endothelial dysfunction https://greenmedinfo.com/category/keywords/endothelial%20dysfunction en Consumption of chocolate containing high concentrations of cocoa enhanced vascular endothelial function. https://greenmedinfo.com/article/consumption-chocolate-containing-high-concentrations-cocoa-enhanced-vascular-e n/a PMID:  J Nutr. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28794213 Abstract Title:  Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa. Abstract:  Background: Cocoa contains polyphenols that are thought to be beneficial for vascular health.Objective: We assessed the impact of chocolate containing distinct concentrations of cocoa on cerebrovascular function and cognition.Methods: Using a counterbalanced within-subject design, we compared the acute impact of consumption of energy-matched chocolate containing 80%, 35%, and 0% single-origin cacao on vascular endothelial function, cognition, and cerebrovascular function in 12 healthy postmenopausal women (mean± SD age: 57.3 ± 5.3 y). Participants attended a familiarization session, followed by 3 experimental trials, each separated by 1 wk. Outcome measures included cerebral blood flow velocity (CBFv) responses, recorded before and during completion of a computerized cognitive assessment battery (CogState); brachial artery flow-mediated dilation (FMD); and hemodynamic responses (heart rate and blood pressure).Results: When CBFv data before and after chocolate intake were compared between conditions through the use of 2-factor ANOVA, an interaction effect (P = 0.003) and main effects for chocolate(P = 0.043) and time (P = 0.001) were evident. Post hoc analysis revealed that both milk chocolate (MC; 35% cocoa; P = 0.02) and dark chocolate (DC; 80% cocoa; P = 0.003) induced significantly lower cerebral blood flow responses during the cognitive tasks, after normalizing for changes in arterial pressure. DC consumption also increased brachial FMD compared with the baseline value before chocolate consumption (P = 0.002), whereas MC and white chocolate (0% cocoa) caused no change (P-interaction between conditions = 0.034).Conclusions: Consumption of chocolate containing high concentrations ofcocoa enhanced vascular endothelial function, which was reflected by improvements in FMD. Cognitive function outcomes did not differ between conditions; however, cerebral blood flow responses during these cognitive tasks were lower in those consuming MC and DC. These findings suggest that chocolatecontaining high concentrations of cocoa may modify the relation between cerebral metabolism and blood flow responses in postmenopausal women. This trial was registered at www.ANZCTR.orgau as ACTRN12616000990426. https://greenmedinfo.com/article/consumption-chocolate-containing-high-concentrations-cocoa-enhanced-vascular-e#comments Chocolate Cocoa Endothelial Dysfunction chocolate Cocoa endothelial dysfunction Human Study Mon, 21 Aug 2017 15:10:43 +0000 greenmedinfo 151918 at https://greenmedinfo.com Kitchen Staple Holds Regenerative Key for Blood Vessels: Onions' Vascular Healing Capacity https://greenmedinfo.com/content/kitchen-staple-holds-regenerative-key-blood-vessels-onions-vascular-healing-ca <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Untitled%20design-5(19).png" style="width: 600px; height: 600px;" /></p> <p><span style="font-size:18px;"><em><strong><span style="font-family: Verdana; letter-spacing: 0px;">Could small daily doses of common kitchen staple onions support long-term heart health? New clinical findings suggest so - the flavonoid quercetin in onion peel extract improved endothelial function markers in just 3 months. &nbsp;</span></strong></em></span></p><p><a href="https://greenmedinfo.com/content/kitchen-staple-holds-regenerative-key-blood-vessels-onions-vascular-healing-ca" target="_blank">read more</a></p> https://greenmedinfo.com/content/kitchen-staple-holds-regenerative-key-blood-vessels-onions-vascular-healing-ca#comments Cardiovascular Diseases Endothelial Dysfunction Onions Quercetin Cardiovascular Disease endothelial dysfunction Onions Fri, 15 Mar 2024 15:06:15 +0000 GMI reporter 290489 at https://greenmedinfo.com Puerarin protects against high glucose-induced acute vascular dysfunction. https://greenmedinfo.com/article/puerarin-protects-against-high-glucose-induced-acute-vascular-dysfunction n/a PMID:  Vascul Pharmacol. 