Acetaminophen (Tylenol) Toxicity https://greenmedinfo.com/category/keywords/Acetaminophen%20%28Tylenol%29%20Toxicity en Chrysin possesses restorative effect against paracetamol induced hepatotoxicity. https://greenmedinfo.com/article/chrysin-possesses-restorative-effect-against-paracetamol-induced-hepatotoxicit n/a PMID:  J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID: 28682524 Abstract Title:  Restorative effects of Chrysin pretreatment on oxidant-antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats: An experimental and biochemical study. Abstract:  Paracetamol (PC) is a widely used analgesic and antipyretic drug, but it leads to acute hepatotoxicity at high doses intakes. This study was aimed to investigate the effects of Chrysin (CR) on hepatotoxicity constituted at high doses of PC in rats. Rats were subjected to oral pretreatment of CR (25 and 50 mg/kg b.w.) via feeding needle for 6 days against hepatotoxicity induced by a single dose of PC (500 mg/kg b.w.) administered orally via feeding needles. Although PC increases lipid peroxidation and liver enzyme activities, it has led to reduction of antioxidant enzyme activities. PC induced inflammatory responses by increasing the levels of TNF-α and IL-1β. Furthermore, PC caused apoptosis and autophagy by increasing activity of Caspase-3 and LC3B level. On the other hand, CR therapy significantly regulated these values in rats. This study demonstrated that CR possesses restorative effect against PC-induced hepatotoxicity by suppressing oxidative stress, inflammation, and apoptotic and autophagic tissue damage. https://greenmedinfo.com/article/chrysin-possesses-restorative-effect-against-paracetamol-induced-hepatotoxicit#comments Acetaminophen (Tylenol) Toxicity Chrysin Lipid Peroxidation Acetaminophen Anti-Apoptotic Antioxidants Hepatoprotective Paracetamol Acetaminophen (Tylenol) Toxicity Anti-Apoptotic Antioxidants Chrysin Hepatoprotective Lipid Peroxidation Animal Study Thu, 08 Feb 2018 03:51:48 +0000 greenmedinfo 159488 at https://greenmedinfo.com Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats. https://greenmedinfo.com/article/commonly-taken-analgesics-could-decrease-germ-cell-number-and-ovarian-size-f1- n/a PMID:  Sci Rep. 2016 Jan 27 ;6:19789. Epub 2016 Jan 27. PMID: 26813099 Abstract Title:  Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences. Abstract:  Analgesics which affect prostaglandin (PG) pathways are used by most pregnant women. As germ cells (GC) undergo developmental and epigenetic changes in fetal life and are PG targets, we investigated if exposure of pregnant rats to analgesics (indomethacin or acetaminophen) affected GC development and reproductive function in resulting offspring (F1) or in the F2 generation. Exposure to either analgesic reduced F1 fetal GC number in both sexes and altered the tempo of fetal GC development sex-dependently, with delayed meiotic entry in oogonia but accelerated GC differentiation in males. These effects persisted in adult F1 females as reduced ovarian and litter size, whereas F1 males recovered normal GC numbers and fertility by adulthood. F2 offspring deriving from an analgesic-exposed F1 parent also exhibited sex-specific changes. F2 males exhibited normal reproductive development whereas F2 females had smaller ovaries and reduced follicle numbers during puberty/adulthood; as similar changes were found for F2 offspring of analgesic-exposed F1 fathers or mothers, we interpret this as potentially indicating an analgesic-induced change to GC in F1. Assuming our results are translatable to humans, they raise concerns that analgesic use in pregnancy could potentially affect fertility of resulting daughters and grand-daughters. https://greenmedinfo.com/article/commonly-taken-analgesics-could-decrease-germ-cell-number-and-ovarian-size-f1-#comments Acetaminophen (Tylenol) Toxicity Infertility: Female Prenatal Chemical Exposures Acetaminophen Analgesic: Non-opioid Indomethacin Paracetamol Acetaminophen (Tylenol) Toxicity Infertility: Female Prenatal Chemical Exposures Transgenerational Epigenetic Modification Animal Study Mon, 26 Jun 2017 19:23:53 +0000 greenmedinfo 149599 at https://greenmedinfo.com Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum. https://greenmedinfo.com/article/early-paracetamol-exposure-produces-major-changes-serotonergic-and-dopaminergi n/a PMID:  Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096 Abstract Title:  Paracetamol - Effect of early exposure on neurotransmission, spatial