Arsenic Trioxide

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4 Diseases Researched for Arsenic Trioxide

Name	AC	CK
Arsenic Poisoning	1	2
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	2
Breast Cancer	1	1
DNA damage	1	1

2 Adverse Pharmacological Actions Researched for Arsenic Trioxide

Name	AC	CK	Focus
Cardiotoxic	1	2
Genotoxic	1	1

Research Articles 4
Cumulative Knowledge Score 6
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Arsenic Trioxide Research

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[+]

Allicin provides protection against arsenic trioxide induced liver injury. Feb 28, 2017

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Pubmed Data : Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Arsenic Poisoning, Oxidative Stress

Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

Additional Keywords : Allicin, Antioxidants, Arsenic Poisoning, NF-kappaB Inhibitor, Nrf2 activation, oxidative stress

Problem Substances : Arsenic Trioxide

[+]

Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity.Nov 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2020 Dec ;22(6):5271-5281. Epub 2020 Oct 14. PMID: 33173984

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Crocetin

Diseases : Arsenic Poisoning, Chemotherapy-Induced Toxicity: Arsenic Trioxide, Leukemia: Acute promyelocytic leukemia

Pharmacological Actions : Cardioprotective

Problem Substances : Arsenic Trioxide

[+]

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015 ;5:14993. Epub 2015 Oct 8. PMID: 26447599

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Problem Substances : Arsenic Trioxide

Adverse Pharmacological Actions : Cardiotoxic

[+]

Crocetin attenuates the oxidative stress, inflammation and apoptosis in arsenic trioxide-induced nephrotoxic rats.Sep 08, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Sep 9 ;88:106959. Epub 2020 Sep 9. PMID: 32919218

Article Published Date : Sep 08, 2020

Study Type : Animal Study

Additional Links

Substances : Crocetin

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Arsenic Trioxide

[+]

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2.Sep 14, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Sep 15 ;8(40):68668-68674. Epub 2017 Aug 2. PMID: 28978146

Article Published Date : Sep 14, 2017

Study Type : Animal Study

Additional Links

Substances : Eriodictyol

Diseases : Arsenic Poisoning, Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Arsenic Trioxide

[+]

Grape seed and skin extract has the potential to protect against arsenic trioxide-induced cardiotoxicity.Jul 28, 2015

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Pubmed Data : Can J Physiol Pharmacol. 2015 Jul 29:1-9. Epub 2015 Jul 29. PMID: 26560635

Article Published Date : Jul 28, 2015

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Arsenic Poisoning, Chemotherapy-Induced Toxicity: Arsenic Trioxide

Pharmacological Actions : Cardioprotective

Additional Keywords : Plant Extracts

Problem Substances : Arsenic Trioxide

[+]

The results of this study demonstrated that ellagic acid has beneficial cardioprotective effects against arsenic trioxide.Dec 31, 2016

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Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117701986. Epub 2017 Jan 1. PMID: 28474970

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Arsenic Poisoning

Pharmacological Actions : Cardioprotective

Problem Substances : Arsenic Trioxide

[+]

These findings suggest that crocetin ameliorates arsenic trioxide-induced hepatic injury.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2020 ;14:1921-1931. Epub 2020 May 19. PMID: 32546959

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Crocetin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Arsenic Trioxide

[+]

Crocin ameliorates arsenic trioxide‑induced cardiotoxicity.Sep 09, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Sep 10 ;131:110713. Epub 2020 Sep 10. PMID: 32920515

Article Published Date : Sep 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Cardiotoxicity: Chemotherapy-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

Problem Substances : Arsenic Trioxide

[+]

Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in Ramos cells.Feb 19, 2017

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Pubmed Data : Leuk Lymphoma. 2017 Feb 20:1-13. Epub 2017 Feb 20. PMID: 28278714

Article Published Date : Feb 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Leukemia: Acute promyelocytic leukemia

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Problem Substances : Arsenic Trioxide

[+]

Cupric sulfate, mercuric chloride and arsenic trioxide cause genetic damage at sublethal concentrations in fish.Aug 01, 2009

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Pubmed Data : Mutat Res. 2009 Aug;678(1):7-12. Epub 2009 Jun 21. PMID: 19545645

Article Published Date : Aug 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage

Problem Substances : Arsenic Trioxide, Cupric Sulfate, Mercury

Adverse Pharmacological Actions : Genotoxic

[+]

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes.May 31, 2018

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Pubmed Data : Toxicol Mech Methods. 2018 Jun ;28(5):353-360. Epub 2018 Jan 18. PMID: 29297235

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C, Vitamin E: alpha tocopherol

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Chemoprotective Agents, Nrf2 activation

Problem Substances : Arsenic Trioxide

[+]

L-ascorbic acid and α-tocopherol reduces hepatotoxicity associated with arsenic trioxide chemotherapy.Apr 30, 2018

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Pubmed Data : Nutr Cancer. 2018 May-Jun;70(4):684-696. Epub 2018 Apr 26. PMID: 29697268

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C, Vitamin E: alpha tocopherol

Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide

Pharmacological Actions : Chemoprotective Agents

Problem Substances : Arsenic Trioxide

[+]

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Jul 15 ;83:456-465. Epub 2016 Jul 15. PMID: 27427852

Article Published Date : Jul 14, 2016

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemotherapeutic, P21 Activation

Problem Substances : Arsenic Trioxide

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Focus Your Research

Click any topic below to filter + focus research

Arsenic Trioxide is a Sub of the following Topic

View the Evidence: 14 Abstracts with Arsenic Trioxide Research

Limited to Members Only

Currently Available Sorting Options

Allicin provides protection against arsenic trioxide induced liver injury. Feb 28, 2017

Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity.Nov 30, 2020

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes.Dec 31, 2014

Crocetin attenuates the oxidative stress, inflammation and apoptosis in arsenic trioxide-induced nephrotoxic rats.Sep 08, 2020

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2.Sep 14, 2017

Grape seed and skin extract has the potential to protect against arsenic trioxide-induced cardiotoxicity.Jul 28, 2015

The results of this study demonstrated that ellagic acid has beneficial cardioprotective effects against arsenic trioxide.Dec 31, 2016

These findings suggest that crocetin ameliorates arsenic trioxide-induced hepatic injury.Dec 31, 2019

Crocin ameliorates arsenic trioxide‑induced cardiotoxicity.Sep 09, 2020

Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in Ramos cells.Feb 19, 2017

Cupric sulfate, mercuric chloride and arsenic trioxide cause genetic damage at sublethal concentrations in fish.Aug 01, 2009

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes.May 31, 2018

L-ascorbic acid and α-tocopherol reduces hepatotoxicity associated with arsenic trioxide chemotherapy.Apr 30, 2018

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Print Options

Arsenic Trioxide

View the Evidence:
14 Abstracts with Arsenic Trioxide Research