Artificial Sweeteners

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113 Diseases Researched for Artificial Sweeteners
NameACCKFocus
Diabetes Mellitus: Type 21196Locked
Insulin Resistance889Locked
Dysbiosis560Locked
Diabetes Mellitus: Type 2: Prevention351Locked
Metabolic Syndrome X250Locked
Cancers: All546Locked
Inflammation1444Locked
Oxidative Stress1344Locked
Urinary Tract Cancer140Locked
Obesity839Locked
Cognitive Decline/Dysfunction435Locked
Cardiovascular Diseases230Locked
Prenatal Chemical Exposures630Locked
Pregnancy Complications324Locked
Kidney Diseases221Locked
Allergy: Cow's Milk 120Locked
Diabetes: Kidney Function 120Locked
Fibromyalgia220Locked
Kidney Damage120Locked
Kidney Failure120Locked
Phenylketonurias120Locked
Bacterial Infections: Resistance/Biofilm Formation218Locked
Infertility: Female315Locked
Chemically-Induced Liver Damage614Locked
Excitotoxicity 313Locked
Acidosis112Locked
Liver Cancer212Locked
Metabolic Acidosis112Locked
Mitochondrial Diseases112Locked
Brain Cancer211Locked
DNA damage411Locked
Infection: Antibiotic Resistant311Locked
Lipid Peroxidation611Locked
Multiple Myeloma211Locked
Non-Hodgkin Lymphoma211Locked
Autism Spectrum Disorders110Locked
C-Reactive Protein110Locked
HIV Infections110Locked
Immune Dysregulation: TH1/TH2 imbalance110Locked
Memory Disorders610Locked
Myocardial Infarction110Locked
Obesity: Childhood110Locked
Puberty: Delayed110Locked
Leukemia59Locked
Antibiotic Toxicity 18Locked
Atherosclerosis38Locked
Hyperglycemia48Locked
Hyperinsulinism38Locked
Overweight 38Locked
Metabolic Diseases37Locked
Ulcerative Colitis37Locked
Brain: Oxidative Stress36Locked
Circadian Dysregulation26Locked
Crohn's Disease36Locked
Infertility: Male36Locked
Lymphoma36Locked
Alzheimer's Disease35Locked
Placental Insufficiency25Locked
Aging14Locked
Appetite Disorders14Locked
Colitis24Locked
Colon Cancer14Locked
Dental Caries14Locked
Fatty Liver14Locked
Inflammatory Bowel Diseases34Locked
Prediabetes24Locked
Dermatitis13Locked
Formaldehyde Toxicity13Locked
Hematologic Diseases23Locked
Parkinson's Disease23Locked
Vaccine-induced Toxicity 13Locked
ALT: Elevated12Locked
AST: Elevated12Locked
Abdominal Obesity (Midsection Fat)12Locked
Aflatoxicosis12Locked
Anxiety12Locked
Bladder Cancer12Locked
Brain Inflammation 12Locked
Brain Ischemia12Locked
Brain: Vascular Congestion12Locked
Diabetes12Locked
Eating Disorders12Locked
Fetal Origin of Adult Disease12Locked
Fibrosis12Locked
HPA Axis Dysregulation12Locked
Hyperlipidemia12Locked
Hypothyroidism12Locked
Immune Disorders: Low Immune Function12Locked
Insulin: Elevated12Locked
Lung Cancer12Locked
Migraine Disorders22Locked
Mitochondrial Dysfunction 12Locked
Neurologic Disorders12Locked
Renal Cancer12Locked
Schwannoma12Locked
Attention Deficit Disorder with Hyperactivity11Locked
Cervical Cancer11Locked
Clostridium Enterocolitis11Locked
Diabetes: Oxidative Stress11Locked
Emotional Disorders11Locked
Escherichia coli Infections11Locked
Glioma11Locked
High Sugar Diet11Locked
Klebsiella Infections11Locked
Learning disorders11Locked
Liver Disease11Locked
Medulloblastoma11Locked
Meningioma11Locked
Mental Disorders11Locked
Neurodegenerative Diseases11Locked
Neurodevelopmental Disorders11Locked
Polycystic Ovary Syndrome11Locked
Stroke: Ischemic11Locked
17 Adverse Pharmacological Actions Researched for Artificial Sweeteners
NameACCKFocus
Neurotoxic2168Locked
Cardiotoxic332Locked
Nephrotoxic120Locked
Carcinogenic619Locked
Inflammatory516Locked
Endocrine Disruptor: Insulin Resistance314Locked
Hepatotoxic411Locked
Irritant110Locked
Oxidant59Locked
Gastrotoxic38Locked
Diabetogenic36Locked
Obesogenic26Locked
Endocrine Disruptor: Thyroid12Locked
Genotoxic12Locked
Glutathione Down-Regulation12Locked
Immunoreactive12Locked
Renotoxic11Locked
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The Following are Sub-Topics of Artificial Sweeteners

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View the Evidence:
189 Abstracts with Artificial Sweeteners Research

[+]

This is a very clear aspartame dose-dependent relationship in describing a toxic effect of aspartame.Feb 22, 2026

Pubmed Data : Curr Neurovasc Res. 2026 Feb 23. Epub 2026 Feb 23. PMID: 41755407
Article Published Date : Feb 22, 2026
Study Type : Meta Analysis
Additional Links
Diseases : Oxidative Stress
Problem Substances : Aspartame
[+]

Women preparing for pregnancy are suggested to reduce aspartame consumption and avoid oxidative stressors of the ovaries.Oct 21, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Oct 22 ;23(21). Epub 2022 Oct 22. PMID: 36361530
Article Published Date : Oct 21, 2022
Study Type : Animal Study, Human Study
Additional Links
Diseases : Infertility: Female, Mitochondrial Diseases
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Acesulfame-potassium and sucralose transfer into breast milk following ingestion of a diet soda.Feb 28, 2018

Pubmed Data : J Pediatr Gastroenterol Nutr. 2018 Mar ;66(3):466-470. PMID: 29077645
Article Published Date : Feb 28, 2018
Study Type : Human Study
Additional Links
Additional Keywords : Breast Feeding, Microbiome, Risk Factors
Problem Substances : Acesulfame potassium , Sucralose (aka Splenda)
[+]

Artificial sweetener consumption is associated with urinary tract tumors. Jul 01, 2008

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Artificial sweeteners and risk of cardiovascular diseases.Sep 06, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 2022 Sep 7 ;378:e071204. Epub 2022 Sep 7. PMID: 36638072
Article Published Date : Sep 06, 2022
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
Adverse Pharmacological Actions : Cardiotoxic
[+]

Artificial sweeteners and risk of type 2 diabetes.Aug 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Care. 2023 Sep 1 ;46(9):1681-1690. PMID: 37490630
Article Published Date : Aug 31, 2023
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Artificial sweeteners induce glucose intolerance by altering the gut microbiota.Sep 16, 2014

Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Article Published Date : Sep 16, 2014
Study Type : Animal Study, Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Dysbiosis, Insulin Resistance, Metabolic Syndrome X
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation.Jan 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ISME J. 2022 Feb ;16(2):543-554. Epub 2021 Sep 1. PMID: 34465899
Article Published Date : Jan 31, 2022
Study Type : Human Study
Additional Links
Diseases : Bacterial Infections: Resistance/Biofilm Formation
Additional Keywords : Horizontal Gene Transfer
Problem Substances : Artificial Sweeteners
[+]

Artificial sweeteners were associated with increased cancer risk.Feb 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Med. 2022 Mar ;19(3):e1003950. Epub 2022 Mar 24. PMID: 35324894
Article Published Date : Feb 28, 2022
Study Type : Human Study
Additional Links
Diseases : Cancers: All
Additional Keywords : Increased Risk
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame
[+]

