Flavonoids https://greenmedinfo.com/category/keywords/Flavonoids en 10 Reasons to Add Andrographis to Your Medicine Cabinet https://greenmedinfo.com/blog/10-reasons-add-andrographis-your-medicine-cabinet <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/10ReasonstoAddAndrographistoYourMedicineCabinet.jpg" style="width: 600px; height: 315px;" title="10 Reasons to Add Andrographis to Your Medicine Cabinet" /></span></span></p> <p><span style="font-size:18px;"><em><strong>Andrographis has the potential to replace a whole host of pharmaceutical drugs, and to improve autoimmune disorders, cancer, metabolic disease, and infection</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/10-reasons-add-andrographis-your-medicine-cabinet" target="_blank">read more</a></p> https://greenmedinfo.com/blog/10-reasons-add-andrographis-your-medicine-cabinet#comments Andrographis Diabetes Diarrhea Fever Flavonoids Inflammation Inflammatory Bowel Diseases Influenza Lupus Erythematosus: Systemic Malaria Oxidative Stress Parasitic Diseases Polyphenols Respiratory Infections Water Health Guide: Herbs and Traditional Knowledge Andrographis Diabetes Diarrhea fever Flavonoids healing foods Inflammation Inflammatory Bowel Diseases influenza natural health POLYPHENOLS traditional herbal formulation water Fri, 29 Dec 2017 20:47:34 +0000 AliLeVere 157852 at https://greenmedinfo.com 8 Healing Properties of Strawberries https://greenmedinfo.com/blog/8-healing-properties-strawberries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Juicy Reasons to Eat More Strawberries" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Strawberries1.jpg" style="width: 500px; height: 333px;" /></p> <p><strong><span style="font-size:18px;"><em>Who doesn't love <a href="/substance/strawberry" rel="dofollow" target="_blank">strawberries</a>? And you don't need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there's lots more to strawberries than the flavor.</em></span><a href="#_edn1" name="_ednref1" title="">[i]</a></strong></p> <p>Their study was <strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/24345049" rel="nofollow" target="_blank">published in the journal <em>Critical Reviews in Food Science and Nutrition</em></a></strong> with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry's status as a "functional food."</p><p><a href="https://greenmedinfo.com/blog/8-healing-properties-strawberries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-healing-properties-strawberries#comments Alzheimer's Disease Anthocyanins Blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases Carotenoids Catechin Ellagic Acid Flavonoids Hyperglycemia Hyperlipidemia Hypertension Kaempferol Naringenin Parkinson's Disease Phytosterols Polyphenols Potassium Quercetin Strawberry Vitamin C Vitamin E Antioxidants Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Anthocyanins Antioxidants blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases CAROTENOIDS Catechin Ellagic Acid Flavonoids hyperglycemia hyperlipidemia hypertension Kaempferol Naringenin Parkinson's disease phytosterols POLYPHENOLS potassium QUERCETIN Strawberry Vitamin C VITAMIN E Sat, 18 Feb 2023 17:30:10 +0000 GMI Research Group 114933 at https://greenmedinfo.com Animal experimentation and cocoa interventions in humans support the anti-inflammatory effect of cocoa compounds. https://greenmedinfo.com/article/animal-experimentation-and-cocoa-interventions-humans-support-anti-inflammator n/a PMID:  Nutrients. 2016 Apr 9 ;8(4):212. Epub 2016 Apr 9. PMID: 27070643 Abstract Title:  Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans. Abstract:  Chronic inflammation has been identified as a necessary step to mediate atherosclerosis and cardiovascular disease and as a relevant stage in the onset and progression of several types of cancer. Considerable attention has recently been focused on the identification of dietary bioactive compounds with anti-inflammatory activities as an alternative natural source for prevention of inflammation-associated diseases. The remarkable capacity of cocoa flavanols as antioxidants, as well as to modulate signaling pathways involved in cellular processes, such as inflammation, metabolism and proliferation, has encouraged research on this type of polyphenols as useful bioactive compounds for