Vaccination: Coronavirus https://greenmedinfo.com/category/disease/Vaccination%3A%20Coronavirus en "Covid Confinement Camps," Predictive Programming & What To Do - Sayer's VIDEO UPDATE https://greenmedinfo.com/blog/covid-confinement-camps-predictive-programming-what-do-sayers-video-update <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"> <div class="media_embed" height="315px" width="560px"> <iframe allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" frameborder="0" height="315px" src="https://www.youtube.com/embed/UW1O5pt4Gi0" width="560px"></iframe></div> </p> <p><span style="font-size:18px;"><em><strong>Sayer Ji gives a crucial update on the <a href="https://www.greenmedinfo.com/blog/216th-week-lockdown-new-covid-film-songbird-scares-hell-out-people-because-it-may4">latest article</a> featured on Greenmedinfo.com related to "COVID Confinement Camps," and predictive programming via the new Hollywood film SONGBIRD, and what action steps to take to become more empowered despite these concerning developments.&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/covid-confinement-camps-predictive-programming-what-do-sayers-video-update" target="_blank">read more</a></p> https://greenmedinfo.com/blog/covid-confinement-camps-predictive-programming-what-do-sayers-video-update#comments Coronavirus Disease Coronavirus Infection Vaccination: Coronavirus Health Guide: Corruption in Science corruption in science medical freedom viral infections Thu, 05 Nov 2020 15:29:17 +0000 Sayer Ji 229078 at https://greenmedinfo.com 329 Deaths + 9,516 Other Injuries Reported Following COVID Vaccine, Latest CDC Data Show https://greenmedinfo.com/blog/329-deaths-9516-other-injuries-reported-following-covid-vaccine-latest-cdc-data-s <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/329_Deaths_9516_Other_Injuries_Reported_Following_COVID_Vaccine-GreenMedInfo(1).jpg" style="width: 600px; height: 315px;" /><br /> <span style="font-size:12px;"><strong>Originally published on <a href="https://childrenshealthdefense.org/defender/329-deaths-9516-other-injuries-reported-following-covid-vaccine-cdc/" rel="dofollow" target="_blank">www.childrenshealthdefense.org</a></strong></span></p> <p><span style="font-size:18px;"><strong><em>The numbers reflect the latest data available as of Jan. 22 from the CDC’s Vaccine Adverse Event Reporting System website. Of the 329 reported deaths, 285 were from the U.S., and 44 were from other countries. The average age of those who died was 76.5</em></strong></span></p><p><a href="https://greenmedinfo.com/blog/329-deaths-9516-other-injuries-reported-following-covid-vaccine-latest-cdc-data-s" target="_blank">read more</a></p> https://greenmedinfo.com/blog/329-deaths-9516-other-injuries-reported-following-covid-vaccine-latest-cdc-data-s#comments Heart Attack Vaccination: All Vaccination: Coronavirus Vaccine-induced Toxicity Chemical and Drug Toxicity Health Guide: Chemical Exposures Health Guide: Corruption in Science Health Guide: Viruses Vaccine Adjuvants Vaccine Effects big pharma corruption in science viral infections Mon, 01 Feb 2021 17:19:38 +0000 Children's Health Defense 233887 at https://greenmedinfo.com A case of multisystem inflammatory syndrome in a 12-Year-old male After COVID-19 mRNA vaccine. https://greenmedinfo.com/article/case-multisystem-inflammatory-syndrome-12-year-old-male-after-covid-19-mrna-va PMID:  Pediatr Infect Dis J. 2022 03 1 ;41(3):e87-e89. PMID: 34978781 Abstract Title:  A Case of Multisystem Inflammatory Syndrome in a 12-Year-old Male After COVID-19 mRNA Vaccine. Abstract:  The pathophysiology of multisystem inflammatory syndrome (MIS) in children (MIS-C) is unknown. It occurs several weeks after COVID-19 infection or exposure; however, MIS is rarely reported after COVID-19 vaccination, and cases are mostly in adults. Herein, we present a 12-year-old male who had no prior COVID-19 infection or exposure and developed MIS-C after his first dose of COVID-19 mRNA vaccine. <p><a