Flavan-3-ols https://greenmedinfo.com/category/keywords/Flavan-3-ols en Acute chocolate intervention can significantly affect human metabolism. https://greenmedinfo.com/article/acute-chocolate-intervention-can-significantly-affect-human-metabolism n/a PMID:  J Proteome Res. 2017 Jul 7 ;16(7):2516-2526. Epub 2017 Jun 15. PMID: 28585834 Abstract Title:  Acute Consumption of Flavan-3-ol-Enriched Dark Chocolate Affects Human Endogenous Metabolism. Abstract:  Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled crossover intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 and 6 h after consumption of chocolates in 42 healthy volunteers using a nontargeted metabolomics approach. Plasma samples were assessed and showed differentiation between time points with no further separation among the three chocolate treatments. Multivariate statistics applied to urine samples could readily separate the postprandial time points and distinguish between the treatments. Most of the markers responsible for the multivariate discrimination between the chocolates were of dietary origin. Interestingly, small but significant level changes were also observed for a subset of endogenous metabolites. (1)H NMR revealed that flavan-3-ol-enriched dark chocolate and standard dark chocolate reduced urinary levels of creatinine, lactate, some amino acids, and related degradation products and increased the levels of pyruvate and 4-hydroxyphenylacetate, a phenolic compound of bacterial origin. This study demonstrates that an acute chocolate intervention can significantly affect human metabolism. https://greenmedinfo.com/article/acute-chocolate-intervention-can-significantly-affect-human-metabolism#comments Chocolate Flavan-3-ols chocolate Flavan-3-ols Human Study Mon, 21 Aug 2017 15:30:26 +0000 greenmedinfo 151924 at https://greenmedinfo.com Flavan 3-ol delayed disuse muscle atrophy by metabolic alteration. https://greenmedinfo.com/article/flavan-3-ol-delayed-disuse-muscle-atrophy-metabolic-alteration n/a PMID:  Exp Gerontol. 2017 Aug 11. Epub 2017 Aug 11. PMID: 28807824 Abstract Title:  Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice. Abstract:  Periods of skeletal muscle disuse, for example due to a sedentary lifestyle or bed rest, are associated with aging and can lead to muscle atrophy. We previously found that the flavan 3-ol fraction derived from cocoa (FL) enhanced energy expenditure with metabolic changes in skeletal muscle. In the present study, we examined the effect of FL on disuse muscle atrophy induced by hindlimb suspension in mice. Male C57BL/6J mice were assigned to four groups as follows: unsuspended-vehicle, unsuspended-FL, suspended-vehicle, and suspended-FL. Mice in the vehicle treatment groups were administered distilled water and those in the FL treatment groups were dosed with FL (50mg/kg/day) for 2weeks. The weights of the gastrocnemius (GC), tibialis anterior (TA), and soleus (SOL), but not the extensor digitorum longus (EDL), decreased significantly in mice with hindlimb suspension (-11.8%, -16.5%, and -41.0%, respectively). This reduction in GC, TA, and SOL mass was inhibited by FL (-5.3%, +2.0%, and -16.6%, respectively). The FL increased the EDL weight>20% with or without hindlimb suspension. The protein level of the ubiquitin ligase, muscle ring finger-1, in the SOL was significantly increased by hindlimb suspension, but inhibited by treatment with FL. Protein expression of p70S6 kinase in the SOL was significantly decreased by hindlimb suspension, and FL treatment inhibited this change. These results suggested that FL delayed disuse muscle atrophy by metabolic alteration. https://greenmedinfo.com/article/flavan-3-ol-delayed-disuse-muscle-atrophy-metabolic-alteration#comments Flavan-3-ols Muscle Atrophy Flavan-3-ols Muscle Atrophy Animal Study Mon, 21 Aug 2017 15:43:28 +0000 greenmedinfo 151926 at https://greenmedinfo.com