nutritional prevention of cardiovascular disease and cancer. Data from numerous studies suggest that cocoa and cocoa-derived flavanols can effectively modify the inflammatory process, and thus potentially provide a benefit to individuals with elevated risk factors for atherosclerosis/cardiovascular pathology and cancer. The present overview will focus on the most recent findings about the effects of cocoa, its main constituents and cocoa derivatives on selected biomarkers of the inflammatory process in cell culture, animal models and human cohorts. https://greenmedinfo.com/article/animal-experimentation-and-cocoa-interventions-humans-support-anti-inflammator#comments Atherosclerosis Cardiovascular Diseases Cocoa Flavonoids Inflammation Anti-Inflammatory Agents Anti-Inflammatory Agents Atherosclerosis Cancer Cardiovascular Diseases Cocoa Flavonoids Inflammation Risk Reduction Review Mon, 23 Jan 2017 23:49:09 +0000 greenmedinfo 142468 at https://greenmedinfo.com Anthocyanins and flavanones are more bioavailable than previously perceived. https://greenmedinfo.com/article/anthocyanins-and-flavanones-are-more-bioavailable-previously-perceived n/a PMID:  Annu Rev Food Sci Technol. 2017 Jan 11. Epub 2017 Jan 11. PMID: 28125348 Abstract Title:  Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence. Abstract:  This review considers recent investigations on the bioavailability of anthocyanins and flavanones. Both flavonoids are significant dietary components and are considered to be poorly bioavailable, as only low levels of phase II metabolites appear in the circulatory system and are excreted in urine. However, when lower molecular weight phenolic and aromatic ring-fission catabolites, produced primarily by the action of the colonic microbiota, are taken into account, it is evident that anthocyanins and flavanones are much more bioavailable than previously envisaged. The metabolic events to which these flavonoids are subjected as they pass along the gastrointestinal tract and are absorbed into the circulatory system prior to their rapid elimination by renal excretion are highlighted. Studies on the impact of other food components and the probiotic intake on flavonoid bioavailability are summarized, as is the bioactivity of metabolites and catabolites assayed using a variety of in vitro model systems. Expected final online publication date for the Annual Review of Food Science and Technology Volume 8 is February 28, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. https://greenmedinfo.com/article/anthocyanins-and-flavanones-are-more-bioavailable-previously-perceived#comments Anthocyanins Flavonoids Anthocyanins Bioavailability Flavonoids Review Wed, 01 Feb 2017 18:08:58 +0000 greenmedinfo 142872 at https://greenmedinfo.com Eat These Foods To Protect Against Ovarian Cancer https://greenmedinfo.com/blog/eat-these-foods-protect-against-ovarian-cancer-1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Eat These Foods To Protect Against Ovarian Cancer" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/apples-with-quercetin-small.jpg" style="width: 400px; height: 300px;" /></p> <p><span style="font-size:16px;"><em><strong>These foods can make the difference in who becomes a victim to ovarian cancer, the most lethal gynecological cancer known.</strong></em></span></p> <p><strong><a href="/disease/ovarian-cancer" target="_blank">Ovarian cancer</a></strong> is the most lethal gynecological cancer in the world.&nbsp; About 20,000 women in the U.S. each year are diagnosed with the disease [many of which, however, may be <strong><a href="/blog/ovarian-cancer-what-we-think-we-know-may-harm-us" target="_blank">overdiagnosed</a></strong>].&nbsp; Unlike some other cancers, researchers haven't been able to identify many risk factors for ovarian cancer that a woman can control.