HPA Axis Dysregulation https://greenmedinfo.com/category/keywords/HPA%20Axis%20Dysregulation en Sucralose inhibits thyroid function and metabolism in doses within the range of the human acceptable daily intake. https://greenmedinfo.com/article/sucralose-inhibits-thyroid-function-and-metabolism-doses-within-range-human-ac n/a PMID:  Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879 Abstract Title:  Type of sweet flavour carrier affects thyroid axis activity in male rats. Abstract:  PURPOSE: Non-nutritive sweeteners are the most widely used food additives worldwide. However, their metabolic outcomes are still a matter of controversy and their effect on the thyroid activity, a key regulator of metabolism, has not been previously studied. Therefore, we aim to determine the influence of the sweet type flavour carrier on selected parameters of thyroid axis activity. METHODS: Male Sprague-Dawley rats (n = 105) were divided into 3 groups fed ad libitum for three weeks isocaloric diets (3.76 ± 0.5 kcal/g): two with the same sweet flavour intensity responded to 10% of sucrose (with sucrose-SC-and sucralose-SU) and one non-sweet diet (NS). To evaluate the post-ingested effects, animals were euthanised at fast and 30, 60, 120, 180 min after meal. RESULTS: The results obtained indicate that both the presence and the type of sweet taste flavour carrier affect thyroid axis activity both at fasting and postprandial state. Compared to diet with sucrose which stimulates thyroid axis activity, sucralose addition diminishes thyroid hormone synthesis as thyroid peroxidase (TPO) activity, plasma thyroxine (T4), and triiodothyronine (T3) concentration was lower than in SC and NS while in non-sweet diet the lowest level of hepatic deiodinase type 1 (DIO1) and the highest reverse T3 (rT3) level indicate on altered thyroid hormone peripheral metabolism. CONCLUSION: Both the presence and the type of sweet flavour carrier have a significant impact on thyroid axis activity. Our findings suggest that this organochlorine sweetener is metabolically active and might exacerbate metabolic disorders via an adverse effect on thyroid hormone metabolism. https://greenmedinfo.com/article/sucralose-inhibits-thyroid-function-and-metabolism-doses-within-range-human-ac#comments HPA Axis Dysregulation Hypothyroidism Overweight Endocrine Disruptor: Thyroid Neurotoxic Sucralose (aka Splenda) HPA Axis Dysregulation hypothyroidism overweight Splenda Sucralose Animal Study Sat, 07 Jan 2017 16:59:00 +0000 greenmedinfo 141628 at https://greenmedinfo.com