Sedative effects https://greenmedinfo.com/category/pharmacological-actions/sedative-effects en A review of cannabinoids in bipolar affective disorder. https://greenmedinfo.com/article/review-cannabinoids-bipolar-affective-disorder n/a PMID:  J Psychopharmacol. 2005 May ;19(3):293-300. PMID: 15888515 Abstract Title:  Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. Abstract:  Bipolar affective disorder is often poorly controlled by prescribed drugs. Cannabis use is common in patients with this disorder and anecdotal reports suggest that some patients take it to alleviate symptoms of both mania and depression. We undertook a literature review of cannabis use by patients with bipolar disorder and of the neuropharmacological properties of cannabinoids suggesting possible therapeutic effects in this condition. No systematic studies of cannabinoids in bipolar disorder were found to exist, although some patients claim that cannabis relieves symptoms of mania and/or depression. The cannabinoids Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) may exert sedative, hypnotic, anxiolytic, antidepressant, antipsychotic and anticonvulsant effects. Pure synthetic cannabinoids, such as dronabinol and nabilone and specific plant extracts containing THC, CBD, or a mixture of the two in known concentrations, are available and can be delivered sublingually. Controlled trials of these cannabinoids as adjunctive medication in bipolar disorder are now indicated. https://greenmedinfo.com/article/review-cannabinoids-bipolar-affective-disorder#comments Bipolar Disorder Cannabidiol Cannabinoids Delta-tetrahydrocannabinol (THC) Anti-Anxiety Agents Antidepressive Agents Sedative effects Anti-Anxiety Agents Antidepressive Agents bipolar disorder Cannabidiol Cannabinoids Delta-tetrahydrocannabinol (THC) Sedative effects Review Fri, 09 Jun 2017 22:58:59 +0000 greenmedinfo 148977 at https://greenmedinfo.com A review of phytochemistry and pharmacology of Lemon verbena. https://greenmedinfo.com/article/review-phytochemistry-and-pharmacology-lemon-verbena PMID:  J Ethnopharmacol. 2018 Aug 10 ;222:34-51. Epub 2018 Apr 23. PMID: 29698776 Abstract Title:  Aloysia citrodora Paláu (Lemon verbena): A review of phytochemistry and pharmacology. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Aloysia citrodora Paláu (Lippia citriodora Kunth), commonly known as&quot;lemon verbena&quot;is a medicinal plant native to South America, North Africa, and South of Europe which is used by native people for several indications such as diarrhea, flatulence, insomnia, and rheumatism.AIM OF THE REVIEW: Despite the wide biological activities of lemon verbena, there is no current review summarizing medicinal properties of the plant; thus, this paper aims to discuss current state of the art regarding the phytochemistry, pharmacology, and therapeutic applications of A. citrodora considering in vitro, in vivo, and clinical studies.MATERIALS AND METHODS: Electronic databases including PubMed, Scifinder, Cochrane library, Scopus, and Science direct were searched with the scientific name of the plant and its synonyms, as well as the common name. All studies on the ethnobotany, phytochemistry, pharmacology, and clinical application of the plant until October 2017 were included in this review.RESULTS: Despite the few number of studies on the ethnopharmacology of the plant, A. citrodora is widely assessed regarding its phytochemistry and biological activities. Neral and geranial are the main ingredients of the essential oil; whereas verbascoside is the most significant component of the extract. Biological activities such as antioxidant, anxiolytic, neuroprotective, anticancer, anesthetic, antimicrobial, and sedative effects are proved in cell cultures, as well as animal studies.CONCLUSIONS: Several pharmacological activities have been reported for A. citrodora; however, the plant is not fully assessed regarding its safety and efficacy in human. Future well-designed human studies are essential to confirm the therapeutic benefits of this plant in clinical settings. <p><a