Aluminum

Name	AC	CK
Aluminum Toxicity	146	376
Vaccine-induced Toxicity	36	124
Macrophagic myofasciitis	15	77
Autism Spectrum Disorders	16	66
Neurodegenerative Diseases	28	48
Alzheimer's Disease	25	47
Heavy Metal Toxicity	7	47
Oxidative Stress	19	42
Breast Cancer	7	38
Autism	6	33
Kidney Failure: Chronic	3	31
Brain Inflammation	14	28
Allergies	3	21
Itching	2	20
DNA damage	4	19
Autoimmune Diseases	8	18
Cognitive Decline/Dysfunction	5	18
Inflammation	8	18
Gulf War Syndrome	3	13
Infant Neurological Development	2	12
Infant Chemical Exposures	2	11
Mercury Poisoning	2	11
Alcohol Toxicity	1	10
All-Cause Mortality	1	10
Atherosclerosis	1	10
Brain: Oxidative Stress	5	10
C-Reactive Protein	1	10
Clostridium Infections	1	10
Dermatitis: Contact	1	10
Diarrhea	1	10
Hemodialysis	1	10
High Cholesterol	1	10
Hypothyroidism	1	10
Immune Dysregulation: TH1/TH2 imbalance	1	10
Infant Mortality	1	10
Intima Media Thickening	1	10
Low Immune Function: Natural Killer Cells	1	10
Memory Disorders	5	10
Premature Birth	1	10
Mitochondrial Dysfunction	4	9
Prenatal Chemical Exposures	4	9
Lipid Peroxidation	4	8
Dementia	3	7
Multiple Sclerosis	3	7
Acrylamide-induced toxicity	3	6
Bone Diseases	2	6
Fluoride Toxicity	3	6
Aging	3	5
Bone Diseases: Metabolic	1	5
Breast Cancer: Triple Negative	1	5
Cancer Metastasis	1	5
Chronic Fatigue Syndrome	3	5
Granuloma	2	5
Autoimmune Syndrome Induced by Adjuvants (ASIA)	3	4
Chemically-Induced Liver Damage	2	4
Kidney Damage: Chemically-Induced	2	4
Osteoporosis	2	4
Stroke	1	4
Stroke: Ischemic	1	4
Testicular Injury: Chemical/Metal Induced	2	4
Amyotrophic Lateral Sclerosis	3	3
Amyotrophic lateral sclerosis (ALS)	2	3
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA)	3	3
Central Nervous System Diseases	1	3
Pseudolymphoma	1	3
Anxiety Disorders	1	2
Cardiovascular Diseases	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Cholestasis	1	2
Colitis	1	2
Dysbiosis	1	2
Fatigue	1	2
Female	2	2
Gastrointestinal Inflammation	1	2
High Fat Diet	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Irritable Bowel Syndrome	1	2
Learning disorders	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Damage	1	2
Lung Damage	1	2
Motor Neuron Disease	1	2
Neuropathic Pain	1	2
Parkinson's Disease	2	2
Peripheral Neuropathies	1	2
Sjogren's Syndrome	1	2
Social Behavior	1	2
Systemic Lupus Erythematosus	1	2
Uremia	1	2
Wound Healing	1	2
Anemia	1	1
Attention Deficit Disorder	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bipolar Disorder	1	1
Bisphenol Toxicity	1	1
Brain: Microglial Activation	1	1
Cancers: Estrogen Responsive	1	1
Cervical Cancer	1	1
Crohn's Disease	1	1
Dyslipidemias	1	1
Encephalopathy	1	1
Estrogen Dominance	1	1
Febrile Seizures	1	1
Fibromyalgia	1	1
Guillain-Barre Syndrome	1	1
Infant Nutrition: Infant Formula	1	1
Lead Poisoning	1	1
Lymphoma	1	1
Myopathies	1	1
Neurodevelopmental Disorders	1	1
Neurologic Disorders	1	1
New Variant Creutzfeldt-Jakob Disease	1	1
Nonalcoholic fatty liver disease (NAFLD)	1	1
Prostate Cancer	1	1
vaccine injury	1	1