Aspartame increases the risk of liver cancer through CASP1 protein.Mar 31, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2025 Apr 1 ;294:118089. Epub 2025 Mar 25. PMID: 40139029
Article Published Date : Mar 31, 2025
Study Type : Human Study
Additional Links
Diseases : Liver Cancer
Additional Keywords : Increased Risk
Problem Substances : Aspartame
[+]

Aspartame may be linked to increasing brain cancer rates. Nov 01, 1996

Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Brain Cancer
Problem Substances : Aspartame
[+]

Association between aspartame consumption and cancer risk.Feb 27, 2026

Pubmed Data : J Nutr. 2026 Feb 28 ;156(5):101460. Epub 2026 Feb 28. PMID: 41765137
Article Published Date : Feb 27, 2026
Study Type : Human Study
Additional Links
Diseases : Cancers: All
Additional Keywords : Increased Risk
Problem Substances : Aspartame
[+]

Association between consumption of low- and no-calorie artificial sweeteners and cognitive decline.Oct 06, 2025

Pubmed Data : Neurology. 2025 Oct 7 ;105(7):e214023. Epub 2025 Sep 3. PMID: 40902134
Article Published Date : Oct 06, 2025
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction
Additional Keywords : Increased Risk
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Sorbitol
Adverse Pharmacological Actions : Neurotoxic
[+]

Both a higher frequency and a longer consumption of artificial sweeteners in packets or tablets was associated with T2D risk.Feb 17, 2017

Pubmed Data : Ann Nutr Metab. 2017 Feb 18 ;70(1):51-58. Epub 2017 Feb 18. PMID: 28214853
Article Published Date : Feb 17, 2017
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners
[+]

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.Sep 30, 2010

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function , Kidney Damage, Kidney Diseases, Kidney Failure
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame
Adverse Pharmacological Actions : Nephrotoxic
[+]

Daily early-life exposures to diet soda and aspartame are associated with autism in males.Aug 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Aug 29 ;15(17). Epub 2023 Aug 29. PMID: 37686804
Article Published Date : Aug 28, 2023
Study Type : Human Study
Additional Links
Diseases : Autism Spectrum Disorders
Additional Keywords : Increased Risk
Problem Substances : Artificially Sweetened Beverages, Aspartame
[+]

Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Family Med Prim Care. 2020 Jan ;9(1):69-71. Epub 2020 Jan 28. PMID: 32110567
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners
[+]

Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men.Dec 31, 2016

Pubmed Data : Am J Clin Nutr. 2017 Jan ;105(1):144-150. Epub 2016 Nov 23. PMID: 27881392
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma. Oct 23, 2012

Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Article Published Date : Oct 23, 2012
Study Type : Human Study
Additional Links
Diseases : Multiple Myeloma, Non-Hodgkin Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Low-calorie sweeteners in personal care products may be important contributors to overall exposure.Feb 21, 2017

Pubmed Data : Am J Clin Nutr. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28228424
Article Published Date : Feb 21, 2017
Study Type : Human Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation.Jan 02, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2025 Jan 3 ;145:113800. Epub 2024 Dec 12. PMID: 39672024
Article Published Date : Jan 02, 2025
Study Type : Human Study
Additional Links
Diseases : Immune Dysregulation: TH1/TH2 imbalance, Prenatal Chemical Exposures
Problem Substances : Aspartame
[+]

Non-nutritive sweeteners consumption during pregnancy and lactation may have adverse effects on infant metabolism.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2019 ;10:1360. Epub 2019 Jun 20. PMID: 31281295
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Prenatal Chemical Exposures
Problem Substances : Artificial Sweeteners
[+]

Nonnutritive sweeteners consumption was positively associated with IL-6 among participants with overweight or obesity.May 31, 2025

Pubmed Data : J Nutr. 2025 Jun ;155(6):1952-1961. Epub 2025 Mar 22. PMID: 40127735
Article Published Date : May 31, 2025
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Inflammation
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Inflammatory
[+]

Results suggest that long-term intakes of aspartame, saccharin, or diet soda may increase AT deposition and risk of incident obesity.Jul 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Obes (Lond). 2023 Jul 13. Epub 2023 Jul 13. PMID: 37443272
Article Published Date : Jul 12, 2023
Study Type : Human Study
Additional Links
Diseases : Obesity
Problem Substances : Aspartame, Saccharin
[+]

Saccharin, sucralose, and acesulfame-potassium were present in 65% of participants' milk samples.Dec 31, 2014

Pubmed Data : J Toxicol Environ Health A. 2015 ;78(16):1029-32. Epub 2015 Aug 12. PMID: 26267522
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sucralose (aka Splenda)
[+]

Sodium lauryl sulfate may have irritant properties in the human face. Jan 01, 2006

Pubmed Data : Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. PMID: 16679819
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Problem Substances : Sodium Cyclamate
Adverse Pharmacological Actions : Irritant
[+]

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load.Apr 29, 2013

Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Article Published Date : Apr 29, 2013
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Insulin Resistance
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance
[+]

The artificial sweetener erythritol and cardiovascular event risk.Feb 28, 2023

Pubmed Data : Nat Med. 2023 Mar ;29(3):710-718. Epub 2023 Feb 27. PMID: 36849732
Article Published Date : Feb 28, 2023
Study Type : Human Study
Additional Links
Diseases : Myocardial Infarction
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Cardiotoxic
[+]

The consumption of diet soda at least daily was associated with significantly greater risks of select incident metabolic syndrome components and type 2 diabetes.Apr 01, 2009

Pubmed Data : Diabetes Care. 2009 Apr;32(4):688-94. Epub 2009 Jan 16. PMID: 19151203
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Metabolic Syndrome X
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages
[+]

The dietary additive excitotoxins MSG and aspartame contribute to fibromyalgia symptoms. Jul 03, 2012

Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Article Published Date : Jul 03, 2012
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia
Therapeutic Actions : Dietary Modification: Glutamic and Aspartic Acid Reduced (G.A.R.D)
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
[+]

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option. Jun 01, 2001

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity , Fibromyalgia
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
[+]

The study found that maternal serum aspartame levels were positively associated with insulin resistance index, total cholesterol, and LDL cholesterol during pregnancy.Nov 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Nov 24 ;14(23). Epub 2022 Nov 24. PMID: 36501030
Article Published Date : Nov 23, 2022
Study Type : Human Study
Additional Links
Diseases : Insulin Resistance, Pregnancy Complications
Problem Substances : Aspartame, Sucralose (aka Splenda)
[+]

These findings illustrated positive associations between intrauterine exposure to artificially sweetened beverage and risk of obesity at 7 years.Jun 05, 2017

Pubmed Data : Int J Epidemiol. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586472
Article Published Date : Jun 05, 2017
Study Type : Human Study
Additional Links
Diseases : Obesity: Childhood
Additional Keywords : Risk Factors, Transgenerational Epigenetic Modification
Problem Substances : Artificial Sweeteners
[+]

These findings suggest long-term aspartame consumption may delay puberty.May 31, 2025

Pubmed Data : J Nutr Biochem. 2025 Jun ;140:109889. Epub 2025 Mar 4. PMID: 40049244
Article Published Date : May 31, 2025
Study Type : Human Study
Additional Links
Diseases : Puberty: Delayed
Problem Substances : Aspartame
[+]

This data suggests that aspartame may contribute to cardiovascular disease risk in HIV.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Forum Infect Dis. 2017 ;4(2):ofx083. Epub 2017 Apr 24. PMID: 28695142
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, HIV Infections, Inflammation
Additional Keywords : aspartame, Cardiovascular Diseases, HIV Infections, Increased Risk, Inflammation
Problem Substances : Aspartame
[+]

Young children with phenylketonuria and cow's milk protein allergy have higher intakes of artificial sweeteners than healthy young children.Sep 08, 2016

Pubmed Data : Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27612000
Article Published Date : Sep 08, 2016
Study Type : Human Study
Additional Links
Diseases : Allergy: Cow's Milk , Phenylketonurias
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
[+]

