punicalagin https://greenmedinfo.com/category/keywords/punicalagin-0 en Peels and flesh extract of Sour-YRP significantly inhibited the proliferation of HepG2 and Hela cancer cells lines. https://greenmedinfo.com/article/peels-and-flesh-extract-sour-yrp-significantly-inhibited-proliferation-hepg2-a n/a PMID:  Springerplus. 2016 ;5(1):914. Epub 2016 Jun 29. PMID: 27386358 Abstract Title:  A systematic determination of polyphenols constituents and cytotoxic ability in fruit parts of pomegranates derived from five Chinese cultivars. Abstract:  Plant polyphenols derived from pomegranates are natural health-promoting components, and their bioactivities are well proved. However, the systematic studies of polyphenols constituents and cytotoxic ability in fruit parts of pomegranates derived from different Chinese cultivars have not been studied yet. In this report, a validated and sensitive HPLC-DAD method and fluorescence spectrophotometric method was established for quantitative analysis of four polyphenols and total phenolic content (TPC) in fruit parts of pomegranates (including peels, flesh, seeds, juices and leaves) derived from five Chinese cultivars, respectively. HPLC analysis was performed on the YMC ODS-A C18 column with gradient elution of MeOH and 0.1 % TFA. Four polyphenols including gallic acid, ellagic acid, punicalagin A&B and punicalin A&B exhibited satisfactory linearity in the concentration ranges of 20-320, 39-624, 74-1184 and 38-608 μg/mL, respectively. The results demonstrated that the amounts of TPC and four polyphenols in different fruit parts of pomegranates varied significantly. Peels of Sour-YRP possessed the highest content of punicalagin A&B (125.23 mg/g), whereas other three polyphenols exhibited only trace. Among the five Chinese cultivars, Sour-YRP contained the highest content of TPC (688.61 mg/g) and could be considered as the desirable botanical source to obtain polyphenols. It is also discovered that low-maturity pomegranate might possessed much higher TPC than high-maturity pomegranate. The optimized HPLC-DAD method could be used for quality control of different pomegranates by identification and quantification of its main polyphenolic components. Furthermore, the in vitro cytotoxicity of different pomegranates fruit parts to cancer cells was evaluated. We discovered that peels and flesh extract of Sour-YRP significantly inhibited the proliferation of HepG2 and Hela cancer cells lines. The results of this work are promising for further investigation and development of pomegranates as therapeutic agent for the treatment ofcancer. https://greenmedinfo.com/article/peels-and-flesh-extract-sour-yrp-significantly-inhibited-proliferation-hepg2-a#comments Cervical Cancer Liver Cancer Pomegranate Pomegranate Peel Punicalagin Antiproliferative Antiproliferative Cervical Cancer liver cancer Plant Extracts pomegranate Pomegranate Peel punicalagin In Vitro Study Thu, 19 Jan 2017 23:11:34 +0000 greenmedinfo 142273 at https://greenmedinfo.com Punicalagin might find good use in wound healing therapy. https://greenmedinfo.com/article/punicalagin-might-find-good-use-wound-healing-therapy n/a PMID:  Molecules. 2016 Aug 22 ;21(8). Epub 2016 Aug 22. PMID: 27556440 Abstract Title:  Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization. Abstract:  The pharmacological activities of many Punica granatum L. components suggest a wide range of clinical applications for the prevention and treatment of diseases where chronic inflammation is believed to play an essential etiologic role. The current work reports a case study analyzing the effect produced by a magistral formulation of ethanolic extracts of Punica granatum peels on a non-healing chronic ulcer. The complete closure of the chronic ulcer that was initially not responsive to standard medical care was observed. A 2% (w/w) P. granatum peels ethanolic extract hydrogel-based formulation (PGHF) was standardized and subjected to physicochemical studies to establish the quality control parameters using, among others, assessment criteria such as optimum appearance, pH range, viscosity and hydrogel disintegration. The stability and quantitative chromatographic data was assessed in storage for six months under two temperature regimes. An efficient HPLC-DAD method was established distinguishing the biomarkers punicalin and punicalagin simultaneously in a single 8 min run. PGHF presented suitable sensorial and physicochemical performance, showing that punicalagin was not significantly affected by storage (p>0.05). Formulations containing extracts with not less than 0.49% (w/w) total punicalagin might find good use in wound healing therapy. https://greenmedinfo.com/article/punicalagin-might-find-good-use-wound-healing-therapy#comments Pomegranate Peel Wound Healing Pomegranate Peel punicalagin wound healing Human: Case Report Thu, 19 Jan 2017 22:48:01 +0000 greenmedinfo 142268 at https://greenmedinfo.com