Name	AC	CK
Neurotoxic	55	128
Inflammatory	10	20
Genotoxic	4	19
Immunotoxic	5	16
Cardiotoxic	3	14
Endocrine Disruptor	3	13
Oxidant	6	13
Immunosuppressive	2	11
Cytotoxic	5	9
Bioaccumulator	5	7
Apoptotic	2	5
Blood Brain Barrier Injury	1	4
Hepatotoxic	2	3
Abortive	1	2
Glutathione Down-Regulation	1	2
Hematoxic	1	2
Hypertensive	1	2
Neurotransmitter Interference	1	2
Carcinogenic	1	1
Dyslipidemic	1	1
Estrogenic	1	1
Excitotoxic	1	1
Hemolytic	1	1
Hypermethylation	1	1
Hypoxia	1	1
Irritant	1	1
Nephrotoxic	1	1

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Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism

Problem Substances : Antacids: Aluminium-Containing, Bile Acid Sequestrants, Calcium Carbonate, Ferrous Sulphate, Phosphate Binders, Proton-Pump Inhibitors, Raloxifene, Sucralfate

[+]

Administration of 240 mg of anthocyanins a day for 30 days caused a substantial increase of glutathione peroxidase and catalase activities. While decreasing the lead, aluminum and cooper concentrations.Oct 31, 2005

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Pubmed Data : Pol Merkur Lekarski. 2005 Nov ;19(113):651-3. PMID: 16498804

Article Published Date : Oct 31, 2005

Study Type : Human Study

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Pubmed Data : J Inorg Biochem. 2007 Sep ;101(9):1344-6. Epub 2007 Jun 12. PMID: 17629949

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity , Breast Cancer

Problem Substances : Aluminum

Adverse Pharmacological Actions : Endocrine Disruptor

[+]

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Inorg Biochem. 2009 Nov;103(11):1555-62. Epub 2009 Aug 20. PMID: 19740540

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Pubmed Data : Sci Rep. 2018 Nov 13 ;8(1):16729. Epub 2018 Nov 13. PMID: 30425257

Article Published Date : Nov 12, 2018

Study Type : Human Study

Additional Links

Diseases : All-Cause Mortality, Aluminum Toxicity , Hemodialysis

Additional Keywords : Increased Risk

Problem Substances : Aluminum

[+]

Breastfed infants in Brazil receiving a full recommended schedule of immunizations showed an exceedingly high exposure of Al (225 to 1750 μg per dose) when compared with estimated levels absorbed from breast milk.Nov 01, 2010

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Pubmed Data : J Expo Sci Environ Epidemiol. 2010 Nov ;20(7):598-601. Epub 2009 Dec 16. PMID: 20010978

Article Published Date : Nov 01, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Inorg Biochem. 2015 Aug 1. Epub 2015 Aug 1. PMID: 26265215

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Pubmed Data : Maedica (Buchar). 2012 Jan ;7(1):38-48. PMID: 23118818

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Diseases : Autism Spectrum Disorders, Heavy Metal Toxicity

Problem Substances : Aluminum, Cadmium, Mercury

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This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.Jan 01, 2009

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Pubmed Data : J Toxicol. 2009 ;2009:532640. Epub 2009 Aug 26. PMID: 20107587

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Pubmed Data : JAMA Pediatr. 2013 Sep ;167(9):870-2. PMID: 23856981

Article Published Date : Sep 01, 2013

Study Type : Human Study

Additional Links

Additional Keywords : Vaccine Research

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Vaccine Adjuvants

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Up-to-date children were exposed to 11-26% more aluminum from vaccines than undervaccinated children between 2004 and 2011.Nov 26, 2015

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Pubmed Data : Vaccine. 2015 Nov 27 ;33(48):6736-44. Epub 2015 Oct 27. PMID: 26518400