&nbsp;</p><p><a href="https://greenmedinfo.com/blog/eat-these-foods-protect-against-ovarian-cancer-1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/eat-these-foods-protect-against-ovarian-cancer-1#comments Anthocyanins Apples Broccoli Brussels Sprouts Cabbage Flavonoids Grapes Kale Onions Oranges Ovarian Cancer Red Wine Tea Anthocyanins apples Broccoli Brussels sprouts Cabbage Flavonoids Grapes Kale Onions Oranges ovarian cancer Red Wine Tue, 04 Nov 2014 15:36:55 +0000 mmking 115190 at https://greenmedinfo.com Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer. https://greenmedinfo.com/article/flavonoids-vegetables-and-fruits-may-be-linked-reduced-risk-colorectal-cancer n/a PMID:  Br J Nutr. 2016 Oct ;116(7):1275-1287. Epub 2016 Sep 21. PMID: 27650133 Abstract Title:  Flavonoid intake from vegetables and fruits is inversely associated with colorectal cancer risk: a case-control study in China. Abstract:  Flavonoids may play an important role in the protective effects of vegetables, fruits and tea against colorectal cancer. However, associations between flavonoids and colorectal cancer risk are inconsistent, and a few studies have evaluated the effect of flavonoids from different dietary sources separately. This study aimed to evaluate associations of flavonoids intake from different dietary sources with colorectal cancer risk in a Chinese population. From July 2010 to December 2015, 1632 eligible colorectal cancer cases and 1632 frequency-matched controls (age and sex) completed in-person interviews. A validated FFQ was used to estimate dietary flavonoids intake. Multivariate logistical regression models were used to calculate the OR and 95 % CI of colorectal cancer risk after adjusting for various confounders. No significant association was found between total flavonoids and colorectal cancer risk, with an adjusted OR of 1·06 (95 % CI 0·85, 1·32) comparing the highest with the lowest quartile. Anthocyanidins, flavanones and flavones intakes from total diet were found to be inversely associated with colorectal cancer risk. Compared with the lowest quartile, the adjusted OR for the highest quartile were 0·80 (95 %CI 0·64, 1·00) for anthocyanidins, 0·28 (95 % CI 0·22, 0·36) for flavanones and 0·54 (95 % CI 0·43, 0·67) for flavones. All subclasses of flavonoids from vegetables and fruits were inversely associated with colorectal cancer. However, no significant association was found between tea flavonoids and colorectal cancer risk. These data indicate that specific flavonoids, specifically flavonoids from vegetables and fruits, may be linked with the reduced risk of colorectal cancer. https://greenmedinfo.com/article/flavonoids-vegetables-and-fruits-may-be-linked-reduced-risk-colorectal-cancer#comments Colorectal Cancer Colorectal Cancer: Prevention Flavonoids Fruit: All Vegetables: All COLORECTAL CANCER Colorectal Cancer: Prevention Flavonoids Fruit: All Risk Reduction Vegetables: All Human Study Wed, 01 Feb 2017 17:56:08 +0000 greenmedinfo 142869 at https://greenmedinfo.com Higher dietary intake of flavonoid may be inversely associated with depressive symptoms. https://greenmedinfo.com/article/higher-dietary-intake-flavonoid-may-be-inversely-associated-depressive-symptom n/a PMID:  Molecules. 2018 Apr 24 ;23(5). Epub 2018 Apr 24. PMID: 29695122 Abstract Title:  Dietary Polyphenol Intake and Depression: Results from the Mediterranean Healthy Eating, Lifestyle and Aging (MEAL) Study. Abstract:  : The epidemiological evidence for a relation between dietary polyphenol intake and depression is limited. Therefore, the aim of this study was to assess the association between habitual dietary intake of total polyphenols, their classes, subclasses and individual compounds and depressive symptoms among the participants of the Mediterranean healthy Eating, Lifestyle and Aging (MEAL) study.: Demographic and dietary characteristics of 1572 adults living in southern Italy were analyzed. Food frequency questionnaires and Phenol-Explorer were used to calculate habitual dietary intakes of polyphenols. The Center for Epidemiologic Studies Depression Scale (CES-D-10) was used as screening tool for depressive symptoms. Multivariate logistic regression analyses were used to test associations and were expressed as odds ratio (OR) and 95% confidence intervals (CI).: A total of 509 individuals reported having depressive symptoms. Based on multivariate logistic regression analyses, total polyphenol intake was not associated with depressive symptoms. After adjustment for potential confounding factors, dietary intake of phenolic acid (OR = 0.64, 95% CI: 0.44, 0.93), flavanones (OR = 0.54, 95% CI: 0.32, 0.91), and anthocyanins (OR = 0.61, 95% CI: 0.42, 0.89) showed significant inverse association with depressive symptoms, when comparing the highest with