Lychee https://greenmedinfo.com/category/keywords/Lychee en Monotherapy with oligonol showed a superior anti-inflammatory efficacy as compared to quantum light and acupuncture monotherapies. https://greenmedinfo.com/article/monotherapy-oligonol-showed-superior-anti-inflammatory-efficacy-compared-quant n/a PMID:  Evid Based Complement Alternat Med. 2015 ;2015:687196. Epub 2015 May 3. PMID: 26064171 Abstract Title:  Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis. Abstract:  This research aimed to compare anti-inflammatory effects of oligonol, acupuncture, and quantum light therapy in rat models of estrogen-induced prostatitis. Adult male Wistar albino rats were grouped as follows: Group I, control (n = 10); Group II, chronic prostatitis (n = 10); Group III, oligonol (n = 10); Group IV, acupuncture (n = 10); Group V, quantum (n = 10); Group VI, oligonol plus quantum (n = 10); Group VII, acupuncture plus oligonol (n = 10); Group VIII, quantum plus acupuncture (n = 10); and Group IX, acupuncture plus quantum plus oligonol (n = 10). Chronic prostatitis (CP) was induced by the administration of 17-beta-estradiol (E2) and dihydrotestosterone (DHT). Oligonol was given for 6 weeks at a dose of 60 mg/day. Acupuncture needles were inserted at CV 3/4 and bilaterally B 32/35 points with 1-hour manual stimulation. Quantum therapy was administered in 5-minute sessions three times weekly for 6 weeks. Lateral lobes of prostates were dissected for histopathologic evaluation. Although all of the treatment modalities tested in this study showed anti-inflammatory effects in the treatment of CP in male rats, a synergistic effect was observed for oligonol plus quantum light combination. Monotherapy with oligonol showed a superior anti-inflammatory efficacy as compared to quantum light and acupuncture monotherapies. https://greenmedinfo.com/article/monotherapy-oligonol-showed-superior-anti-inflammatory-efficacy-compared-quant#comments Inflammation Lychee Acupuncture Anti-Inflammatory Agents Light Therapy Acupuncture Anti-Inflammatory Agents light therapy Lychee Natural Substance Synergy Animal Study Tue, 04 Apr 2017 17:53:06 +0000 greenmedinfo 145885 at https://greenmedinfo.com Oligonol attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic mice. https://greenmedinfo.com/article/oligonol-attenuates-gluco-lipotoxicity-mediated-renal-disorder-type-2-diabetic n/a PMID:  Drug Discov Ther. 2015 Feb ;9(1):13-22. PMID: 25788048 Abstract Title:  Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice. Abstract:  Oligonol is a phenolic product derived from lychee fruit extract containing catechin-type monomers and oligomers of proanthocyanidins, produced by a manufacturing process which converts polyphenol polymers into oligomers. These proanthocyanidins have been reported to exhibit beneficial bioactivities in many studies, and so oligonol, a rich source of polyphenol, is expected to show favorable effects on various chronic diseases. This article summarizes recent work whether oligonol has an ameliorative effect on diabetic indices and renal disorders associated with gluco-lipotoxicity-mediated oxidative stress, inflammation, and apoptosis in db/db mice with diabetes. Oligonol was able to improve diabetic indices, prevent the development of diabetic renal disease, and preserve renal cells and the renal morphological structure via the attenuation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced oxidative stress, inhibition of advanced glycation endproduct (AGE) generation, and prevention of apoptosis-induced cell death in db/db mice, being independent of changes in the body weight or serum glucose levels. The present study provides important evidence that oligonol exhibits a pleiotropic effect, representing renoprotective effects against the development of diabetic complications in type 2 diabetic db/db mice. https://greenmedinfo.com/article/oligonol-attenuates-gluco-lipotoxicity-mediated-renal-disorder-type-2-diabetic#comments Advanced Glycation End products (AGE) Diabetes Mellitus: Type 2 Lychee Anti-Apoptotic Anti-Glycation Agents Renoprotective Advanced Glycation End products (AGE) Diabetes mellitus: Type 2 Gene Expression Regulation Lychee Animal Study Tue, 04 Apr 2017 18:52:07 +0000 greenmedinfo 145891 at https://greenmedinfo.com Oligonol has protective activity against oxidative stress-induced inflammation. https://greenmedinfo.com/article/oligonol-has-protective-activity-against-oxidative-stress-induced-inflammation n/a PMID:  Nutr Res Pract. 2015 Apr ;9(2):123-8. Epub 2014 Nov 1. PMID: 25861417 Abstract Title:  Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell. Abstract:  BACKGROUND/OBJECTIVES: Natural products or active components with a protective effect against oxidative stress have attracted significant attention for prevention and treatment of degenerative disease. Oligonol is a low molecular weight polyphenol containing catechin-type monomers and oligomers derived from Litchi chinensis Sonn. We investigated the protective effect and its related mechanism of oligonol against oxidative stress. MATERIALS/METHODS: Oxidative stress in C6 glial cells was induced by hydrogen peroxide (H2O2) and the protective effects of oligonol on cell viability, nitric oxide (NO) and reactive oxygen species (ROS) synthesis, and mRNA expression related to oxidative stress were determined. RESULTS: Treatment with oligonol inhibited NO and ROS formation under cellular oxidative stress in C6 glial cells. In addition, it recovered cell viability in a dose dependent-manner. Treatment with oligonol also resulted in down-regulated mRNA expression related to oxidative stress, nuclear factor kappa-B (NF-κB) p65, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS), compared