Article Published Date : Nov 26, 2015

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

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Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum Hydroxide, Vaccine Adjuvants

Adverse Pharmacological Actions : Immunotoxic

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A case of multiple sclerosis improvement following removal of heavy metal intoxication has been reported.Mar 22, 2012

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Pubmed Data : Biometals. 2012 Mar 22. Epub 2012 Mar 22. PMID: 22438029

Article Published Date : Mar 22, 2012

Study Type : Human: Case Report

Additional Links

Diseases : Multiple Sclerosis

Problem Substances : Aluminum, Cadmium, Lead, Mercury

Adverse Pharmacological Actions : Neurotoxic

[+]

A case report of aluminum granuloma after DTaP-IPV vaccination.Jan 01, 2019

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Pubmed Data : Pediatr Dermatol. 2019 Jan ;36(1):e17-e19. Epub 2018 Nov 28. PMID: 30488642

Six case reports of childhood macrophagic myofasciitis presenting with hypotonia, developmental delay, and seizures.Apr 01, 2004

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Pubmed Data : Neuromuscul Disord. 2004 Apr ;14(4):246-52. PMID: 15019702

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Pubmed Data : Pathophysiology. 2015 Mar ;22(1):39-48. Epub 2014 Dec 13. PMID: 25577494

Article Published Date : Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov ;87(22):9024-7. PMID: 2247478

Pubmed Data : Toxicol Lett. 2000 Jan 5;111(3):235-42. PMID: 10643868

Article Published Date : Jan 05, 2000

Study Type : Animal Study

Additional Links

Problem Substances : Aluminum Hydroxide

Adverse Pharmacological Actions : Hematoxic

[+]

Aluminum impairs liver transport function which is counteracted by vitamin E.Jun 01, 2007

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Pubmed Data : Biol Trace Elem Res. 2007 Jun ;116(3):329-48. PMID: 17709913

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Cholestasis, Lipid Peroxidation, Oxidative Stress

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

[+]

Aluminum increases free iron in the brain which may contribute to neurodegeneration.Nov 01, 2001

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Pubmed Data : J Inorg Biochem. 2001 Nov ;87(1-2):9-14. PMID: 11709207

Article Published Date : Nov 01, 2001

Study Type : Animal Study

Additional Links

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Superoxide Dismutase Up-regulation

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

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Aluminum is predominantly identified in macrophages after administration to normal mice.Mar 01, 1996

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Pubmed Data : Pharmacol Toxicol. 1996 Mar ;78(3):123-8. PMID: 8882343

Article Published Date : Mar 01, 1996

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Aluminum Hydroxide, Vaccine Adjuvants

[+]

Aluminum nanoparticles are more neurotoxic than micrometer aluminum.Jun 01, 2018

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Pubmed Data : Biol Trace Elem Res. 2018 Jun ;183(2):261-269. Epub 2017 Aug 30. PMID: 28856594

Article Published Date : Jun 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(6):e0127665. Epub 2015 Jun 4. PMID: 26042788

Article Published Date : Dec 31, 2014

Study Type : Insect Study

Additional Links

Diseases : Aluminum Toxicity

Additional Keywords : Bee Colony Collapse

Problem Substances : Aluminum

[+]

Calcium carbonate is associated with the progression of kidney calcification in uremic rats. Sep 01, 2002

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Pubmed Data : J Am Soc Nephrol. 2002 Sep;13(9):2299-308. PMID: 12191974

Article Published Date : Sep 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Uremia

Problem Substances : Antacids: Aluminium-Containing, Calcium Carbonate

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Centella asiatica alleviates AlCl 3-induced cognitive impairment, oxidative stress, and neurodegeneration.Jan 03, 2022

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Pubmed Data : Biol Trace Elem Res. 2022 Jan 4. Epub 2022 Jan 4. PMID: 34984596

Article Published Date : Jan 03, 2022

Study Type : Animal Study

Additional Links

Substances : Gotu Kola

Diseases : Aluminum Toxicity , Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Aluminum