the lowest quartile. Moreover, flavanones and anthocyanins, were associated with depressive symptoms in a dose-response manner. Among individual compounds, inverse association was observed for quercetin (OR = 0.53, 95% CI: 0.32, 0.86) and naringenin (OR = 0.51, 95% CI: 0.30, 0.85), for the highest versus lowest quartile of intake. When taking into consideration the major sources of the polyphenols, only citrus fruits and wine consumption was inversely associated with depressive symptoms (Q4 vs. Q1: OR= 0.51, 95% CI: 0.35, 0.75; Q4 vs. Q1: OR = 0.53, 95% CI: 0.38, 0.74, respectively).: Higher dietary intake of flavonoid may be inversely associated with depressive symptoms. Further studies are needed to definitively confirm these observed associations. https://greenmedinfo.com/article/higher-dietary-intake-flavonoid-may-be-inversely-associated-depressive-symptom#comments Depression Flavonoids Depression Flavonoids Risk Reduction Human Study Thu, 31 May 2018 22:43:36 +0000 greenmedinfo 165058 at https://greenmedinfo.com Intake of fisetin during pregnancy in rats ameliorated in utero mercury exposure induced neurotoxicity outcomes. https://greenmedinfo.com/article/intake-fisetin-during-pregnancy-rats-ameliorated-utero-mercury-exposure-induce n/a PMID:  Biol Trace Elem Res. 2017 Jun ;177(2):297-315. Epub 2016 Nov 4. PMID: 27815688 Abstract Title:  Effect of Gestational Intake of Fisetin (3,3&#039;,4&#039;,7-Tetrahydroxyflavone) on Developmental Methyl Mercury Neurotoxicity in F1 Generation Rats. Abstract:  Methyl mercury (MeHg) is a developmental neurotoxin that causes irreversible cognitive damage in offspring of gestationally exposed mothers. Currently, no preventive drugs are established against MeHg developmental neurotoxicity. The neuroprotective effect of gestational administration of a flavanoid against in utero toxicity of MeHg is not explored much. Hence, the present study validated the effect of a bioactive flavanoid, fisetin, on MeHg developmental neurotoxicity outcomes in rat offspring at postnatal weaning age. Pregnant Wistar rats were simultaneously given MeHg (1.5 mg/kg b.w.) and two doses of fisetin (10 and 50 mg/kg b.w. in two separate groups) orally from gestational day (GD) 5 till parturition. Accordingly, after parturition, on postnatal day (PND) 24, weaning F1 generation rats were studied for motor and cognitive behavioural changes. Biochemical and histopathological changes were also studied in the cerebral cortex, cerebellum and hippocampus on PND 25. Administration of fisetin during pregnancy prevented behavioural impairment due to transplacental MeHg exposure in weaning rats. Fisetin decreased the levels of oxidative stress markers, increased enzymatic and non-enzymatic antioxidant levels and increased the activity of membrane-bound ATPases and cholinergic function in F1 generation rats. In light microscopic studies, fisetin treatment protected the specific offspring brain regions from significant morphological aberrations. Between thetwo doses of fisetin studied, 10 mg/kg b.w. was found to be more satisfactory and effective than 50 mg/kg b.w. The present study shows that intake of fisetin during pregnancy in rats ameliorated in utero MeHg exposure-induced neurotoxicity outcomes in postnatal weaning F1 generation rats. https://greenmedinfo.com/article/intake-fisetin-during-pregnancy-rats-ameliorated-utero-mercury-exposure-induce#comments Fisetin Flavonoids Mercury Poisoning Neurodegenerative Diseases Oxidative Stress Prenatal Chemical Exposures Mercury Neuroprotective Agents Fisetin Flavonoids Mercury Poisoning Methylmercury Neurodegenerative diseases oxidative stress Prenatal Chemical Exposures Animal Study Wed, 19 Jul 2017 22:44:08 +0000 greenmedinfo 150696 at https://greenmedinfo.com Morus alba leaves flavonoid extract and Morus alba leaves powder treatment could be useful agents in diabetes improvement. https://greenmedinfo.com/article/morus-alba-leaves-flavonoid-extract-and-morus-alba-leaves-powder-treatment-cou n/a PMID:  Cell Mol Biol (Noisy-le-grand). 