Anti-Ulcer Agents https://greenmedinfo.com/category/keywords/Anti-Ulcer%20Agents en Baicalein could be used as a cytoprotective and anti-ulcerogenic agent in gastric ulcers. https://greenmedinfo.com/article/baicalein-could-be-used-cytoprotective-and-anti-ulcerogenic-agent-gastric-ulce n/a PMID:  Chem Biol Interact. 2016 Oct 22 ;260:33-41. Epub 2016 Aug 22. PMID: 27780710 Abstract Title:  The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms. Abstract:  Many flavonoids have been shown to present good results for the treatment of gastric ulcers. Baicalein, a bioactive flavonoid derived from the Scutellaria baicalensis Georgi root, possesses several biological effects, such as anti-inflammatory and antioxidant. This study was conducted to assess the gastroprotective properties of baicalein. Anti-ulcerogenic assay was performed using the protocol of ulcer induced by ethanol/HCl in mice; then, the role of presynapticα2-receptors, sulfhydryl (SH) compounds, nitric oxide (NO), prostaglandin (PG) and ATP-sensitive K(+) (KATP) channels in gastroprotection of baicalein was investigated. The levels of reduced glutathione (GSH) and the myeloperoxidase (MPO) activity were measured in the gastric mucosa. Parameters ofgastric secretion (volume, [H(+)] and pH) were determined with or without the presence of the secretagogue agent histamine, as well as mucus in gastric contents, by the pylorus ligation model. In vitro H(+),K(+)-ATPase activity was also determined. Baicalein (10, 30 and 100 mg/kg) exhibited a doserelated gastroprotective effect (P &lt; 0.001) against acidified ethanol-induced lesions. The intraperitoneal treatment of mice with a α2-adrenoreceptor antagonist (yohimbine; 2 mg/kg), a SH compounds blocker (N-ethylmaleimide, NEM; 10 mg/kg), a non-selective inhibitor of NO synthase (Nw-nitro-L-arginine methyl ester hydrochloride, L-NAME; 10 mg/kg), a non-selective inhibitor of cyclo-oxygenase (indomethacin; 10 mg/kg) or a KATP channel blocker (glibenclamide; 10 mg/kg) was able to reverse (P &lt; 0.001) the gastroprotective response caused by baicalein (30 mg/kg). Baicalein (30 mg/kg; P &lt; 0.05) was able to increase GSH levels and decreasing MPO activity. The intraduodenal treatment with baicalein (30 and 100 mg/kg) significantly increased (P &lt; 0.05) the gastric mucus secretion. Additionally, the treatment with baicalein reduced (30 and 100 mg/kg; P &lt; 0.05) the secretion volume and total acid secretion, and also increased (10, 30 and 100 mg/kg; P &lt; 0.001) the pH value, after pylorus ligature. Baicalein (30 mg/kg) was also effective in inhibiting the effects of histamine on gastric secretion (volume, [H(+)] and pH; P &lt; 0.001). Baicalein at 10 and 30 μg/mL showed anti-H(+),K(+)-ATPase activity. In conclusion, the present results provide convincing evidence that baicalein could be used as a cytoprotective (preventive effect) and anti-ulcerogenic (anti-secretory effect) agent in the gastric ulcers. https://greenmedinfo.com/article/baicalein-could-be-used-cytoprotective-and-anti-ulcerogenic-agent-gastric-ulce#comments Baicalein Gastric Ulcers Anti-Ulcer Agents Prophylactic Agents Anti-Ulcer Agents Baicalein Gastric Ulcers Prophylactic Agents Animal Study Mon, 21 Nov 2016 20:53:27 +0000 greenmedinfo 139225 at https://greenmedinfo.com Curcuminoids for Ulcerative Colitis: A Review of the Evidence https://greenmedinfo.com/blog/curcuminoids-ulcerative-colitis-review-evidence <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Untitled%20design-5(9).png" style="width: 600px; height: 600px;" /></p> <p><span style="font-size:18px;"><em><strong><span style="font-family: Verdana; letter-spacing: 0px;">For UC patients struggling with standard therapies, a ray of hope emerges in the form of an ancient golden spice.</span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/curcuminoids-ulcerative-colitis-review-evidence" target="_blank">read more</a></p> https://greenmedinfo.com/blog/curcuminoids-ulcerative-colitis-review-evidence#comments Colitis: Ulcerative Crohn's Disease Curcumin Curcuminoids Turmeric Anti-Ulcer Agents Cancer Health Guide: Alzheimer's Health Guide: Farm/Pharma Face Off Health Guide: Food-Brain Connection Health Guide: Herbs and Traditional Knowledge Health Guide: Medicinal Spices Health Guide: Turmeric Health Guides: Healing Foods Stress Anti-Ulcer Agents Crohn's Disease Curcuminoids Turmeric Thu, 18 Jan 2024 20:41:55 +0000 GMI reporter 286722 at https://greenmedinfo.com Double-Blind Trial: Vitamin C Decreases Amputations by Half for Foot Ulcer Patients https://greenmedinfo.com/blog/double-blind-trial-vitamin-c-decreases-amputations-half-foot-ulcer-patients <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Untitled%20design-5(12).png" style="width: 600px; height: 600px;" /></p> <p><span style="font-size:18px;"><em><strong><span style="font-family: Verdana; letter-spacing: 0px;">Foot ulcers and wounds often fail to heal with conventional treatment. Studies report only 30-50% of chronic foot ulcers heal with standard wound care including debridement, moist dressings, and offloading pressure.<sup>1</sup> Up to 28% of patients with <a href="/disease/diabetic-ulcer" rel="dofollow" target="_blank">diabetic foot ulcers</a> require amputation within 5 years.<sup>2</sup> These poor outcomes persist despite new wound care technologies and drug trials costing billions of dollars.<sup>3&nbsp;</sup></span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/double-blind-trial-vitamin-c-decreases-amputations-half-foot-ulcer-patients" target="_blank">read more</a></p> https://greenmedinfo.com/blog/double-blind-trial-vitamin-c-decreases-amputations-half-foot-ulcer-patients#comments Diabetic Ulcer Vitamin C Athletic Performance Diabetogenic Food Philosophy Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Ulcerogenic anti-diabetic Anti-Ulcer Agents Mon, 22 Jan 2024 12:01:29 +0000 GMI reporter 286838 at https://greenmedinfo.com