[+]

Cheese in a serving of frozen pizzas had up to 14 mg of Al, from basic sodium aluminium phosphate.Mar 01, 2005

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Pubmed Data : Pathophysiology. 2015 Jun ;22(2):105-15. Epub 2015 Apr 2. PMID: 25863844

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Neurodegenerative Diseases

Additional Keywords : Increased Risk

Problem Substances : Aluminum, Fluoride, Sodium Fluoride

Adverse Pharmacological Actions : Neurotoxic

[+]

Extra virgin olive oil can decrease the frequency of cardiac complications and genotoxicity induced by co-exposure to aluminum and acrylamide.Sep 01, 2015

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Pubmed Data : Food Funct. 2015 Sep 2 ;6(9):3098-108. PMID: 26215160

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Pubmed Data : Environ Toxicol Pharmacol. 2017 Mar ;50:32-36. Epub 2017 Jan 18. PMID: 28119228

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Folic Acid

Diseases : Aluminum Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Aluminum

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Garden cress has a protective effect on aluminium induced impairment of the liver and kidneys. Dec 31, 2018

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Pubmed Data : J Autoimmun. 2014 Nov ;54:21-32. Epub 2014 Jul 16. PMID: 25042822

Article Published Date : Oct 31, 2014

Study Type : Animal Study

Additional Links

Diseases : Anxiety Disorders, Systemic Lupus Erythematosus, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: Hepatitis B

Problem Substances : Aluminum Hydroxide

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Inhibitory potentials of Cymbopogon citratus oil against aluminium-induced behavioral deficits and neuropathology.Sep 29, 2020

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Pubmed Data : Appl Microbiol Biotechnol. 2016 Feb ;100(4):1891-900. Epub 2015 Nov 26. PMID: 26610803

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Aluminum Toxicity , Brain: Oxidative Stress, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Aluminum

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L. plantarum CCFM639 has the potential to be a dietary supplement ingredient that provides protection against Al-induced gut injury.Dec 01, 2016

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Pubmed Data : Nutrients. 2016 Dec 2 ;8(12). Epub 2016 Dec 2. PMID: 27918411

Article Published Date : Dec 01, 2016

Study Type : Animal Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Aluminum Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aluminum

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Lavender oil and especially linalool could be a potential agent for improving cognitive impairment in Alzheimer's disease.Dec 31, 2016

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Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7426538. Epub 2017 Apr 26. PMID: 28529531

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Pubmed Data : J Mol Neurosci. 2011 Mar ;43(3):284-9. Epub 2010 Aug 20. PMID: 20725867

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Dysfunction

Additional Keywords : brain health

Problem Substances : Aluminum, Heavy Metals

Adverse Pharmacological Actions : Neurotoxic, Oxidant

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Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation.Mar 31, 2019

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Pubmed Data : J Inorg Biochem. 2019 Apr ;193:143-151. Epub 2019 Feb 1. PMID: 30743053

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Pubmed Data : J Pineal Res. 2005 Sep ;39(2):129-36. PMID: 16098089

Article Published Date : Aug 31, 2005

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aluminum Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Gene Expression Regulation

Problem Substances : Aluminum

[+]

Memory enhancement of acteoside in a senescent mice model.Jul 31, 2015

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Pubmed Data : Phytother Res. 2015 Aug ;29(8):1131-6. Epub 2015 Apr 21. PMID: 25900014

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Verbascoside

Diseases : Aging, Aluminum Toxicity , Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

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Pubmed Data : Exp Gerontol. 2008 Apr ;43(4):330-8. Epub 2008 Feb 2. PMID: 18337038

Article Published Date : Mar 31, 2008

Study Type : Animal Study

Additional Links

Diseases : Aging, Aluminum Toxicity

Problem Substances : Aluminum

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Protective effects of alpha-ketoglutarate against aluminum toxicity in Drosophila melanogaster.Nov 29, 2018