2016 May 30 ;62(6):112-8. Epub 2016 May 30. PMID: 27262814 Abstract Title:  The effect of Morus alba leaves extract and powder on resistin levels and liver transaminase enzymes activities in diabetes. Abstract:  The current study was designed to investigate the changes of the resistin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels of diabetic rats after treatment with Morus alba leaves flavonoid extract (MLE) and Morus alba leaves powder (MLP). Thirty male wistar rats in five groups including control and diabetic groups were included. Diabetic groups consisted of diabetic control, sham and treated group with MLE and MLP. Type 2 diabetes was induced in rats by administration of streptozotocin (STZ) and - nicotinamide. The serum concentrations of resistin and insulin in the study groups were identified by ELISA. ALT and AST activities were assayed by spectrophotometer. For the first time, it was shown that the uptake of MLE and MLP by diabetic rats could significantly decrease the serum fasting blood sugar (FBS), resistin levels and enzymes activity of ALT and AST and increases the concentration of serum insulin significantly (P&lt;0.05). in comparison with the sham group and diabetic control. The results showed that there was no significant difference between the anti-diabetic and inflammatory properties of MLE and MLP. In this study, the possible protective effect of MLE and MLP administration was evaluated against destructive effect of STZ on liver and pancreas function in diabetic rats. The results showed that these effects may play an important role in the regulating of adipokines secretion such as resistin and insulin secretion which are involved in the control of diabetes and obesity. MLE and MLP treatment could be useful agents in combination with other therapies in diabetes improvement. https://greenmedinfo.com/article/morus-alba-leaves-flavonoid-extract-and-morus-alba-leaves-powder-treatment-cou#comments Diabetes Mellitus: Type 2 Flavonoids White Mulberry Anti-Inflammatory Agents Hypoglycemic Agents Anti-Inflammatory Agents Diabetes mellitus: Type 2 Flavonoids Hypoglycemic Agents Phytotherapy Plant Extracts White Mulberry Animal Study Wed, 22 Feb 2017 01:00:45 +0000 greenmedinfo 143837 at https://greenmedinfo.com Studies also show that catechins may prevent the formation of amyloid-β plaques and enhance cognitive functions. https://greenmedinfo.com/article/studies-also-show-catechins-may-prevent-formation-amyloid-plaques-and-enhance- n/a PMID:  J Alzheimers Dis. 2017 May 30. Epub 2017 May 30. PMID: 28582855 Abstract Title:  Diabetes and Alzheimer&#039;s Disease: Can Tea Phytochemicals Play a Role in Prevention? Abstract:  Dementia and diabetes mellitus are prevalent disorders in the elderly population. While recognized as two distinct diseases, diabetes has more recently recognized as a significant contributor to risk for developing dementia, and some studies make reference to type 3 diabetes, a condition resulting from insulin resistance in the brain. Alzheimer&#039;s disease, the most common form of dementia, and diabetes, interestingly, share underlying pathological processes, commonality in risk factors, and, importantly, pathways for intervention. Tea has been suggested to possess potent antioxidant properties rich in phytochemicals including, flavonoids, tannins, caffeine, polyphenols, boheic acid, theophylline, theobromine, anthocyanins, gallic acid, and finally epigallocatechin-3-gallate, considered the most potent active ingredient. Flavonoid phytochemicals, known as catechins, within tea offer potential benefits for reducing the risk of diabetes and Alzheimer&#039;s disease by targeting common risk factors, including obesity, hyperlipidemia, hypertension, cardiovascular disease, and stroke. Studies also show that catechins may prevent the formation of amyloid-β plaques and enhance cognitive functions, and thus may be useful in treating patients who have Alzheimer&#039;s disease or dementia. Furthermore, other phytochemicals found within tea offer important antioxidant properties along with innate properties capable of modulating intracellular neuronal signaltransduction pathways and mitochondrial function. https://greenmedinfo.com/article/studies-also-show-catechins-may-prevent-formation-amyloid-plaques-and-enhance-#comments Alzheimer's Disease Anthocyanins Caffeine Catechin Diabetic Complications EGCG (Epigallocatechin gallate) Flavonoids Gallic Acid Polyphenols Theophylline Antioxidants Neuroprotective Agents Alzheimer's disease Anthocyanins Antioxidants caffeine Catechin Diabetic Complications EGCG (Epigallocatechin gallate) Flavonoids Gallic Acid Neuroprotective Agents POLYPHENOLS Theophylline Review Wed, 07 Jun 2017 18:21:14 +0000 greenmedinfo 148778 at https://greenmedinfo.com Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress. https://greenmedinfo.com/article/tartary-buckwheat-flavonoids-ameliorate-high-fructose-induced-insulin-resistan n/a PMID:  Food Funct. 