Artificial Sweeteners

Name	AC	CK
Diabetes Mellitus: Type 2	7	82
Insulin Resistance	7	69
Dysbiosis	5	60
Diabetes Mellitus: Type 2: Prevention	3	51
Metabolic Syndrome X	2	50
Urinary Tract Cancer	1	40
Kidney Diseases	2	21
Allergy: Cow's Milk	1	20
Diabetes: Kidney Function	1	20
Fibromyalgia	2	20
Kidney Damage	1	20
Kidney Failure	1	20
Phenylketonurias	1	20
Inflammation	4	18
Obesity	6	17
Prenatal Chemical Exposures	4	16
Excitotoxicity	3	13
Acidosis	1	12
Chemically-Induced Liver Damage	5	12
Metabolic Acidosis	1	12
Brain Cancer	2	11
DNA damage	4	11
Cardiovascular Diseases	1	10
HIV Infections	1	10
Lipid Peroxidation	5	10
Multiple Myeloma	1	10
Non-Hodgkin Lymphoma	1	10
Obesity: Childhood	1	10
Leukemia	5	9
Hyperinsulinism	3	8
Overweight	3	8
Oxidative Stress	4	8
Metabolic Diseases	3	7
Brain: Oxidative Stress	3	6
Cancers: All	3	6
Crohn's Disease	3	6
Hyperglycemia	3	6
Lymphoma	3	6
Aging	1	4
Appetite Disorders	1	4
Atherosclerosis	1	4
Circadian Dysregulation	1	4
Colon Cancer	1	4
Dental Caries	1	4
Fatty Liver	1	4
Dermatitis	1	3
Formaldehyde Toxicity	1	3
Hematologic Diseases	2	3
Vaccine-induced Toxicity	1	3
ALT: Elevated	1	2
AST: Elevated	1	2
Abdominal Obesity (Midsection Fat)	1	2
Alzheimer's Disease	1	2
Bladder Cancer	1	2
Brain Inflammation	1	2
Brain: Vascular Congestion	1	2
Cognitive Decline/Dysfunction	1	2
Diabetes	1	2
Eating Disorders	1	2
Fetal Origin of Adult Disease	1	2
HPA Axis Dysregulation	1	2
Hyperlipidemia	1	2
Hypothyroidism	1	2
Immune Disorders: Low Immune Function	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	2	2
Insulin: Elevated	1	2
Liver Cancer	1	2
Lung Cancer	1	2
Migraine Disorders	2	2
Neurologic Disorders	1	2
Parkinson's Disease	1	2
Placental Insufficiency	1	2
Prediabetes	1	2
Pregnancy Complications	1	2
Renal Cancer	1	2
Schwannoma	1	2
Attention Deficit Disorder with Hyperactivity	1	1
Cervical Cancer	1	1
Clostridium Enterocolitis	1	1
Emotional Disorders	1	1
Glioma	1	1
High Sugar Diet	1	1
Learning disorders	1	1
Medulloblastoma	1	1
Meningioma	1	1
Mental Disorders	1	1
Neurodevelopmental Disorders	1	1
Ulcerative Colitis	1	1

Name	AC	CK
Neurotoxic	14	28
Nephrotoxic	1	20
Carcinogenic	6	19
Endocrine Disruptor: Insulin Resistance	3	14
Hepatotoxic	4	11
Irritant	1	10
Oxidant	4	8
Diabetogenic	3	6
Obesogenic	2	6
Endocrine Disruptor: Thyroid	1	2
Gastrotoxic	1	2
Genotoxic	1	2
Glutathione Down-Regulation	1	2
Immunoreactive	1	2
Inflammatory	2	2
Renotoxic	1	1

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Pubmed Data : Am J Clin Nutr. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28228424

Article Published Date : Feb 21, 2017

Study Type : Human Study

Additional Links

Problem Substances : Sucralose (aka Splenda)

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Non-nutritive sweeteners consumption during pregnancy and lactation may have adverse effects on infant metabolism.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2019 ;10:1360. Epub 2019 Jun 20. PMID: 31281295

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Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524

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Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989

Article Published Date : Jun 01, 2001

Study Type : Human Study

Additional Links

Diseases : Excitotoxicity , Fibromyalgia

Problem Substances : Aspartame, Monosodium Glutamate (MSG)

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These findings illustrated positive associations between intrauterine exposure to artificially sweetened beverage and risk of obesity at 7 years.Jun 05, 2017

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Pubmed Data : Int J Epidemiol. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586472

