Brain Damage: Hypoxic Ischemic Insult https://greenmedinfo.com/category/keywords/Brain%20Damage%3A%20Hypoxic%20Ischemic%20Insult en Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage. https://greenmedinfo.com/article/cannabidiol-reduces-lung-injury-induced-hypoxic-ischemic-brain-damage n/a PMID:  Pediatr Res. 2017 Apr 7. Epub 2017 Apr 7. PMID: 28388598 Abstract Title:  Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage in newborn piglets. Abstract:  BACKGROUND: Brain hypoxic-ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario. METHODS: Newborn piglets received i.v. vehicle, CBD or CBD+WAY100635 (5-HT1A receptor antagonist) after HI brain damage (carotid flow interruption and FiO2 0.10 for 30 min). Total lung compliance (TLC), oxygenation index (OI) and extravascular lung water content (EVLW) were monitored for six hours. Histological damage, interleukin (IL)-1ß concentration and oxidative stress were assessed in brain and lung tissue. Total protein content was determined in bronchoalveolar lavage fluid (BALF). RESULTS: CBD prevented HI-induced deleterious effects on TLC and OI and reduced lung histological damage, modulating inflammation (decreased leukocyte infiltration and IL-1 concentration) and reducing protein content in BALF and EVLW. These effects were related to CBD-induced anti-inflammatory changes in the brain. HI did not increase oxidative stress in the lungs. In the lungs, WAY100635 blunted CBD's beneficial effects on histological damage, IL-1 concentration and EVLW. CONCLUSIONS: CBD reduced brain HI-induced distant lung damage, with 5-HT1A receptor involvement in these effects. Whether CBD's effects on lungs were due to anti-inflammatory effects on the brain or to direct effects on lungs remains to be elucidated.Pediatric Research accepted article preview online, 07 April 2017. doi:10.1038/pr.2017.104. https://greenmedinfo.com/article/cannabidiol-reduces-lung-injury-induced-hypoxic-ischemic-brain-damage#comments Brain Damage: Hypoxic Ischemic Insult Cannabidiol Anti-Inflammatory Agents Neuroprotective Agents Anti-Inflammatory Agents Brain Damage: Hypoxic Ischemic Insult Cannabidiol Neuroprotective Agents Animal Study Mon, 24 Apr 2017 15:51:49 +0000 greenmedinfo 146689 at https://greenmedinfo.com