Naringenin https://greenmedinfo.com/category/keywords/Naringenin en 8 Healing Properties of Strawberries https://greenmedinfo.com/blog/8-healing-properties-strawberries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Juicy Reasons to Eat More Strawberries" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Strawberries1.jpg" style="width: 500px; height: 333px;" /></p> <p><strong><span style="font-size:18px;"><em>Who doesn't love <a href="/substance/strawberry" rel="dofollow" target="_blank">strawberries</a>? And you don't need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there's lots more to strawberries than the flavor.</em></span><a href="#_edn1" name="_ednref1" title="">[i]</a></strong></p> <p>Their study was <strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/24345049" rel="nofollow" target="_blank">published in the journal <em>Critical Reviews in Food Science and Nutrition</em></a></strong> with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry's status as a "functional food."</p><p><a href="https://greenmedinfo.com/blog/8-healing-properties-strawberries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-healing-properties-strawberries#comments Alzheimer's Disease Anthocyanins Blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases Carotenoids Catechin Ellagic Acid Flavonoids Hyperglycemia Hyperlipidemia Hypertension Kaempferol Naringenin Parkinson's Disease Phytosterols Polyphenols Potassium Quercetin Strawberry Vitamin C Vitamin E Antioxidants Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Anthocyanins Antioxidants blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases CAROTENOIDS Catechin Ellagic Acid Flavonoids hyperglycemia hyperlipidemia hypertension Kaempferol Naringenin Parkinson's disease phytosterols POLYPHENOLS potassium QUERCETIN Strawberry Vitamin C VITAMIN E Sat, 18 Feb 2023 17:30:10 +0000 GMI Research Group 114933 at https://greenmedinfo.com Isolated mangiferin and naringenin exert antidiabetic effects. https://greenmedinfo.com/article/isolated-mangiferin-and-naringenin-exert-antidiabetic-effects n/a PMID:  Chem Biol Interact. 2018 Jan 25 ;280:33-44. Epub 2017 Dec 6. PMID: 29223569 Abstract Title:  Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation. Abstract:  In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. SA1 and SA2 were orally administered to streptozotocin-induced diabetic rats at 50 and 100 mg/kg daily for 15 days. Blood glucose level, serum lipid profile, oxidative stress parameters, histopathology, docking, molecular parameters, and NMR-based metabolic perturbation studies were performed to investigate the pharmacological activities of SA1 and SA2. Results suggested that both compounds reduced blood glucose level, restored body weight, and normalized lipid concentrations in the serum and oxidative stress biomarkers in the liver and pancreas. In addition, the docking study on several diabetes-associated targets revealed that both compounds had a strong binding affinity towardsperoxisome proliferator-activated receptor gamma (PPARγ) and glucose transporter type 4 (GLUT4). Further real-time reverse transcription polymerase chain reaction and western blot analyses were performed to confirm the gene and protein expression levels of PPARγ and GLUT4 in the pancreatic tissues. Data obtained from the molecular studies showed that both compounds exhibited antidiabetic effects through dual activation of PPARγ/GLUT4 signaling pathways. Finally, the NMR-based metabolic studies showed that both compounds normalized the diabetogenic metabolites in the serum. Altogether, we concluded that SA1 and SA2 might be potential antidiabetic lead compounds for future drug development. https://greenmedinfo.com/article/isolated-mangiferin-and-naringenin-exert-antidiabetic-effects#comments Diabetes Mellitus: Type 2 Mangiferin Naringenin Antioxidants Hepatoprotective Hypoglycemic Agents Hypolipidemic Pancreato Protective Agents Antioxidants Diabetes mellitus: Type 2 Hepatoprotective Hypoglycemic Agents Hypolipidemic Mangiferin Naringenin Pancreato Protective Agents Animal Study Tue, 23 Jan 2018 17:04:08 +0000 greenmedinfo 158688 at https://greenmedinfo.com Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge. https://greenmedinfo.com/article/naringenin-ameliorates-learning-and-memory-impairment-following-systemic-lipop n/a PMID:  Eur J Pharmacol. 