href="https://greenmedinfo.com/article/review-phytochemistry-and-pharmacology-lemon-verbena" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-phytochemistry-and-pharmacology-lemon-verbena#comments Lemon Verbena Anti-Anxiety Agents Antimicrobial Antioxidants Chemotherapeutic Neuroprotective Agents Sedative effects Review Tue, 11 Sep 2018 18:11:08 +0000 greenmedinfo 170460 at https://greenmedinfo.com Ancient Medical Miracle Rediscovered by Modern Science - Laurus Nobilis https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2013<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;"><img alt="Ancient Medical Miracle Rediscovered by Modern Science - Laurus Nobilis" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/ken@sinfullywholesome.com/images/Laurus%20Nobilis%20research.jpg" style="width: 800px; height: 400px;" /></p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p> <p dir="ltr" style="line-height:1.15;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p><p><a href="https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis" target="_blank">read more</a></p> https://greenmedinfo.com/blog/ancient-medical-miracle-rediscovered-modern-science-laurus-nobilis#comments Acne Alzheimer's Arthritis Athlete's foot Bay Laurel Bay Leaves Cardiovascular Disease Cholesterol Alternatives to Blood Pressure Medication Cholesterol Ratio: ldl/hdl Cradle Cap Diabetes Eczema Gastric Ulcers Jock Itch Laurus Nobilis. True Laurel Leukemia Melanoma MRSA Neurodegenerative Diseases Parkinson&#039;s Pityriasis Versicolor Psoriasis Ringworm Rosacea SARS Scalp ringworm Skin Cancer Tinea Versicolor ACE inhibitory effects Anti-catarrhal Anti-fungal effects Anti-leukemia Effects Anti-melanoma effectsAntibacterial effects Anticonvulsive effects Antioxidant Effects Arthritis Bactericidal Blood Sugar Problems Cancer Cicatrizing agent Cold and Flu Ethanol absorption effects Expectorant For Goodness Sake Fungicidal Health Guide: Aging Health Guide: Alzheimer's Health Guide: Herbs and Traditional Knowledge Health Guide: HIV/AIDS Research Health Guide: Medicinal Spices Health Guide: Mental Health Health Guide: Statin Drugs Health Guide: Viruses Health Guides: Healing Foods Heart Health Infant and Children's Heatlh Men's Health Neuromuscular effects Potent analgesic Sedative effects Sympathetic and parasympathic regulator Virucidal Women's Health Wound Healing Effects Aleppo Soap Antioxidant Bay Laurel Bay Leaves Cardiovascular Disease Cholesterol Alternatives to Blood Pressure Medication Cholesterol Ratio: ldl/hdl Diabetes Gastric Ulcers Laurel Laurel Berry Oil Laurel Essential Oil Laurel Oil Laurel Soap Laurus Nobilis leukemia melanoma Neurodegenerative diseases Pityriasis versicolor Ringworm Scalp ringworm skin cancer Skin diesases Tinea versicolor True Laurel Sat, 07 Sep 2013 18:10:44 +0000 sinfullywholesome 109672 at https://greenmedinfo.com Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa. https://greenmedinfo.com/article/anxiolytic-and-sedative-activities-passiflora-edulis-f-flavicarpa PMID:  J Ethnopharmacol. 2010 Mar 2 ;128(1):148-53. Epub 2010 Jan 4. PMID: 20051259 Abstract Title:  Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa. Abstract:  AIM OF THE STUDY: Many plants in the genus Passiflora have long been used in traditional folk medicines as a remedy for many neurogenic diseases in many countries. A number of species of the genus was studied about their neuropharmacological activities, but the results were inconsistent. No literature reported neuropharmacological studies on Passiflora edulis f. flavicarpa as yet. The present study was aimed at evaluating the anxiolytic and sedative activities of Passiflora edulis f. flavicarpa.MATERIALS AND METHODS: Swiss albino mice were used as experimental animals in elevated plus-maze (EPM) test and spontaneous activity (SA) test to assay the behavioral effects of ethanolic extract (EE) of the aerial part of Passiflora edulis f. flavicarpa and its fractions, viz. petrol ether extract (PEE), ethyl acetate extract (EAE), n-BuOH extract (BE) and aqueous extract (AE), together with subfractions of