href="https://greenmedinfo.com/article/case-multisystem-inflammatory-syndrome-12-year-old-male-after-covid-19-mrna-va" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-multisystem-inflammatory-syndrome-12-year-old-male-after-covid-19-mrna-va#comments Inflammation Vaccination: Coronavirus Inflammatory Vaccination: COVID-19 Risk Factors Human: Case Report Sun, 20 Feb 2022 20:01:17 +0000 greenmedinfo 253687 at https://greenmedinfo.com A perspective on potential antibody-dependent enhancement of SARS-CoV-2. https://greenmedinfo.com/article/perspective-potential-antibody-dependent-enhancement-sars-cov-2 PMID:  Nature. 2020 08 ;584(7821):353-363. Epub 2020 Jul 13. PMID: 32659783 Abstract Title:  A perspective on potential antibody-dependent enhancement of SARS-CoV-2. Abstract:  Antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection against any virus have a theoretical potential to amplify the infection or trigger harmful immunopathology. This possibility requires careful consideration at this critical point in the pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we review observations relevant to the risks of ADE of disease, and their potential implications for SARS-CoV-2 infection. At present, there are no known clinical findings, immunological assays or biomarkers that can differentiate any severe viral infection from immune-enhanced disease, whether by measuring antibodies, T cells or intrinsic host responses. In vitro systems and animal models do not predict the risk of ADE of disease, in part because protective and potentially detrimental antibody-mediated mechanisms are the same and designing animal models depends on understanding how antiviral host responses may become harmful in humans. The implications of our lack of knowledge are twofold. First, comprehensive studies are urgently needed to define clinical correlates of protective immunity against SARS-CoV-2. Second, because ADE of disease cannot be reliably predicted after either vaccination or treatment with antibodies-regardless of what virus is the causative agent-it will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 move forward. <p><a href="https://greenmedinfo.com/article/perspective-potential-antibody-dependent-enhancement-sars-cov-2" target="_blank">read more</a></p> https://greenmedinfo.com/article/perspective-potential-antibody-dependent-enhancement-sars-cov-2#comments Vaccination: Coronavirus Vaccination: COVID-19 Antibody Dependent Enhancement Review Mon, 06 Sep 2021 20:51:09 +0000 greenmedinfo 245486 at https://greenmedinfo.com Adverse effects of COVID-19 vaccines and measures to prevent them. https://greenmedinfo.com/article/adverse-effects-covid-19-vaccines-and-measures-prevent-them PMID:  Virol J. 2022 Jun 5 ;19(1):100. Epub 2022 Jun 5. PMID: 35659687 Abstract Title:  Adverse effects of COVID-19 vaccines and measures to prevent them. Abstract:  Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency recommendations, frequent COVID-19 booster shots could adversely affect the immune response and may not be feasible. The decrease in immunity can be caused by several factors such as N1-methylpseudouridine, the spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. These clinical alterations may explain the association reported between COVID-19 vaccination and shingles. As a safety measure, further booster vaccinations should be discontinued. In addition, the date of vaccination should be recorded in the medical record of patients. Several practical measures to prevent a decrease in immunity have been reported. These include limiting the use of non-steroidal anti-inflammatory drugs, including acetaminophen to maintain deep body temperature, appropriate use of antibiotics, smoking cessation, stress control, and limiting the use of lipid emulsions, including propofol, which may cause perioperative immunosuppression. In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients. <p><a href="https://greenmedinfo.com/article/adverse-effects-covid-19-vaccines-and-measures-prevent-them" target="_blank">read