Aspartame consumption during pregnancy impairs placenta growth in mice.Feb 28, 2023

Pubmed Data : J Nutr Biochem. 2023 Mar ;113:109228. Epub 2022 Nov 23. PMID: 36435291
Article Published Date : Feb 28, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Placental Insufficiency
Problem Substances : Aspartame
[+]

Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported.Mar 30, 2012

Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Article Published Date : Mar 30, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Acidosis, Metabolic Acidosis
Additional Keywords : False Diabetic Ketoacidosis
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame, Sodium Cyclamate
[+]

Systemic allergic contact dermatitis after formaldehyde-containing influenza vaccination.Aug 31, 2015

Pubmed Data : J Cutan Med Surg. 2015 Sep-Oct;19(5):504-6. Epub 2015 Apr 15. PMID: 25876644
Article Published Date : Aug 31, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Dermatitis, Formaldehyde Toxicity, Vaccine-induced Toxicity
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Vaccination: Influenza
Problem Substances : Aspartame, Formaldehyde, Thimerosal
[+]

Acceptable daily intake of aspartame aggravates enteritis pathology and systemic inflammation in colitis mouse model.Nov 30, 2024

Pubmed Data : J Food Sci. 2024 Dec ;89(12):10202-10221. Epub 2024 Oct 30. PMID: 39475342
Article Published Date : Nov 30, 2024
Study Type : Animal Study
Additional Links
Diseases : Colitis, Inflammation, Ulcerative Colitis
Problem Substances : Aspartame
Adverse Pharmacological Actions : Inflammatory
[+]

Acesulfame K acts directly on the pancreatic islets and potentiates glucose-induced insulin release.Jul 01, 1987

Pubmed Data : Horm Metab Res. 1987 Jul;19(7):285-9. PMID: 2887503
Article Published Date : Jul 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
[+]

Acesulfame stimulates insulin secretion. Jun 01, 1987

Pubmed Data : Horm Metab Res. 1987 Jun;19(6):233-8. PMID: 2887500
Article Published Date : Jun 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
[+]

Acute exposure to environmentally relevant concentrations of sucralose disrupts embryonic development.Jul 09, 2022

Pubmed Data : Sci Total Environ. 2022 Jul 10 ;829:154689. Epub 2022 Mar 18. PMID: 35314215
Article Published Date : Jul 09, 2022
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Prenatal Chemical Exposures
Problem Substances : Artificial Sweeteners, Sucralose (aka Splenda)
[+]

Antihyperglycemic and hepatoprotective properties of miracle fruit compared to aspartame in alloxan-induced diabetic mice.Oct 31, 2020

Pubmed Data : J Integr Med. 2020 Nov ;18(6):514-521. Epub 2020 Sep 5. PMID: 32958414
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Miracle Fruit
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants, Hepatoprotective, Hypoglycemic Agents
Additional Keywords : Plant Extracts
Problem Substances : Aspartame
[+]

Artificial sweeteners and male infertility: Network toxicology and experimental evidence reveal FGFR1 as the critical target.Mar 31, 2026

Pubmed Data : Reprod Toxicol. 2026 Apr ;141:109191. Epub 2026 Feb 17. PMID: 41713522
Article Published Date : Mar 31, 2026
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male
Problem Substances : Aspartame
[+]

Artificial sweeteners cause cytoplasmic fatty change of varying degrees.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Coll Physicians Surg Pak. 2019 Sep ;29(9):848-851. PMID: 31455480
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Problem Substances : Aspartame, Sucralose (aka Splenda)
[+]

Aspartame acts as a chemical stressor because of increased corticosterone level and increased lipid peroxidation and nitric oxide level induce generation of free radicals in serum.Feb 28, 2015

Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation
Additional Keywords : Cytokines
Problem Substances : Aspartame
Adverse Pharmacological Actions : Immunoreactive, Oxidant
[+]

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.Sep 30, 2010

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Liver Cancer, Lung Cancer, Prenatal Chemical Exposures
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate. Jan 01, 2007

Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cancers: All
Problem Substances : Aspartame
[+]

Aspartame and saccharin led to overexpression of the key oncogene (h-Ras) and the downregulation of the tumor suppressor gene (P27) in all treated rats.May 31, 2015

Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):247-55. Epub 2015 May 26. PMID: 26015492
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Additional Keywords : Gene Expression, Tumor Suppressor Genes
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males. Jan 01, 2012

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Insulin Resistance
Problem Substances : Aspartame
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic
[+]

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.Jan 01, 1998

Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame decreases fat deposits in mice at a cost of mild cardiac hypertrophy and reduced cognitive performance.Dec 31, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2026 Jan ;194:118891. Epub 2025 Dec 12. PMID: 41389628
Article Published Date : Dec 31, 2025
Study Type : Animal Study
Additional Links
Diseases : Cardiomegaly, Cognitive Decline/Dysfunction
Problem Substances : Aspartame
Adverse Pharmacological Actions : Cardiotoxic, Neurotoxic
[+]

Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression.Feb 28, 2026

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2026 Mar 1 ;312:119938. Epub 2026 Feb 27. PMID: 41762991
Article Published Date : Feb 28, 2026
Study Type : Animal Study
Additional Links
Diseases : Brain Ischemia, Inflammation, Mitochondrial Dysfunction
Problem Substances : Aspartame
[+]

Aspartame exposure may leads to decreased expression of colorectal tight junction genes Claudin-1 and Occludin and intestinal mechanical barrier damage.May 05, 2025

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2025 May 6 ;59(5):677-685. PMID: 40374358
Article Published Date : May 05, 2025
Study Type : Animal Study
Additional Links
Additional Keywords : Gene Expression
Problem Substances : Aspartame
Adverse Pharmacological Actions : Gastrotoxic
[+]

Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis.Jun 14, 2012

Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Article Published Date : Jun 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia, Insulin: Elevated, Insulin Resistance
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Diabetogenic, Endocrine Disruptor: Insulin Resistance
[+]

Aspartame induced a significant decrease in the mean placental weight and the mean thickness of both labyrinth and basal zones.Jun 30, 2019

Pubmed Data : Ann Anat. 2019 Jul ;224:133-141. Epub 2019 May 18. PMID: 31108189
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Diseases : Placental Insufficiency, Pregnancy Complications
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Aspartame induces brain oxidative stress and vascular congestion in the animal model. Mar 02, 2012

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, Brain: Vascular Congestion
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame influenced the gut microbial composition which could lead to the development of metabolic disease.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Metabolic Diseases, Obesity
Additional Keywords : Increased Risk, Microbiota
Problem Substances : Aspartame
[+]

Aspartame ingestion led to alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers.Aug 23, 2016

Pubmed Data : J Chem Neuroanat. 2016 Aug 24 ;78:42-56. Epub 2016 Aug 24. PMID: 27565676
Article Published Date : Aug 23, 2016
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame intake corresponding to common doses results in signs of neurotoxicity in rats. Jun 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2074-9. Epub 2008 Feb 8. PMID: 18343556
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Neurologic Disorders
Problem Substances : Aspartame
[+]

Aspartame intake during pregnancy induces placental dysfunction through impaired mitochondrial function and biogenesis modulation.Nov 30, 2024

Pubmed Data : Placenta. 2024 Dec ;158:285-292. Epub 2024 Nov 8. PMID: 39547074
Article Published Date : Nov 30, 2024
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Pregnancy Complications
Problem Substances : Aspartame
[+]

Aspartame is a multipotential carcinogenic agent even at doses well below the current acceptable daily intake. Mar 01, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Aspartame is associated with neurological dysfunction. Dec 01, 2007

Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame may induce redox and lipid imbalance in rats via mechanism that involves oxidative stress and depletion of glutathione-dependent system.Aug 05, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507
Article Published Date : Aug 05, 2015
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]