memory and motor performance in rats. Abstract:  In the present study we examined the effect of prenatal and early life paracetamol exposure on neurotransmission and its behavioural manifestation in rat male pups. In order to assess the ability of spatial learning and memory consolidation and the level of physical and exploratory activity we conducted a series of behavioural tests: Staircase Test, Hole Board Test and Water Maze. The concentrations of monoamines, metabolites and amino acids were determined using High Performance Liquid Chromatography in the prefrontal cortex, hippocampus and striatum. The effect on spatial memory and exploratory behaviour was most pronounced in animals treated with the lower dose of paracetamol. In this group we have observed a much lower motor activity and decreased head-dipping behaviour. Simultaneously, the number of crossings in the Water Maze under the previous platform position during the probe trial was significantly higher in rats treated with paracetamol at the dose of 5mg/kg. There was also a preference for a new location of a platform to the original position of the platform in the reversal probe trial of this group. These results indicate that early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum. At the same time, administration of the drug in early life results in the spectacular change in the amino acid level, in particular in the hippocampus and cortex. This has been reflected in the behaviour of animals in the Water Maze and Hole Board Test (without any noticeable impact on the Staircase Test). https://greenmedinfo.com/article/early-paracetamol-exposure-produces-major-changes-serotonergic-and-dopaminergi#comments Acetaminophen (Tylenol) Toxicity Prenatal Chemical Exposures Acetaminophen Paracetamol Acetaminophen Acetaminophen (Tylenol) Toxicity paracetamol Prenatal Chemical Exposures Animal Study Mon, 26 Jun 2017 21:17:54 +0000 greenmedinfo 149614 at https://greenmedinfo.com Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen. https://greenmedinfo.com/article/lycopene-natural-compound-was-able-inhibit-production-ros-and-mitigate-damage- n/a PMID:  Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599 Abstract Title:  Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice. Abstract:  Our aim was to investigate the antioxidant potential of lycopene in different experimental liver models: in vitro, to evaluate the influence of lycopene on reactive oxygen species (ROS) production mediated by the PKC pathway and in vivo, to evaluate the protective effects of lycopene in an experimental model of hepatotoxicity. The in vitro study assessed the lycopene antioxidant potential by the quantification of ROS production in SK-Hep-1 cells unstimulated or stimulated by an activator of the PKC pathway. The role of NADPH oxidase was evaluated by measuring its inhibition potential using an inhibitor of this enzyme. In the in vivo study, male C57BL/6 mice received lycopene (10 or 100 mg/kgby oral gavage) and 1 h later, acetaminophen (APAP) (500 mg/kg) was administrated. Lycopene decreased ROS production in SK-Hep-1 cells through inhibition of NADPH oxidase, brought about in the PKC pathway. Lycopene improved hepatotoxicity acting as an antioxidant, reduced GSSG and regulated tGSHand CAT levels, reduced oxidative damage primarily by decreasing protein carbonylation, promoted the downregulation of MMP-2 and reduced areas of necrosis improving the general appearance of the lesion in C57BL/6 mice. Lycopene is a natural compound that was able to inhibit the production of ROS in vitro and mitigate the damage caused by APAP overdose in vivo. https://greenmedinfo.com/article/lycopene-natural-compound-was-able-inhibit-production-ros-and-mitigate-damage-#comments Acetaminophen (Tylenol) Toxicity Carotenoids Liver Damage: Drug-Induced Lycopene Oxidative Stress Acetaminophen Antioxidants Hepatoprotective Matrix metalloproteinase-2 (MMP-2) inhibitor Paracetamol Acetaminophen (Tylenol) Toxicity Antioxidants CAROTENOIDS Hepatoprotective Liver Damage: Drug-Induced lycopene Matrix metalloproteinase-2 (MMP-2) inhibitor oxidative stress Animal Study In Vitro Study Fri, 05 May 2017 17:47:48 +0000 greenmedinfo 147311 at https://greenmedinfo.com Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice. https://greenmedinfo.com/article/lycopene-pretreatment-improves-hepatotoxicity-induced-acetaminophen-mice n/a PMID:  Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152 Abstract Title:  Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Abstract:  Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500mg/kg (APAP); acetaminophen 500mg/kg+lycopene 10mg/kg (APAP+L10), and acetaminophen 500mg/kg+lycopene 100mg/kg (APAP+L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1β expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events. https://greenmedinfo.com/article/lycopene-pretreatment-improves-hepatotoxicity-induced-acetaminophen-mice#comments Acetaminophen (Tylenol) Toxicity Liver Damage: Drug-Induced Lycopene Acetaminophen Anti-Inflammatory Agents Hepatoprotective Interleukin-1 beta downregulation Matrix metalloproteinase-2 (MMP-2) inhibitor Paracetamol Acetaminophen (Tylenol) Toxicity Anti-Inflammatory Agents Hepatoprotective Liver Damage: Drug-Induced lycopene Animal Study Fri, 05 May 2017 17:09:46 +0000 greenmedinfo 147305 at https://greenmedinfo.com Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds. https://greenmedinfo.com/article/maternal-acetaminophen-use-during-pregnancy-was-associated-lower-performance-i n/a PMID:  Epidemiology. 2016 Nov ;27(6):912-8. PMID: 27479646 Abstract Title:  Prenatal Use of Acetaminophen and Child IQ: A Danish Cohort Study. Abstract:  BACKGROUND: Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy, and recently has been linked to hyperactivity and behavioral problems in children. We examine whether prenatal use of acetaminophen affects children&#039;s intelligence quotient (IQ). METHODS: We studied 1,491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Acetaminophen use in pregnancy was prospectively recorded in three telephone interviews. Child IQ was assessed at age 5 with the Wechsler Primary and Preschool Scales of Intelligence-Revised (WPPSI-R) administered by trained psychologists. We employed linear regression analysis, adjusting for maternal IQ and other confounding factors, and assessed interactions between acetaminophen and indications for use. RESULTS: Both maternal fever in pregnancy and acetaminophen use were associated with child IQ. Children born to mothers using acetaminophen without reporting fever scored on average 3.4 points lower (95% confidence interval [CI]: 0.30 to 6.6 points) on performance IQ compared with offspring of mothers who neither experienced fever nor took acetaminophen. Estimated effects for acetaminophen were stronger for first or second trimester use. Children born to mothers reporting fever without using acetaminophen also scored lower on verbal (2.7 points, 95% CI: -0.19, 5.6) and performance IQ (4.3 points, 95% CI: 0.30, 8.3); IQ scores were not affected if mothers with fever used acetaminophen. CONCLUSIONS: Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds. However, acetaminophen treatment of maternal fever in pregnancy showed an apparent compensatory association with child IQ scores. (See video abstract at http://links.lww.com/EDE/B87.). https://greenmedinfo.com/article/maternal-acetaminophen-use-during-pregnancy-was-associated-lower-performance-i#comments Acetaminophen (Tylenol) Toxicity Prenatal Chemical Exposures Acetaminophen Paracetamol Acetaminophen Acetaminophen (Tylenol) Toxicity paracetamol Prenatal Chemical Exposures Human Study Mon, 26 Jun 2017 19:39:13 +0000 greenmedinfo 149600 at https://greenmedinfo.com Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds. https://greenmedinfo.com/article/maternal-paracetamol-use-during-pregnancy-could-be-associated-poorer-attention n/a PMID:  Int J Epidemiol. 2016 Dec 1 ;45(6):2009-2017. PMID: 28031314 Abstract Title:  Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years. Abstract:  Methods: We studied 1491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Prenatal paracetamol use was prospectively recorded in three telephone interviews. Trained psychologists assessed child&#039;s attention function using the Test of Everyday Attention for Children at Five (TEACh-5). Parents and preschool teachers completed Behaviour Rating Inventory of Executive Function (BRIEF) to assess executive functions. We estimated the differences of composite mean outcome scores, and odds ratios (OR) for subnormal attention or executive function (defined as 1 standard deviation below the mean), adjusting for maternal IQ, maternal mental health, indications for paracetamol use and other potential confounders. Results: First trimester use of paracetamol was associated with poorer attention scores in childhood [mean difference -0.34, 95% confidence interval (CI) -0.63, -0.05 for overall attention, and -0.25, 95% CI -0.50, 