Vagus Nerve Stimulation

Name	AC	CK
Depression	40	338
Migraines	20	189
Epilepsy	16	147
Tinnitus	13	106
Insomnia	6	82
Headache: Cluster	5	53
Stroke	7	46
Inflammation	16	45
Fibromyalgia	6	42
Stroke: Attenuation/Recovery	5	42
Cognitive Decline/Dysfunction	5	41
Rheumatoid Arthritis	12	41
Anxiety	7	36
Dyspepsia	4	34
Constipation	3	32
Fatigue	4	31
Post-Traumatic Stress Disorders (PTSD)	4	24
Postural tachycardia syndrome (POTS)	5	24
Chronic Pain	3	23
Crohn's Disease	5	23
Headache	4	22
Inflammatory Bowel Diseases	11	22
Overweight	1	20
Sjogren's Syndrome	2	20
Irritable Bowel Syndrome	6	16
Heart Failure	2	12
Stroke: Ischemic	7	12
Menstrual Migraine	2	11
Parkinson's Disease	7	11
Bipolar Disorder	1	10
Breast Cancer	1	10
Cancer: Fatigue	1	10
Cerebral Palsy	1	10
Cesarean Section	1	10
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	10
Coronavirus Disease (Covid-19)	1	10
Delirium	1	10
Dementia	1	10
Depression: Breast Cancer Related	1	10
Dysautonomia	1	10
Dysmenorrhea	1	10
Hemodialysis	1	10
Low Back Pain	1	10
Lupus Erythematosus: Systemic	1	10
Neck Pain	1	10
Obsessive-Compulsive Disorder	1	10
Osteoarthritis: Knee	1	10
Parasympathetic Nervous System Diseases	1	10
Postoperative Recovery	1	10
Postoperative infections	1	10
Rosacea	1	10
Seizures	1	10
Subarachnoid hemorrhage	1	10
Temporomandibular Joint Disorders	1	10
Vertigo	1	10
Oxidative Stress	4	6
Ischemia	3	5
Alzheimer's Disease	3	4
Atopic Dermatitis	2	4
Brain Ischemia	3	4
Colitis	2	4
Lipopolysaccharide-Induced Toxicity	2	4
Systemic Lupus Erythematosus	3	4
Autism Spectrum Disorders	2	3
Brain Inflammation	2	3
Lung Inflammation	2	3
Osteoarthritis	2	3
Psoriasis	2	3
Arthritis	1	2
Autoimmune Diseases	2	2
Brain: Microglial Activation	1	2
Cerebral Ischemia	1	2
Endotoxemia	1	2
Gulf War Syndrome	1	2
Kidney Damage	1	2
Mastitis	1	2
Memory Disorders	1	2
Multiple Sclerosis	1	2
Myocardial Infarction	1	2
Neurodegenerative Diseases	2	2
Otitis media	1	2
Periodontitis	1	2
Schizophrenia	2	2
Traumatic Brain Injury	1	2
Attention Deficit Hyperactivity Disorder	1	1
Cardiac Arrhythmias	1	1
Central Nervous System Diseases	1	1
Chronic Fatigue Syndrome	1	1
Chronic Kidney Disease (CKD)	1	1
Crohn	1	1
Eczema	1	1
Gastroparesis	1	1
Headaches	1	1
Huntington Disease	1	1
Neurodevelopmental Disorders	1	1
Polymyalgia Rheumatica	1	1
Spondylitis: Ankylosing	1	1
Ulcerative Colitis	1	1
Vitiligo	1	1

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Auricular vagus nerve stimulation can be an effective and safe non-drug treatment in patients with specific chronic and acute postoperative pain conditions.Nov 30, 2024

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Pubmed Data : BMJ Open. 2025 Dec 30 ;15(12):e106662. Epub 2025 Dec 30. PMID: 41469051

Article Published Date : Dec 29, 2025

Study Type : Meta Analysis, Review

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Diseases : Stroke

Therapeutic Actions : Vagus Nerve Stimulation

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The results of the analysis preliminarily demonstrated that taVNS therapy can effectively ameliorate the symptoms of major depressive disorder.Nov 30, 2018

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The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy.May 31, 2022

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Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder with peripartum onset.Oct 31, 2022

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Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression.Dec 31, 2024

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Pubmed Data : Brain Stimul. 2025 ;18(3):690-700. Epub 2024 Dec 18. PMID: 39701918

Article Published Date : Dec 31, 2024

Study Type : Human Study

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Diseases : Depression

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Antidepressive Agents

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Exploring the interplay between depressive symptoms and seizure outcomes.Sep 30, 2025

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Pubmed Data : Brain Stimul. 2014 ;7(6):871-7. Epub 2014 Jul 16. PMID: 25164906