more</a></p> https://greenmedinfo.com/article/adverse-effects-covid-19-vaccines-and-measures-prevent-them#comments Vaccination: Coronavirus Immunosuppressive Vaccination: COVID-19 Antibody-Dependent Enhancement SARS-CoV-2 Spike Protein Commentary Wed, 08 Jun 2022 18:23:19 +0000 greenmedinfo 258767 at https://greenmedinfo.com After the Lockdown: A Global Coronavirus Vaccination Program https://greenmedinfo.com/blog/after-lockdown-global-coronavirus-vaccination-program <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/After_the_Lockdown-A_Global_Coronavirus_Vaccination_Program-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /><br /> <span style="font-size:12px;"><strong>Originally published on&nbsp;<a href="https://www.globalresearch.ca/after-the-lockdown-a-global-coronavirus-vaccination-program/5706547" rel="dofollow" target="_blank">www.globalresearch.ca</a></strong></span></p> <p>The <a href="/disease/coronavirus-disease" rel="dofollow" target="_blank"><strong>COV-19</strong></a> vaccineis now front page news. Yet the first tests were conducted in mid-March and there was virtually no coverage. The following article by Prof. Michel Chossudovsky</p> <p>was first published by Global Research on March 17, 2020, following the first tests of a vaccine conducted by Moderna Inc. with human volunteers in Seattle on March 16.</p> <p>***</p><p><a href="https://greenmedinfo.com/blog/after-lockdown-global-coronavirus-vaccination-program" target="_blank">read more</a></p> https://greenmedinfo.com/blog/after-lockdown-global-coronavirus-vaccination-program#comments Coronavirus Disease Coronavirus Infection Influenza Vaccination: Coronavirus Health Guide: Corruption in Science Health Guide: Viruses Vaccine Rights corruption in science medical freedom viral infections Fri, 22 May 2020 20:42:37 +0000 CentreForResearchOnGlobalization 220794 at https://greenmedinfo.com Antibody dependent enhancement due to original antigenic sin and the development of SARS. https://greenmedinfo.com/article/antibody-dependent-enhancement-due-original-antigenic-sin-and-development-sars PMID:  Front Immunol. 2020 ;11:1120. Epub 2020 Jun 5. PMID: 32582200 Abstract Title:  Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS. Abstract:  Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical signs of infections in children, second, the early appearance of IgG in certain patients. From the point of view of immune system physiology, such an early rise of specific IgG is expected in secondary immune responses when memory to a cross-reactive antigen is present, usually from an earlier infection with a coronavirus. It is actually typical for the immune system to respond, to what it already knows, a phenomenon that has been observed in many infections with closely related viruses and has been termed &quot;original antigenic sin.&quot; The question then arises whether such cross-reactive antibodies are protective or not against the new virus. The worst scenario would be when such cross-reactive memory antibodies to related coronaviruses would not only be non-protective but even enhance infection and the clinical course. Such a phenomenon of antibody dependent enhancement (ADE) has already been described in several viral infections. Thus, the development of IgG against SARS-CoV-2 in the course of COVID-19 might not be a simple sign of viral clearance and developing protection against the virus. On the contrary, due to cross-reaction to related coronavirus strains from earlier infections, in certain patients IgG might enhance clinical progression due to ADE. The patient&#039;s viral history of coronavirus infection might be crucial to the development of the current infection with SARS-CoV-2. Furthermore, it poses a note of caution when treating COVID-19 patients with convalescent sera. <p><a href="https://greenmedinfo.com/article/antibody-dependent-enhancement-due-original-antigenic-sin-and-development-sars" target="_blank">read more</a></p> https://greenmedinfo.com/article/antibody-dependent-enhancement-due-original-antigenic-sin-and-development-sars#comments Coronavirus Infection Vaccination: Coronavirus Antibody Dependent Enhancement Review Tue, 07 Sep 2021 02:15:06 +0000 greenmedinfo 245510 at https://greenmedinfo.com Antibody-mediated phagocytic activity and complement deposition were reduced in sera after the third immunization. https://greenmedinfo.com/article/antibody-mediated-phagocytic-activity-and-complement-deposition-were-reduced-s PMID:  Sci Immunol. 