0.01 for selective attention]. Children prenatally exposed to paracetamol were also at a higher risk for subnormal overall attention (OR = 1.5, 95% CI 1.0, 2.5), selective attention difficulties (OR = 1.5, 95% CI 1.0, 2.4), and parent-rated subnormal executive function (metacognition index, OR = 1.5, 95% CI 0.9, 2.3). The risks for subnormal overall attention or executive function were elevated with longer duration of paracetamol use in pregnancy. Conclusions: We found some evidence that maternal paracetamol use during pregnancy was associated with poorer attention and executive function in 5-year-olds. https://greenmedinfo.com/article/maternal-paracetamol-use-during-pregnancy-could-be-associated-poorer-attention#comments Acetaminophen (Tylenol) Toxicity Prenatal Chemical Exposures Acetaminophen Paracetamol Acetaminophen Acetaminophen (Tylenol) Toxicity paracetamol Prenatal Chemical Exposures Human Study Mon, 26 Jun 2017 21:47:59 +0000 greenmedinfo 149616 at https://greenmedinfo.com Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons https://greenmedinfo.com/article/maternal-use-mild-analgesics-during-pregnancy-associated-reduced-anogenital-di n/a PMID:  Hum Reprod. 2017 Jan ;32(1):223-231. Epub 2016 Nov 16. PMID: 27852690 Abstract Title:  Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs. Abstract:  STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring? SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls. WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e.g. ibuprofen and acetyl salicylic acid) have endocrine disrupting properties and in utero exposure reduces AGD in male rats. In humans, maternal exposure has been associated with cryptorchidism and hypospadias in male offspring but no studies have examined AGD. STUDY DESIGN, SIZE, DURATION: A prospective birth cohort study. Between 2010 and 2012, 2500 pregnant women were recruited from the Odense Child Cohort. Children were examined 3 months after the expected date of birth. PARTICIPANTS/MATERIALS, SETTING, METHODS: Pregnant women were asked about use of medication including mild analgesics (paracetamol and NSAID) during pregnancy at recruitment (gestational age (GA) week 10-27) and at GA week 28. AGD and penile width were measured 3 months after expected date of birth by trained personnel. A total of 1027 women answered both questionnaires and their children were examined. Associations between prenatal exposure to mild analgesics and AGD and penile width were estimated using multivariable linear regression adjusting for age and weight-for-age SD score. MAIN RESULTS AND THE ROLE OF CHANCE: A total of 40% of the women reported use of paracetamol and/or NSAIDs (4.4%) during the first 28 weeks of pregnancy. Exposure to analgesics during pregnancy was associated with a reduced AGD in boys, although statistically significant only for NSAIDs. The association was significant among 20 boys exposed to both paracetamol and NSAIDs (AGD -4.1 mm; CI 95%: -6.4; -1.7). Maternal intake of analgesics did not show any clear association with AGD in female offspring. No effect on penile width was found. LIMITATIONS REASONS FOR CAUTION: Only 27 boys and 18 girls were exposed to NSAIDs and most of them were also exposed to paracetamol. This makes it impossible to distinguish between exposures to NSAIDs alone and a potential mixture effect. Moreover, use of mild analgesics was self-reported up to 2 months after intake, which could have caused misclassification of exposure but is probably not associated with AGD as this was unknown to the women at time of reply to the questionnaire thereby underestimating the association. Confounding by indication may also explain our findings, as the condition for which the analgesic was taken may be associated with a reduction in AGD, rather than the use of the analgesic medication. This is the first study to report such an association in humans and further studies are needed to confirm our findings. WIDER IMPLICATIONS OF THE FINDINGS: A negative association was observed between exposure to analgesics during pregnancy and AGD in boys, suggesting disruption of androgen action. The health implications of a shorter AGD are still uncertain, but in cross-sectional studies among adult men a shorter AGD is associated with poorer semen quality and lower testosterone. As 41% of the women used these painkillers the finding are of public health importance and pregnant women should be advised about the potentially harmful effects of painkiller use. STUDY FUNDING/COMPETING