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7375136. Epub 2020 Oct 19. PMID: 33133350

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aluminum Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Renoprotective

Problem Substances : Aluminum

[+]

Problem Substances : Aluminum, Vaccine Adjuvants

Adverse Pharmacological Actions : Bioaccumulator, Neurotoxic

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Treatment with quercetin may represent a therapeutic strategy to attenuate the neuronal death against aluminum-induced neurodegeneration.Mar 01, 2016

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Pubmed Data : Neuroscience. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26944603

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Pubmed Data : Pharmacol Toxicol. 2001 Apr ;88(4):159-67. PMID: 11322172

Article Published Date : Apr 01, 2001

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Pubmed Data : Biol Trace Elem Res. 2018 May 7. Epub 2018 May 7. PMID: 29732485

Article Published Date : May 06, 2018

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Aluminum Toxicity , Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

A significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders.Jun 30, 2013

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Pubmed Data : Immunol Res. 2013 Jul ;56(2-3):304-16. PMID: 23609067

Article Published Date : Jun 30, 2013

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Autism Spectrum Disorders

Problem Substances : Aluminum, Vaccine Adjuvants

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A wide range of metals have been identified to have estrogenic properties.May 01, 2006

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Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):191-7. PMID: 16489580

Article Published Date : May 01, 2006

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Pubmed Data : Vaccine. 1995 Oct ;13(14):1263-76. PMID: 8585280

Article Published Date : Sep 30, 1995

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum, Vaccine Adjuvants

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Adverse reactions after injection of adsorbed DTP vaccine are not due only to pertussis organisms or pertussis components in the vaccine.Sep 30, 1991

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Pubmed Data : Vaccine. 1991 Oct ;9(10):699-702. PMID: 1759487

Article Published Date : Sep 30, 1991

Pubmed Data : Morphologie. 2016 Jun ;100(329):85-94. Epub 2016 Apr 6. PMID: 26948677

Article Published Date : Jun 01, 2016

Study Type : Review

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Pubmed Data : Z Lebensm Unters Forsch. 1994 Apr;198(4):313-6. PMID: 8197828

Article Published Date : Apr 01, 1994

Study Type : In Vitro Study

Additional Links

Problem Substances : Aluminium Cans, Sugary soda

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Aluminium has been demonstrated to impact the CNS at every level, including by changing gene expression.Dec 31, 2013

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Pubmed Data : Immunotherapy. 2014 ;6(10):1055-71. PMID: 25428645

Article Published Date : Dec 31, 2013

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Pubmed Data : Food Addit Contam Part B Surveill. 2018 Jun ;11(2):153-159. Epub 2018 Mar 16. PMID: 29486656

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum

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Aluminium may play an active role in the pathogenesis of critical neuropathologic lesion in Alzheimer's disease and other related disorders.Jan 01, 2006

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Pubmed Data : J Alzheimers Dis. 2006 ;9(3 Suppl):291-300. PMID: 17004365

Article Published Date : Jan 01, 2006

Study Type : Review

Additional Links

Diseases : Neurodegenerative Diseases

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

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Pubmed Data : World J Pediatr. 2014 May ;10(2):101-7. Epub 2014 May 7. PMID: 24801228

Article Published Date : Apr 30, 2014

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum, Infant Formula

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Aluminum exposures during neonatal and pediatric parenteral nutrition can impair bone mineralization and delay neurological development.Sep 30, 2014

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Pubmed Data : Crit Rev Toxicol. 2014 Oct ;44 Suppl 4:1-80. PMID: 25233067

Article Published Date : Sep 30, 2014

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum, Aluminum oxide

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Aluminum has been recurrently shown to cause encephalopathy and is connected to Alzheimer's disease.Jan 01, 2017

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Pubmed Data : Adv Neurobiol. 2017 ;18:183-197. PMID: 28889268