Aspartame negatively impacted the reproductive system of female mice.Aug 13, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Reprod Biol Endocrinol. 2023 Aug 14 ;21(1):73. Epub 2023 Aug 14. PMID: 37580716
Article Published Date : Aug 13, 2023
Study Type : Animal Study
Additional Links
Diseases : Infertility: Female
Problem Substances : Aspartame
[+]

Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate. Jan 01, 2002

Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Formate
[+]

Aspartames break down product phenylalanine, can inhibit the protective effects of intestinal alkaline phosphatase.Nov 17, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Physiol Nutr Metab. 2016 Nov 18:1-7. Epub 2016 Nov 18. PMID: 27997218
Article Published Date : Nov 17, 2016
Study Type : Animal Study
Additional Links
Diseases : Insulin Resistance, Obesity
Additional Keywords : Artificial Sweeteners, aspartame, Insulin Resistance, obesity, Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
Adverse Pharmacological Actions : Obesogenic
[+]

Aspatame is associated with the creation of numerous cancers in rats. Sep 01, 2006

Pubmed Data : Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Bladder Cancer, Leukemia, Lymphoma, Renal Cancer, Schwannoma
Problem Substances : Aspartame
[+]

Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium.Sep 27, 2018

Pubmed Data : Metab Brain Dis. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30264280
Article Published Date : Sep 27, 2018
Study Type : Animal Study
Additional Links
Problem Substances : Acesulfame potassium , Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Beta-caryophyllene mitigates the cognitive impairment caused by repeated exposure to aspartame.Sep 12, 2023

Pubmed Data : Behav Brain Res. 2023 Sep 13 ;453:114615. Epub 2023 Aug 7. PMID: 37558167
Article Published Date : Sep 12, 2023
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Memory Disorders
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel.Aug 31, 2013

Pubmed Data : Arch Oral Biol. 2013 Sep ;58(9):1116-22. Epub 2013 Apr 28. PMID: 23631998
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Dental Caries
Problem Substances : Aspartame, Sucralose (aka Splenda), Sucrose
[+]

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Feb 1 ;11:701-707. Epub 2017 Feb 1. PMID: 28187322
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage
Problem Substances : Aspartame
[+]

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. Aug 31, 2012

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Excitotoxicity , Lipid Peroxidation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model.May 05, 2025

Pubmed Data : Cell Metab. 2025 May 6 ;37(5):1043-1045. PMID: 40334641
Article Published Date : May 05, 2025
Study Type : Animal Study
Additional Links
Diseases : Atherosclerosis
Additional Keywords : Increased Risk
Problem Substances : Aspartame
Adverse Pharmacological Actions : Cardiotoxic
[+]

Erythritol aggravates gut inflammation and anxiety-like behavioral disorders induced by acute dextran sulfate sodium administration in mice.Oct 24, 2023

Pubmed Data : Biosci Biotechnol Biochem. 2023 Oct 25 ;87(11):1354-1363. PMID: 37604788
Article Published Date : Oct 24, 2023
Study Type : Animal Study
Additional Links
Diseases : Anxiety, Colitis, Inflammation, Inflammatory Bowel Diseases
Problem Substances : Artificial Sweeteners
[+]

Exposure to very low doses of a mixture of chemicals induces genotoxic effects as well as monotonic cytotoxic effects in a tissue-dependent manner.Sep 11, 2019

Pubmed Data : Toxicol Lett. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31521832
Article Published Date : Sep 11, 2019
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Inflammation
Additional Keywords : Increased Risk, Synergistic Toxicity
Problem Substances : Aspartame, Bisphenol A , Glyphosate, Parabens, Sodium Benzoate
Adverse Pharmacological Actions : Genotoxic
[+]

In the quest for the ideal sweetener: Aspartame exacerbates selected biomarkers in the fruit fly ( Drosophila melanogaster) model of Alzheimer's disease more than sucrose.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Brain. 2023 ;4:100090. Epub 2023 Jul 30. PMID: 37559954
Article Published Date : Dec 31, 2022
Study Type : Insect Study
Additional Links
Diseases : Alzheimer's Disease
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

In utero exposure to commercial artificial sweeteners affects mice development and mammary gland structure.Jan 31, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Feb ;26(5):5054-5064. Epub 2019 Jan 3. PMID: 30607847
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Fetal Origin of Adult Disease, Prenatal Chemical Exposures
Problem Substances : Artificial Sweeteners
[+]

Increased dopaminergic degeneration and complications with chronic aspartame consumption and more injury in male groups.Nov 01, 2017

Pubmed Data : Arch Physiol Biochem. 2017 Nov 2:1-8. Epub 2017 Nov 2. PMID: 29096532
Article Published Date : Nov 01, 2017
Study Type : Animal Study
Additional Links
Diseases : Parkinson's Disease
Problem Substances : Aspartame
[+]

Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila.Nov 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nat Commun. 2017 Nov 27 ;8(1):1803. Epub 2017 Nov 27. PMID: 29180783
Article Published Date : Nov 26, 2017
Study Type : Insect Study
Additional Links
Problem Substances : Artificial Sweeteners
[+]

Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model.Jan 31, 2021

Pubmed Data : Environ Toxicol. 2021 Feb ;36(2):223-237. Epub 2020 Sep 20. PMID: 32951320
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Aspartame
[+]

Intense sweetness can surpass cocaine reward in the animal model. Jan 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2007 ;2(8):e698. Epub 2007 Aug 1. PMID: 17668074
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Saccharin
[+]

It is suggestive that sucralose should be taken with caution to avoid hepatic damage.Aug 01, 2018

Pubmed Data : Morphologie. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30078469
Article Published Date : Aug 01, 2018
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Hepatotoxic
[+]

Learning and memory deficits produced by aspartame are heritable via the paternal lineage.Aug 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2023 Aug 31 ;13(1):14326. Epub 2023 Aug 31. PMID: 37652922
Article Published Date : Aug 30, 2023
Study Type : Animal Study
Additional Links
Diseases : Memory Disorders
Additional Keywords : Transgenerational inheritance
Problem Substances : Aspartame
[+]

Life-span exposure to low doses of aspartame beginning during prenatal life increases leukemia and lymphoma rates in rats.Sep 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver.Jun 01, 2011

Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : ALT: Elevated, AST: Elevated, Chemically-Induced Liver Damage, Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Oxidant
[+]

Long-term aspartame administration leads to fibrosis, inflammasome activation, and gluconeogenesis impairment in the liver.Jan 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biology (Basel). 2021 Jan 22 ;10(2). Epub 2021 Jan 22. PMID: 33499218
Article Published Date : Jan 21, 2021
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fibrosis, Inflammation
Problem Substances : Aspartame
[+]

Long-term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity in rats.Apr 15, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801
Article Published Date : Apr 15, 2018
Study Type : Animal Study
Additional Links
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Neurotoxic
[+]

Long-term soft drink and aspartame intake induces hepatic damage.Apr 18, 2017

Pubmed Data : Nutr Res. 2017 Apr 19. Epub 2017 Apr 19. PMID: 28465000
Article Published Date : Apr 18, 2017
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Hyperglycemia
Additional Keywords : Increased Risk
Problem Substances : Aspartame, High Fructose Corn Syrup, Sugar Sweetened Beverages
[+]

Maternal sweeteners intake during gestation and lactation affects learning and memory in female offspring.Feb 09, 2021

Pubmed Data : J Med Food. 2021 Feb 10. Epub 2021 Feb 10. PMID: 33570459
Article Published Date : Feb 09, 2021
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]

N-acetyl-L-cysteine and folic acid can ameliorate the toxic effect of aspartame on the rat's cerebral cortex.Apr 30, 2018

Pubmed Data : Ultrastruct Pathol. 2018 May-Jun;42(3):228-245. Epub 2018 Feb 26. PMID: 29482444
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Folate, Folic Acid , NAC (N-acetyl-L-cysteine)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]

Nicotinamide riboside alleviates sweeteners-induced brain and cognitive impairments.Mar 02, 2025

Pubmed Data : Food Funct. 2025 Mar 3 ;16(5):1947-1968. Epub 2025 Mar 3. PMID: 39957299
Article Published Date : Mar 02, 2025
Study Type : Animal Study
Additional Links
Substances : Nicotinamide
Diseases : Cognitive Decline/Dysfunction, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

Non-caloric artificial sweeteners can disturb the circadian sleep-wake cycle and cause behavioural inactivity in mice.Mar 25, 2016

Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909
Article Published Date : Mar 25, 2016
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation
Problem Substances : Artificial Sweeteners, Saccharin
[+]

Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Microbes. 2023 ;15(1):2157698. PMID: 36524841
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Diseases : Antibiotic Toxicity , Bacterial Infections: Resistance/Biofilm Formation, Infection: Antibiotic Resistant
Additional Keywords : Antibiotic Resistance, Infection: Antibiotic Resistant
Problem Substances : Acesulfame potassium , Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

Non-nutritive sweetened beverages impair therapeutic benefits of metformin in prediabetic diet-induced obese mice.May 24, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 May 25 ;15(11). Epub 2023 May 25. PMID: 37299435
Article Published Date : May 24, 2023
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Obesity, Prediabetes
Additional Keywords : Metformin
Problem Substances : High Fructose Corn Syrup, Saccharin
[+]

Non-nutritive sweetener aspartame disrupts circadian behavior and causes memory impairment in mice.Oct 22, 2024

Pubmed Data : J Agric Food Chem. 2024 Oct 23 ;72(42):23478-23492. Epub 2024 Oct 9. PMID: 39382230
Article Published Date : Oct 22, 2024
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Memory Disorders
Additional Keywords : Circadian Rhythm
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(7):e0199080. Epub 2018 Jul 5. PMID: 29975731
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis
Additional Keywords : Microbiota
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sucralose (aka Splenda)
[+]

Omega-3 has neuroprotective effects against aspartame-induced neuronal and astrocytic degeneration.Dec 19, 2016

Pubmed Data : Anat Rec (Hoboken). 2016 Dec 20. Epub 2016 Dec 20. PMID: 27998013
Article Published Date : Dec 19, 2016
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

Oral aspartame significantly altered behaviour, anti-oxidant status and morphology of the hippocampus in mice.Dec 30, 2016

Pubmed Data : Neurobiol Learn Mem. 2016 Dec 31 ;139:76-88. Epub 2016 Dec 31. PMID: 28049023
Article Published Date : Dec 30, 2016
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Oral exposure to an acceptable daily intake dose of aspartame induced a delayed proinflammatory cytokine response in the cerebrospinal fluid.Jul 31, 2023

Pubmed Data : Food Chem Toxicol. 2023 Aug ;178:113931. Epub 2023 Jul 11. PMID: 37437708
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Inflammation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Inflammatory
[+]

Pimpinella anisum oil displays a protective action against aspartame neurotoxicity.Apr 30, 2014

Pubmed Data : Ultrastruct Pathol. 2014 May ;38(3):224-36. Epub 2014 Mar 31. PMID: 24684500
Article Published Date : Apr 30, 2014
Study Type : Animal Study
Additional Links
Substances : Anise
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Essential Oils
Problem Substances : Aspartame
[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Jun 18, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067
Article Published Date : Jun 18, 2013
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prediabetes
Problem Substances : Aspartame, Monosodium Glutamate (MSG), Trans Fatty Acids
Adverse Pharmacological Actions : Diabetogenic
[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Dec 31, 1969

Study Type : Animal Study
Additional Links
Diseases : Abdominal Obesity (Midsection Fat), Diabetes, Obesity, Overweight
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Diabetogenic, Obesogenic
[+]

Prolonged exposure to high doses of aspartame may regulate gene expression by altering global DNA methylation levels in the liver, kidney, and pancreatic tissues.Apr 20, 2026

Pubmed Data : Nutr Health. 2026 Apr 21:2601060261443466. Epub 2026 Apr 21. PMID: 42012419
Article Published Date : Apr 20, 2026
Study Type : Animal Study
Additional Links
Additional Keywords : DNA Methylation
Problem Substances : Artificial Sweeteners, Aspartame
[+]

Repeated co-exposure to aflatoxin B1 and aspartame disrupts the central nervous system homeostasis.Mar 31, 2023

Pubmed Data : J Food Sci. 2023 Apr ;88(4):1731-1742. Epub 2023 Feb 15. PMID: 36789859
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Aflatoxicosis, Oxidative Stress
Problem Substances : Aflatoxin, Aspartame
[+]

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.Oct 18, 2012

Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Article Published Date : Oct 18, 2012
Study Type : Animal Study
Additional Links
Diseases : Appetite Disorders, Obesity, Overweight
Problem Substances : Aspartame, Saccharin
[+]

Seaweed Sargassum vulgare is a promising functional food ingredient to minimize aspartame-associated toxicity.Jul 22, 2020

Pubmed Data : Int J Environ Health Res. 2020 Jul 23:1-20. Epub 2020 Jul 23. PMID: 32705899
Article Published Date : Jul 22, 2020
Study Type : Animal Study
Additional Links
Substances : Seaweed
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspartame
[+]

Sesame oil ameliorates aspartame-induced immunotoxicity in mice.Sep 23, 2025

Pubmed Data : J Mol Histol. 2025 Sep 24 ;56(5):326. Epub 2025 Sep 24. PMID: 40991121
Article Published Date : Sep 23, 2025
Study Type : Animal Study
Additional Links
Substances : Sesame Seed Oil
Pharmacological Actions : Antioxidants
Problem Substances : Aspartame
Adverse Pharmacological Actions : Immunoreactive
[+]

Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.Feb 14, 2017

Pubmed Data : Pathophysiology. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28254270
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]

Subchronic intake of aspartame and soft drink significantly disrupted the brain energy production.Jun 27, 2017

Pubmed Data : Metab Brain Dis. 2017 Jun 28. Epub 2017 Jun 28. PMID: 28660358
Article Published Date : Jun 27, 2017
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.Dec 31, 2015

Pubmed Data : Int J Occup Environ Health. 2016 Jan ;22(1):7-17. Epub 2016 Jan 29. PMID: 27078173
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Hematologic Diseases, Leukemia
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Carcinogenic
[+]

Sucralose causes bowel enlargement, kidney mineralization and abnormal pelvic tissue changes in rats.Jun 01, 1990

Pubmed Data : Food Chem Toxicol. 1990 Jun;28(6):449-55. PMID: 2210518
Article Published Date : Jun 01, 1990
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis.Oct 03, 2021

Pubmed Data : Food Funct. 2021 Oct 4 ;12(19):9380-9390. Epub 2021 Oct 4. PMID: 34606537
Article Published Date : Oct 03, 2021
Study Type : Animal Study
Additional Links
Diseases : Ulcerative Colitis
Problem Substances : Artificial Sweeteners, Sucralose (aka Splenda)
Adverse Pharmacological Actions : Gastrotoxic
[+]

Sucralose has been demonstrated to be carcinogenic and otherwise toxic in rats. Jan 01, 2000

Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S71-89. PMID: 10882819
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose induces biochemical responses, including neurotoxicity, in Daphnia magna.Dec 31, 2013

Pubmed Data : PLoS One. 2014 ;9(4):e92771. Epub 2014 Apr 3. PMID: 24699280
Article Published Date : Dec 31, 2013
Study Type : Insect Study
Additional Links
Diseases : Lipid Peroxidation
Additional Keywords : Lipid Peroxidation, Splenda, Sucralose
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
[+]

Sucralose inhibits thyroid function and metabolism in doses within the range of the human acceptable daily intake. Dec 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879
Article Published Date : Dec 30, 2016
Study Type : Animal Study
Additional Links
Diseases : HPA Axis Dysregulation, Hypothyroidism, Overweight
Additional Keywords : HPA Axis Dysregulation, hypothyroidism, overweight, Splenda, Sucralose
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid, Neurotoxic
[+]

Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.Jul 11, 2016

Pubmed Data : Cell Metab. 2016 Jul 12 ;24(1):75-90. PMID: 27411010
Article Published Date : Jul 11, 2016
Study Type : Animal Study
Additional Links
Diseases : Eating Disorders
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose reduces the weight of spleen and thymus in rats.Aug 01, 2005

Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S53-69. PMID: 10882818
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Diseases : Immune Disorders: Low Immune Function
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose represents an ecotoxicological contaminant that significantly affects the behavior of animals. Jan 01, 2012

Pubmed Data : Chemosphere. 2012 Jan ;86(1):50-5. Epub 2011 Sep 28. PMID: 21955350
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Additional Keywords : Environmental Pollutant, Environmental Toxicity
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose was found to have accumulated in fatty tissues of animals. Aug 20, 2018

Pubmed Data : J Toxicol Environ Health A. 2018 Aug 21:1-11. Epub 2018 Aug 21. PMID: 30130461
Article Published Date : Aug 20, 2018
Study Type : Animal Study
Additional Links
Additional Keywords : Bioaccumulation
Problem Substances : Sucralose (aka Splenda)
[+]

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation.May 05, 2025

Pubmed Data : Cell Metab. 2025 May 6 ;37(5):1075-1088.e7. Epub 2025 Feb 19. PMID: 39978336
Article Published Date : May 05, 2025
Study Type : Animal Study
Additional Links
Diseases : Atherosclerosis, Inflammation
Additional Keywords : Increased Risk
Problem Substances : Aspartame
[+]

The administration of Splenda (sucralose) to rats at a dose far below the US FDA Acceptable Daily intake for sucralose exhibited numerous adverse effects in the gastrointesintal tract of male rats.Jan 01, 2008

Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(6):e0178426. Epub 2017 Jun 8. PMID: 28594855
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis, Inflammation, Obesity
Additional Keywords : Microbiome
Problem Substances : Acesulfame potassium , Artificial Sweeteners
[+]

The artificial sweetener Splenda intake promotes changes in expression of c-Fos and NeuN in hypothalamus and hippocampus of rats.Dec 31, 2017

Pubmed Data : Brain Res. 2018 12 1 ;1700:181-189. Epub 2018 Sep 7. PMID: 30201258
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
[+]

The artificial sweetener splenda promotes gut proteobacteria, dysbiosis, and myeloperoxidase reactivity in Crohn's disease-like ileitisMar 14, 2018

Pubmed Data : Inflamm Bowel Dis. 2018 Mar 15. Epub 2018 Mar 15. PMID: 29554272
Article Published Date : Mar 14, 2018
Study Type : Animal Study
Additional Links
Diseases : Crohn's Disease, Dysbiosis
Problem Substances : Artificial Sweeteners, Sucralose (aka Splenda)
[+]

The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats.Oct 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 Nov ;9(11):e21693. Epub 2023 Nov 3. PMID: 38027700
Article Published Date : Oct 31, 2023
Study Type : Animal Study
Additional Links
Substances : Bitter Melon, Turmeric
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function.May 31, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Appl Physiol (1985). 2025 Jun 1 ;138(6):1571-1577. Epub 2025 Jun 3. PMID: 40459966
Article Published Date : May 31, 2025
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Neurotoxic
[+]

There was a significant decrease in sperm function of aspartame treated animals.Apr 26, 2017

Pubmed Data : Int J Impot Res. 2017 Apr 27. Epub 2017 Apr 27. PMID: 28446800
Article Published Date : Apr 26, 2017
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Aspartame
[+]

These findings demonstrate that aspartame metabolites could be a contributing factor for the development of oxidative stress in the brain.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Apr ;26(2):903-916. Epub 2017 Dec 6. PMID: 29567262
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

These findings suggest that long-term consumption of aspartame leads to hyperglycemia and hyperlipidemia, as well as to oxidative stress in erythrocytes.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biosci. 2014 Dec ;39(5):859-66. PMID: 25431414
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia, Hyperlipidemia, Lipid Peroxidation, Oxidative Stress
Additional Keywords : Increased Risk
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]

These results reveal that the aspartame molecule is inherently amyloidogenic.May 27, 2019

Pubmed Data : ACS Nano. 2019 May 28 ;13(5):6033-6049. Epub 2019 May 6. PMID: 31021591
Article Published Date : May 27, 2019
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

This study describes the fate of artificial sweeteners, including the fraction found in SPM and in sludge, in addition to the aqueous portion of wastewater in WWTPs.Dec 01, 2014

Pubmed Data : Environ Sci Technol. 2014 Dec 2 ;48(23):13668-74. Epub 2014 Nov 14. PMID: 25365516
Article Published Date : Dec 01, 2014
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollutant
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

two-week supplementation of a low carbohydrate diet with sucralose, saccharin or acesulfame-K up-regulated intestinal SGLT1 expression levels to Sep 17, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Article Published Date : Sep 17, 2007
Study Type : Animal Study
Additional Links
Additional Keywords : Cephalic Phase Effect
Problem Substances : Acesulfame potassium , Saccharin, Sucralose (aka Splenda)
[+]

Vitamin E could ameliorate some of aspartames induced memory impairments and cortical cells loss in mPFC.Nov 20, 2017

Pubmed Data : Acta Histochem. 2017 Nov 21. Epub 2017 Nov 21. PMID: 29169694
Article Published Date : Nov 20, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

Acesulfame has not received adequate toxicity testing. Jan 01, 2010

Pubmed Data : Int J Occup Environ Health. 2010 Jan-Mar;16(1):89-96. PMID: 20166324
Article Published Date : Jan 01, 2010
Study Type : Commentary
Additional Links
Problem Substances : Acesulfame potassium
[+]

Acesulfame potassium has been shown to have clastogenic (chromosome-damaging) activity within the no-toxic-effect levels of the WHO and FAO. Dec 01, 1997

Pubmed Data : Food Chem Toxicol. 1997 Dec;35(12):1177-9. PMID: 9449223
Article Published Date : Dec 01, 1997
Study Type : In Vitro Study
Additional Links
Problem Substances : Acesulfame potassium
[+]

Analysis suggests that aspartame may contribute to ischemic brain injury.Jul 03, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2025 Jul 4 ;15(1):23871. Epub 2025 Jul 4. PMID: 40615604
Article Published Date : Jul 03, 2025
Study Type : Review
Additional Links
Diseases : Stroke: Ischemic
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Artificial sweetener enhances the spread of antibiotic resistance genes during anaerobic digestion.Jul 31, 2023

Pubmed Data : Environ Sci Technol. 2023 Aug 1 ;57(30):10919-10928. Epub 2023 Jul 20. PMID: 37475130
Article Published Date : Jul 31, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Infection: Antibiotic Resistant
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Antibiotic Resistance, Horizontal Gene Transfer
Problem Substances : Acesulfame potassium , Artificial Sweeteners
[+]

Aspartame and its metabolites cause oxidative stress and mitochondrial and lipid alterations in SH-SY5Y cells.Mar 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Mar 18 ;15(6). Epub 2023 Mar 18. PMID: 36986196
Article Published Date : Mar 17, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Neurodegenerative Diseases
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]

Aspartame and its potential neurocognitive effects in humans. Jul 02, 2025

Pubmed Data : Nutr Rev. 2025 Jul 3. Epub 2025 Jul 3. PMID: 40608001
Article Published Date : Jul 02, 2025
Study Type : Review
Additional Links
Diseases : Cognitive Decline/Dysfunction, Memory Disorders, Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.Mar 01, 2006

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity, Excitotoxicity , Neurodevelopmental Disorders
Additional Keywords : Drug-Plant-Vitamin Synergies
Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver. Mar 01, 2010

Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282
Article Published Date : Mar 01, 2010
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