2009 Mar-Apr;50(3-4):110-5. Epub 2008 Nov 24. PMID: 19073281 Abstract Title:  Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. Abstract:  OBJECTIVE: To investigate the antioxidant and vascular protective effect of puerarin, an isoflavone glycoside known in traditional Chinese medicine on vascular reactivity subsequent to high glucose stress. METHODS: The thoracic aortic rings with or without endothelium from male SD rats were mounted in an organ bath. Isometric contraction of aortic rings was measured. HO-1 protein expression and HO activity were also evaluated. RESULTS: (1) After incubation with 44 mmol/L of high glucose for 2 or 4 h, the vascular contraction responses to phenylephrine (PE) and relaxation response to acetylcholine (Ach) decreased in an endothelium-dependent manner; (2) Coincubation with puerarin (10(-10)-10(-8) mol/L) and high glucose, the high glucose-induced vasoconstriction and vasodilation dysfunction was partly inhibited in a dose-dependent manner; (3) Puerarin increased the HO-1 protein expression and HO activity of thoracic aorta. ZnPP (an inhibitor of heme oxygenase-1) offset the protective effect of puerarin. CONCLUSION: Puerarin could alleviate the high glucose-induced acute endothelium-dependent vascular dysfunction in rat aortic rings. HO-1 activity was proposed as a mechanism to account for the protection of vascular responses by puerarin. https://greenmedinfo.com/article/puerarin-protects-against-high-glucose-induced-acute-vascular-dysfunction#comments Endothelial Dysfunction Puerarin Antioxidants Heme oxygenase-1 up-regulation Antioxidants endothelial dysfunction Heme oxygenase-1 up-regulation Puerarin In Vitro Study Wed, 06 Jun 2018 23:20:26 +0000 greenmedinfo 165386 at https://greenmedinfo.com These data corroborated that crocetin could restore the dysfunction of diabetic endothelial progenitor cells. https://greenmedinfo.com/article/these-data-corroborated-crocetin-could-restore-dysfunction-diabetic-endothelia n/a PMID:  Life Sci. 2017 Jul 15 ;181:9-16. Epub 2017 May 18. PMID: 28528862 Abstract Title:  Crocetin restores diabetic endothelial progenitor cell dysfunction by enhancing NO bioavailability via regulation of PI3K/AKT-eNOS and ROS pathways. Abstract:  AIMS: Endothelial progenitor cell (EPC) dysfunction underlies a critical risk factor in diabetic vascular complications due to function defect in restoring endothelium injury. Crocetin has attracted increasing attention in several vascular-related diseases. In present study, we aimed to explore the role of crocetin in diabetic EPC dysfunction. MAIN METHODS: EPCs were isolated from bone marrow in diabetic mice and identified using the fluorescence staining and flow cytometry. After exposure to various doses of crocetin, cell viability was detected by MTT assy. Then, colony formation, lactate dehydrogenase (LDH) release, cell apoptosis and caspase-3 activity were assessed. The underlying mechanism was also investigated by western blotting. KEY FINDINGS: EPCs from diabetic mice exhibited dysfunction under hyperglycemia condition. Interestingly, crocetin treatment alleviated the impairment in diabetic EPC proliferation and colony formation. Simultaneously, the increases in LDH release, cell apoptosis and caspase-3 activity were also restrained following crocetin stimulation. Additionally, EPC migration response to SDF-1 was also impaired under diabetic condition, which was partly restored by crocetin. Mechanism analysis manifested that administration with crocetin repaired the damage in the activation of PI3K/AKT-eNOS pathway and NO production, but attenuated ROS elevation in diabetic EPCs. Importantly, preconditioning with antagonist of LY294002 (for PI3K/AKT) or N(G)-monomethyl-l-arginine (for eNOS) antagonized the beneficial effect of crocetin on diabetic EPC dysfunction. SIGNIFICANCE: These data corroborated that crocetin could restore