Article Published Date : Jan 01, 2017

Pubmed Data : Clin Lab Med. 1990 Jun ;10(2):403-22. PMID: 2197055

Article Published Date : Jun 01, 1990

Study Type : Review

Additional Links

Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Kidney Failure: Chronic, Parkinson's Disease

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

Adverse Pharmacological Actions : Bioaccumulator, Nephrotoxic, Neurotoxic

[+]

aluminum may induce apoptosis in astrocytes via ER stress by impairing the protein-folding machinery.Dec 31, 2010

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Pubmed Data : Environ Health Prev Med. 2011 Jan ;16(1):16-24. Epub 2010 Jun 22. PMID: 21432213

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Aluminum Toxicity

Additional Keywords : Gene Expression

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization.Mar 08, 2011

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Pubmed Data : Int J Alzheimers Dis. 2011 Mar 8 ;2011:276393. Epub 2011 Mar 8. PMID: 21423554

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Pubmed Data : Front Neurol. 2015 ;6:4. Epub 2015 Feb 5. PMID: 25699008

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Autoimmune Diseases, Macrophagic myofasciitis

Additional Keywords : Biopersistence, Genomic Variation, Gulf War Syndrome, Risk Factors

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum Hydroxide

Adverse Pharmacological Actions : Neurotoxic

[+]

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Pubmed Data : Neurochem Res. 2012 Mar ;37(3):639-46. Epub 2011 Dec 1. PMID: 22130689

Article Published Date : Feb 29, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Aluminum Toxicity , Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aluminum

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[+]

Febrile reaction was noted in approximately 60% of the children given alum-adjuvanted whole virion inactivated H5N1 vaccine. Jan 01, 2011

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Pubmed Data : Yakugaku Zasshi. 2011 ;131(12):1723-31. PMID: 22129866

Article Published Date : Jan 01, 2011

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Febrile Seizures, Vaccine-induced Toxicity

Problem Substances : Aluminum Hydroxide, Vaccine Adjuvants

[+]

Folic acid protected neuronal cells against aluminium maltolate induced apoptosis.Apr 24, 2016

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Pubmed Data : Neurochem Res. 2016 Apr 25. Epub 2016 Apr 25. PMID: 27113042

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Pubmed Data : BMC Pediatr. 2010;10:63. Epub 2010 Aug 31. PMID: 20807425

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Infant Chemical Exposures, Infant Nutrition: Infant Formula

Problem Substances : Aluminum, Infant Formula

[+]

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Pubmed Data : Neurotoxicology. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26687397

Pubmed Data : Neurotoxicol Teratol. 1995 Jul-Aug;17(4):515-21. PMID: 7565498

Article Published Date : Jul 01, 1995

Study Type : Review

Additional Links

Additional Keywords : Pregnancy

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

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Pubmed Data : Toxicology. 2014 Jan 6 ;315:1-7. Epub 2013 Nov 1. PMID: 24189189

Article Published Date : Jan 05, 2014

Study Type : Review

Additional Links

Diseases : Aging, Aluminum Toxicity , Neurodegenerative Diseases, Vaccine-induced Toxicity

Problem Substances : Aluminum

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Recent studies implicate a web of mechanisms in the development of vaccine adjuvant-induced autoimmune diseases.Sep 30, 2015

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Pubmed Data : Autoimmun Rev. 2015 Oct ;14(10):880-8. Epub 2015 May 29. PMID: 26031899

Article Published Date : Sep 30, 2015

Study Type : Review

Additional Links

Diseases : Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), Autoimmune Diseases, Vaccine-induced Toxicity

Problem Substances : Aluminum, Vaccine Adjuvants

[+]

Role of citrus fruit juices in prevention of kidney stone disease.Nov 16, 2021

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View the Evidence: 311 Abstracts with Aluminum Research

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Chronic exposure to aluminum is associated with increased risk of Alzheimer's disease.Jan 01, 2016

This meta-analysis shows that the data available on the safety of aluminum adjuvants is severely lacking. There is also only data available for aluminum hydroxide and does not consider the toxicity of amorphous aluminum hydroxyphosphate.Feb 01, 2004