Article Published Date : Jun 05, 2017

Study Type : Human Study

Additional Links

Diseases : Obesity: Childhood

Additional Keywords : Risk Factors, Transgenerational Epigenetic Modification

Problem Substances : Artificial Sweeteners

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This data suggests that aspartame may contribute to cardiovascular disease risk in HIV.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Diseases : Lipid Peroxidation

Additional Keywords : Cytokines

Problem Substances : Aspartame

Adverse Pharmacological Actions : Immunoreactive, Oxidant

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Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.Sep 30, 2010

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Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530

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Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Insulin Resistance

Problem Substances : Aspartame

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic

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Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.Jan 01, 1998

Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Diseases : Metabolic Diseases, Obesity

Additional Keywords : Increased Risk, Microbiota

Problem Substances : Aspartame

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Aspartame is associated with neurological dysfunction. Dec 01, 2007

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Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Aspartame

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Aspartame may induce redox and lipid imbalance in rats via mechanism that involves oxidative stress and depletion of glutathione-dependent system.Aug 05, 2015

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507

Article Published Date : Aug 05, 2015

Study Type : Animal Study

Additional Links

Diseases : Lipid Peroxidation

Problem Substances : Aspartame

Adverse Pharmacological Actions : Oxidant

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Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate. Jan 01, 2002

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Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Problem Substances : Aspartame, Formaldehyde, Formate

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Aspartames break down product phenylalanine, can inhibit the protective effects of intestinal alkaline phosphatase.Nov 17, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Appl Physiol Nutr Metab. 2016 Nov 18:1-7. Epub 2016 Nov 18. PMID: 27997218

Article Published Date : Nov 17, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801

Article Published Date : Apr 15, 2018

Study Type : Animal Study

Additional Links

Problem Substances : Artificial Sweeteners

Adverse Pharmacological Actions : Neurotoxic

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Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Dec 31, 1969

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Study Type : Animal Study

Additional Links

Diseases : Abdominal Obesity (Midsection Fat), Diabetes, Obesity, Overweight

Problem Substances : Aspartame, Monosodium Glutamate (MSG)

Adverse Pharmacological Actions : Diabetogenic, Obesogenic

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Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Jun 18, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067

Article Published Date : Jun 18, 2013

Study Type : Transgenic Animal Study

Additional Links

Diseases : Prediabetes

Problem Substances : Aspartame, Monosodium Glutamate (MSG), Trans Fatty Acids

Adverse Pharmacological Actions : Diabetogenic

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Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.Oct 18, 2012

Pubmed Data : PLoS One. 2014 ;9(4):e92771. Epub 2014 Apr 3. PMID: 24699280

Article Published Date : Dec 31, 2013

Study Type : Insect Study

Additional Links

Diseases : Lipid Peroxidation

Additional Keywords : Lipid Peroxidation, Splenda, Sucralose

Problem Substances : Sucralose (aka Splenda)

Adverse Pharmacological Actions : Neurotoxic

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Sucralose inhibits thyroid function and metabolism in doses within the range of the human acceptable daily intake. Dec 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879

Article Published Date : Dec 30, 2016

Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Problem Substances : Sucralose (aka Splenda)

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The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in mice.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(6):e0178426. Epub 2017 Jun 8. PMID: 28594855

Pubmed Data : Food Chem Toxicol. 1997 Dec;35(12):1177-9. PMID: 9449223

Article Published Date : Dec 01, 1997

Study Type : In Vitro Study

Additional Links

Problem Substances : Acesulfame potassium

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Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.Mar 01, 2006

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Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Diseases : Attention Deficit Disorder with Hyperactivity, Excitotoxicity , Neurodevelopmental Disorders

Additional Keywords : Drug-Plant-Vitamin Synergies

Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow

Adverse Pharmacological Actions : Neurotoxic

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Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver. Mar 01, 2010

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Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282

Article Published Date : Mar 01, 2010

Study Type : Commentary

Additional Links

Problem Substances : Aspartame

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Problem Substances : Aspartame

Adverse Pharmacological Actions : Hepatotoxic, Renotoxic

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Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132

Article Published Date : Dec 31, 2012

Study Type : Review

Additional Links

Diseases : Brain Cancer, Glioma, Medulloblastoma, Meningioma

Problem Substances : Aspartame

Adverse Pharmacological Actions : Carcinogenic

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Acesulfame-potassium and sucralose transfer into breast milk following ingestion of a diet soda.Feb 28, 2018

Artificial sweetener consumption is associated with urinary tract tumors. Jul 01, 2008