Aspartame is broken down into formaldehyde in various tissues and may contribute to migraines. May 01, 2008

Pubmed Data : Dermatitis. 2008 May-Jun;19(3):E10-1. PMID: 18627677
Article Published Date : May 01, 2008
Study Type : Commentary
Additional Links
Diseases : Migraine Disorders
Problem Substances : Aspartame
[+]

Aspartame may be associated with certain mental disorders, compromised learning and emotional functioning. Apr 01, 2008

Pubmed Data : Eur J Clin Nutr. 2008 Apr;62(4):451-62. Epub 2007 Aug 8. PMID: 17684524
Article Published Date : Apr 01, 2008
Study Type : Review
Additional Links
Diseases : Emotional Disorders, Learning disorders, Mental Disorders
Problem Substances : Aspartame
[+]

Aspartame may be responsible for adverse neurobehavioral health outcomes.Feb 14, 2017

Pubmed Data : Nutr Neurosci. 2017 Feb 15:1-11. Epub 2017 Feb 15. PMID: 28198207
Article Published Date : Feb 14, 2017
Study Type : Review
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame may influence cardiovascular health through coordinated modulation of inflammatory and apoptotic pathways.Nov 20, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2025 Nov 21 ;104(47):e46012. PMID: 41305757
Article Published Date : Nov 20, 2025
Study Type : In Vitro Study
Additional Links
Diseases : Cardiovascular Diseases, Inflammation
Problem Substances : Aspartame
[+]

Aspartame may influence cardiovascular health through coordinated modulation of inflammatory and apoptotic pathways.Nov 20, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2025 Nov 21 ;104(47):e46012. PMID: 41305757
Article Published Date : Nov 20, 2025
Study Type : In Vitro Study
Additional Links
Diseases : Cardiovascular Diseases, Inflammation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Cardiotoxic
[+]

Aspartame metabolites have an adverse effect on human red blood cell enzyme activity. Jan 01, 2006

Pubmed Data : Pharmacol Res. 2006 Jan;53(1):1-5. Epub 2005 Aug 29. PMID: 16129618
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame promotes ovarian cancer progression.Feb 28, 2026

Pubmed Data : Food Chem Toxicol. 2026 Mar ;209:115901. Epub 2025 Dec 12. PMID: 41391619
Article Published Date : Feb 28, 2026
Study Type : In Vitro Study
Additional Links
Diseases : Ovarian Cancer
Additional Keywords : Increased Risk
Problem Substances : Aspartame
[+]

Aspartame safety as a food sweetener and related health hazards. Aug 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Aug 18 ;15(16). Epub 2023 Aug 18. PMID: 37630817
Article Published Date : Aug 17, 2023
Study Type : Review
Additional Links
Diseases : Multiple Myeloma, Non-Hodgkin Lymphoma
Problem Substances : Aspartame
[+]

Aspartame significantly down-regulates mRNA expression of tumor suppressor gene p53 and apoptotic gene bax in the cancer cells.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2016 Jul ;23(4):503-6. Epub 2015 Jun 15. PMID: 27298583
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Cervical Cancer
Additional Keywords : Disease Progression, Risk Factors
Problem Substances : Aspartame
[+]

Aspartame use and Parkinson's disease: review of associated effects on neurotransmitters, oxidative stress, and cognition.Jul 02, 2023

Pubmed Data : Nutr Neurosci. 2023 Jul 3:1-14. Epub 2023 Jul 3. PMID: 37395401
Article Published Date : Jul 02, 2023
Study Type : Review
Additional Links
Diseases : Lipid Peroxidation, Memory Disorders, Oxidative Stress, Parkinson's Disease
Problem Substances : Aspartame
[+]

Aspartame, Acesulfame potassium and Saccharin have potential genotoxicity. Jan 01, 2008

Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Acesulfame potassium , Aspartame, Saccharin
[+]

Aspartame-sweetened tap w ater: transformation products and 2,6-dichloro-1,4-benzoquinone formation.Jan 09, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Technol. 2023 Jan 10 ;57(3):1332-41. Epub 2023 Jan 10. PMID: 36628463
Article Published Date : Jan 09, 2023
Study Type : In Vitro Study
Additional Links
Additional Keywords : Disinfection by-products: In Drinking Water
Problem Substances : Aspartame, Disinfection by-products: In Drinking Water
[+]

Based on an animal study which showed aspartame contains cancer the FDA should reevaluate its position on aspartame being safe under all conditions. Oct 01, 2007

Pubmed Data : Int J Occup Environ Health. 2007 Oct-Dec;13(4):446-8. PMID: 18085058
Article Published Date : Oct 01, 2007
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

Consumption of artificial sweeteners might contribute to increases in risks for obesity or its attendant negative health outcomes.Jul 06, 2016

Pubmed Data : Rev Endocr Metab Disord. 2016 Jul 7. Epub 2016 Jul 7. PMID: 27387506
Article Published Date : Jul 06, 2016
Study Type : Review
Additional Links
Diseases : Metabolic Diseases, Obesity
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]

EFSA's toxicological assessment of aspartame: was it even-handedly trying to identify possible unreliable positives and unreliable negatives?Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Public Health. 2019 ;77:34. Epub 2019 Jul 15. PMID: 31338189
Article Published Date : Dec 31, 2018
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

Formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxic effects on rat thymus cells. Jan 01, 2003

Pubmed Data : J Pharmacol Sci. 2003 Jan;91(1):83-6. PMID: 12686735
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Methanol
[+]

Increased sucralose consumption may explain why Canada has the highest incidence of inflammatory bowel disease in the world. Sep 01, 2011

Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763
Article Published Date : Sep 01, 2011
Study Type : Review
Additional Links
Diseases : Crohn's Disease, Inflammatory Bowel Diseases, Ulcerative Colitis
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
[+]

Investigating the impact of aspartame on Alzheimer's disease through network toxicology and molecular docking.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2025 ;12:1733469. Epub 2026 Jan 9. PMID: 41586222
Article Published Date : Dec 31, 2024
Study Type : In Vitro Study
Additional Links
Diseases : Alzheimer's Disease
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Investigation of the toxic mechanism of aspartame on female infertility using network toxicology and molecular docking approaches.Aug 28, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2025 Aug 29 ;104(35):e44154. PMID: 40898547
Article Published Date : Aug 28, 2025
Study Type : In Vitro Study
Additional Links
Diseases : Infertility: Female
Problem Substances : Aspartame
[+]

Long term consumption of artificial sweeteners might accelerate atherosclerosis and aging. May 01, 2011

Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Aging, Atherosclerosis
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Long-term consumption of aspartame led to a dose-dependent increased production of free radicals in renal tissues as well as kidney injury.Sep 30, 2017

Pubmed Data : Iran J Kidney Dis. 2017 Oct ;11(5):339-343. PMID: 29038387
Article Published Date : Sep 30, 2017
Study Type : Review
Additional Links
Substances : aspartame
Diseases : Kidney Diseases
Additional Keywords : aspartame, Kidney Diseases
Problem Substances : Aspartame
Adverse Pharmacological Actions : Hepatotoxic, Renotoxic
[+]

MASLD and aspartame: are new studies in the horizon? Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2023 ;10:1266918. Epub 2023 Dec 8. PMID: 38143439
Article Published Date : Dec 31, 2022
Study Type : Review
Additional Links
Diseases : Inflammation, Liver Disease
Problem Substances : Aspartame
[+]

Measuring artificial sweeteners toxicity using a bioluminescent bacterial panel.Sep 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 25 ;23(10). Epub 2018 Sep 25. PMID: 30257473
Article Published Date : Sep 24, 2018
Study Type : In Vitro Study
Additional Links
Additional Keywords : Microbiome
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Sucralose (aka Splenda)
[+]

Molecular crosstalk between artificial sweetener aspartame and diabetes-linked insulin hormone unveils possible amyloidosis risks.Aug 27, 2025