Article Published Date : Dec 31, 2013

Study Type : Human Study

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Diseases : Heart Failure

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Neuromodulatory

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Non-invasive vagus nerve stimulation is an effective treatment that reduces the number of menstrual migraine/menstrually related migraine days.Nov 30, 2016

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Pubmed Data : J Headache Pain. 2016 Dec ;17(1):91. Epub 2016 Oct 3. PMID: 27699586

Article Published Date : Nov 30, 2016

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Pubmed Data : Neurology. 2018 Jul 24 ;91(4):e364-e373. Epub 2018 Jun 15. PMID: 29907608

Article Published Date : Jul 23, 2018

Study Type : Human Study

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Diseases : Migraines

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Analgesics

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Noninvasive vagus nerve stimulation in postural tachycardia syndrome.Jan 31, 2024

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Safety and efficacy of vagus nerve stimulation in fibromyalgia.Aug 31, 2011

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TaVNS is a promising, safe, and cost-effective therapeutic method for mild and moderate major depressive disorder.Apr 30, 2016

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Pubmed Data : Neuromodulation. 2025 Jun ;28(4):672-681. Epub 2025 Mar 19. PMID: 40117415

Article Published Date : May 31, 2025

Study Type : Human Study

Additional Links

Diseases : Anxiety, Depression

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

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TaVNS significantly decreased depression and anxiety symptoms in patients admitted to the inpatient unit.May 31, 2025

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Pubmed Data : Neuromodulation. 2025 Jun ;28(4):672-681. Epub 2025 Mar 19. PMID: 40117415

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Pubmed Data : Brain Stimul. 2022 ;15(6):1405-1414. Epub 2022 Sep 21. PMID: 36150665

Article Published Date : Dec 31, 2021

Study Type : Human Study

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Diseases : Cognitive Decline/Dysfunction, Dementia

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Neuroprotective Agents

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The efficacy of transcutaneous auricular Vagus nerve stimulation in non-specific chronic neck pain.Apr 23, 2026

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Pubmed Data : J Back Musculoskelet Rehabil. 2026 Apr 24:10538127261435675. Epub 2026 Apr 24. PMID: 42029130

Article Published Date : Apr 23, 2026

Study Type : Human Study

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Diseases : Neck Pain

Therapeutic Actions : Vagus Nerve Stimulation

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The findings suggest that tVNS has potential benefit in reducing the daily burden of tinnitus and depression levels.May 31, 2026

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Pubmed Data : Eur Arch Otorhinolaryngol. 2026 Jun ;283(6):3605-3615. Epub 2026 Feb 24. PMID: 41735554

Article Published Date : May 31, 2026

Study Type : Human Study

Additional Links

Diseases : Tinnitus

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Anti-Anxiety Agents

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The instant effects of continuous transcutaneous auricular vagus nerve stimulation at acupoints on the functional Connectivity of amygdala in migraine without aura.Dec 31, 2019

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Pubmed Data : Ear Hear. 2015 ;36(3):e76-85. PMID: 25437140

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Diseases : Tinnitus

Therapeutic Actions : Vagus Nerve Stimulation

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Treating depression with transcutaneous auricular vagus nerve stimulation.Dec 31, 2017

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Pubmed Data : Front Psychiatry. 2018 ;9:20. Epub 2018 Feb 5. PMID: 29459836

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Diseases : Depression

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Antidepressive Agents

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Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve.Dec 31, 2014

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Placebo-controlled vagus nerve stimulation paired with tones in a patient with refractory tinnitus.Mar 31, 2015

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Pubmed Data : Otol Neurotol. 2015 Apr ;36(4):575-80. PMID: 25689839

Article Published Date : Mar 31, 2015

Study Type : Human: Case Report

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Diseases : Tinnitus

Therapeutic Actions : Sound Therapy, Vagus Nerve Stimulation

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TaVNS was effective and safe in the management of chronic migraine in the reported pediatric patient.Dec 31, 2024

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Pubmed Data : Front Pain Res (Lausanne). 2025 ;6:1686043. Epub 2025 Nov 10. PMID: 41293746

Article Published Date : Dec 31, 2024

Study Type : Human: Case Report

Additional Links

Diseases : Migraines

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Prophylactic Agents

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Application of tVNS alone produced improved social interaction and mood and alleviated salicylate-induced tinnitus severity.Feb 05, 2024

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Pubmed Data : Exp Dermatol. 2026 Jun ;35(6):e70297. PMID: 42281200

Article Published Date : May 31, 2026

Study Type : Animal Study

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Diseases : Atopic Dermatitis, Inflammation, Psoriasis

Therapeutic Actions : Vagus Nerve Stimulation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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