with the control group treated with H2O2. In particular, expression of NF-κB p65, COX-2, and iNOS was effectively reduced to the normal level by treatment with 10 µg/mL and 25 µg/mL of oligonol. CONCLUSIONS: These results indicate that oligonol has protective activity against oxidative stress-induced inflammation. Oligonol might be a promising agent for treatment of degenerative diseases through inhibition of ROS formation and NF-κB pathway gene expression. https://greenmedinfo.com/article/oligonol-has-protective-activity-against-oxidative-stress-induced-inflammation#comments Inflammation Lychee Oxidative Stress Anti-Inflammatory Agents Antioxidants Cyclooxygenase Inhibitors NF-kappaB Inhibitor Anti-Inflammatory Agents Antioxidants Cyclooxygenase Inhibitors Inflammation Lychee NF-kappaB Inhibitor oxidative stress In Vitro Study Tue, 04 Apr 2017 18:19:35 +0000 greenmedinfo 145888 at https://greenmedinfo.com Oligonol improves Aβ(25-35)-induced memory deficit and cognition impairment. https://greenmedinfo.com/article/oligonol-improves-25-35-induced-memory-deficit-and-cognition-impairment n/a PMID:  Nutr Res. 2014 Jul ;34(7):595-603. Epub 2014 Jun 14. PMID: 25150118 Abstract Title:  Oligonol improves memory and cognition under an amyloidβ(25-35)-induced Alzheimer's mouse model. Abstract:  Alzheimer's disease is an age-dependent progressive neurodegenerative disorder that results in impairments of memory and cognitive function. It is hypothesized that oligonol has ameliorative effects on memory impairment and reduced cognitive functions in mice with Alzheimer's disease induced by amyloidβ(25-35) (Aβ(25-35)) injection. The protective effect of an oligonol against Aβ(25-35)-induced memory impairment was investigated in an in vivo Alzheimer's mouse model. The aggregation of Aβ25-35 was induced by incubation at 37°C for 3 days before injection into mice brains (5 nmol/mouse), andthen oligonol was orally administered at 100 and 200 mg/kg of body weight for 2 weeks. Memory and cognition were observed in T-maze, object recognition, and Morris water maze tests. The group injected with Aβ(25-35) showed impairments in both recognition and memory. However, novel object recognition and new route awareness abilities were dose dependently improved by the oral administration of oligonol. In addition, the results of the Morris water maze test indicated that oligonol exerted protective activity against cognitive impairment induced by Aβ(25-35). Furthermore, nitric oxide formation and lipid peroxidation were significantly elevated by Aβ(25-35), whereas oligonol treatment significantly decreased nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys. The present results suggest that oligonol improves Aβ(25-35)-induced memory deficit and cognition impairment. https://greenmedinfo.com/article/oligonol-improves-25-35-induced-memory-deficit-and-cognition-impairment#comments Lipid Peroxidation Lychee Memory Disorders Antioxidants Neuroprotective Agents Nitric Oxide Inhibitor Antioxidants Lipid Peroxidation Lychee Memory Disorders Phytotherapy Plant Extracts Animal Study Tue, 04 Apr 2017 19:18:52 +0000 greenmedinfo 145893 at https://greenmedinfo.com Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis. https://greenmedinfo.com/article/oligonol-effective-protecting-against-dss-induced-mouse-colitis-and-colon-carc n/a PMID:  Antioxid Redox Signal. 2013 Jul 10 ;19(2):102-14. Epub 2013 May 15. PMID: 23394584 Abstract Title:  Oligonol inhibits dextran sulfate sodium-induced colitis and colonic adenoma formation in mice. Abstract:  AIMS: To evaluate the effects of oligonol administration on experimentally induced colitis and colonic adenoma formation. RESULTS: Oral administration of oligonol protected against mouse colitis induced by dextran sulfate sodium (DSS). Under the same experimental conditions, oligonol administration significantly inhibited the activation of nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 3 and expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cyclin D1 in the mouse colon. Further, oligonol inhibited azoxymethane-initiated and DSS-promoted adenoma formation in the mouse colon. Oligonol administration also attenuated lipid peroxidation (malondialdehyde) and protein oxidation (4-hydroxy-2-nonenal), thereby preventing oxidative stress-induced apoptosis of colonic epithelial cells. In vitro studies demonstrated that oligonol treatment reduced lipopolysaccharide-induced expression of interleukin (IL)-1β, tumor necrosis factor α, il-6, cox-2, and inos in murine macrophage RAW 264.7 cells. In another study, oligonol upregulated the antioxidant gene expression in the intestinal epithelial CCD841CoN cells and in the mouse colon. INNOVATION: Oligonol, an innovative formulation of catechin-type oligomers derived from the lychee fruit extract, was tested in this study for the first time to evaluate its effects on experimentally induced colitis and colonic adenoma formation in mice. CONCLUSION: Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis, suggesting that this polyphenol formulation may have a potential for the amelioration of inflammatory bowel disease and related disorders. https://greenmedinfo.com/article/oligonol-effective-protecting-against-dss-induced-mouse-colitis-and-colon-carc#comments Colitis Colon Cancer Inflammation Lipid Peroxidation Lychee Oxidative Stress Anticarcinogenic Agents Antioxidants Cyclooxygenase 2 Inhibitors Interleukin-1 beta downregulation NF-kappaB Inhibitor Tumor Necrosis Factor (TNF) Alpha Inhibitor Colitis COLON CANCER Inflammation Lipid Peroxidation Lychee oxidative stress Animal Study Tue, 04 Apr 2017 19:45:13 +0000 greenmedinfo 145894 at https://greenmedinfo.com