2018 Mar 5. Epub 2018 Mar 5. PMID: 29518393 Abstract Title:  Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat. Abstract:  Systemic inflammation following infection is usually associated with long-term complications including cognitive deficit and dementia. Neuroinflammation and cognitive decline are also main hallmarks of several neurological conditions. Naringenin is a citrus flavanone with anti-inflammatory, neuroprotective, and antioxidant potential. In this study, the protective effect of naringenin against lipopolysaccharide (LPS)-induced cognitive decline was evaluated in the rat. LPS was daily injected at a dose of 167μg/kg for 1 week and naringenin was administered p.o. at doses of 25, 50, or 100mg/kg/day. Treatment of LPS-injected rats with naringenin dose-dependently improved spatial recognition memory in Y maze, discrimination ratio in novel object discrimination task, and retention and recall capability inpassive avoidance test. Furthermore, naringenin lowered hippocampal malondialdehyde (MDA) as an index of lipid peroxidation and improved antioxidant defensive system comprising superoxide dismutase (SOD), catalase, and glutathione (GSH) in addition to decreasing acetylcholinesterase (AChE) activity.Additionally, naringenin was able to lower hippocampal nuclear factor-kappaB (NF-κB), toll-like receptor 4 (TLR4), tumor necrosis factor α (TNFα), cyclooxygenase-2 (COX2), inducible nitric oxide synthase (iNOS), glial fibrillary acidic protein (GFAP) level and its immunoreactivity, and to elevate nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Taken together, naringenin could alleviate LPS-induced cognitive deficits and neuroinflammation, as was evident from attenuation of oxidative stress and AChE and modulation of Nrf2/NF-κB/TNFα/COX2/iNOS/TLR4/GFAP. https://greenmedinfo.com/article/naringenin-ameliorates-learning-and-memory-impairment-following-systemic-lipop#comments Lipopolysaccharide-Induced Toxicity Memory Disorders Naringenin Anti-Inflammatory Agents Cyclooxygenase 2 Inhibitors Neuroprotective Agents NF-kappaB Inhibitor Nrf2 activation Tumor Necrosis Factor (TNF) Alpha Inhibitor Anti-Inflammatory Agents Lipopolysaccharide-Induced Toxicity Memory Disorders Naringenin Animal Study Sat, 10 Mar 2018 03:05:12 +0000 greenmedinfo 161004 at https://greenmedinfo.com Naringenin decreases α-synuclein expression and neuroinflammation in Parkinson's disease model. https://greenmedinfo.com/article/naringenin-decreases-synuclein-expression-and-neuroinflammation-parkinsons-dis n/a PMID:  Neurotox Res. 2018 Feb 9. Epub 2018 Feb 9. PMID: 29427283 Abstract Title:  Naringenin Decreasesα-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson&#039;s Disease Model in Mice. Abstract:  The present study was designed to ascertain the role of naringenin (NGN), a citrus fruit flavanone, against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-inducedα-synuclein (SYN) pathology and neuroinflammation in a mouse model. NGN was administered to C57BL/6J mice once a day for 5 consecutive days prior to the MPTP intoxication. On day 5, 40-50 min after the NGN or vehicle administration, MPTP was injected in two divided doses (2× 40 mg/kg, i.p. at 16 h apart). The animals were observed for motor functions 48 h after the first MPTP injection. The animals were then euthanized, the brains collected to analyze SYN pathology, cytokines, and oxidative stress levels in the substantia nigra region. The NGN significantly downregulated SYN and upregulated dopamine transporter (DAT) and tyrosine hydroxylase (TH) protein expressions. It also downregulated tumor necrosis factor-α (TNFα) and interleukin 1β (IL1β) mRNA expressions and improved superoxide dismutase levels. It also reduced glutathione levels when compared to vehicle-treated PD animals. The upregulation of TH corroborates to an increase in dopamine, DOPAC, and homovanillic acid turnover and motor functions with NGN treatment. To summarize, NGN, a dietary flavone, has the potential to counteract MPTP-induced dopaminergic degeneration by regulating SYN pathology, neuroinflammation, and oxidative stress. This warrants the investigation of NGN&#039;s potential effects in a genetic model of PD. https://greenmedinfo.com/article/naringenin-decreases-synuclein-expression-and-neuroinflammation-parkinsons-dis#comments Brain Inflammation Naringenin Parkinson's Disease Anti-Inflammatory Agents Antioxidants Interleukin-1 beta downregulation Neuroprotective Agents Tumor Necrosis Factor (TNF) Alpha Inhibitor Anti-Inflammatory Agents Antioxidants Brain Inflammation Naringenin Parkinson's disease Animal Study Sat, 10 Mar 2018 03:24:14 +0000 greenmedinfo 161005 at https://greenmedinfo.com Naringenin exerts anti-inflammatory effects in paraquat-treated SH-SY5Y cells. https://greenmedinfo.com/article/naringenin-exerts-anti-inflammatory-effects-paraquat-treated-sh-sy5y-cells n/a PMID:  Neurochem Res. 2018 Feb 6. Epub 2018 Feb 6. PMID: 29411263 Abstract Title:  Naringenin Exerts Anti-inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Associated with the Nrf2/HO-1 Axis. Abstract:  Naringenin (NGN; 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; CHO), a flavanone, is found in citrus fruits and has been viewed as an antioxidant and anti-inflammatory agent. NGN is a potent inducer of the nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the expression of heme oxygenase-1 (HO-1), an enzyme exhibiting both antioxidant and anti-inflammatory effects. The complete mechanism by which NGN exerts anti-inflammatory actions is not completely understood yet. Therefore, we investigated here whether NGN would be able to reduce the inflammation induced by paraquat (PQ) in SH-SY5Y cells. Additionally, we analyzed the mechanism associated with the NGN-induced anti-inflammatory effect. We found that a pretreatment with NGN at 80 µM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in PQ-treated SH-SY5Y cells. The production of nitric oxide (NO) and levels of cyclooxygenase-2 (COX-2) and of the inducible isoform of nitric oxide synthase (iNOS) were downregulated by NGN in the cells exposed to PQ. Moreover, NGN downregulated the activation of the nuclear factor-κB (NF-κB) in PQ-treated cells. The anti-apoptotic and anti-inflammatory effects promoted by NGN were abolished by ZnPP IX (a specific inhibitor of HO-1) or by knockdown of Nrf2 by small interfering RNA (siRNA). Therefore, NGN induced anti-inflammatory effects in PQ-treated SH-SY5Y cells by a mechanism associated with the Nrf2/HO-1 signaling pathway. https://greenmedinfo.com/article/naringenin-exerts-anti-inflammatory-effects-paraquat-treated-sh-sy5y-cells#comments Naringenin Pesticide Toxicity Anti-Inflammatory Agents Cyclooxygenase 2 Inhibitors Heme oxygenase-1 up-regulation Interleukin-1 beta downregulation Nitric Oxide Inhibitor Nrf2 activation Tumor Necrosis Factor (TNF) Alpha Inhibitor Anti-Inflammatory Agents Naringenin Pesticide Toxicity In Vitro Study Sat, 10 Mar 2018 03:34:09 +0000 greenmedinfo 161006 at https://greenmedinfo.com Naringenin may have a potential to ameliorate autoimmune disease by favourably modulating autoimmune response. https://greenmedinfo.com/article/naringenin-may-have-potential-ameliorate-autoimmune-disease-favourably-modulat n/a PMID:  J Nutr Biochem. 2017 Dec 11 ;54:130-139. Epub 2017 Dec 11. PMID: 29331869 Abstract Title:  Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice. Abstract:  Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune encephalomyelitis (EAE), a rodent model of human multiple sclerosis, we determined the effect of dietary naringenin (0.5%) on autoimmune disease. We found that naringenin reduced the incidence, delayed the onset, and attenuated the symptoms of EAE, which were accompanied by reduced immune cell infiltration and demyelination in the spinal cord. Additionally, the pro-inflammatory CD4+ T cell subsets Th1, Th9, and Th17 cells together with their respective transcription factors T-bet, PU.1, and RORγt were reduced in both the central nervous system (CNS) and lymph nodes of EAE mice fed naringenin while no difference was found in Th2 and regulatory T cell (Treg) populations in either CNS or lymph nodes between the two groups. We further showed that pathologic T cell proliferation induced by exvivo re-stimulation with MOG35-55 and proinflammatory cytokines IL-6 and TNF-α were lower in naringenin-fed mice than in the control mice. Additionally, we found that naringenin treatment inhibited mRNA expression of CXCL10 (Th1 recruiting chemokine), vascular cell adhesion molecule-1 (VCAM-1), and VLA-4 (VCAM-1 ligand) in the CNS of EAE mice. Altogether, these results indicate that naringenin may have a potential to ameliorate autoimmune disease by favorably modulating autoimmune response. https://greenmedinfo.com/article/naringenin-may-have-potential-ameliorate-autoimmune-disease-favourably-modulat#comments Autoimmune Diseases Naringenin