2022 Dec 22:eade2798. Epub 2022 Dec 22. PMID: 36548397 Abstract Title:  Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. Abstract:  RNA vaccines are efficient preventive measures to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7-18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9-2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2. <p><a href="https://greenmedinfo.com/article/antibody-mediated-phagocytic-activity-and-complement-deposition-were-reduced-s" target="_blank">read more</a></p> https://greenmedinfo.com/article/antibody-mediated-phagocytic-activity-and-complement-deposition-were-reduced-s#comments Vaccination: Coronavirus Vaccine-induced Toxicity Immunosuppressive Vaccination: COVID-19 Human Study Wed, 28 Dec 2022 03:11:41 +0000 greenmedinfo 268542 at https://greenmedinfo.com Autoantibody release in children after corona virus mRNA vaccination: a risk factor of multisystem inflammatory syndrome? https://greenmedinfo.com/article/autoantibody-release-children-after-corona-virus-mrna-vaccination-risk-factor- PMID:  Vaccines (Basel). 2021 Nov 18 ;9(11). Epub 2021 Nov 18. PMID: 34835284 Abstract Title:  Autoantibody Release in Children after Corona Virus mRNA Vaccination: A Risk Factor of Multisystem Inflammatory Syndrome? Abstract:  Multisystem inflammatory syndrome (MIS) is a new systemic inflammatory acute onset disease that mainly affects children (MIS-C) and, at a lesser frequency, adults (MIS-A); it typically occurs 3-6 weeks after acute SARS-CoV infection. It has been postulated and shown in adults that MIS may occur after SARS-CoV-2 vaccination (MIS-V). Our current case is one of the first published cases with a multisystem inflammatory syndrome in an 18-year-old adolescent after the SARS-CoV-2 vaccine from Pfizer/BionTech (BNT162b2), who fulfills the published level 1 criteria for a definitive disease: age3 consecutive days, pericardial effusion, elevated CRP/NT-BNP/Troponin T/D-dimeres, cardiac involvement, and positive SARS-CoV-2 antibodies. The disease starts 10 weeks after the second vaccination, with a fever (up to 40°C) and was treated with amoxicillin for suspected pneumonia. The SARS CoV-2-PCR and several antigen tests were negative. With an ongoing fever, he was hospitalized 14 days later. A pericardial effusion (10 mm) was diagnosed by echocardiography. The C-reactive protein (174 mg/L), NT-BNP (280 pg/mL), and Troponin T (28 pg/mL) values were elevated. Due to highly elevated D-dimeres (&gt;35,000μg/L), a pulmonary embolism was excluded by thoracal computer tomography. If the boy did not improve with intravenous antibiotics, he was treated with intravenous immunoglobulins; however, the therapy was discontinued after 230 mg/kg if he developed high fever and hypotension. A further specializedclinic treated him with colchicine and ibuprofen. The MIS-V was discovered late, 4 months after the onset of the disease. As recently shown in four children with MIS-C after SARS-CoV-2 infection and a girl with Hashimoto thyroiditis after BNT162b2 vaccination, we found elevated functional autoantibodies against G-protein-coupled receptors that may be important for pathophysiology but are not conclusive for the diagnosis of MIS-C. Conclusion: We are aware that a misattribution of MIS-V as a severe complication of coronavirus vaccination can lead to increased vaccine hesitancy and blunt the global COVID-19 vaccination drive. However, the pediatric