the dysfunction of diabetic EPCs by enhancing NO bioavailability via regulation of PI3K/AKT-eNOS and ROS pathways. Therefore, this research supports a potential promising therapeutic aspect for diabetic patients. https://greenmedinfo.com/article/these-data-corroborated-crocetin-could-restore-dysfunction-diabetic-endothelia#comments Crocetin Diabetic Complications Endothelial Dysfunction Antioxidants Nitric Oxide Enhancer Antioxidants Crocetin Diabetic Complications endothelial dysfunction Endothelial Progenitor Cells (EPCs) Nitric Oxide Enhancer In Vitro Study Fri, 14 Jul 2017 01:54:04 +0000 greenmedinfo 150419 at https://greenmedinfo.com Turmeric: Better Than Aspirin For Heart Disease Prevention? https://greenmedinfo.com/blog/turmeric-extract-helps-open-your-arteries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter" dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;"><img alt="Is Turmeric Better Than Aspirin For Heart Disease Prevention? " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/turmeric_dilates_arteries_greenmedinfo.png.jpg" style="width: 600px; height: 400px;" title="Turmeric: Better Than Aspirin For Heart Disease Prevention? " /></p> <p class="rtecenter" dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;">&nbsp;</p><p><a href="https://greenmedinfo.com/blog/turmeric-extract-helps-open-your-arteries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/turmeric-extract-helps-open-your-arteries#comments Cardiovascular Disease: Prevention Curcumin Endothelial Dysfunction Turmeric Anticoagulants Aspirin Cardioprotective Health Guide: Turmeric Heart Health Warfarin Aspirin Alternatives better than aspirin cardioprotection CURCUMIN endothelial dysfunction FMD Superiority of Natural Substances versus Drugs turmeric heart Thu, 22 Sep 2016 19:48:21 +0000 Sayer Ji 135362 at https://greenmedinfo.com Walnut consumption significantly improved endothelial function. https://greenmedinfo.com/article/walnut-consumption-significantly-improved-endothelial-function n/a PMID:  Clin Nutr. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28457654 Abstract Title:  Effect of nut consumption on vascular endothelial function: A systematic review and meta-analysis of randomized controlled trials. Abstract:  OBJECTIVE: nut consumption has consistently been found to be associated with a reduced risk of cardiovascular diseases (CVD) and mortality in prospective studies. However, its effect on endothelial function, a prognostic marker of CVD, is still controversial in clinical trials. This meta-analysis of randomized controlled trials (RCTs) aimed to quantitatively assess the effect of nuts on vascular endothelial function. METHODS: Major electronic databases were searched for published RCTs that reported the effect of nuts on flow mediated dilation (FMD) as a measurement of endothelial function in the adult population (age eighteen years or over). We calculated the pooled estimates of weighted mean differences (WMDs) and their 95% confidence intervals (CIs) by using random-effects models. RESULTS: A total of nine papers (10 trials) involving 374 participants were included. The pooled estimates found that nut consumption significantly improved FMD (WMD: 0.41%; 95% CI: 0.18%, 0.63%; P = 0.001). Moderate and marginally significant heterogeneity was observed among the studies (I(2) = 39.5%, P = 0.094). Subgroup analyses indicated that walnuts significantly improved FMD (WMD: 0.39%; 95% CI: 0.16%, 0.63%; P = 0.001). In addition, nut consumption had a significant effect on FMD in the trials with study duration&lt;18 weeks, nut dose&lt;67 g/d, or subjects with baseline FMD ≥8.6%. CONCLUSIONS: Nut consumption significantly improved endothelial function. However, the beneficial effect was limited to walnuts. More studies examining the effect of other nuts on endothelial function are needed in the future. https://greenmedinfo.com/article/walnut-consumption-significantly-improved-endothelial-function#comments Endothelial Dysfunction Walnut endothelial dysfunction Meta Analysis Walnut Review Wed, 07 Jun 2017 20:07:30 +0000 greenmedinfo 148787 at https://greenmedinfo.com