Antipsychotic Drugs

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45 Diseases Researched for Antipsychotic Drugs
NameACCKFocus
Dementia230Locked
Fractures: Bone230Locked
Schizophrenia322Locked
Metabolic Diseases221Locked
All-Cause Mortality120Locked
Hip Fracture120Locked
Suicidal Behavior220Locked
Hyperlipidemia212Locked
Inflammation212Locked
Metabolic Syndrome X211Locked
C-Reactive Protein110Locked
Cardiac Arrest110Locked
Cardiac Arrhythmias110Locked
Child Mortality 110Locked
Cirrhosis: Liver110Locked
Endocrine Diseases110Locked
Endocrine Imbalances110Locked
Hormone Imbalances110Locked
Hyponatremia110Locked
Parkinson's Disease110Locked
Pulmonary Embolism110Locked
Stroke: Ischemic110Locked
Tourette Syndrome110Locked
Dyslipidemias34Locked
Oxidative Stress24Locked
Neuroleptic Malignant Syndrome13Locked
Atherosclerosis12Locked
Brain: Oxidative Stress12Locked
Hyperglycemia12Locked
Hypertension12Locked
Infertility: Female12Locked
Lipid Peroxidation12Locked
Pneumonia22Locked
Prenatal Chemical Exposures12Locked
Psychiatric Disorders12Locked
Weight Gain: Drug-Induced12Locked
Candidiasis11Locked
Cardiac Mortality 11Locked
Dental Diseases11Locked
Dysbiosis11Locked
Electron Transport Chain Deficiencies: Mitochondrial11Locked
Infection: Antibiotic Resistant11Locked
Mitochondrial Dysfunction 11Locked
Mouth Dryness11Locked
Obesity11Locked
3 Adverse Pharmacological Actions Researched for Antipsychotic Drugs
NameACCKFocus
Neurotoxic222Locked
Cardiotoxic312Locked
Endocrine Disruptor110Locked

View the Evidence:
41 Abstracts with Antipsychotic Drugs Research

[+]

Prescribing of antipsychotic drugs for dementia or for other mental health care should be avoided.Feb 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Alzheimers Dis Rep. 2018 Feb 2 ;2(1):1-26. Epub 2018 Feb 2. PMID: 30480245
Article Published Date : Feb 01, 2018
Study Type : Meta Analysis, Review
Additional Links
Diseases : All-Cause Mortality, Dementia
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

There is good evidence to support the existence of both metabolic and neurological adverse effects in children treated with second-generation antipsychotics.Jul 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Saf. 2011 Aug 1 ;34(8):651-68. PMID: 21751826
Article Published Date : Jul 31, 2011
Study Type : Meta Analysis, Review
Additional Links
Diseases : Metabolic Diseases
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Risperidone
Adverse Pharmacological Actions : Neurotoxic
[+]

Users of first-generation antipsychotics were at a higher risk of hip fracture.Mar 31, 2017

Pubmed Data : Osteoporos Int. 2017 Apr ;28(4):1167-1178. Epub 2017 Jan 12. PMID: 28083669
Article Published Date : Mar 31, 2017
Study Type : Meta Analysis, Review
Additional Links
Diseases : Fractures: Bone, Hip Fracture
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

An analysis of cases reported to U.S. poison control centers concerning morbidity and mortality associated with depression medications.Apr 30, 2017

Pubmed Data : Am J Psychiatry. 2017 May 1 ;174(5):438-450. Epub 2017 Jan 31. PMID: 28135844
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk, Mortality
Problem Substances : Antidepressants, Antipsychotic Drugs, Carbamazepine, Olanzapine, Quetiapine
[+]

An elevated serum level of C-reactive protein is associated with increased serum concentrations of the atypical antipsychotic drugs clozapine, quetiapine, and risperidone.Jun 02, 2015

Pubmed Data : Psychopharmacology (Berl). 2015 Jun 3. Epub 2015 Jun 3. PMID: 26032842
Article Published Date : Jun 02, 2015
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Inflammation
Additional Keywords : Drug Metabolism, Increased Risk
Problem Substances : Antipsychotic Drugs, Clozapine, Quetiapine, Risperidone
[+]

Antipsychotic exposure significantly increases the risk of pulmonary embolism.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Psychiatry. 2015 ;15:92. Epub 2015 Apr 29. PMID: 25924683
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Pulmonary Embolism
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

Antipsychotic treatment of nondiabetic drug naive schizophrenia patients was associated with adverse effects on glucose regulation. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Rural Pract. 2015 Jan ;6(1):17-22. PMID: 25552846
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Schizophrenia
Additional Keywords : Glucose Dysregulation, Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