"Circulating levels of metals are related to carotid atherosclerosis in elderly."Dec 15, 2011

19 cases of persistent (lasting for many years) itching nodules after vaccination with aluminum-adsorbed vaccines. Hypersensitivity to aluminum may also occur in infants following DTaP/polio + HiB vaccination. Nov 01, 2005

A number of commonly used drugs interfere with the absorption of levothyroxine. Dec 01, 2009

Administration of 240 mg of anthocyanins a day for 30 days caused a substantial increase of glutathione peroxidase and catalase activities. While decreasing the lead, aluminum and cooper concentrations.Oct 31, 2005

Aluminium content is higher in nipple aspirate fluid of breast cancer-affected women versus healthy controls. Apr 01, 2011

Aluminium in brain tissue in familial Alzheimer's disease.Feb 28, 2017

Aluminium is found in human breast tissue and may be connected to breast cancer incidence. Sep 01, 2007

Aluminium, carbonyls and cytokines in human nipple aspirate fluids: Possible relationship between inflammation, oxidative stress and breast cancer microenvironment.Jul 11, 2013

Aluminum accumulates in the brain and affects iron metabolism.Jan 01, 1998

Aluminum can be distributed to the brain both in patients with renal insufficiency and healthy controls. Dec 01, 1987

Aluminum can induce persistent itching nodules that itch for median time of 5 years.Feb 01, 2013

Aluminum hydroxide can precipitate persistent itching granulomas. This study reported that 5 children's symptoms did not resolve within the 8 year observation period.May 01, 1992

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.Nov 01, 2009

Aluminum hydroxide-induced macrophagic myofasciitis (MMF) associated with vaccination has been reported. Nov 01, 2011

Aluminum vaccine adjuvants appear to contribute to the rising prevalence of autism.Nov 01, 2011

Association of serum aluminum levels with mortality in patients on chronic hemodialysis.Nov 12, 2018

Breastfed infants in Brazil receiving a full recommended schedule of immunizations showed an exceedingly high exposure of Al (225 to 1750 μg per dose) when compared with estimated levels absorbed from breast milk.Nov 01, 2010

Hair mercury levels in ASD patients were more than 3-fold and 2-fold higher as compared to the controls and children with catatonia in ASD.Dec 31, 2018

Immunization of children who have been shown to be allergic to aluminium should be carried out with vaccines which do not contain aluminium.Jun 29, 1992

In infancy, exposures to aluminum and thimerosal binary mixtures is associated with increased risk of tics and other developmental disorders.Dec 01, 2019

In the present study, intracytoplasmic inclusions were constantly detected in macrophages of the MMF lesions and were shown to contain aluminium by three different methods.Aug 31, 2001

Increased aluminum content in certain brain structures is correlated with higher silicon concentration in alcoholic use disorder.May 02, 2019

Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs.Apr 03, 2013

Lead and mercury negatively affect infant milestones like walking and talking.Apr 01, 2014

Levels of mercury, lead, and aluminum in the hair of autistic children are higher than controls.Dec 31, 2014

Long-term persistence of vaccine-derived aluminum hydroxide within the body assessed by MMF is associated with cognitive dysfunction.Oct 31, 2009

Macrophagic myofasciitis in children is a localized reaction to vaccination.May 31, 2008

Parenteral nutrition formulas for neonates have potentially toxic levels of aluminum.Feb 01, 2010

Selective accumulation of aluminum in cerebral arteries in Alzheimer's disease.Aug 31, 2013

The association with DTwP vaccines and increased infant mortality in females may be due to vaccine adjuvants and Th2 polarizing effects.Jan 01, 2011

The brain aluminium content is extraordinarily high in people with autism. Feb 28, 2018

The CDC's safety data for aluminum adjuvant safety in infants is based on the pharmacokinetics of a non-adjuvant aluminum compound in one adult male.Nov 28, 2011