population is at a higher risk for MIS-C and a very low risk for COVID-19 mortality. The publication of such cases is very important to make doctors aware of this complication of the vaccination, so that therapy with intravenous immunoglobulinscan be initiated at an early stage. <p><a href="https://greenmedinfo.com/article/autoantibody-release-children-after-corona-virus-mrna-vaccination-risk-factor-" target="_blank">read more</a></p> https://greenmedinfo.com/article/autoantibody-release-children-after-corona-virus-mrna-vaccination-risk-factor-#comments Inflammation Vaccination: Coronavirus Inflammatory Vaccination: COVID-19 Risk Factors Human: Case Report Sun, 20 Feb 2022 20:38:34 +0000 greenmedinfo 253690 at https://greenmedinfo.com Autopsy histopathologic cardiac findings in two adolescents following the second COVID-19 vaccine dose. https://greenmedinfo.com/article/autopsy-histopathologic-cardiac-findings-two-adolescents-following-second-covi PMID:  Arch Pathol Lab Med. 2022 Feb 14. Epub 2022 Feb 14. PMID: 35157759 Abstract Title:  Autopsy Histopathologic Cardiac Findings in Two Adolescents Following the Second COVID-19 Vaccine Dose. Abstract:  CONTEXT: - Myocarditis in adolescents has been diagnosed clinically following the administration of the second dose of an mRNA vaccine for coronavirus disease 2019 (COVID-19).OBJECTIVE: - To examine the autopsy microscopic cardiac findings in adolescent deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-19 dose to determine if the &quot;myocarditis&quot; described in these instances has the typical histopathology of myocarditis.DESIGN: - Clinical and autopsy investigation of two teenage boys who died shortly following administration of the second Pfizer-BioNTech COVID-19 dose.RESULTS: - The microscopic examination revealed features resembling a catecholamine-induced injury, not typical myocarditis pathology.CONCLUSIONS: - The myocardial injury seen in these post-vaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy. <p><a href="https://greenmedinfo.com/article/autopsy-histopathologic-cardiac-findings-two-adolescents-following-second-covi" target="_blank">read more</a></p> https://greenmedinfo.com/article/autopsy-histopathologic-cardiac-findings-two-adolescents-following-second-covi#comments Myocarditis Vaccination: Coronavirus Vaccination: COVID-19 Increased Risk Human: Case Report Sun, 20 Feb 2022 02:34:44 +0000 greenmedinfo 253667 at https://greenmedinfo.com Be aware of SARS-CoV-2 spike protein: There is more than meets the eye. https://greenmedinfo.com/article/be-aware-sars-cov-2-spike-protein-there-more-meets-eye PMID:  J Biol Regul Homeost Agents. 2021 06 8 ;35(3). Epub 2021 Jun 8. PMID: 34100279 Abstract Title:  Be aware of SARS-CoV-2 spike protein: There is more than meets the eye. Abstract:  The COVID-19 pandemic necessitated the rapid production of vaccines aimed at the production of neutralizing antibodies against the COVID-19 spike protein required for the corona virus binding to target cells. The best well-known vaccines have utilized either mRNA or an adenovirus vector to direct human cells to produce the spike protein against which the body produces mostly neutralizing antibodies. However, recent reports have raised some skepticism as to the biologic actions of the spike protein and the types of antibodies produced. One paper reported that certain antibodies in the blood of infected patients appear to change the shape of the spike protein so as to make it more likely to bind to cells, while other papers showed that the spike protein by itself (without being part of the corona virus) can damage endothelial cells and disrupt the blood-brain barrier. These findings may be even more relevant to the pathogenesis of long-COVID syndrome that may affect as many as 50% of those infected with SARS-CoV-2. In COVID-19, a response to oxidative stress is required by increasing anti-oxidant enzymes. In this regard, it is known that polyphenols are natural anti-oxidants with