Phytoncides https://greenmedinfo.com/category/keywords/Phytoncides en Phytoncide nanomolecules might be a potential therapeutic approach to prevent or treat atheroscrelosis and restenosis. https://greenmedinfo.com/article/phytoncide-nanomolecules-might-be-potential-therapeutic-approach-prevent-or-tr PMID:  J Nanosci Nanotechnol. 2015 Jan ;15(1):112-5. PMID: 26328312 Abstract Title:  Phytoncide, Nanochemicals from Chamaecyparis obtusa, Inhibits Proliferation and Migration of Vascular Smooth Muscle Cells. Abstract:  Phytoncide, nanochemicals extracted from Chamaecyparis obtusa (C. obtusa), is reported to possess many pharmacological activities including immunological stimulating, anti-cancer, antioxidant, and antiinflammatory activities. However, the effect of phytoncide in vascuar diseases, especially on the behavior of vascular smooth muscle cells, has not yet been clearly elucidated. Therefore, in the present study, we investigated the effects of 15 kinds of phytoncide by various extraction conditions from C. obtusa on the proliferation and migration in rat aortic smooth muscle cells (RAoSMCs). First of all, we determined the concentration of each extracts not having cytotoxicity by MTT assay. We observed that the proliferation rate measured using BrdU assay was significantly reduced by supercritical fluid, steam distillation, Me-OH, and hexane extraction fraction in order with higher extent, respectively. Moreover, the treatment of above nanofractions inhibit the migration of RAoSMCs by 40%, 60%, and 30%, respectively, both in 2-D wound healing assay and 3-D boyden chamber assay. Immunoblot revealed that the phosphorylated levels of Akt and ERK were significantly reduced in nanofractions treated RAoSMCs. Taken together, these data suggest that phytoncide extracted from C. obtusa inhibits proliferation and migration in RAoSMCs via the modulation of phosphorylated levels of Akt and ERK. Therefore, phytoncide nanomolecules might be a potential therapeutic approach to prevent or treat atheroscrelosis and restenosis. <p><a href="https://greenmedinfo.com/article/phytoncide-nanomolecules-might-be-potential-therapeutic-approach-prevent-or-tr" target="_blank">read more</a></p> https://greenmedinfo.com/article/phytoncide-nanomolecules-might-be-potential-therapeutic-approach-prevent-or-tr#comments Arteriosclerosis Japanese cypress Restenosis Antimutagenic Agents Antiproliferative Shinrin-yoku (taking in the atmosphere of the forest) Phytoncides In Vitro Study Tue, 09 May 2017 17:32:20 +0000 greenmedinfo 147468 at https://greenmedinfo.com Phytoncides have antioxidant effects and antimicrobial activites. https://greenmedinfo.com/article/phytoncides-have-antioxidant-effects-and-antimicrobial-activites PMID:  Biocontrol Sci. 2008 Mar ;13(1):23-7. PMID: 18432113 Abstract Title:  Antioxidant effects and antimicrobial activites of phytoncide. Abstract:  Physiological activities of four types of phytoncide solutions (A, AB, CY and D-types), prepared from various plants widely distributed in nature, were examined. We assayed these phytoncide solutions, testing for active oxygen inhibition, DPPH radical scavenging effects, nitrogen monoxide inhibition, and lipid peroxide inhibition. The AB- and D-types of phytoncide solutions especially showed comparably potent antioxidant effects. Antibacterial and antifungal assays were conducted using the AB- and D-types, with results showing significant inhibitory activities with these solutions. <p><a href="https://greenmedinfo.com/article/phytoncides-have-antioxidant-effects-and-antimicrobial-activites" target="_blank">read more</a></p> https://greenmedinfo.com/article/phytoncides-have-antioxidant-effects-and-antimicrobial-activites#comments Anti-Bacterial Agents Antioxidants Phytoncides Plant Oils In Vitro Study Tue, 09 May 2017 17:26:31 +0000 greenmedinfo 147465 at https://greenmedinfo.com Phytoncides reduced the cardiovascular response to restraint stress in stroke-prone spontaneously hypertensive rats. https://greenmedinfo.com/article/phytoncides-reduced-cardiovascular-response-restraint-stress-stroke-prone-sp-0 PMID:  Clin Exp Pharmacol Physiol. 2004 Dec ;31 Suppl 2:S27-8. PMID: 15649280 Abstract Title:  Effects of phytoncides on blood pressure under restraint stress in SHRSP. Abstract:  1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 vs 207.7 +/- 3.4 mmHg, respectively, P<p><a href="https://greenmedinfo.com/article/phytoncides-reduced-cardiovascular-response-restraint-stress-stroke-prone-sp-0" target="_blank">read more</a></p> https://greenmedinfo.com/article/phytoncides-reduced-cardiovascular-response-restraint-stress-stroke-prone-sp-0#comments Hypertension Antihypertensive Agents Shinrin-yoku (taking in the atmosphere of the forest) Phytoncides Animal Study Tue, 09 May 2017 16:59:44 +0000 greenmedinfo 147462 at https://greenmedinfo.com Phytoncides significantly enhance human natural killer activity. https://greenmedinfo.com/article/phytoncides-significantly-enhance-human-natural-killer-activity n/a PMID:  Immunopharmacol Immunotoxicol. 2006 ;28(2):319-33. PMID: 16873099 Abstract Title:  Phytoncides (wood essential oils) induce human natural killer cell activity. Abstract:  To explore the effect of forest bathing on the human immune system, we investigated the effect of phytoncides (wood essential oils) on natural killer (NK) activity and the expression of perforin, granzyme A and granulysin in human NK cells. We used NK-92MI cell, an interleukin-2 independent human NK cell line derived from the NK-92 cell, in the present study. NK-92MI cells express the CD56 surface marker, perforin, granzyme A, and granulysin by flow cytometry and are highly cytotoxic to K562 cells in chromium release assay. Phytoncides significantly increase cytolytic activity of NK-92MI cells in a dose-dependent manner and significantly increase the expression of perforin, granzyme A, and granulysin in the NK-92MI cells. Phytoncides also partially, but significantly, restore the decreased human NK activity and the decreased perforin, granzyme A, and granulysin expression in NK-92MI cells induced by dimethyl 2,2-dichlorovinyl phosphate (DDVP), an organophosphorus pesticide. Pretreatment with phytoncides partially prevents DDVP-induced inhibition of NK activity. Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin. https://greenmedinfo.com/article/phytoncides-significantly-enhance-human-natural-killer-activity#comments Immunostimulatory Shinrin-yoku (taking in the atmosphere of the forest) Phytoncides Plant Oils Human In Vitro Tue, 09 May 2017 16:37:32 +0000 greenmedinfo 147457 at https://greenmedinfo.com