Benzodiazepine use is associated with increased mortality risk in patients with schizophreniaApr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Psychiatry. 2016 May ;77(5):661-7. PMID: 27249075
Article Published Date : Apr 30, 2016
Study Type : Human Study
Additional Links
Diseases : Schizophrenia, Suicidal Behavior
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Benzodiazepines
[+]

Clinical study of progesterone combined with vitamin B6 in the treatment of amenorrhea endocrine disorders caused by antipsychotics.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Comput Math Methods Med. 2022 ;2022:2436322. Epub 2022 Aug 28. PMID: 36072776
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Progesterone, Vitamin B-6
Additional Keywords : Natural Substance Synergy
Problem Substances : Antipsychotic Drugs
[+]

HTR2C genetic variants may be involved in the susceptibility to metabolic syndrome in patients treated with atypical antipsychotics.Feb 12, 2018

Pubmed Data : J Pharm Pharmacol. 2018 Feb 13. Epub 2018 Feb 13. PMID: 29441581
Article Published Date : Feb 12, 2018
Study Type : Human Study
Additional Links
Diseases : Metabolic Syndrome X
Additional Keywords : Genomic Variation
Problem Substances : Antipsychotic Drugs
[+]

Integrated therapy of acupuncture and plant extracts achieves the similar effect on infantile tourette syndrome to haloperidol tablets, but the side effects of it are less.Jan 31, 2015

Pubmed Data : Zhongguo Zhen Jiu. 2015 Feb ;35(2):141-4. PMID: 25854020
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Tourette Syndrome
Therapeutic Actions : Acupuncture, Integrative Medicine
Additional Keywords : Plant Extracts, Therapeutic Action Superior to Drug Therapy
Problem Substances : Antipsychotic Drugs
[+]

Psychoactive medications are associated with an increased adjusted risk of falls and fall-related injuries in hospitalized patients with cirrhosis.Mar 25, 2015

Pubmed Data : Clin Gastroenterol Hepatol. 2015 Mar 26. Epub 2015 Mar 26. PMID: 25818078
Article Published Date : Mar 25, 2015
Study Type : Human Study
Additional Links
Diseases : Cirrhosis: Liver
Additional Keywords : Elderly, Increased Risk
Problem Substances : Antipsychotic Drugs, Benzodiazepines
[+]

Red yeast rice could be a promising agent to prevent or treat second-generation antipsychotic-induced hyperlipidemia.Mar 31, 2018

Pubmed Data : Complement Ther Med. 2018 Apr ;37:167-171. Epub 2018 Mar 15. PMID: 29609929
Article Published Date : Mar 31, 2018
Study Type : Human Study
Additional Links
Substances : Red Yeast Rice
Diseases : Hyperlipidemia
Additional Keywords : Risk Reduction
Problem Substances : Antipsychotic Drugs
[+]

Separate or concurrent use of antiemetics and antipsychotics showed increased risks of Parkinson's disease.Dec 10, 2018

Pubmed Data : Int J Clin Pharmacol Ther. 2018 Dec 11. Epub 2018 Dec 11. PMID: 30526811
Article Published Date : Dec 10, 2018
Study Type : Human Study
Additional Links
Diseases : Parkinson's Disease
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

There was an association between antipsychotic therapy and hospitalization due to hyponatremia.Nov 30, 2018

Pubmed Data : Eur J Intern Med. 2018 Dec 1. Epub 2018 Dec 1. PMID: 30514607
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Diseases : Hyponatremia
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

These findings suggest that antipsychotic use is associated with increased risk of unexpected death among children and youths.Dec 11, 2018

Pubmed Data : JAMA Psychiatry. 2018 Dec 12. Epub 2018 Dec 12. PMID: 30540347
Article Published Date : Dec 11, 2018
Study Type : Human Study
Additional Links
Diseases : Child Mortality
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

These results revealed that participants who took antipsychotics were 1.70 times more likely to complete suicide compared with those who did not.Feb 28, 2017

Pubmed Data : Pharmacopsychiatry. 2017 Mar ;50(2):69-73. Epub 2016 Sep 5. PMID: 27595297
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Diseases : Suicidal Behavior
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Antipsychotic Drugs, Benzodiazepines
[+]

This study confirmed a greater risk of ischemic stroke with chlorpromazine and haloperidol when compared with risperidone in the elderly.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(3):e0119931. Epub 2015 Mar 19. PMID: 25790285
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Stroke: Ischemic
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