2017 Jul 17. Epub 2017 Jul 17. PMID: 28714504 Abstract Title:  Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2/HO-1 pathways in mice. Abstract:  The present study was conducted to explore the effects of a purified tartary buckwheat flavonoid fraction (TBF) on insulin resistance and hepatic oxidative stress in mice fed high fructose in drinking water (20%) for 8 weeks. The results indicated that continuous administration of TBF dose-dependently improved the insulin sensitivity and glucose intolerance in high fructose-fed mice. TBF treatment also reversed the reduced level of insulin action on the phosphorylation of insulin receptor substrate-1 (IRS-1), protein kinase B (Akt) and phosphatidylinositol 3-kinase (PI3K), as well as the translocation of glucose transporter type 4 (GLUT4) in the insulin-resistant liver. Furthermore, TBF was found to exert high antioxidant capacity as it acts as a shield against oxidative stress induced by high fructose by restoring the antioxidant status, and modulating nuclear factor E2 related factor 2 (Nrf2) translocation to the nucleus with subsequently up-regulated antioxidative enzyme protein expression. Histopathological examinations revealed that impaired pancreatic/hepatic tissues were effectively restored in high fructose-fed mice following TBF treatment. Our results show that TBF intake is effective in preventing the conversion of high fructose-induced insulin resistance and hepatic oxidative stress in mice by improving the insulin signaling molecules and the Nrf2 signal pathway in the liver. https://greenmedinfo.com/article/tartary-buckwheat-flavonoids-ameliorate-high-fructose-induced-insulin-resistan#comments Buckwheat Flavonoids High Fructose Diet Insulin Resistance Antioxidants Heme oxygenase-1 up-regulation Nrf2 activation Antioxidants Buckwheat Flavonoids High Fructose Diet Insulin Resistance Animal Study Wed, 09 Aug 2017 15:59:27 +0000 greenmedinfo 151387 at https://greenmedinfo.com The flavonoid glycoside astragalin may be a new therapeutic agent for the management of menopausal symptoms. https://greenmedinfo.com/article/flavonoid-glycoside-astragalin-may-be-new-therapeutic-agent-management-menopau n/a PMID:  Molecules. 2016 May 21 ;21(5). Epub 2016 May 21. PMID: 27213327 Abstract Title:  Astragalin, a Flavonoid from Morus alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause. Abstract:  BACKGROUND: To determine the mechanism by which the flavonoid glycoside astragalin (AST) reduces ovarian failure in an aged rat model of menopause. METHODS: The in vivo effect of AST on granulosa cell (GC) apoptosis in aged female rats was determined using flow cytometry. In vitro, the effects of AST on cultured GCs were investigated using the MTT proliferation assay and western blot assays. RESULTS: Aged rats had significantly higher GC apoptosis as compared with young female rats. Treatment of aged rats with AST (all three doses; p&lt;0.01) or Progynova (p&lt;0.01) significantly reduced GC apoptosis as compared with the aged controls. The proportions of total apoptotic GCs was 25.70%, 86.65%, 47.04%, 27.02%, 42.09% and 56.42% in the normal, aged, 17β-estradiol (E₂), high dose AST, medium dose AST, and low dose AST-treated groups, respectively. Significant increases of serum E₂ and P₄ levels, as well as altered levels of serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels. In cultured rat GCs, AST stimulated GC proliferation, E₂ and progesterone (P₄) secretion, reduced apoptosis, reduced the level of the pro-apoptotic protein Bcl-2 (p&lt;0.01), but had no effect on BAX. CONCLUSIONS: AST enhanced ovarian function in aged female rats by increasing E₂ and P₄ levels, and reducing ovarian GC apoptosis via a mechanism involving Bcl-2. These data demonstrate a new pharmacological activity for AST, as well as a novel mechanism of action, and further suggest that AST may be a new therapeutic agent for the management of