Arsenic Trioxide

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4 Diseases Researched for Arsenic Trioxide
NameACCKFocus
Arsenic Poisoning12Locked
Chemotherapy-Induced Toxicity: Arsenic Trioxide12Locked
Breast Cancer11Locked
DNA damage11Locked
2 Adverse Pharmacological Actions Researched for Arsenic Trioxide
NameACCKFocus
Cardiotoxic12Locked
Genotoxic11Locked
Related Topics

Arsenic Trioxide is a Sub of the following Topic

View the Evidence:
25 Abstracts with Arsenic Trioxide Research

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Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2021 Nov-Dec;35(6):3157-3163. PMID: 34697146
Article Published Date : Oct 31, 2021
Study Type : Human In Vitro
Additional Links
Substances : Crocetin
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Chemoprotective Agents
Problem Substances : Arsenic Trioxide
[+]

Allicin provides protection against arsenic trioxide induced liver injury. Feb 28, 2017

Pubmed Data : Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Arsenic Poisoning, Oxidative Stress
Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Allicin, Antioxidants, Arsenic Poisoning, NF-kappaB Inhibitor, Nrf2 activation, oxidative stress
Problem Substances : Arsenic Trioxide
[+]

Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Dec ;22(6):5271-5281. Epub 2020 Oct 14. PMID: 33173984
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Arsenic Poisoning, Chemotherapy-Induced Toxicity: Arsenic Trioxide, Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:14993. Epub 2015 Oct 8. PMID: 26447599
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Problem Substances : Arsenic Trioxide
Adverse Pharmacological Actions : Cardiotoxic
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Based on activation of p62-Keap1-Nrf2 pathway, hesperidin protects arsenic-trioxide-induced cardiotoxicity.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:758670. Epub 2021 Oct 13. PMID: 34721041
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Chemoprotective Agents, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Enhancer
Problem Substances : Arsenic Trioxide
[+]

Crocetin attenuates the oxidative stress, inflammation and apoptosis in arsenic trioxide-induced nephrotoxic rats.Sep 08, 2020

Pubmed Data : Int Immunopharmacol. 2020 Sep 9 ;88:106959. Epub 2020 Sep 9. PMID: 32919218
Article Published Date : Sep 08, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 15 ;8(40):68668-68674. Epub 2017 Aug 2. PMID: 28978146
Article Published Date : Sep 14, 2017
Study Type : Animal Study
Additional Links
Substances : Eriodictyol
Diseases : Arsenic Poisoning, Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Arsenic Trioxide
[+]

Grape seed and skin extract has the potential to protect against arsenic trioxide-induced cardiotoxicity.Jul 28, 2015

Pubmed Data : Can J Physiol Pharmacol. 2015 Jul 29:1-9. Epub 2015 Jul 29. PMID: 26560635
Article Published Date : Jul 28, 2015
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Arsenic Poisoning, Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
Problem Substances : Arsenic Trioxide
[+]

Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2022 Jan-Dec;36:20587384211073397. PMID: 35088608
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Arsenic Trioxide
[+]

Protective effects of 6-gingerol on cardiotoxicity induced by arsenic trioxide.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:868393. Epub 2022 Apr 28. PMID: 35571130
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

The results of this study demonstrated that ellagic acid has beneficial cardioprotective effects against arsenic trioxide.Dec 31, 2016

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117701986. Epub 2017 Jan 1. PMID: 28474970
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Arsenic Poisoning
Pharmacological Actions : Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

These findings suggest that crocetin ameliorates arsenic trioxide-induced hepatic injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:1921-1931. Epub 2020 May 19. PMID: 32546959
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

Aloin protects against arsenic trioxide-induced myocardial membrane damage and release of inflammatory cytokines.Dec 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 08 ;393(8):1365-1372. Epub 2020 Feb 6. PMID: 32025748
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

Crocin ameliorates arsenic trioxide‑induced cardiotoxicity.Sep 09, 2020

Pubmed Data : Biomed Pharmacother. 2020 Sep 10 ;131:110713. Epub 2020 Sep 10. PMID: 32920515
Article Published Date : Sep 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cardiotoxicity: Chemotherapy-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Arsenic Trioxide
[+]

Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in Ramos cells.Feb 19, 2017

Pubmed Data : Leuk Lymphoma. 2017 Feb 20:1-13. Epub 2017 Feb 20. PMID: 28278714
Article Published Date : Feb 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Problem Substances : Arsenic Trioxide
[+]

Cupric sulfate, mercuric chloride and arsenic trioxide cause genetic damage at sublethal concentrations in fish.Aug 01, 2009

Pubmed Data : Mutat Res. 2009 Aug;678(1):7-12. Epub 2009 Jun 21. PMID: 19545645
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Arsenic Trioxide, Cupric Sulfate, Mercury
Adverse Pharmacological Actions : Genotoxic
[+]

Effect of lycopene on As2O3 induced oxidative stress in SH-SY5Y cells .Mar 31, 2021

Pubmed Data : Mol Biol Rep. 2021 Apr ;48(4):3205-3212. Epub 2021 May 4. PMID: 33948854
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Arsenic Trioxide
[+]

Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis.Dec 31, 2021

Pubmed Data : Pharmacol Res Perspect. 2022 04 ;10(2):e00914. PMID: 35171536
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice.Sep 30, 2021

Pubmed Data : Int Immunopharmacol. 2021 Oct ;99:108024. Epub 2021 Jul 29. PMID: 34333357
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes.May 31, 2018

Pubmed Data : Toxicol Mech Methods. 2018 Jun ;28(5):353-360. Epub 2018 Jan 18. PMID: 29297235
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C, Vitamin E: alpha tocopherol
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Chemoprotective Agents, Nrf2 activation
Problem Substances : Arsenic Trioxide
[+]

L-ascorbic acid and α-tocopherol reduces hepatotoxicity associated with arsenic trioxide chemotherapy.Apr 30, 2018

Pubmed Data : Nutr Cancer. 2018 May-Jun;70(4):684-696. Epub 2018 Apr 26. PMID: 29697268
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C, Vitamin E: alpha tocopherol
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Chemoprotective Agents
Problem Substances : Arsenic Trioxide
[+]

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul 15 ;83:456-465. Epub 2016 Jul 15. PMID: 27427852
Article Published Date : Jul 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemotherapeutic, P21 Activation
Problem Substances : Arsenic Trioxide
[+]

Phloretin alleviates arsenic trioxide-induced apoptosis of H9c2 cardiomyoblasts.May 25, 2021

Pubmed Data : Cardiovasc Toxicol. 2021 May 26. Epub 2021 May 26. PMID: 34037972
Article Published Date : May 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents
Problem Substances : Arsenic Trioxide
[+]

Protective effects and possible mechanism of 6-gingerol against arsenic trioxide-induced nephrotoxicity.Jun 17, 2022

Pubmed Data : Int Immunopharmacol. 2022 Jun 18 ;110:108926. Epub 2022 Jun 18. PMID: 35728306
Article Published Date : Jun 17, 2022
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Arsenic Trioxide
[+]

Protective effects of baicalin on arsenic trioxide-induced oxidative damage and apoptosis in human umbilical vein endothelial cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2021 Jan-Feb;35(1):155-162. PMID: 33402461
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic
Problem Substances : Arsenic Trioxide

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