INTERESTS: The study was funded by the Danish Environmental Protection Agency by way of the Center on Endocrine Disruptors Danish Center for Hormone Disrupting Chemicals, the Danish Foundation for Scientific Innovation and Technology (09-067180), the Danish Research Council (4004-00352B_FSS), Novo Nordic Foundation (NNF15OC0017734), Ronald McDonald Children Foundation, K.A. Rohde&#039;s and wife&#039;s Foundation, Odense University Hospital and Region of Southern Denmark, Municipality of Odense, the Danish Council for Strategic Research, Program Commission on Health, Food and Welfare (2101-08-0058), Odense University Hospital Research Foundation and Odense Patient data Exploratory Network (OPEN). The authors declare they have no competing interests. TRIAL REGISTRATION NUMBER: Not applicable. https://greenmedinfo.com/article/maternal-use-mild-analgesics-during-pregnancy-associated-reduced-anogenital-di#comments Acetaminophen (Tylenol) Toxicity Acetaminophen Analgesic: Non-opioid Acetaminophen Acetaminophen (Tylenol) Toxicity Analgesic: Non-opioid Risk Factors Human Study Mon, 26 Jun 2017 22:04:01 +0000 greenmedinfo 149619 at https://greenmedinfo.com Prenatal and postnatal paracetamol exposure results in modulation of cerebellar neurotransmission with changes concerning mainly 5-HIAA and MHPG levels. https://greenmedinfo.com/article/prenatal-and-postnatal-paracetamol-exposure-results-modulation-cerebellar-neur n/a PMID:  Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980 Abstract Title:  Cerebellar level of neurotransmitters in rats exposed to paracetamol during development. Abstract:  BACKGROUND: The present study was designed to clarify the effect of prenatal and postnatal paracetamol administration on the neurotransmitter level and balance of amino acids in the cerebellum. METHODS: Biochemical analysis to determine the concentration of neurotransmitters in this brain structure was performed on two-month-old Wistar male rats previously exposed to paracetamol in doses of 5 (P5, n=10) or 15mg/kg (P15, n=10) throughout the entire prenatal period, lactation and until the completion of the second month of life, when the experiment was terminated. Control animals were given tapped water (Con, n=10). The cerebellar concentration of monoamines, their metabolites and amino acids were assayed using High Performance Liquid Chromatography (HPLC). RESULTS: The present experiment demonstrates that prenatal and postnatal paracetamol exposure results in modulation of cerebellar neurotransmission with changes concerning mainly 5-HIAA and MHPG levels. CONCLUSION: The effect of paracetamol on monoaminergic neurotransmission in the cerebellum is reflected by changes in the level of catabolic end-products of serotonin (5-HIAA) and noradrenaline (MHPG) degradation. Further work is required to define the mechanism of action and impact of prenatal and postnatal exposure to paracetamol in the cerebellum and other structures of the central nervous system (CNS). https://greenmedinfo.com/article/prenatal-and-postnatal-paracetamol-exposure-results-modulation-cerebellar-neur#comments Acetaminophen (Tylenol) Toxicity Prenatal Chemical Exposures Acetaminophen Neurotoxic Paracetamol Acetaminophen Acetaminophen (Tylenol) Toxicity paracetamol Prenatal Chemical Exposures Animal Study Mon, 26 Jun 2017 22:38:06 +0000 greenmedinfo 149621 at https://greenmedinfo.com Prenatal exposures and the development of childhood wheezing illnesses. https://greenmedinfo.com/article/prenatal-exposures-and-development-childhood-wheezing-illnesses n/a PMID:  Curr Opin Allergy Clin Immunol. 2017 Apr ;17(2):110-115. PMID: 28079560 Abstract Title:  Prenatal exposures and the development of childhood wheezing illnesses. Abstract:  PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes. There is insufficient evidence to support an association between in-utero exposure to acetaminophen or prenatal levels of specific nutrients (such as vitamin D, folic acid, or polyunsaturated fatty acids) and childhood wheezing illnesses. SUMMARY: Several common potentially modifiable prenatal exposures appear to be consistently associated with childhood wheezing illnesses (e.g. parental smoking, outdoor air pollution, and maternal stress). However, the effect of many other prenatal exposures on the onset of childhood wheezing illnesses remains unclear. The existing scientific evidence from the past year does not allow us to make any new recommendations on primary prevention measures. Intervention studies