Trazodone is not a uniformly safer alternative to atypical antipsychotics, given the similar risk of falls and fractures among older adults with dementia.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CMAJ. 2018 Nov 26 ;190(47):E1376-E1383. PMID: 30478215
Article Published Date : Nov 25, 2018
Study Type : Human Study
Additional Links
Diseases : Dementia, Fractures: Bone
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Trazodone
[+]

Use of antipsychotic drugs is associated with an increased risk of ventricular arrhythmia and sudden cardiac death.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Am Heart Assoc. 2015 Feb ;4(2). Epub 2015 Feb 23. PMID: 25713294
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Cardiac Arrest, Cardiac Arrhythmias
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Various medications alter salivary biomarker levels and diurnal variation in children.May 01, 2007

Pubmed Data : Child Dev. 2007 May-Jun;78(3):927-37. PMID: 17517013
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Endocrine Diseases, Endocrine Imbalances, Hormone Imbalances
Problem Substances : Adderall, ADHD Drugs, Antidepressants, Antihypertensive Drugs, Antipsychotic Drugs, Concerta
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Clinicians should be aware that neuroleptic malignant syndrome is virtually associated with all antipsychotics, including those most recently marketed.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drugs R D. 2015 Mar ;15(1):45-62. PMID: 25578944
Article Published Date : Feb 28, 2015
Study Type : Human: Case Report, Review
Additional Links
Diseases : Neuroleptic Malignant Syndrome
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

alpha-mangostin reduces the negative effects of olanzapine.Jan 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2022 Feb ;25(2):198-207. PMID: 35655598
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Mango
Diseases : Weight Gain: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic
Additional Keywords : Anti-Obesity Agents
Problem Substances : Antipsychotic Drugs, Olanzapine
[+]

Berberine supplementation in psychiatric patients could be a preventive approach to reduce the metabolic adverse effects of antipsychotics.Apr 14, 2020

Pubmed Data : Life Sci. 2020 Apr 15 ;247:117442. Epub 2020 Feb 17. PMID: 32081663
Article Published Date : Apr 14, 2020
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Psychiatric Disorders
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Risk Reduction
Problem Substances : Antipsychotic Drugs
[+]

Cannabidiol acts in the dorsal striatum to improve haloperidol-induced catalepsy.Apr 26, 2016

Pubmed Data : Behav Brain Res. 2016 Apr 27 ;309:22-28. Epub 2016 Apr 27. PMID: 27131780
Article Published Date : Apr 26, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Antipsychotic Drugs
[+]

Haloperidol and clozapine may induce oxidative stress in brain and liver, respectively, consistent with the documented adverse effects of these agents.Mar 29, 2015

Pubmed Data : Neurosci Lett. 2015 Mar 30 ;591:36-40. Epub 2015 Feb 13. PMID: 25684243
Article Published Date : Mar 29, 2015
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, Lipid Peroxidation, Oxidative Stress
Additional Keywords : Haloperidol, Increased Risk
Problem Substances : Antipsychotic Drugs, Clozapine
[+]

Naringin treatment improved main clozapine-induced adverse effects.Feb 02, 2021

Pubmed Data : Drug Dev Res. 2021 Feb 3. Epub 2021 Feb 3. PMID: 33537987
Article Published Date : Feb 02, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Dyslipidemias, Hyperglycemia, Schizophrenia
Pharmacological Actions : Anticholesteremic Agents, Gastrointestinal Agents, Hypoglycemic Agents, Hypolipidemic
Problem Substances : Antipsychotic Drugs
[+]

Olanzapine may exacerbate atherosclerosis by deregulating hepatic lipid metabolism and worsening hyperlipidemia and aortic inflammation.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;50(4):1216-1229. Epub 2018 Oct 24. PMID: 30355932
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Atherosclerosis, Hyperlipidemia, Hypertension, Inflammation
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Olanzapine
[+]

Prenatally drug treated rat offspring displayed post natal developmental delay till postnatal day 70, and these young adult rats displayed cognitive impairment.Apr 30, 2015

Pubmed Data : Int J Dev Neurosci. 2015 May ;42:59-67. Epub 2015 Feb 23. PMID: 25720310
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Fetal Neurotoxicity
Problem Substances : Antipsychotic Drugs, Quetiapine
Adverse Pharmacological Actions : Neurotoxic
[+]

Taxifolin can be beneficial in treating oxidative ovarian damage, infertility, and reproductive dysfunctions induced by clozapine and haloperidol.May 31, 2021