BE, viz. BEF-I, BEF-II, BEF-III, BEF-IV and isoorientin, a flavonoid component isolated from BEF-III.RESULTS: In the EPM test, single-dose oral administration of EE (300 mg/kg and 400mg/kg), BE (125 mg/kg and 200mg/kg), AE (200mg/kg and 300 mg/kg), BEF-I (200mg/kg), BEF-II (200mg/kg), BEF-III (100mg/kg), or isoorientin (20mg/kg) resulted in anxiolytic-like effects, but a sedative-like activity was produced at higher doses, such as 300 mg/kg of BE, 200mg/kg of BEF-III, or 40 mg/kg and 80 mg/kg of isoorientin. The results of the SA test manifested that treatment with 400mg/kg of EE, 300 mg/kg of BE, or 40 mg/kg and 80 mg/kg of isoorientin compromised motor activity in mice, which are in line with the results of the EPM test.CONCLUSIONS: The aerial part of Passiflora edulis f. flavicarpa was anxiolytic at low dose but sedative at high dose. Flavonoids are important active constituents. Since AE contained little flavonoids, it was conjectured that there were other components responsible for the anxiolytic effect of Passiflora edulis f. flavicarpa besides flavonoids. <p><a href="https://greenmedinfo.com/article/anxiolytic-and-sedative-activities-passiflora-edulis-f-flavicarpa" target="_blank">read more</a></p> https://greenmedinfo.com/article/anxiolytic-and-sedative-activities-passiflora-edulis-f-flavicarpa#comments Anxiety Passion Flower Anti-Anxiety Agents Sedative effects Plant Extracts Animal Study Sat, 18 Aug 2018 01:35:59 +0000 greenmedinfo 169298 at https://greenmedinfo.com Ashwagandha could be of potential use to improve sleep parameters in patients with insomnia and anxiety. https://greenmedinfo.com/article/ashwagandha-could-be-potential-use-improve-sleep-parameters-patients-insomnia- PMID:  Cureus. 2019 Sep 28 ;11(9):e5797. Epub 2019 Sep 28. PMID: 31728244 Abstract Title:  Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Abstract:  Introduction Insomnia is a prevalent sleep disorder that can profoundly impact a person&#039;s physical health and mental wellbeing. Most of the currently available drugs for insomnia exert adverse effects. Hence, alternative herbal therapies could be effective in treating insomnia. Ashwagandha, a proven&quot;Rasayana&quot;from ancient Ayurveda is having the required potential to treat insomnia. Objective To determine the efficacy and safety of Ashwagandha root extract in patients with insomnia and anxiety. Methods This was a randomized, double-blind, placebo-controlled study conducted at Prakruti Hospital, Kalwa, Maharashtra, India. A total of 60 patients were randomly divided into two groups: test (n = 40) and placebo (n = 20) in a randomization ratio of 2:1. Test product was a capsule containing highest concentration full-spectrum Ashwagandha root extract 300 mg, and the placebo was an identical capsule containing starch. Both treatments were given twice daily with milk or water for 10 weeks. Sleep actigraphy (Respironics Philips) was used for assessment of sleep onset latency (SOL), total sleep time (TST), sleep efficiency (SE) and wake after sleep onset (WASO). Other assessments were total time in bed (sleep log), mental alertness on rising, sleep quality, Pittsburgh Sleep Quality Index (PSQI), and Hamilton Anxiety Rating Scale (HAM-A) scales. Results Two patients, one from each group, did not complete study and the per-protocol dataset (n = 58) included 29 and 19 patients from test and placebo, respectively. The baseline parameters were similar in the two groups at baseline. The sleep onset latency was improved in both test and placebo at five and 10 weeks. However, the SOL was significantly shorter (p, 0.019) after 10 weeks with test [29.00 (7.14)] compared to placebo [33.94 (7.65)]. Also, significant improvement in SE scores was observed with Ashwagandha which was 75.63 (2.70) for test at the baseline and increased to 83.48 (2.83) after 10 weeks, whereas for placebo the SE scores changed from 75.14 (3.73) at baseline to 79.68 (3.59) after 10 weeks. Similarly, significant improvement in sleepquality was observed with test compared to placebo (p, 0.002). Significant improvement was observed