (MeHg) is a developmental neurotoxin that causes irreversible cognitive damage in offspring of gestationally exposed mothers. Currently, no preventive drugs are established against MeHg developmental neurotoxicity. The neuroprotective effect of gestational administration of a flavanoid against in utero toxicity of MeHg is not explored much. Hence, the present study validated the effect of a bioactive flavanoid, fisetin, on MeHg developmental neurotoxicity outcomes in rat offspring at postnatal weaning age. Pregnant Wistar rats were simultaneously given MeHg (1.5 mg/kg b.w.) and two doses of fisetin (10 and 50 mg/kg b.w. in two separate groups) orally from gestational day (GD) 5 till parturition. Accordingly, after parturition, on postnatal day (PND) 24, weaning F1 generation rats were studied for motor and cognitive behavioural changes. Biochemical and histopathological changes were also studied in the cerebral cortex, cerebellum and hippocampus on PND 25. Administration of fisetin during pregnancy prevented behavioural impairment due to transplacental MeHg exposure in weaning rats. Fisetin decreased the levels of oxidative stress markers, increased enzymatic and non-enzymatic antioxidant levels and increased the activity of membrane-bound ATPases and cholinergic function in F1 generation rats. In light microscopic studies, fisetin treatment protected the specific offspring brain regions from significant morphological aberrations. Between thetwo doses of fisetin studied, 10 mg/kg b.w. was found to be more satisfactory and effective than 50 mg/kg b.w. The present study shows that intake of fisetin during pregnancy in rats ameliorated in utero MeHg exposure-induced neurotoxicity outcomes in postnatal weaning F1 generation rats. https://greenmedinfo.com/article/intake-fisetin-during-pregnancy-rats-ameliorated-utero-mercury-exposure-induce#comments Fisetin Flavonoids Mercury Poisoning Neurodegenerative Diseases Oxidative Stress Prenatal Chemical Exposures Mercury Neuroprotective Agents Fisetin Flavonoids Mercury Poisoning Methylmercury Neurodegenerative diseases oxidative stress Prenatal Chemical Exposures Animal Study Wed, 19 Jul 2017 22:44:08 +0000 greenmedinfo 150696 at https://greenmedinfo.com Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. https://greenmedinfo.com/article/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic- n/a PMID:  Life Sci. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29287782 Abstract Title:  Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. Abstract:  AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress. For this purpose, young rats were orally treated with naringenin (NAR), curcumin (CUR) and quercetin (QUE) at a dose of 50mg/kg, 200mg/kg and 50mg/kg respectively for 16days. At 4th day of drug administration cognitive functions were monitored by Morris water maze test. In MWM cognitive functions in terms of learning acquisition (1h after training), retention (24h after training), memory extinction (4days after training), and reconsolidation (8 and 12days after training) were monitored. Biochemical and neurochemical analysis were done in whole brain. KEY FINDINGS: Treatment of NAR, CUR and QUE significantly enhanced learning acquisition, memory retention and reconsolidation and prevented memory extinction. Treatment of NAR and QUE prevented the alteration of brain antioxidant defence system by enhancing antioxidant enzyme activities and increasing antioxidant compound concentration. Oxidative stress in terms of lipid peroxidation was significantly prevented in treated rats. Serotonergic and cholinergic improvement was also found in treated rats. SIGNIFICANCE: The present study therefore provides biological evidence supporting the usefulness of these polyphenolic compounds in daily life for improvement of cognitive abilities and hence may have a potential role in the management of dementia and related disorders. https://greenmedinfo.com/article/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-#comments Curcumin Naringenin Neurodegenerative Diseases Quercetin Antioxidants Neuroprotective Agents Antioxidants CURCUMIN Naringenin Neurodegenerative diseases Neuroprotective Agents QUERCETIN Animal Study Tue, 23 Jan 2018 18:16:18 +0000 greenmedinfo 158696 at https://greenmedinfo.com Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. https://greenmedinfo.com/article/royal-jelly-well-known-its-protective-effects-reproductive-health-neurodegener n/a PMID:  Oxid Med Cell Longev. 