Pubmed Data : J Obstet Gynaecol Res. 2021 Jun ;47(6):2140-2148. Epub 2021 Mar 23. PMID: 33754437
Article Published Date : May 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Infertility: Female, Oxidative Stress
Pharmacological Actions : Antioxidants
Problem Substances : Antipsychotic Drugs, Clozapine
[+]

Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine.Oct 31, 2016

Pubmed Data : Lasers Med Sci. 2016 Nov ;31(8):1651-1656. Epub 2016 Jul 20. PMID: 27437987
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
Problem Substances : Antipsychotic Drugs
[+]

A review of Antipsychotics and cardiovascular risks.Nov 30, 2018

Pubmed Data : Psychiatry Res. 2018 Dec ;270:341-347. Epub 2018 Sep 18. PMID: 30292087
Article Published Date : Nov 30, 2018
Study Type : Review
Additional Links
Diseases : Cardiac Mortality
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Antipsychotic adverse effects are diverse and frequently experienced, but are not often systematically assessed.Mar 31, 2015

Pubmed Data : J Psychopharmacol. 2015 Apr ;29(4):353-62. Epub 2014 Dec 16. PMID: 25516373
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Diseases : Dyslipidemias, Metabolic Diseases
Additional Keywords : Adverse Events
Problem Substances : Antipsychotic Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Antipsychotic medication use in nursing home residents was found to have variable efficacy when used off-label with an increased risk of many adverse events.May 31, 2015

Pubmed Data : Health Policy. 2015 Jun ;119(6):802-813. Epub 2015 Feb 28. PMID: 25791166
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Additional Keywords : Elderly, Increased Risk
Problem Substances : Antipsychotic Drugs
[+]

Berberine could be used as a potential adjuvant to prevent dyslipidemia and obesity caused by the use of second-generation antipsychotic medication.Nov 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Nov 9 ;17(11). Epub 2016 Aug 9. PMID: 27834848
Article Published Date : Nov 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Dyslipidemias, Obesity
Pharmacological Actions : Prophylactic Agents
Problem Substances : Antipsychotic Drugs, Olanzapine
[+]

Curcumin accelerates the release of exosomes containing cholesterol from cells with impaired intracellular cholesterol trafficking due to antipsychotic treatment.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(10):e0141829. Epub 2015 Oct 30. PMID: 26517556
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Cytoprotective
Problem Substances : Antipsychotic Drugs
[+]

Drugs with anticholinergic and antiadrenergic effects such as tricyclic antidepressants may cause dry mouth and related complications such as candidiasis and other oral infections.Dec 31, 2013

Pubmed Data : Int J Psychiatry Med. 2014 ;48(3):185-97. PMID: 25492713
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Candidiasis, Dental Diseases, Mouth Dryness
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Antipsychotic Drugs, Beta Blockers
[+]

Extensive impact of non-antibiotic drugs on human gut bacteria.Mar 18, 2018

Pubmed Data : Nature. 2018 Mar 19. Epub 2018 Mar 19. PMID: 29555994
Article Published Date : Mar 18, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Dysbiosis, Infection: Antibiotic Resistant
Additional Keywords : Risk Factors
Problem Substances : Antipsychotic Drugs
[+]

Proton-pump inhibitors, corticosteroid and antipsychotic drugs was independently associated with an increased risk for community-acquired pneumonia.Sep 30, 2018

Pubmed Data : Expert Opin Drug Saf. 2018 Oct ;17(10):991-1003. Epub 2018 Sep 17. PMID: 30196729
Article Published Date : Sep 30, 2018
Study Type : Review
Additional Links
Diseases : Pneumonia
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Corticosteroid, Proton-Pump Inhibitors
[+]

Second generation antipsychotic drugs could induce mitochondrial alterations that could increase the risk of metabolic syndrome.Feb 11, 2018

Pubmed Data : Eur Neuropsychopharmacol. 2018 Feb 12. Epub 2018 Feb 12. PMID: 29449054
Article Published Date : Feb 11, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Electron Transport Chain Deficiencies: Mitochondrial, Metabolic Syndrome X, Mitochondrial Dysfunction
Problem Substances : Antipsychotic Drugs
[+]

The review of current observational evidence suggests that exposure to first generation and second generation AP drugs are associated with an increased risk of pneumonia.May 26, 2015

Pubmed Data : Pharmacoepidemiol Drug Saf. 2015 May 27. Epub 2015 May 27. PMID: 26017021
Article Published Date : May 26, 2015
Study Type : Review
Additional Links
Diseases : Pneumonia
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs

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