in all other sleep parameters, i.e., SOL, SE, PSQI and anxiety (HAM-A scores) with Ashwagandha root extract treatment for 10 weeks. Conclusion Ashwagandha root extract is a natural compound with sleep-inducing potential, well tolerated and improves sleep quality and sleep onset latency in patients with insomnia at a dose of 300 mg extract twice daily. It could be of potential use to improve sleep parameters in patients with insomnia and anxiety, but need further large-scale studies. <p><a href="https://greenmedinfo.com/article/ashwagandha-could-be-potential-use-improve-sleep-parameters-patients-insomnia-" target="_blank">read more</a></p> https://greenmedinfo.com/article/ashwagandha-could-be-potential-use-improve-sleep-parameters-patients-insomnia-#comments Anxiety Ashwagandha Insomnia Sedative effects Human Study Thu, 30 Jan 2020 20:44:27 +0000 greenmedinfo 209982 at https://greenmedinfo.com Assessment of valerian for conscious sedation of patients during the extraction of impacted mandibular third molars. https://greenmedinfo.com/article/assessment-valerian-conscious-sedation-patients-during-extraction-impacted-man PMID:  J Oral Maxillofac Surg. 2019 Sep ;77(9):1796.e1-1796.e8. Epub 2019 May 9. PMID: 31158346 Abstract Title:  Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study. Abstract:  PURPOSE: The objective of the present study was to evaluate the effectiveness of an herbal drug (valerian) to control anxiety during mandibular third molar extraction compared with a reference benzodiazepine drug commonly used in dental procedures (midazolam).MATERIALS AND METHODS: Twenty anxious patients with an indication for bilateral extraction of mandibular third molars were selected. The patients received capsules containing valerian 100 mg or midazolam 15 mg orally 60 minutes before the procedures in a randomized, split-mouth, crossover design. Changes in the physiological parameters (eg, oxygen saturation, heart rate, blood pressure, respiratory rate) were assessed at specific times during surgery, and the patients completed a questionnaire postoperatively. The data were analyzed using the Wilcoxon and paired t tests, with a significance level of 5%.RESULTS: No statistically significant differences in oxygen saturation were observed, regardless of the drug used. However, the other physiological parameters were significantly lower when the patients had taken midazolam compared with valerian. Somnolence was the most common side effect reported with both drugs.CONCLUSIONS: Although midazolam was more effective in reducing the physiological parameters studied, valerian seemed to provide the comfort and relaxation required, with no sedation and less somnolence than midazolam, during third molar extraction. Further studies are necessary before valerian can be clinically recommended. <p><a href="https://greenmedinfo.com/article/assessment-valerian-conscious-sedation-patients-during-extraction-impacted-man" target="_blank">read more</a></p> https://greenmedinfo.com/article/assessment-valerian-conscious-sedation-patients-during-extraction-impacted-man#comments Dental Care Tooth Extraction: Wisdom Valerian Sedative effects Plant Extracts Human Study Mon, 26 Dec 2022 10:52:44 +0000 greenmedinfo 268350 at https://greenmedinfo.com Behavioral pharmacology of five uncommon passiflora species indicates sedative and anxiolytic-like potential. https://greenmedinfo.com/article/behavioral-pharmacology-five-uncommon-passiflora-species-indicates-sedative-an PMID:  Cent Nerv Syst Agents Med Chem. 2022 Apr 26. Epub 2022 Apr 26. PMID: 35473529 Abstract Title:  Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential. Abstract:  BACKGROUND: There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects.OBJECTIVE: In this study, we performed an interspecific pharmacological comparison of five little investigated Passiflora species, all native to Brazil: P. bahiensis, P. coccinea, P. quadrangularis, P. sidaefolia, and P. vitifolia.METHOD: Extracts were administered to mice before behavioral testing, which included a general pharmacological screening and