menopausal symptoms. https://greenmedinfo.com/article/flavonoid-glycoside-astragalin-may-be-new-therapeutic-agent-management-menopau#comments Flavonoids Menopausal Syndrome White Mulberry Anti-Apoptotic Anti-Apoptotic Flavonoids Menopausal Syndrome White Mulberry Animal Study Wed, 22 Feb 2017 01:13:50 +0000 greenmedinfo 143839 at https://greenmedinfo.com The results of the present study add to the current literature further evidence of the association between higher flavonoid intake and decreased body weight. https://greenmedinfo.com/article/results-present-study-add-current-literature-further-evidence-association-betw n/a PMID:  Int J Food Sci Nutr. 2018 Mar 26:1-10. Epub 2018 Mar 26. PMID: 29575952 Abstract Title:  Association between dietary flavonoids intake and obesity in a cohort of adults living in the Mediterranean area. Abstract:  Dietary polyphenols, including flavonoids, are abundantly present in a healthy and balanced diet. Evidence for their role in preventing non-communicable diseases is emerging. We examined the association between estimated habitual intake of dietary flavonoid and obesity in a cohort study. After adjusting for potential confounding factors, inverse association between total flavonoid intake and excess weight (BMI ≥25) was found (OR = 0.66, 95% CI: 0.45, 0.99); among individual classes of flavonoids, only flavanones were inversely associated with excess body weight (OR = 0.68, 95% CI: 0.48, 0.97). However, when considering adjustment for dietary factors (adherence to the Mediterranean diet), theassociations were no more significant. When considering obesity as the outcome (BMI ≥30), individuals with high intake of total flavonoids and flavonols resulted less likely to be obese (OR = 0.38, 95% CI: 0.21, 0.66 and OR = 0.63, 95% CI: 0.39, 0.99, respectively), even after adjustmentfor confounding factors. The results of the present study add to the current literature further evidence of the association between higher flavonoid intake and decreased body weight. Further studies are needed to confirm retrieved association. https://greenmedinfo.com/article/results-present-study-add-current-literature-further-evidence-association-betw#comments Flavonoids Obesity Anti-Obesity Agents Flavonoids obesity Human Study Thu, 31 May 2018 23:10:32 +0000 greenmedinfo 165069 at https://greenmedinfo.com These results suggest fisetin in combination with gemcitabine as a candidate for use in improved anticancer regimens. https://greenmedinfo.com/article/these-results-suggest-fisetin-combination-gemcitabine-candidate-use-improved-a n/a PMID:  Anticancer Res. 2016 11 ;36(11):6109-6116. PMID: 27793939 Abstract Title:  Fisetin Reduces Cell Viability Through Up-Regulation of Phosphorylation of ERK1/2 in Cholangiocarcinoma Cells. Abstract:  BACKGROUND: Cholangiocarcinoma (CCA) is a malignancy with poor prognosis and limited therapeutic options. Effective prevention and treatment of CCA require developing novel anticancer agents and improved therapeutic regimens. As natural products are concidered a rich source of potential anticancer agents, we investigated the anticancer effect of fisetin in combination with gemcitabine. MATERIALS AND METHODS: Cytotoxic effect of fisetin and gemcitabine on a human CCA cell line SNU-308 was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and apoptosis assay using propidium iodine and annexin V. Molecular mechanisms of fisetin action in CCA were investigated by western blotting. RESULTS: Fisetin was found to inhibit survival of CCA cells, through strongly phosphorylating ERK. It also induced cellular apoptosis additively in combination with gemcitabine. Expression of cellular proliferative markers, such as phospho-p65 and myelocytomatosis (MYC), were reduced by fisetin. CONCLUSION: These results suggest fisetin in combination with gemcitabine as a candidate for use in improved anticancer regimens. https://greenmedinfo.com/article/these-results-suggest-fisetin-combination-gemcitabine-candidate-use-improved-a#comments Cholangiocarcinoma Fisetin Flavonoids Antiproliferative Apoptotic Chemotherapeutic Antiproliferative Apoptotic Chemotherapeutic Chemotherapeutic Synergy: Gemcitabine Cholangiocarcinoma Fisetin Flavonoids In Vitro Study Wed, 19 Jul 2017 22:59:41 +0000 greenmedinfo 150702 at https://greenmedinfo.com