2017 ;2017:1259510. Epub 2017 Jul 26. PMID: 28814983 Abstract Title:  Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Abstract:  BACKGROUND: There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. SCOPE AND APPROACH: In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. KEY FINDINGS AND CONCLUSIONS: An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions. https://greenmedinfo.com/article/royal-jelly-well-known-its-protective-effects-reproductive-health-neurodegener#comments Aging Bee Propolis Honey Neurodegenerative Diseases Royal Jelly Wound Healing Anti-Inflammatory Agents Neuroprotective Agents Aging Anti-Inflammatory Agents bee propolis Honey Neurodegenerative diseases Neuroprotective Agents Royal Jelly wound healing Review Thu, 08 Feb 2018 03:39:23 +0000 greenmedinfo 159486 at https://greenmedinfo.com Sulforphane's antioxidant properties make it an effective neuroprotective agent. More studies are needed to determine the exact implications in neurological disease. https://greenmedinfo.com/article/sulforphanes-antioxidant-properties-make-it-effective-neuroprotective-agent-mo PMID:  Brain Circ. 2019 Apr-Jun;5(2):74-83. Epub 2019 Jun 27. PMID: 31334360 Abstract Title:  The neuroprotective mechanisms and effects of sulforaphane. Abstract:  Sulforaphane (SFN) is a phytochemical found in cruciferous vegetables. It has been shown to have many protective effects against many diseases, including multiple types of cancer. SFN is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathway. Upregulation of Nrf2-ARE increases the availability of multiple antioxidants. A substantial amount of preclinical research regarding the ability of SFN to protect the nervous system from many diseases and toxins has been done, but only a few small human trials have been completed. Preclinical data suggest that SFN protects the nervous system through multiple mechanisms and may help reduce the risk of many diseases and reduce the burden of symptoms in existing conditions. This review focuses on the literature regarding the protective effects of SFN on the nervous system. A discussion of neuroprotective mechanisms is followed by a discussion of the protective effects elicited by SFN administration in a multitude of neurological diseases and toxin exposures. SFN is a promising neuroprotective phytochemical which needs further human trials to evaluate its efficacy in preventing and decreasing the burden of many neurological diseases. <p><a href="https://greenmedinfo.com/article/sulforphanes-antioxidant-properties-make-it-effective-neuroprotective-agent-mo" target="_blank">read more</a></p> https://greenmedinfo.com/article/sulforphanes-antioxidant-properties-make-it-effective-neuroprotective-agent-mo#comments Sulforaphane Antioxidant antioxidant Antioxidant Effects Antioxidants antioxidants neuro-protective Neuroprotective Agents NF-E2-Related Factor-2 (Nrf2) Modulator Nrf2 activation Antioxidant effects Antioxidant Systems Cruciferous Vegetables Neurodegenerative diseases Neuroprotective Agents Nrf2 activation Phytotherapy Sulforaphane Review Wed, 24 Jul 2019 18:33:49 +0000 greenmedinfo 191800 at https://greenmedinfo.com The critical review results indicate that compounds in avocado are unique antioxidants, and thus may be promising as effective neuropreventive agents. https://greenmedinfo.com/article/critical-review-results-indicate-compounds-avocado-are-unique-antioxidants-and n/a PMID:  Adv Neurobiol. 2016 ;12:337-54. PMID: 27651262 Abstract Title:  Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases. Abstract:  Avocados have a high content of phytochemicals especially antioxidants with potential neuroprotective effect. Aging is the major risk factor for neurodegenerative diseases such as Alzheimer&#039;s and Parkinson&#039;s diseases. A large body of evidence indicates that oxidative stress is involved in the pathophysiology of these diseases. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. There is evidence for increased oxidative damage to macromolecules in amyotrophic lateral sclerosis, Huntington&#039;s disease, Parkinson&#039;s disease, and Alzheimer&#039;s disease. Thus, antioxidants have been used for their effectiveness in reducing these deleterious effects and neuronal death in many in vitro and in vivo studies. The critical review results indicate that compounds in avocado are unique antioxidants, preferentially suppressing radical generation, and thus may be promising as effective neuropreventive agents. The diverse array of bioactive nutrients present in avocado plays a pivotal role in the prevention and cure of various neurodegenerative diseases. https://greenmedinfo.com/article/critical-review-results-indicate-compounds-avocado-are-unique-antioxidants-and#comments Alzheimer's Disease Amyotrophic lateral sclerosis (ALS) Avocado Huntington Disease Neurodegenerative Diseases Parkinson's Disease Antioxidants Neuroprotective Agents Alzheimer's disease Amyotrophic lateral sclerosis (ALS) Avocado Huntington Disease Neurodegenerative diseases Parkinson's disease Review Tue, 07 Feb 2017 17:08:36 +0000 greenmedinfo 143100 at https://greenmedinfo.com These results indicate that SIRT1 and TORC1 might play an important mediating role in aluminium -induced long-term memory impairment. https://greenmedinfo.com/article/these-results-indicate-sirt1-and-torc1-might-play-important-mediating-role-alu n/a PMID:  Basic Clin Pharmacol Toxicol. 