anxiolytic-like effect investigation.RESULTS: Three of the species [P. coccinea, P. quadrangularis, and P. sidaefolia] induced a decrease in locomotor activity of mice; P. coccinea also reduced the latency to sleep. Importantly, none of the species interfered with motor coordination. Oral administration evoked no severe signs of toxicity even at higher doses. Regarding the anxiolytic-like profile, P. sidaefolia reduced the anxious-like behavior in the Holeboard test in a similar way to the positive control, Passiflora incarnata, while not affecting total motricity.CONCLUSION: These results indicate that P. coccinea, P. quadrangularis, and P. sidaefolia reduced the general activity of mice and confer a calmative/sedative potential to these three species, which must be further elucidated by future investigations. <p><a href="https://greenmedinfo.com/article/behavioral-pharmacology-five-uncommon-passiflora-species-indicates-sedative-an" target="_blank">read more</a></p> https://greenmedinfo.com/article/behavioral-pharmacology-five-uncommon-passiflora-species-indicates-sedative-an#comments Anxiety Passion fruit Anti-Anxiety Agents Sedative effects Animal Study Mon, 18 Jul 2022 00:05:49 +0000 greenmedinfo 260661 at https://greenmedinfo.com Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor. https://greenmedinfo.com/article/curcuminoids-major-turmeric-component-have-sleep-enhancing-effect-targeting-hi PMID:  Food Funct. 2022 Dec 13 ;13(24):12697-12706. Epub 2022 Dec 13. PMID: 36408594 Abstract Title:  Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor. Abstract:  Turmeric () had been considered as a universal panacea in functional foods and traditional medicines. In recent, the sedative-hypnotic effect of turmeric extract (TE) was reported. However, sleep-promoting compounds in TE have been not yet demonstrated. Curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) are the major constituents of turmeric being responsible for its various biological activities. Therefore, they can be first assumed to be sedative-hypnotic compounds of TE. In the present study, we aimed to investigate the effects and underlying mechanisms of curcuminoids and each constituent on the sleep-wake cycle of mice. Molecular docking studies, histamine H1 receptor (H1R) binding assays, and H1R knockout animal studies were used to investigate the molecular mechanisms underlying the sleep-promoting effects. Curcuminoids and their constituents reduced sleep latency and increased sleep duration in the pentobarbital-induced sleep test in mice. In addition, curcuminoids significantly increased the duration of NREMS and reduced sleep latency without altering the REMS and delta activity. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin were predicted to interact with H1R in the molecular model. In the binding affinity assay, we found that curcuminoids, as well as their constituents, significantly bind to H1R with thevalue of 1.49μg mL. Furthermore, sleep latency was reduced and NREMS frequency was increased following curcuminoid administration in wild-type mice but not in H1R knockout mice. Therefore, we conclude that curcuminoids reduce sleep latency and enhance the quantity of NREMS by acting as modulators of H1R, indicating their usefulness in treating insomnia. <p><a href="https://greenmedinfo.com/article/curcuminoids-major-turmeric-component-have-sleep-enhancing-effect-targeting-hi" target="_blank">read more</a></p> https://greenmedinfo.com/article/curcuminoids-major-turmeric-component-have-sleep-enhancing-effect-targeting-hi#comments Curcuminoids Insomnia Sedative effects Plant Extracts Animal Study Fri, 27 Jan 2023 01:43:28 +0000 greenmedinfo 270111 at https://greenmedinfo.com Effects of tangerine essential oil on brain waves, moods, and sleep onset latency. https://greenmedinfo.com/article/effects-tangerine-essential-oil-brain-waves-moods-and-sleep-onset-latency PMID:  Molecules. 