Angiotensin-Converting Enzyme (ACE) Inhibitor

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8 Diseases Researched for Angiotensin-Converting Enzyme (ACE) Inhibitor

Name	AC	CK
Hypertension	5	50
Heart Failure	3	30
Cardiovascular Diseases	3	22
Birth Defects	2	20
Statin-Induced Pathologies	2	20
Coronary Artery Disease	1	10
Drug-Induced Toxicity	1	10
Macular Degeneration	1	10

2 Adverse Pharmacological Actions Researched for Angiotensin-Converting Enzyme (ACE) Inhibitor

Name	AC	CK	Focus
Cardiotoxic	1	10
Teratogenic	1	10

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

View the Evidence:
11 Abstracts with Angiotensin-Converting Enzyme (ACE) Inhibitor Research

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A large randomized trial following 4100+ men and women with heart failure and normal ejection fraction (>=45%) over 4+ years found no improvement in study outcomes or survival with irbesartan as compared to placebo.Dec 04, 2008

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Pubmed Data : N Engl J Med. 2008 Dec 4;359(23):2456-67. Epub 2008 Nov 11. PMID: 19001508

Article Published Date : Dec 04, 2008

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Heart Failure, Hypertension

Additional Keywords : Drugs that are no Better than Placebo

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Irbesartan (trade name Avapro)

[+]

ACE Inhibitors/Angiotensin II type 1 receptor antagonists do not reduce hospitalisations in older patients with heart failure. Jan 01, 2007

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Pubmed Data : Drugs Aging. 2007;24(11):945-55. PMID: 17953461

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Diseases : Heart Failure

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Angiotensin Receptor Blockers (ARBs)

[+]

Beta Blockers, Calcium Channel Blockers, and Angiotensin-Converting Enzyme (ACE) Inhibitors increase the risk of ischemic stroke in comparison to a Diuretic alone. Jan 08, 2001

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Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):37-43. PMID: 11146696

Article Published Date : Jan 08, 2001

Study Type : Human Study

Additional Links

Diseases : Hypertension

Pharmacological Actions : Calcium Channel Blockers

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Beta Blockers

[+]

Beta Blockers, Calcium Channel Blockers, Angiotensin-Converting Enzyme (ACE) Inhibitor in combination with Diuretics are associated wtih increased risk for cardiovascular mortality versus Diuretics alone. Dec 15, 2004

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Pubmed Data : JAMA. 2004 Dec 15;292(23):2849-59. PMID: 15598916

Article Published Date : Dec 15, 2004

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Hypertension

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Beta Blockers

Adverse Pharmacological Actions : Cardiotoxic

[+]

Exposure to ACE inhibitors during the first trimester increases the risk of major congenital malformations.Jun 08, 2006

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Pubmed Data : N Engl J Med. 2006 Jun 8;354(23):2443-51. PMID: 16760444

Article Published Date : Jun 08, 2006

Study Type : Human Study

Additional Links

Diseases : Birth Defects

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor

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Risk documentation occured in only 20% of women age 15-45 prescribed a medication known to contribute to birth defects. May 01, 2011

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Pubmed Data : J Am Board Fam Med. 2011 May-Jun;24(3):262-71. PMID: 21551398

Article Published Date : May 01, 2011

Study Type : Human Study

Additional Links

Diseases : Birth Defects, Drug-Induced Toxicity , Statin-Induced Pathologies

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Angiotensin Receptor Blockers (ARBs), Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

The homeopathic crataegus preparation cralonin is as good as conventional treatments for mild cardiac insufficiency.May 31, 2003

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Pubmed Data : Eur J Heart Fail. 2003 Jun ;5(3):319-26. PMID: 12798830

Article Published Date : May 31, 2003

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Coronary Artery Disease, Heart Failure, Hypertension

Additional Keywords : Homeopathic Vs. Conventional Treatment, Phytotherapy, Significant Treatment Outcome

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor

[+]

These results suggest that green tea and Rooibos tea may have cardiovascular effects through inhibition of ACE activity.May 01, 2010

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Pubmed Data : Public Health Nutr. 2010 May ;13(5):730-7. Epub 2010 Feb 10. PMID: 20144258

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Substances : Tea

Diseases : Hypertension

Pharmacological Actions : ACE inhibitory effects, Antihypertensive Agents

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor

[+]

Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) increase the risk of age-related macular degeneration.Jan 01, 2008

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Pubmed Data : Curr Drug Saf. 2008 Jan ;3(1):24-6. PMID: 18690977

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Diseases : Macular Degeneration, Statin-Induced Pathologies

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Statin Drugs

[+]

Citrus peels could help in the management of cardiovascular diseases Aug 10, 2018

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Pubmed Data : J Complement Integr Med. 2018 Aug 11 ;16(1). Epub 2018 Aug 11. PMID: 30099413

Article Published Date : Aug 10, 2018

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Lemon, Orange: Mandarin, Pomelo

Diseases : Cardiovascular Diseases

Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Antioxidants

Additional Keywords : Plant Extracts

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor

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"Biogenic peptides and their potential use."Jan 01, 2003

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Pubmed Data : Curr Pharm Des. 2003 ;9(16):1345-55. PMID: 12769742

Article Published Date : Jan 01, 2003

Study Type : Review

Additional Links

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Food Opioids

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD