Crocin https://greenmedinfo.com/category/keywords/Crocin en A comprehensive review on anticancer mechanisms of crocin. https://greenmedinfo.com/article/comprehensive-review-anticancer-mechanisms-crocin n/a PMID:  J Pharm Pharmacol. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28675431 Abstract Title:  A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin. Abstract:  OBJECTIVES: Crocin is derived from dried stigmas of Crocus sativus L. (saffron). It has long been used to prevent and treat various diseases. Although crocin is suggested as one of the most effective cancer therapeutic constituents of saffron stigma, its exact molecular mechanisms are not fully understood. In this study, we reviewed anticancer effects of crocin and its underlying molecular mechanisms. KEY FINDINGS: While several mechanisms may account for the antitumour activity of crocin, alteration of expression/activity of the genes and also epigenetic changes may be considered as necessary phenomena. These alternations may lead to inhibition of cancer cells' proliferation or/and induction of apoptosis through various mechanism including inhibition of synthesis of DNA and RNA, interaction with cellular topoisomerase, suppression of the telomerase activity and active STAT3, and targeting of microtubules. Moreover, this carotenoid could reverse the epithelial-mesenchymal transition and inhibit metastasis. CONCLUSIONS: Knowing molecular mechanisms of antitumoral agents could guide us to choose the best chemotherapeutic compound especially for targeted therapy and also provide insights about possible side effects. https://greenmedinfo.com/article/comprehensive-review-anticancer-mechanisms-crocin#comments Cancers: All Crocin Anti-metastatic Antiproliferative Apoptotic Chemotherapeutic Telomerase Inhibitor Anti-metastatic Antiproliferative Apoptotic Cancers: All Chemotherapeutic Crocin Telomerase Inhibitor Review Fri, 14 Jul 2017 01:19:14 +0000 greenmedinfo 150415 at https://greenmedinfo.com Crocin possesses hepatoprotective effects against BPA-induced liver toxicity. https://greenmedinfo.com/article/crocin-possesses-hepatoprotective-effects-against-bpa-induced-liver-toxicity n/a PMID:  Food Chem Toxicol. 2017 Jul 5. Epub 2017 Jul 5. PMID: 28689058 Abstract Title:  Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression. Abstract:  Bisphenol A (BPA) is an artificial environmental endocrine disrupting chemical and commonly used as a monomer of polycarbonate plastics and epoxy resins. The aim of the present study is to investigate the hepatoprotective effects of crocin, a constituent of saffron, against BPA-induced liver toxicity. We showed that treatment of male Wistar rats with 0.5 mg/kg BPA for 30 days increased the level of 8-isoprostane, decreased the level of reduced glutathione, elevated serum levels of aspartate aminotransferase, lactate dehydrogenase, triglyceride, and glucose, and induced periportal inflammation. Western blot results revealed that BPA increased the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK1/2), and mitogen-activated protein kinase-activated protein kinase (MAPKAPK), but not p38. BPA also reduced the Akt signaling activation and upregulated microRNA (miR-122) expression. Moreover, we showed herethat crocin 20 mg/kg administration ameliorated liver damage and improved elevated levels of TG and liver enzymes of BPA-treated rats possibly though antioxidant activity, downregulation of miR-122 transcript level and lowering the phosphorylation of JNK, ERK1/2, and MAPKAPK and subsequently theiractivities. Overall, the findings suggest that crocin possesses hepatoprotective effects against BPA-induced liver toxicity by enhancing the antioxidative defense system and regulation of important signaling pathway activities and miR-122 expression. https://greenmedinfo.com/article/crocin-possesses-hepatoprotective-effects-against-bpa-induced-liver-toxicity#comments Bisphenol Toxicity Crocin Antioxidants Bisphenol A Hepatoprotective MicroRNA modulator Antioxidants Bisphenol Toxicity Crocin Hepatoprotective MicroRNA modulator Animal Study Fri, 14 Jul 2017 00:31:42 +0000 greenmedinfo 150413 at https://greenmedinfo.com Voluntary exercise and diet supplementation with crocin could have beneficial effects in prevention of cardiovascular disease. https://greenmedinfo.com/article/voluntary-exercise-and-diet-supplementation-crocin-could-have-beneficial-effec n/a PMID:  Arq Bras Cardiol. 2017 Jun 29:0. Epub 2017 Jun 29. PMID: 28678929 Abstract Title:  Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis. Abstract:  Background:: Crocin is reported to have a wide range of biological activities such as cardiovascular protection. Recent epidemiologic studies have shown that exercise reduces cardiovascular morbidity and mortality in the general population. Objective:: The aim of this study was to evaluate the effect of crocin and voluntary exercise on miR-126 and miR-210 expression levels and angiogenesis in the heart tissue. Methods:: Animals were divided into 4 groups: control, exercise, crocin, and exercise-crocin. Animals received oral administration of crocin (50 mg/kg) or performed voluntary exercise alone or together for 8 weeks. Akt, ERK1/2 protein levels, miR-126 and miR-210 expression were measured in the heart tissue. Immunohistochemical method was used to detect CD31 in the heart tissue. Results:: Akt and ERK1/2 levels of the heart tissue were higher in crocin treated group and voluntary exercise trained group after 8 weeks. Combination of crocin and exercise also significantly enhanced Akt and ERK1/2 levels in the heart tissue. MiR-126, miR-210 expression and CD31 in the heart increased in both crocin and voluntary exercise groups compared with control group. In addition, combination of exercise and crocin amplified their effect on miR-126 and miR-210 expression, and angiogenesis. Conclusion:: Crocin and voluntary exercise improve heart angiogenesis possibly through enhancement of miR-126 and miR-210 expression. Voluntary exercise and diet supplementation with crocin could have beneficial effects in prevention of cardiovascular disease. Fundamentos:: A crocina tem uma vasta gama de atividades biológicas, tais como a proteção cardiovascular. Estudos epidemiológicos recentes demonstraram que o exercício reduz a morbidade e a mortalidade cardiovasculares na população em geral. Objetivo:: O objetivo deste estudo foi avaliar o efeito da crocina e do exercício voluntário nos níveis de expressão miR-126 e miR-210 e na angiogênese no tecido cardíaco. Métodos:: Os animais foram divididos em 4 grupos: controle, exercício, crocina e exercício-crocina. Os animais receberam a administração oral de crocina (50 mg/kg) ou realizaram exercício voluntário sozinhos ou em conjunto durante 8 semanas. Os níveis de proteína Akt, ERK1/2, e a expressão de miR-126 e miR-210 foram medidos no tecido cardíaco. O métodoimunohistoquímico foi utilizado para detectar CD31 no tecido cardíaco. Resultados:: Os níveis de Akt e ERK1/2 do tecido cardíaco foram maiores no grupo tratado com crocina e no grupo de exercício voluntário após 8 semanas. A combinação de crocina e exercício também aumentou significativamente os níveis de Akt e ERK1/2 no tecido cardíaco. A expressão de MiR-126, miR-210 e CD31 no coração aumentou tanto em no grupo de crocina como no grupo de exercício voluntário em comparação com o grupo de controle. Além disso, a combinação de exercício e crocina amplificou seu efeito na expressão de miR-126 e miR-210 e angiogênese. Conclusão:: A Crocina e o exercício voluntário melhoram a angiogênese cardíaca possivelmente através do aumento da expressão de miR-126 e miR-210. O exercício voluntário e a suplementação dietética com crocina podem ter efeitos benéficos na prevenção de doenças cardiovasculares. https://greenmedinfo.com/article/voluntary-exercise-and-diet-supplementation-crocin-could-have-beneficial-effec#comments Cardiovascular Diseases Crocin Cardioprotective Exercise MicroRNA modulator Cardioprotective Cardiovascular Diseases Crocin exercise MicroRNA modulator Animal Study Fri, 14 Jul 2017 00:49:17 +0000 greenmedinfo 150414 at https://greenmedinfo.com