Pubmed Data : Biomacromolecules. 2025 Aug 28. Epub 2025 Aug 28. PMID: 40875339
Article Published Date : Aug 27, 2025
Study Type : In Vitro Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Non-caloric artificial sweeteners exhibit antimicrobial activity against bacteria and promote bacterial evolution of antibiotic tolerance.Apr 03, 2022

Pubmed Data : J Hazard Mater. 2022 Apr 4 ;433:128840. Epub 2022 Apr 4. PMID: 35398799
Article Published Date : Apr 03, 2022
Study Type : In Vitro Study
Additional Links
Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Klebsiella Infections
Additional Keywords : Antibiotic Resistance, Risk Factors
Problem Substances : Artificial Sweeteners
[+]

Non-nutritive artificial sweeteners as an emerging contaminant in environment.Apr 14, 2019

Pubmed Data : Ecotoxicol Environ Saf. 2019 Apr 15 ;170:699-707. Epub 2018 Dec 20. PMID: 30580164
Article Published Date : Apr 14, 2019
Study Type : Review
Additional Links
Additional Keywords : Environmental Pollution
Problem Substances : Artificial Sweeteners
[+]

Omega-3 fatty acids may be a therapeutic agent to reduce the aspartame induced biochemical and morphological alterations in normal renal cells.Sep 06, 2017

Pubmed Data : Biofactors. 2017 Sep 7. Epub 2017 Sep 7. PMID: 28881099
Article Published Date : Sep 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : DNA damage
Pharmacological Actions : Renoprotective
Problem Substances : Aspartame
[+]

Preconception and gestational sugar and alternative sweetener consumption may negatively impact pregnancy outcomes and offspring health.Dec 02, 2018

Pubmed Data : Proc Nutr Soc. 2018 Dec 3:1-10. Epub 2018 Dec 3. PMID: 30501650
Article Published Date : Dec 02, 2018
Study Type : Review
Additional Links
Diseases : High Sugar Diet
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]

Reducing the intake of added sugars could translate to reduced diabetes-related morbidity and premature mortality for populations.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mayo Clin Proc. 2015 Mar ;90(3):372-81. Epub 2015 Jan 29. PMID: 25639270
Article Published Date : Feb 28, 2015
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention
Additional Keywords : Risk Reduction
Problem Substances : Artificial Sweeteners, High Fructose Corn Syrup
[+]

Saccharin consumption may potentially alter the intestinal integrity in humans.Jun 24, 2018

Pubmed Data : Food Funct. 2018 Jun 25. Epub 2018 Jun 25. PMID: 29938270
Article Published Date : Jun 24, 2018
Study Type : In Vitro Study
Additional Links
Problem Substances : Artificial Sweeteners, Saccharin
Adverse Pharmacological Actions : Gastrotoxic
[+]

Stability of aspartame in the soft drinks: Identification of the novel phototransformation products and their toxicity evaluation.Oct 31, 2023

Pubmed Data : Food Res Int. 2023 Nov ;173(Pt 1):113365. Epub 2023 Aug 7. PMID: 37803662
Article Published Date : Oct 31, 2023
Study Type : Review
Additional Links
Problem Substances : Artificial Sweeteners, Aspartame
[+]

Sucralose and sodium saccharin seemed to elicit the greatest degree of DNA fragmentation of all the sweeteners tested in all the cell lines used.Dec 31, 2014

Pubmed Data : Drug Chem Toxicol. 2015 ;38(3):318-27. Epub 2014 Oct 15. PMID: 25317478
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Colon Cancer, DNA damage
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sodium Cyclamate
[+]

Sucralose consumption may contribute to inflammatory bowel disease. Apr 21, 2012

Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395
Article Published Date : Apr 21, 2012
Study Type : Review
Additional Links
Diseases : Clostridium Enterocolitis, Crohn's Disease, Inflammatory Bowel Diseases
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
[+]

Sucralose in e-liquids can lead to significant production of solvent degradation products.Jun 16, 2019

Pubmed Data : Chem Res Toxicol. 2019 Jun 17 ;32(6):1241-1249. Epub 2019 May 23. PMID: 31079450
Article Published Date : Jun 16, 2019
Study Type : In Vitro Study
Additional Links
Problem Substances : Electronic Cigarettes, Sucralose (aka Splenda)
[+]

Sucralose is found in drinking water tested with a low rate of removal (11%) and serving 28 million people. Aug 31, 2011

Pubmed Data : Environ Sci Technol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21879743
Article Published Date : Aug 31, 2011
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose is largely resistant to natural breakdown processes and accumulates in the environment with unknown consequences for human and environmental health. Dec 13, 1901

Pubmed Data : Environ Sci Technol. 2011 Jan 14. [Epub ahead of print]. PMID: 21235203
Study Type : In Vitro Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose may be a migraine trigger.Sep 01, 2006

Pubmed Data : Headache. 2006 Sep;46(8):1303-4. PMID: 16942478
Article Published Date : Sep 01, 2006
Study Type : Commentary
Additional Links
Diseases : Migraine Disorders
Problem Substances : Sucralose (aka Splenda)
[+]

Sucralose, aspartame and saccharin have been shown to disrupt the balance and diversity of gut microbiota.Apr 13, 2016

Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Article Published Date : Apr 13, 2016
Study Type : Bacterial
Additional Links
Diseases : Dysbiosis, Metabolic Diseases
Additional Keywords : Microbiota, Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on pancreatic beta cells. Nov 01, 1998

Pubmed Data : Cell Signal. 1998 Nov;10(10):727-33. PMID: 9884024
Article Published Date : Nov 01, 1998
Study Type : In Vitro Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sodium Cyclamate
[+]

The consumption of aspartame is associated with higher serum levels of a benzene metabolite associated with blood disorders and leukemia. Jan 01, 2006

Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134
Article Published Date : Jan 01, 2006
Study Type : Commentary
Additional Links
Diseases : Hematologic Diseases, Leukemia
Problem Substances : Aspartame, Benzene
[+]

The high sweetness of alternative tobacco products makes these products attractive to adolescents.May 22, 2016

Pubmed Data : Nicotine Tob Res. 2016 May 23. Epub 2016 May 23. PMID: 27217475
Article Published Date : May 22, 2016
Study Type : In Vitro Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Electronic Cigarettes
[+]

These results suggest a potential role for artificial sweeteners in exacerbating PCOS progression through inflammatory and metabolic pathways.Nov 30, 2025

Pubmed Data : Reprod Toxicol. 2025 Dec ;138:109073. Epub 2025 Sep 25. PMID: 41015327
Article Published Date : Nov 30, 2025
Study Type : Review
Additional Links
Diseases : Inflammation, Polycystic Ovary Syndrome
Problem Substances : Artificial Sweeteners
[+]

This review provides evidence that raise concerns that aspartame may exacerbate T2D and add to the global burden of disease.May 30, 2017

Pubmed Data : Curr Diabetes Rev. 2017 May 31. Epub 2017 May 31. PMID: 28571543
Article Published Date : May 30, 2017
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

This systematic review of animal studies suggests a possible mechanistic association between the consumption of certain artificial sweeteners and systemic inflammation.Oct 15, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2025 Oct 16 ;17(20). Epub 2025 Oct 16. PMID: 41156503
Article Published Date : Oct 15, 2025
Study Type : Review
Additional Links
Diseases : Inflammation
Problem Substances : Aspartame, Saccharin
[+]

Toxic effects of aspartame metabolites on astrocytes and neurons.Dec 31, 2012

Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Diseases : Brain Cancer, Glioma, Medulloblastoma, Meningioma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Various food additives, preservatives, fungicides and artificial sweeteners have been demonstrated to have the potential to damage DNA in gastrointestinal organs. Aug 26, 2002

Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Article Published Date : Aug 26, 2002
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Biphenyl, Butylated hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), Saccharin, Sodium Cyclamate, Sodium o-phenylphenol, Sucralose (aka Splenda), Thiabendazole

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