2020 Oct 21 ;25(20). Epub 2020 Oct 21. PMID: 33096890 Abstract Title:  Effects of Tangerine Essential Oil on Brain Waves, Moods, and Sleep Onset Latency. Abstract:  Tangerine () is one of the most important crops of Thailand with a total harvest that exceeds 100,000 tons. Citrus essential oils are widely used as aromatherapy and medicinal agents. The effect of tangerine essential oil on human brain waves and sleep activity has not been reported. In the present study, we therefore evaluated these effects of tangerine essential oil by measurement of electroencephalography (EEG) activity with 32 channel platforms according to the international 10-20 system in 10 male and 10 female subjects. Then the sleep onset latency was studied to further confirm the effect on sleep activity. The results revealed that different concentrations, subthreshold to suprathreshold, of tangerine oil gave different brain responses. Undiluted tangerine oil inhalation reduced slow and fast alpha wave powers and elevated low and mid beta wave powers. The subthreshold and threshold dilution showed the opposite effect to the brain compared with suprathreshold concentration. Inhalation of threshold concentration showed effectively decreased alpha and beta wave powers and increased theta wave power, which emphasize its sedative effect. The reduction of sleep onset latency was confirmed with the implementation of the observed sedative effect of tangerine oil. <p><a href="https://greenmedinfo.com/article/effects-tangerine-essential-oil-brain-waves-moods-and-sleep-onset-latency" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-tangerine-essential-oil-brain-waves-moods-and-sleep-onset-latency#comments Orange Sleep Disorders Sedative effects Essential Oils Human Study Thu, 31 Dec 2020 22:27:24 +0000 greenmedinfo 232072 at https://greenmedinfo.com Nelumbo nucifera seed extract promotes sleep in drosophila melanogaster. https://greenmedinfo.com/article/nelumbo-nucifera-seed-extract-promotes-sleep-drosophila-melanogaster PMID:  Biol Pharm Bull. 2018 ;41(3):399-408. PMID: 29491217 Abstract Title:  Nelumbo nucifera Seed Extract Promotes Sleep in Drosophila melanogaster. Abstract:  The sleep-promoting effects of the water extract of Nelumbo nucifera seeds (NNE) were investigated in an invertebrate model. The effects of NNE on the subjective nighttime activity, sleep episodes, and sleep time were determined using Drosophila melanogaster and locomotor activity monitoring systems in basal and caffeine-induced arousal conditions. The movements of fruit flies were analyzed using the Noldus EthoVision-XT system, and the levels of neuromodulators were analyzed using HPLC. Expression of neuromodulator receptors was analyzed using real-time PCR. NNE was shown to contain neurotransmission-related components;γ-aminobutyric acid (GABA) (2.33±0.22 mg/g), tryptophan (2.00±0.06 mg/g), quinidine (0.55±0.33 mg/g), and neferine (0.16±0.01 mg/g). The total activity of flies during nighttime was decreased by 52% with 1.0% NNE treatment. In the individual and collective conditions, the subjective nighttime activities (45/38%) and sleep bouts (20/14%) of flies was significantly decreased with NNE treatment, while total sleep times (10/27%) were significantly increased. This sleep-promoting effect is more pronounced in caffeine-treated conditions; the nighttime activity of flies was reduced by 53%, but total sleep time was increased by 60%. Our video-tracking analysis showed a significant decrease of the moving distance and velocity of flies by NNE. This NNE-mediated sleep-promoting effect was associated with up-regulation of GABA/GABAand serotonin receptors. The NNE-mediated increase of GABA content was identified in flies. These results demonstrate that NNE effectively promotes sleep in flies by regulating the GABAergic/serotonergic neuromodulators, and could be an alternative agent for sleep promotion. <p><a href="https://greenmedinfo.com/article/nelumbo-nucifera-seed-extract-promotes-sleep-drosophila-melanogaster" target="_blank">read more</a></p> https://greenmedinfo.com/article/nelumbo-nucifera-seed-extract-promotes-sleep-drosophila-melanogaster#comments Lotus Sleep Disorders Sedative effects Insect Study Mon, 26 Mar 2018 20:15:55 +0000 greenmedinfo 161689 at https://greenmedinfo.com Palmitoylethanolamide for sleep disturbance. https://greenmedinfo.com/article/palmitoylethanolamide-sleep-disturbance PMID:  Sleep Sci Pract. 