will best demonstrate whether changing the prenatal environment can prevent childhood wheezing illnesses and asthma. https://greenmedinfo.com/article/prenatal-exposures-and-development-childhood-wheezing-illnesses#comments Acetaminophen (Tylenol) Toxicity Prenatal Chemical Exposures Wheezing: Infants Acetaminophen (Tylenol) Toxicity Environmental Factors Prenatal Chemical Exposures Risk Factors Wheezing: Infants Review Mon, 26 Jun 2017 20:18:19 +0000 greenmedinfo 149606 at https://greenmedinfo.com The Powerful Aspirin Alternative Your Doctor Never Told You About https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><img alt="The Powerful Aspirin Alternative Your Doctor Never Told You About" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/clueless_doctor_greenmedinfo.jpg" title="The Powerful Aspirin Alternative Your Doctor Never Told You About" /></span></span></p> <p><span style="font-size:18px;"><em><strong><span style="font-family:verdana,geneva,sans-serif;">Given that&nbsp;<a href="https://greenmedinfo.com/blog/aspirin-your-heart-continuing-devaluation-aspirins-resume" target="_blank">cardiovascular disease prevention guidelines</a>&nbsp;now recommend against daily low-dose aspirin use, natural, safe and effective alternatives are needed now more than ever. Thankfully, one particularly therapeutic alternative has been known about by the biomedical research community for decades...</span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2" target="_blank">read more</a></p> https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2#comments Acetaminophen (Tylenol) Toxicity Aspirin-Induced Toxicity Cardiovascular Disease: Prevention Clotting Deep Vein Thrombosis Ibuprofen Toxicity NSAID-induced toxicity Post-Thrombotic Syndrome Pycnogenol (Pine Bark) Venous Insufficiency Venous Thromboembolism (VTE) Anti-Platelet Aspirin Heart Health Ibuprofen Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Tylenol Acetaminophen (Tylenol) Toxicity anti-clotting antiplatelet Aspirin Aspirin Alternatives Aspirin-Induced Toxicity bleeding Cardiovascular Disease Ibuprofen pine bark pycnogenol Fri, 12 Apr 2019 11:18:20 +0000 Sayer Ji 115570 at https://greenmedinfo.com This data provide strong evidence that prenatal acetaminophen interferes with maternal immune and endocrine adaptation to pregnancy. https://greenmedinfo.com/article/data-provide-strong-evidence-prenatal-acetaminophen-interferes-maternal-immu-0 n/a PMID:  Am J Pathol. 2015 Oct ;185(10):2805-18. Epub 2015 Aug 5. PMID: 26254283 Abstract Title:  Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice. Abstract:  Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to treat fever or pain and recommended to pregnant women by their physicians. Recent epidemiological studies reveal an association between prenatal APAP use and an increased risk for asthma. Our aim was to identify the effects of APAP in pregnancy using a mouse model. Allogeneically mated C57Bl/6J females were injected i.p. with 50 or 250 mg/kg APAP or phosphate-buffered saline on gestation day 12.5; nonpregnant females served as controls. Tissue samples were obtained 1 or 4 days after injection. APAP-induced liver toxicity was mirrored by significantly increased plasma alanine aminotransferase levels. In uterus-draining lymph nodes of pregnant dams, the frequencies of mature dendritic cells and regulatory T cells significantly increased on 250 mg/kg APAP. Plasma progesterone levels significantly decreased in dams injected with APAP, accompanied by a morphologically altered placenta. Although overall litter sizes and number of fetal loss remained unaltered, a reduced fetal weight and a lower frequency of hematopoietic stem cells in the fetal liver were observed on APAP treatment. Our data provide strong evidence that prenatal APAP interferes with maternal immune and endocrine adaptation to pregnancy, affects placental function, and impairs fetal maturation and immune development. The latter may have long-lasting consequences on children&#039;s immunity and account for the increased risk for asthma observed in humans. https://greenmedinfo.com/article/data-provide-strong-evidence-prenatal-acetaminophen-interferes-maternal-immu-0#comments Acetaminophen (Tylenol) Toxicity Asthma Prenatal Chemical Exposures Acetaminophen Immunotoxic Paracetamol Acetaminophen Acetaminophen (Tylenol) Toxicity Asthma paracetamol Prenatal Chemical Exposures Animal Study Mon, 26 Jun 2017 19:14:23 +0000 greenmedinfo 149597 at https://greenmedinfo.com