Immunomodulatory Autoimmune Diseases Immunomodulatory Naringenin Animal Study Tue, 23 Jan 2018 17:59:48 +0000 greenmedinfo 158695 at https://greenmedinfo.com Naringenin suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon. https://greenmedinfo.com/article/naringenin-suppresses-development-precancerous-lesions-controlling-hyperprolif n/a PMID:  Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID: 29345053 Abstract Title:  Naringenin (4,5,7-trihydroxyflavanone) suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon of Wistar rats. Abstract:  Colon cancer is a world-wide health problem and one of the most dangerous type of cancer, affecting both men and women. Naringenin (4, 5, 7-trihydroxyflavanone) is one of the major flavone glycoside present in citrus fruits. Naringenin has long been used in Chinese&#039;s traditional medicine because of its exceptional pharmacological properties and non-toxic nature. In the present study, we investigated the chemopreventive potential of Naringenin against 1,2-dimethyhydrazine (DMH)-induced precancerous lesions, that is, aberrant crypt foci (ACF) and mucin depleted foci (MDF), and its role in regulating the oxidative stress, inflammation and hyperproliferation, in the colon of Wistar rats. Animals were divided into five groups. In groups 3-5, Naringenin was administered at the dose of 50 mg/kg b. wt. orally while in groups 2-4, DMH was administered subcutaneously in the groin at the dose of 20 mg/kg b. wt. once a week for first 5 weeks and animals were euthanized after 10 weeks. Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-κB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-α and it also prevented the depletion of the mucous layer. Our findings suggest that Naringenin has strong chemopreventive potential against DMH-induced colon carcinogenesis but further studies are warranted to elucidate the precise mechanism of action of Naringenin. https://greenmedinfo.com/article/naringenin-suppresses-development-precancerous-lesions-controlling-hyperprolif#comments Colon Cancer: Prevention Naringenin Anti-Inflammatory Agents Anticarcinogenic Agents Chemopreventive Cyclooxygenase 2 Inhibitors NF-kappaB Inhibitor Anti-Inflammatory Agents Anticarcinogenic Agents Colon Cancer: Prevention Naringenin Animal Study Tue, 23 Jan 2018 17:53:32 +0000 greenmedinfo 158692 at https://greenmedinfo.com Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. https://greenmedinfo.com/article/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic- n/a PMID:  Life Sci. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29287782 Abstract Title:  Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. Abstract:  AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress. For this purpose, young rats were orally treated with naringenin (NAR), curcumin (CUR) and quercetin (QUE) at a dose of 50mg/kg, 200mg/kg and 50mg/kg respectively for 16days. At 4th day of drug administration cognitive functions were monitored by Morris water maze test. In MWM cognitive functions in terms of learning acquisition (1h after training), retention (24h after training), memory extinction (4days after training), and reconsolidation (8 and 12days after training) were monitored. Biochemical and neurochemical analysis were done in whole brain. KEY FINDINGS: Treatment of NAR, CUR and QUE significantly enhanced learning acquisition, memory retention and reconsolidation and prevented memory extinction. Treatment of NAR and QUE prevented the alteration of brain antioxidant defence system by enhancing antioxidant enzyme activities and increasing antioxidant compound concentration. Oxidative stress in terms of lipid peroxidation was significantly prevented in treated rats. Serotonergic and cholinergic improvement was also found in treated rats. SIGNIFICANCE: The present study therefore provides biological evidence supporting the usefulness of these polyphenolic compounds in daily life for improvement of cognitive abilities and hence may have a potential role in the management of dementia and related disorders. https://greenmedinfo.com/article/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-#comments Curcumin Naringenin Neurodegenerative Diseases Quercetin Antioxidants Neuroprotective Agents Antioxidants CURCUMIN Naringenin Neurodegenerative diseases Neuroprotective Agents QUERCETIN Animal Study Tue, 23 Jan 2018 18:16:18 +0000 greenmedinfo 158696 at https://greenmedinfo.com