2017 Oct ;121(4):342-352. Epub 2017 Jun 19. PMID: 28429887 Abstract Title:  Effects of Aluminium on Long-Term Memory in Rats and on SIRT1 Mediating the Transcription of CREB-Dependent Gene in Hippocampus. Abstract:  Epidemiological investigations have shown that aluminium (Al) is an important neurotoxicant which can be absorbed by organisms via various routes. Previous studies have confirmed that exposure to Al could cause neurodegenerative diseases, decline CREB phosphorylation and then down-regulate the transcription and protein expression of its target genes including BDNF. However, recent studies revealed that CREB activation alone was far from enough to activate the expression of long-term memory (LTM)-related genes; there might be other regulatory factors involved in this process. Several studies showed that TORC1 might be involved in regulating the transcription of downstream target genes as well. Also, TORC1 could be mediated by SIRT1 during the formation of LTM. However, the role of CREB regulating system in Al-induced LTM impairment was still not utterly elucidated till now. This study was designed to establish the rat model of subchronic Al exposure to observe the neuroethology, regulatory factor levels and molecular biological alterations in hippocampal cells. The results showed that, with the increasing AlCl3 dose, blood Al content increased gradually; morphology of the hippocampus and neuronal ultrastructure were aberrant; in the Morris water maze test, the escape latency and distance travelled became longer, swimming traces turned more complicated in the place navigation test; intracellular Ca2+ , cAMP levels declined significantly in AlCl3 -treated rats, followed by abated nuclear translocation of TORC1 and decreased SIRT1, TORC1 and pCREB levels. These results indicate that SIRT1 and TORC1 might play an important mediating role in Al-induced LTM impairment. https://greenmedinfo.com/article/these-results-indicate-sirt1-and-torc1-might-play-important-mediating-role-alu#comments Aluminum Toxicity Memory Disorders Neurodegenerative Diseases Aluminum aluminum aluminum toxicity Memory Disorders Neurodegenerative diseases Animal Study Thu, 08 Feb 2018 01:23:31 +0000 greenmedinfo 159467 at https://greenmedinfo.com Thymoquinone protects against cobalt chloride-induced neurotoxicity. https://greenmedinfo.com/article/thymoquinone-protects-against-cobalt-chloride-induced-neurotoxicity n/a PMID:  J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):843-853. PMID: 29254287 Abstract Title:  Thymoquinone protects against cobalt chloride-induced neurotoxicity via Nrf2/GCL-regulated glutathione homeostasis. Abstract:  The prevalence of neurodegenerative diseases worldwide has increased dramatically in the last decades. Hypoxia and oxidative stress play a central role in the pathogenesis of neurodegenerative diseases. Thymoquinone (TQ) is a monoterpenoid hydrocarbon compound that possesses potent antioxidant activity. In the current study, we investigated the neuroprotective effects of TQ against CoCl2, a widely used hypoxia-inducing agent. We found that TQ inhibited CoCl2-indcued cytotoxicity in vitro, as reflected by an increase of cell viability and decrease of apoptosis in CoCl2-treated PC12 cells. TQ exhibited a potent protective effect against CoCl2-induced neurotoxicity in vivo, as evidenced by decreased time spent to find the platform site in the Probe trials, reduced escape latencies, decreased traveling distance and reduction of apoptotic cell death in brains in CoCl2-treated rats. CoCl2-resulted decrease of glutathione (GSH) and increase of malondialdehyde (MDA) levels were significantly inhibited by TQ. Inhibition of GSH synthesis by buthionine sulphoximine (BSO) significantly attenuated TQ-induced neuroprotective effects against CoCl2 in rats and in PC12 cells. TQ could upregulate nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/glutamate-cysteine ligase catalytic subunit (GCLc) and Nrf2/glutamate-cysteine ligase modifier subunit (GCLm) pathway which contributed to antioxidant and neuroprotective effects of TQ. In summary, we found that TQ exhibited protective effects against neurotoxicity via upregulation of Nrf2/GCL signaling. Upregulation of Nrf2/GCL signaling promoted the synthesis of GSH and contributed to attenuation of oxidative stress, neuronal cell apoptosis and neurotoxicity. These data have appointed a new path toward the understanding of the neuroprotective activities of TQ. https://greenmedinfo.com/article/thymoquinone-protects-against-cobalt-chloride-induced-neurotoxicity#comments Neurodegenerative Diseases Thymoquinone Antioxidants Cobalt Neuroprotective Agents Nrf2 activation Antioxidants Cobalt Neurodegenerative diseases Neuroprotective Agents Nrf2 activation thymoquinone In Vitro Study Tue, 09 Jan 2018 19:25:04 +0000 greenmedinfo 158249 at https://greenmedinfo.com