Graft vs Host Disease https://greenmedinfo.com/category/keywords/Graft%20vs%20Host%20Disease en EGCG ameliorates lethal graft versus host disease and reduces related target organ damage. https://greenmedinfo.com/article/egcg-ameliorates-lethal-graft-versus-host-disease-and-reduces-related-target-o n/a PMID:  PLoS One. 2017 ;12(1):e0169630. Epub 2017 Jan 19. PMID: 28103249 Abstract Title:  The Green Tea Catechin Epigallocatechin Gallate Ameliorates Graft-versus-Host Disease. Abstract:  Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is a standard treatment for leukemia and other hematologic malignancies. The major complication of allo-HSCT is graft-versus-host-disease (GVHD), a progressive inflammatory illness characterized by donor immune cells attacking the organs of the recipient. Current GVHD prevention and treatment strategies use immune suppressive drugs and/or anti-T cell reagents these can lead to increased risk of infections and tumor relapse. Recent research demonstrated that epigallocatechin gallate (EGCG), a component found in green tea leaves at a level of 25-35% at dry weight, may be useful in the inhibition of GVHD due to its immune modulatory, anti-oxidative and anti-angiogenic capacities. In murine allo-HSCT recipients treated with EGCG, we found significantly reduced GVHD scores, reduced target organ GVHD and improved survival. EGCG treated allo-HSCT recipients had significantly higher numbers of regulatory T cells in GVHD target organs and in the blood. Furthermore, EGCG treatment resulted in diminished oxidative stress indicated by significant changes of glutathione blood levels as well as glutathione peroxidase in the colon. In summary, our study provides novel evidence demonstrating that EGCG ameliorates lethal GVHD and reduces GVHD-related target organ damage. Possible mechanisms are increased regulatory T cell numbers and reduced oxidative stress. https://greenmedinfo.com/article/egcg-ameliorates-lethal-graft-versus-host-disease-and-reduces-related-target-o#comments EGCG (Epigallocatechin gallate) Graft vs Host Disease Antioxidants Immunomodulatory Antioxidants EGCG (Epigallocatechin gallate) Graft vs Host Disease Hematopoietic Stem Cells Immunomodulatory Risk Reduction Animal Study Tue, 24 Jan 2017 00:44:41 +0000 greenmedinfo 142473 at https://greenmedinfo.com