Anti-HIV Agents https://greenmedinfo.com/category/keywords/Anti-HIV%20Agents en Justiprocumin B displayed potent activity against a broad spectrum of HIV strains. https://greenmedinfo.com/article/justiprocumin-b-displayed-potent-activity-against-broad-spectrum-hiv-strains n/a PMID:  Phytochemistry. 2017 Apr ;136:94-100. Epub 2017 Jan 19. PMID: 28110956 Abstract Title:  Anti-HIV diphyllin glycosides from Justicia gendarussa. Abstract:  In a search for new anti-HIV active leads from over several thousands of plant extracts, we have identified a potent plant lead. The active plant is determined as Justicia gendarussa (Acanthaceae), a medicinal plant that has been used for the treatment of injury, arthritis and rheumatism in Asia including China. Our bioassay-guided fractionation of the methanol extract of the stems and barks of the plant led to the isolation of two anti-HIV compounds, justiprocumins A and B. The compounds are identified as new arylnaphthalide lignans (ANL) glycosides. We further determined that the ANL glycosides are the chemical constituents that contribute to the anti-HIV activity of this plant. Justiprocumin B displayed potent activity against a broad spectrum of HIV strains with IC50 values in the range of 15-21 nM (AZT, IC50 77-95 nM). The compound also displayed potent inhibitory activity against the NRTI (nucleoside reverse transcriptase inhibitor)-resistant isolate (HIV-11617-1) of the analogue (AZT) as well as the NNRTI (non-nucleoside reverse transcriptase inhibitor)-resistant isolate (HIV-1N119) of the analogue (nevaripine). https://greenmedinfo.com/article/justiprocumin-b-displayed-potent-activity-against-broad-spectrum-hiv-strains#comments HIV Infections Justicia gendarussa Anti-HIV Agents Anti-Retroviral Agents Anti-HIV Agents Anti-Retroviral Agents HIV Infections Justicia gendarussa In Vitro Study Thu, 15 Jun 2017 16:48:26 +0000 greenmedinfo 149178 at https://greenmedinfo.com