The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature.Jul 31, 2015

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.Dec 21, 2005

The use of aluminum utensils for cooking meals is associated with chronic aluminum toxicity.Mar 31, 2019

The vaccines containing the adjuvant aluminium hydroxide may trigger macrophagic myofasciitis in some patients.Dec 31, 2014

These results provide a neurobiological substrate for brain dysfunction in aluminum hydroxide adjuvant-induced macrophagic myofasciitis patients.Dec 31, 2014

This data supports the historic evidence that heavy metals play a role in the development of ASD.Dec 31, 2011

This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.Jan 01, 2009

This study found an unexpectedly high incidence of intense, long-lasting persistent itching nodules (median duration of 4 years) after the use of aluminum-adsorbed vaccines.Dec 08, 2003

This study identified 3-6 cases of persistent itching nodules, lasting at least 2 months, for every 10,000 vaccinations.Sep 09, 2004

This study is the only study examining changes in serum and urinary levels of aluminum in 15 infants after a routine 2-month vaccination. The data for the post-vacc measurements are missing.Sep 01, 2013

Up-to-date children were exposed to 11-26% more aluminum from vaccines than undervaccinated children between 2004 and 2011.Nov 26, 2015

Using morin stain, this study demonstrates that macrophagic myofasciitis (mostly pediatric) patient's macrophages test positive for aluminum.Jan 01, 2017

Aluminum could increase the migration of human breast cancer cells irrespective of their oestrogen responsiveness.Sep 07, 2015

Aluminum hydroxide-stimulated macrophages contain large and persistent intracellular crystalline inclusions.Aug 13, 2004

Aluminum in neurological and neurodegenerative disease.Jan 30, 2019

Aluminum induces inflammatory and proteolytic alterations in human monocytic cell line.Sep 20, 2015

Aluminum inhibits iron uptake in vitro.Dec 01, 1990

Aluminum nanoparticles are genotoxic in vitro.Feb 01, 2016

Iron influences the binding of aluminum to transferrin.May 01, 1997

Most human placental samples contain aluminum. Aug 31, 2010

NP concentrations over 200 μg/mL are large enough to induce cytotoxic and genotoxic effects to cells.May 01, 2015

Thimerosal at low nanomolar concentrations was able to induce significant cellular toxicity in human neuron and fetal cells.May 31, 2009

Transferrin enhances the osteotoxic effects of aluminum.Apr 01, 1991

The pathogenic role of aluminium hydroxide is now recognized by the presence of chronic fatigue syndrome, macrophagic myofasciitis and subcutaneous pseudolymphoma, linked to intramuscular injection of aluminium hydroxide-containing vaccines.Mar 14, 2012

A case of multiple sclerosis improvement following removal of heavy metal intoxication has been reported.Mar 22, 2012

A case report of aluminum granuloma after DTaP-IPV vaccination.Jan 01, 2019

Central nervous system disease in patients with macrophagic myofasciitis.Apr 30, 2001

Elevated urinary excretion of aluminium and iron in multiple sclerosis has been observed. Oct 01, 2006

Macrophagic myofasciitis associated with vaccine-derived aluminium.Jul 31, 2005

Neomycin, aluminum, and thimerosal can trigger allergic reactions to vaccines.Mar 01, 1988

Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination.Aug 31, 2018

Six case reports of childhood macrophagic myofasciitis presenting with hypotonia, developmental delay, and seizures.Apr 01, 2004

This case report described a man whose occupational exposure to aluminum suggests a role for aluminum in disease aetiology.Feb 10, 2014

"Aluminium content of drinking waters, fruit juices and soft drinks: contribution to dietary intake."Jun 26, 2002

A histological study of toxic effects of aluminium sulfate on rat hippocampus.Jan 31, 2015

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

Administration of resveratrol along with aluminum + fluoride showed significant reversal of oxidative stress and neuronal damage.May 31, 2016

Aluminum

View the Evidence:
311 Abstracts with Aluminum Research