multiple health effects. Hence, there are even more reasons to intervene with the use of anti-oxidant compounds, such as luteolin, in addition to available vaccines and anti-inflammatory drugs to prevent the harmful actions of the spike protein. <p><a href="https://greenmedinfo.com/article/be-aware-sars-cov-2-spike-protein-there-more-meets-eye" target="_blank">read more</a></p> https://greenmedinfo.com/article/be-aware-sars-cov-2-spike-protein-there-more-meets-eye#comments Coronavirus Infection Luteolin Vaccination: Coronavirus Antioxidants SARS-CoV-2 Spike Protein Commentary Sun, 13 Jun 2021 19:35:41 +0000 greenmedinfo 241206 at https://greenmedinfo.com Bill Gates and Intellectual Ventures Funds Microchip Implant Vaccine Technology https://greenmedinfo.com/blog/bill-gates-and-intellectual-ventures-funds-microchip-implant-vaccine-technology1 <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/tracy@greenmedinfo.com/images/Screen%20Shot%202020-04-13%20at%2010_42_32%20AM.png" style="width: 513px; height: 328px;" /></p> <p><span style="font-size:18px;"><em><strong>The Bill and Melinda Gates Foundation has donated more than $21 million towards developing a vaccine technology that uses a tattoo-like mechanism which injects invisible nanoparticles under the skin that is now being tested in a vaccine against the virus that causes <a href="/disease/coronavirus-disease" rel="dofollow" target="_blank">COVID-19</a></strong></em></span></p> <p>The microneedle technology is also being wed to injectable technology, funded by the Bill and Melinda Gates Foundation, which embeds under the skin a vaccination record visible by near infrared light that can be read by smartphone technology.</p><p><a href="https://greenmedinfo.com/blog/bill-gates-and-intellectual-ventures-funds-microchip-implant-vaccine-technology1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/bill-gates-and-intellectual-ventures-funds-microchip-implant-vaccine-technology1#comments Coronavirus Disease Vaccination: Coronavirus Vaccination: All Vaccine Rights corruption technology viral infections Tue, 14 Apr 2020 12:34:39 +0000 celestewriter 218465 at https://greenmedinfo.com Biodistribution of mRNA COVID-19 vaccines in human breast milk. https://greenmedinfo.com/article/biodistribution-mrna-covid-19-vaccines-human-breast-milk PMID:  EBioMedicine. 2023 Sep 19 ;96:104800. Epub 2023 Sep 19. PMID: 37734205 Abstract Title:  Biodistribution of mRNA COVID-19 vaccines in human breast milk. Abstract:  BACKGROUND: COVID-19 mRNA vaccines play a vital role in the fight against SARS-CoV-2 infection. However, lactating women have been largely excluded from most vaccine clinical trials. As a result, limited research has been conducted on the systemic distribution of vaccine mRNA during lactation and whether it is excreted in human breast milk (BM). Here, we evaluated if COVID-19 vaccine mRNA is detectable in BM after maternal vaccination and determined its potential translational activity.METHODS: We collected BM samples from 13 lactating, healthy, post-partum women before and after COVID-19 mRNA vaccination. Vaccine mRNA in whole BM and BM extracellular vesicles (EVs) was assayed using quantitative Droplet Digital PCR, and its integrity and translational activity were evaluated.FINDINGS: Of 13 lactating women receiving the vaccine (20 exposures), trace mRNA amounts were detected in 10 exposures up to 45 h post-vaccination. The mRNA was concentrated in the BM EVs; however, these EVs neither expressed SARS-COV-2 spike protein nor induced its expression in the HT-29 cell line. Linkage analysis suggests vaccine mRNA integrity was reduced to 12-25% in BM.INTERPRETATION: Our findings demonstrate that the COVID-19 vaccine mRNA is not confined to the injection site but spreads systemically and is packaged into BM EVs. However, as only trace quantities are present and a clear translational activity is absent, we believe breastfeeding post-vaccination is safe, especially 48 h after