Pterocarpus marsupium https://greenmedinfo.com/category/keywords/Pterocarpus%20marsupium en Compounds from P. marsupium have antibacterial, antidiabetic, anti-inflammatory, and analgesic activities. https://greenmedinfo.com/article/compounds-p-marsupium-have-antibacterial-antidiabetic-anti-inflammatory-and-an n/a PMID:  J Intercult Ethnopharmacol. 2017 Apr-Jun;6(2):170-176. Epub 2017 Apr 12. PMID: 28512598 Abstract Title:  Phytochemical screening and study of antioxidant, antimicrobial, antidiabetic, anti-inflammatory and analgesic activities of extracts from stem wood of Pterocarpus marsupium Roxburgh. Abstract:  AIMS: The main aims of the study were to evaluate the phytochemical constituents and to study the antioxidant, antimicrobial, antidiabetic, anti-inflammatory, and analgesic activities of extracts from stem wood of Pterocarpus marsupium. MATERIALS AND METHODS: Ethanol, acetone and isopropyl alcohol (IPA) (1:1) extracts of stem wood of P. marsupium were subjected to phytochemical screening and analysis of biological activities from August 2015 to January 2016. The antioxidant assay was carried out using 2, 2-diphenyl-1-picrylhydrazyl scavenging method, antimicrobial activity testing by cup diffusion method, antidiabetic test evaluation by oral glucose tolerance test in mice, anti-inflammatory effect was evaluated by hind paw edema method in mice and analgesic test evaluation by a chemical writhing method in mice. RESULTS: The results of the study revealed that P. marsupium is a source of various phytoconstituents such as alkaloids, glycosides, saponins, tannins, proteins, carbohydrates, cardiac glycosides, flavonoids, and terpenoids. Both the acetone and IPA extract as well as the ethanol extract of stem wood of P. marsupium exhibited a dose-dependent antioxidant activity. Acetone and IPA extract showed antibacterial activity against Gram-positive bacteria, while the ethanolic extract was found to possess antidiabetic activity. The antidiabetic activity of the extract was found to be time and dose-dependent. Similarly, the acetone and IPA extract was found to have anti-inflammatory activity, which was also time and dose-dependent. Furthermore, the ethanolic extract showed analgesic activity, which was dose-dependent. The ethanolic extract was found to be nontoxic. CONCLUSIONS: Thus, this study laid sufficient background for the further research on extracts from stem wood of P. marsupium for identification, subsequent purification and isolation of compounds having antibacterial, antidiabetic, anti-inflammatory, and analgesic activities. https://greenmedinfo.com/article/compounds-p-marsupium-have-antibacterial-antidiabetic-anti-inflammatory-and-an#comments Gram-Positive Bacterial Infections Inflammation Pterocarpus marsupium Analgesics Anti-Bacterial Agents Anti-Inflammatory Agents Hypoglycemic Agents Analgesics Anti-Bacterial Agents Anti-Inflammatory Agents Dose Response Gram-Positive Bacterial Infections Hypoglycemic Agents Inflammation Plant Extracts Pterocarpus marsupium In Vitro Study Wed, 28 Jun 2017 20:52:21 +0000 greenmedinfo 149703 at https://greenmedinfo.com Preliminary results indicate a selective cytotoxicity of an aqueous extract of Pterocarpus marsupium towards the cancer cells. https://greenmedinfo.com/article/preliminary-results-indicate-selective-cytotoxicity-aqueous-extract-pterocarpu n/a PMID:  Planta Med. 2016 Sep ;82(14):1295-301. Epub 2016 Apr 28. PMID: 27124243 Abstract Title:  Characterization of the Volatile and Nonvolatile Fractions of Heartwood Aqueous Extract from Pterocarpus marsupium and Evaluation of Its Cytotoxicity against Cancer Cell Lines. Abstract:  Pterocarpus marsupium is a well-known plant due to its healing properties, in particular, the use of its aqueous extract is able to reduce blood sugar levels and blood triglyceride concentrations. Although this plant has already been widely studied, a complete characterization of its aqueous extract has not been reported. The present study deals with the characterization of the aqueous extract of P. marsupium in order to obtain a full fingerprint of the volatile and nonvolatile constituents. The volatile constituents were identified by CG-MS, whereas the nonvolatile fraction was characterized by UHPLC-MS/MS using a nontarget approach. Several compounds were identified, in particular, polyphenolic species belonging to the class of proanthocyanidins. Cytotoxicity tests were carried out on four different cancer cell lines and three different non-tumoral cell lines. Preliminary results indicate a selective cytotoxicity of the aqueous extract towards the cancer cells. The potential cytotoxicity due to the presence of metals in the aqueous extract was ruled out by testing an aqueous mixture of the metals at the same concentration found in the P. marsupium extract. https://greenmedinfo.com/article/preliminary-results-indicate-selective-cytotoxicity-aqueous-extract-pterocarpu#comments Cancers: All Pterocarpus marsupium Cytotoxic Cancers: All Cytotoxic Plant Extracts Pterocarpus marsupium Selective Cytotoxicity In Vitro Study Wed, 28 Jun 2017 21:00:44 +0000 greenmedinfo 149704 at https://greenmedinfo.com Pterocarpus marsupium extract showed a promising antioxidant effect, as well as hypoglycemic activity. https://greenmedinfo.com/article/pterocarpus-marsupium-extract-showed-promising-antioxidant-effect-well-hypogly n/a PMID:  Nat Prod Commun. 2015 Nov ;10(11):1843-6. PMID: 26749811 Abstract Title:  Renoprotective Effects, Protein Thiols and Liver Glycogen Content of Alloxan-induced Diabetic Rats Treated with Different Fractions of Heartwood of Pterocarpus marsupium. Abstract:  Oxidative stress is believed to be a pathogenic factor in the development of diabetic complications. In the present study, we aimed to evaluate the effects of different fractions of heart wood of Pterocarpus marsupium on antioxidant enzyme like protein thiols and also check the efficacy of the extract for the protection of the renal function in alloxan induced diabetic rats. The present study also investigates the levels of liver glycogen which are considered as the best biomarker for assaying the hypoglycemic activity of any drug. Diabetes was induced by administering alloxan dissolved in saline, while the normal control group was given propylene glycol. Diabetes induced animals were randomly assigned into different groups. Blood samples were collected from all the experimental and control groups. Estimation of urea, uric acid and creatinine along with protein thiols was made on day 30 only. At the end, all the animals were sacrificed to collect liver tissue to analyze glycogen content. The 30 days treatment with various extracts (75 mg/kg body wt) significantly lowered protein thiol levels, which probably represents increased utilization for neutralizing free radicals. There was no significant increase in the levels of renal parameters in the extract treated groups which revealed that the employed dose of the extract is nontoxic to the kidney. There was also a significant decrease in the glycogen content in insulin and alcohol-extract treated groups and should be encouraging for the treatment of diabetes mellitus. The extract showed a promising antioxidant effect, as well as hypoglycemic activity, and should be encouraged for the treatment of diabetes. https://greenmedinfo.com/article/pterocarpus-marsupium-extract-showed-promising-antioxidant-effect-well-hypogly#comments Hyperglycemia Pterocarpus marsupium Antioxidants Hypoglycemic Agents Renoprotective Antioxidants hyperglycemia Hypoglycemic Agents Phytotherapy Plant Extracts Pterocarpus marsupium Renoprotective Animal Study Wed, 28 Jun 2017 21:13:48 +0000 greenmedinfo 149706 at https://greenmedinfo.com