2021 ;5(1):12. Epub 2021 Sep 10. PMID: 34522787 Abstract Title:  Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study. Abstract:  Background: Sleep is essential for wellbeing, yet sleep disturbance is a common problem linked to a wide range of health conditions. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide proposed to promote better sleep via potential interaction with the endocannabinoid system.Methods: This double-blind, randomised study on 103 adults compared the efficacy and tolerability of 8 weeks of daily supplemented PEA formulation (350 mg Levagen + ®) to a placebo. Sleep quality and quantity were measured using wrist actigraphy, a sleep diary and questionnaires.Results: At week 8, PEA supplementation reduced sleep onset latency, time to feel completely awake and improved cognition on waking. After 8 weeks, both groups improved their sleep quality and quantity scores similarly. There was no difference between groups at baseline or week 8 for sleep quantity or quality as measured from actigraphy or sleep diaries.Conclusion: These findings support PEA as a potential sleeping aid capable of reducing sleep onset time and improving cognition on waking.Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12618001339246. Registered 9August 2018. <p><a href="https://greenmedinfo.com/article/palmitoylethanolamide-sleep-disturbance" target="_blank">read more</a></p> https://greenmedinfo.com/article/palmitoylethanolamide-sleep-disturbance#comments Sleep Disorders Sedative effects Human Study Mon, 04 Oct 2021 01:19:38 +0000 greenmedinfo 246785 at https://greenmedinfo.com Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders. https://greenmedinfo.com/article/safety-and-efficacy-melatonin-clonazepam-and-trazodone-patients-parkinsons-dis PMID:  Neurol Sci. 2022 Oct ;43(10):6141-6148. Epub 2022 Jun 6. PMID: 35660990 Abstract Title:  Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson&#039;s disease and sleep disorders: a randomized, double-blind trial. Abstract:  BACKGROUND: Sleep disturbances are common non-motor symptoms of Parkinson&#039;s disease (PD). We aimed to compare the safety and efficacy of trazodone with melatonin and clonazepam in patients with PD and sleep complaints.METHODS: This single-center, double-blind, randomized clinical trial was conducted on PD patients with subjective sleep complaints. Eligible patients were randomized 1:1:1 to receive melatonin 3 mg/day, clonazepam 1 mg/day, or trazodone 50 mg/day for 4 weeks. The primary outcome measure was the changes in Pittsburgh Sleep Quality Index (PSQI) scores. The mean change in Epworth Sleepiness Scale (ESS) and RBD screening questionnaire (RBDSQ) was considered as the secondary outcome measures.RESULTS: A total of 112 eligible patients were randomized and 93 participants, melatonin (n = 31), trazodone (n = 31), and clonazepam (n = 31), completed the study. There was a significant decrease in PSQI scores after 4 weeks of treatment in all groups. The mean changes of PSQI from baseline were similar among the treatment arms (P = 0.325). Mean changes of RBDSQ and ESS from baseline were significantly different between study arms (P <p><a href="https://greenmedinfo.com/article/safety-and-efficacy-melatonin-clonazepam-and-trazodone-patients-parkinsons-dis" target="_blank">read more</a></p> https://greenmedinfo.com/article/safety-and-efficacy-melatonin-clonazepam-and-trazodone-patients-parkinsons-dis#comments Melatonin Parkinson's Disease Sleep Disorders Sedative effects Natural Substances Versus Drugs Human Study Sun, 07 Jan 2024 20:24:44 +0000 greenmedinfo 286059 at https://greenmedinfo.com Sleep promotion by 3-hydroxy-4-iminobutyric acid in walnut. https://greenmedinfo.com/article/sleep-promotion-3-hydroxy-4-iminobutyric-acid-walnut PMID:  Research (Wash D C). 