vaccination. Nevertheless, since the minimum mRNA vaccine dose to elicit an immune reaction in infants<p><a href="https://greenmedinfo.com/article/biodistribution-mrna-covid-19-vaccines-human-breast-milk" target="_blank">read more</a></p> https://greenmedinfo.com/article/biodistribution-mrna-covid-19-vaccines-human-breast-milk#comments Vaccination: Coronavirus Vaccine-induced Toxicity Vaccination: COVID-19 SARS-CoV-2 Spike Protein Human Study Fri, 22 Sep 2023 21:21:37 +0000 greenmedinfo 280986 at https://greenmedinfo.com Blue toes' following vaccination with the BNT162b2 mRNA COVID-19 vaccine. https://greenmedinfo.com/article/blue-toes-following-vaccination-bnt162b2-mrna-covid-19-vaccine PMID:  J Travel Med. 2021 Feb 23. Epub 2021 Feb 23. PMID: 33620081 Abstract Title:  &#039;Blue toes&#039; following vaccination with the BNT162b2 mRNA COVID-19 vaccine. Abstract:  Highlights: COVID toes can be encountered in young individuals during acute COVID-19 infection while it results from the direct action of Spike protein on vessels. We report the case of COVID toes during the French campaign of vaccination that occurred 4 days after the vaccination with the Pfizer-BioNTech mRNA vaccine against COVID-19. <p><a href="https://greenmedinfo.com/article/blue-toes-following-vaccination-bnt162b2-mrna-covid-19-vaccine" target="_blank">read more</a></p> https://greenmedinfo.com/article/blue-toes-following-vaccination-bnt162b2-mrna-covid-19-vaccine#comments Vaccination: Coronavirus Vaccination: All Human: Case Report Wed, 10 Mar 2021 01:47:52 +0000 greenmedinfo 236066 at https://greenmedinfo.com Case report: cytomegalovirus reactivation and pericarditis following ChAdOx1 nCoV-19 vaccination against SARS-CoV-2. https://greenmedinfo.com/article/case-report-cytomegalovirus-reactivation-and-pericarditis-following-chadox1-nc PMID:  Front Immunol. 2021 ;12:784145. Epub 2022 Jan 18. PMID: 35116025 Abstract Title:  Case Report: Cytomegalovirus Reactivation and Pericarditis Following ChAdOx1 nCoV-19 Vaccination Against SARS-CoV-2. Abstract:  As the coronavirus disease 2019 (COVID-19) pandemic is ongoing and new variants of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are emerging, there is an urgent need for vaccines to protect individuals at high risk for complications and to potentially control disease outbreaks by herd immunity. Surveillance of rare safety issues related to these vaccines is progressing, since more granular data emerge about adverse events of SARS-CoV-2 vaccines during post-marketing surveillance. Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) reactivation has already been reported in COVID-19 patients. In addition, adverse events after SARS-CoV-2 mRNA vaccination have also been in the context of varicella zoster virus (VZV) reactivation and directly associated with the mRNA vaccine. We present the first case of CMV reactivation and pericarditis in temporal association with SARS-CoV-2 vaccination, particularly adenovirus-based DNA vector vaccine ChAdOx1 nCoV-19 against SARS-CoV-2. After initiation of antiviral therapy with oral valganciclovir, CMV viremia disappeared and clinical symptoms rapidly improved. Since huge vaccination programs are ongoing worldwide, post-marketing surveillance systems must be in place to assess vaccine safety that is important for the detection of any events. In the context of the hundreds of millions of individuals to be vaccinated against SARS-CoV-2, a potential causal association with CMV reactivation may result in a considerable number of cases with potentially severe complications. <p><a href="https://greenmedinfo.com/article/case-report-cytomegalovirus-reactivation-and-pericarditis-following-chadox1-nc" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-cytomegalovirus-reactivation-and-pericarditis-following-chadox1-nc#comments Cytomegalovirus Infections Pericarditis Vaccination: Coronavirus Risk Factors Human: Case Report Sun, 20 Feb 2022 03:52:57 +0000 greenmedinfo 253676 at https://greenmedinfo.com