Chemotherapy and Radiation Toxicity https://greenmedinfo.com/category/keywords/Chemotherapy%20and%20Radiation%20Toxicity en Hippophae extract counters neuronal tissue injuries and changes in neurotransmitters: implications in radiation protection. https://greenmedinfo.com/article/hippophae-extract-counters-neuronal-tissue-injuries-and-changes-neurotransmitt n/a PMID:  Pharm Biol. 2017 Dec ;55(1):1833-1842. PMID: 28552029 Abstract Title:  A standardized Hippophae extract (SBL-1) counters neuronal tissue injuries and changes in neurotransmitters: implications in radiation protection. Abstract:  CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. Understanding CTA in rats is important because its process is considered parallel to nausea and vomiting in humans. OBJECTIVE: This study investigated the levels of neurotransmitters, antioxidant defences and histological changes in rats showing radiation CTA, and their modification by SBL-1. MATERIALS AND METHODS: The inbred male Sprague-Dawley rats (age 65 days, weighing 190 ± 10 g) were used. Saccharin-preferring rats were selected using standard procedure and divided into groups. Group I (untreated control) was administered sterile water, group II wasCo-γ-irradiated (2 Gy), and group III was administered SBL-1 before irradiation. Observations were recorded up to day 5. RESULTS: Irradiation (2 Gy) caused (i) non-recoverable CTA (≥ 64.7 ± 5.0%); (ii) degenerative changes in cerebral cortex, amygdala and hippocampus; (iii) increases in brain dopamine (DA, 63.4%), norepinephrine (NE, 157%), epinephrine (E, 233%), plasma NE (103%) and E (160%); and (iv) decreases in brain superoxide dismutase (67%), catalase (60%) and glutathione (51%). SBL-1 treatment (12 mg/kg body weight) 30 min before irradiation (i) countered brain injuries, (ii) reduced CTA (38.7 ± 3.0%, day 1) and (iii) normalized brain DA, NE, E, superoxide dismutase, catalase and CTA from day 3 onwards. DISCUSSION AND CONCLUSION: Radiation CTA was coupled with brain injuries, disturbances in neurotransmitters and antioxidant defences. SBL-1 pretreatment countered these disturbances, indicating neuroprotective action. https://greenmedinfo.com/article/hippophae-extract-counters-neuronal-tissue-injuries-and-changes-neurotransmitt#comments Chemotherapy and Radiation Toxicity Oxidative Stress Sea buckthorn Antioxidants Neuroprotective Agents Radioprotective Antioxidants Chemotherapy and Radiation Toxicity Neuroprotective Agents oxidative stress Plant Extracts Radioprotective Sea buckthorn Animal Study Sat, 07 Apr 2018 16:03:58 +0000 greenmedinfo 162347 at https://greenmedinfo.com Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility. https://greenmedinfo.com/article/honey-can-decrease-side-effects-chemotherapy-reproductive-system-and-prevent-s n/a PMID:  J Complement Integr Med. 2018 May 23. Epub 2018 May 23. PMID: 29791311 Abstract Title:  Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury. Abstract:  Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. Materials and methods Forty adult's male wistar rats were divided into four groups of ischemia-reperfusion (IR), honey + ischemia-reperfusion (HIR), Busulfan (B) and Busulfan intraperitoneally+ honey (BH). The seminiferous tubules were rated for their modified spermatogenesis index (SI) by Johnsons score. Detection of single- and double-stranded DNA breaks at the early stages of apoptosis was performed using the in-situ cell death detection kit. Total serum concentration of Follicle-stimulating hormone (FSH) , Luteinizing hormone (LH) and testosterone was measured using ELISA. All data were expressed as mean± SD and significance was set at p≤0.05. Results Honey improved SI in the HIR and BH groups and serum levels of FSH and LH in the BH and HIR groups (p<0.001). Also, serum levels of testosterone were significantly higher in BH and HIR groups. But, apoptotic cells in IR and B groups significantly increased (p<0.001), while in HIR and BH groups, the number of apoptotic cells decreased and the positive cells of TUNEL (TdT-mediated dUTP-X nick end labelling) staining were detected in spermatocytes and spermatid. Discussion Pretreatment with honey protect testis against chemotherapy and testicular IR injury, increase FSH and LH and testosterone and decrease the cellular damage and apoptosis. Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility. https://greenmedinfo.com/article/honey-can-decrease-side-effects-chemotherapy-reproductive-system-and-prevent-s#comments Chemotherapy and Radiation Toxicity Honey Chemoprotective Agents Chemoprotective Agents Chemotherapy and Radiation Toxicity Honey Animal Study Tue, 05 Jun 2018 20:39:16 +0000 greenmedinfo 165293 at https://greenmedinfo.com