2023 ;6:0216. Epub 2023 Sep 19. PMID: 37732131 Abstract Title:  Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut. Abstract:  Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human well-being. Concomitantly, the walnut () confers numerous salutary biological activities pertaining to sleep. Nevertheless, the sedative and hypnotic capacities of walnut&#039;s functional constituents remain obscure. In this investigation, we analyzed the sedative and hypnotic components of the walnutand innovatively discovered a compound, defined as 3-hydroxy-4-iminobutyric acid (HIBA), which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters (GABA, DA, etc.) within the brain and serum of mice. Subsequently, a metabolomics approach of the serum, basal ganglia, hypothalamus, and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep promotion. Our data reveal that HIBA can regulate the metabolism of basal ganglia (sphingolipids, acylcarnitines, etc.), possibly in relation to HIBA&#039;s influence on the gut microbiome (,,, etc.). Therefore, we introduce a novel natural product, HIBA, and explicate the modulation of sleep promotion in mice based on the microbiota-gut-brain axis. This study contributes fresh insights toward natural product-based sleep research. <p><a href="https://greenmedinfo.com/article/sleep-promotion-3-hydroxy-4-iminobutyric-acid-walnut" target="_blank">read more</a></p> https://greenmedinfo.com/article/sleep-promotion-3-hydroxy-4-iminobutyric-acid-walnut#comments Sleep Disorders Walnut Sedative effects Gut-brain Axis Animal Study Mon, 08 Jan 2024 22:31:11 +0000 greenmedinfo 286123 at https://greenmedinfo.com The data show that the Passiflora extract has not only sedative but also antiradical activity. https://greenmedinfo.com/article/data-show-passiflora-extract-has-not-only-sedative-also-antiradical-activity PMID:  Acta Pol Pharm. 2008 Sep-Oct;65(5):577-83. PMID: 19051605 Abstract Title:  Antiradical activities of the extract of Passiflora incarnata. Abstract:  The objective of this work was to investigate the aqueous and ethanolic extracts of passionflower and the influence of the flavonoids they contain on the antiradical activity by DPPH* and ABTS* + methods. The data show that the Passiflora extract has not only sedative but also antiradical activity. The ethanol extract catches free radicals more effectively than the water extract. The strongest antiradical effect among the investigated flavonoids (chlorogenic acid, hyperosid, isovitexin, caffeic acid, quercetin, luteolin, orentin, rutin, scutelarein, vicenin and vitexin) was predetermined by vicenin, isovitexin and orentin. The antiradical activity increases with the increase of the concentration of the mentioned materials. <p><a href="https://greenmedinfo.com/article/data-show-passiflora-extract-has-not-only-sedative-also-antiradical-activity" target="_blank">read more</a></p> https://greenmedinfo.com/article/data-show-passiflora-extract-has-not-only-sedative-also-antiradical-activity#comments Flavonoids Oxidative Stress Passion Flower Antioxidants Sedative effects Plant Extracts In Vitro Study Sat, 18 Aug 2018 02:59:02 +0000 greenmedinfo 169305 at https://greenmedinfo.com The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway. https://greenmedinfo.com/article/sedative-activity-flavonoids-passiflora-quadrangularis-mediated-through-gabaer PMID:  Biomed Pharmacother. 2018 Apr ;100:388-393. Epub 2018 Feb 16. PMID: 29454287 Abstract Title:  The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway. Abstract:  The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2&#039;&#039;-O-xyloside, vitexin-2&#039;&#039;-O-glucoside, orientin-2&#039;&#039;-O-xyloside and orientin-2&#039;&#039;-O-glucoside. Vitexin-2&quot;-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice. <p><a href="https://greenmedinfo.com/article/sedative-activity-flavonoids-passiflora-quadrangularis-mediated-through-gabaer" target="_blank">read more</a></p> https://greenmedinfo.com/article/sedative-activity-flavonoids-passiflora-quadrangularis-mediated-through-gabaer#comments Passion Flower Sedative effects In Vitro Study Mon, 26 Mar 2018 17:44:37 +0000 greenmedinfo 161678 at https://greenmedinfo.com