Aspartame

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77 Diseases Researched for Aspartame
NameACCKFocus
Fibromyalgia220Locked
Insulin Resistance517Locked
Inflammation416Locked
Excitotoxicity 313Locked
Brain Cancer211Locked
Diabetes Mellitus: Type 2211Locked
Dysbiosis211Locked
Kidney Diseases211Locked
Allergy: Cow's Milk 110Locked
Cardiovascular Diseases110Locked
Chemically-Induced Liver Damage510Locked
Diabetes Mellitus: Type 2: Prevention110Locked
Diabetes: Kidney Function 110Locked
HIV Infections110Locked
Kidney Damage110Locked
Kidney Failure110Locked
Metabolic Syndrome X110Locked
Multiple Myeloma110Locked
Non-Hodgkin Lymphoma110Locked
Phenylketonurias110Locked
Urinary Tract Cancer110Locked
Lipid Peroxidation48Locked
Obesity48Locked
Oxidative Stress48Locked
Leukemia47Locked
Brain: Oxidative Stress36Locked
Hyperglycemia36Locked
Lymphoma36Locked
Cancers: All24Locked
Overweight 24Locked
Acidosis13Locked
DNA damage33Locked
Dermatitis13Locked
Formaldehyde Toxicity13Locked
Metabolic Acidosis13Locked
Metabolic Diseases23Locked
Vaccine-induced Toxicity 13Locked
ALT: Elevated12Locked
AST: Elevated12Locked
Abdominal Obesity (Midsection Fat)12Locked
Alzheimer's Disease12Locked
Appetite Disorders12Locked
Bladder Cancer12Locked
Brain Inflammation 12Locked
Brain: Vascular Congestion12Locked
Cognitive Decline/Dysfunction12Locked
Dental Caries12Locked
Diabetes12Locked
Fatty Liver12Locked
Fibrosis12Locked
Hyperlipidemia12Locked
Infertility: Male12Locked
Insulin: Elevated12Locked
Liver Cancer12Locked
Lung Cancer12Locked
Neurologic Disorders12Locked
Parkinson's Disease12Locked
Placental Insufficiency12Locked
Prediabetes12Locked
Pregnancy Complications12Locked
Prenatal Chemical Exposures12Locked
Renal Cancer12Locked
Schwannoma12Locked
Aging11Locked
Atherosclerosis11Locked
Attention Deficit Disorder with Hyperactivity11Locked
Cervical Cancer11Locked
Colon Cancer11Locked
Emotional Disorders11Locked
Glioma11Locked
Hematologic Diseases11Locked
Learning disorders11Locked
Medulloblastoma11Locked
Meningioma11Locked
Mental Disorders11Locked
Migraine Disorders11Locked
Neurodevelopmental Disorders11Locked
12 Adverse Pharmacological Actions Researched for Aspartame
NameACCKFocus
Neurotoxic1018Locked
Carcinogenic517Locked
Nephrotoxic110Locked
Oxidant48Locked
Diabetogenic36Locked
Hepatotoxic35Locked
Endocrine Disruptor: Insulin Resistance24Locked
Obesogenic24Locked
Genotoxic12Locked
Glutathione Down-Regulation12Locked
Immunoreactive12Locked
Renotoxic11Locked
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View the Evidence:
78 Abstracts with Aspartame Research

[+]

Artificial sweetener consumption is associated with urinary tract tumors. Jul 01, 2008

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Artificial sweeteners induce glucose intolerance by altering the gut microbiota.Sep 16, 2014

Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Article Published Date : Sep 16, 2014
Study Type : Animal Study, Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Dysbiosis, Insulin Resistance, Metabolic Syndrome X
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

Aspartame may be linked to increasing brain cancer rates. Nov 01, 1996

Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Brain Cancer
Problem Substances : Aspartame
[+]

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.Sep 30, 2010

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function , Kidney Damage, Kidney Diseases, Kidney Failure
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame
Adverse Pharmacological Actions : Nephrotoxic
[+]

Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men.Dec 31, 2016

Pubmed Data : Am J Clin Nutr. 2017 Jan ;105(1):144-150. Epub 2016 Nov 23. PMID: 27881392
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma. Oct 23, 2012

Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Article Published Date : Oct 23, 2012
Study Type : Human Study
Additional Links
Diseases : Multiple Myeloma, Non-Hodgkin Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

The dietary additive excitotoxins MSG and aspartame contribute to fibromyalgia symptoms. Jul 03, 2012

Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Article Published Date : Jul 03, 2012
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia
Therapeutic Actions : Dietary Modification: Glutamic and Aspartic Acid Reduced (G.A.R.D)
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
[+]

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option. Jun 01, 2001

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity , Fibromyalgia
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
[+]

This data suggests that aspartame may contribute to cardiovascular disease risk in HIV.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Forum Infect Dis. 2017 ;4(2):ofx083. Epub 2017 Apr 24. PMID: 28695142
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, HIV Infections, Inflammation
Additional Keywords : aspartame, Cardiovascular Diseases, HIV Infections, Increased Risk, Inflammation
Problem Substances : Aspartame
[+]

Young children with phenylketonuria and cow's milk protein allergy have higher intakes of artificial sweeteners than healthy young children.Sep 08, 2016

Pubmed Data : Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27612000
Article Published Date : Sep 08, 2016
Study Type : Human Study
Additional Links
Diseases : Allergy: Cow's Milk , Phenylketonurias
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
[+]

Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported.Mar 30, 2012

Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Article Published Date : Mar 30, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Acidosis, Metabolic Acidosis
Additional Keywords : False Diabetic Ketoacidosis
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame, Sodium Cyclamate
[+]

Systemic allergic contact dermatitis after formaldehyde-containing influenza vaccination.Aug 31, 2015

Pubmed Data : J Cutan Med Surg. 2015 Sep-Oct;19(5):504-6. Epub 2015 Apr 15. PMID: 25876644
Article Published Date : Aug 31, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Dermatitis, Formaldehyde Toxicity, Vaccine-induced Toxicity
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Vaccination: Influenza
Problem Substances : Aspartame, Formaldehyde, Thimerosal
[+]

Artificial sweeteners cause cytoplasmic fatty change of varying degrees.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Coll Physicians Surg Pak. 2019 Sep ;29(9):848-851. PMID: 31455480
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Problem Substances : Aspartame, Sucralose (aka Splenda)
[+]

Aspartame acts as a chemical stressor because of increased corticosterone level and increased lipid peroxidation and nitric oxide level induce generation of free radicals in serum.Feb 28, 2015

Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation
Additional Keywords : Cytokines
Problem Substances : Aspartame
Adverse Pharmacological Actions : Immunoreactive, Oxidant
[+]

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.Sep 30, 2010

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Liver Cancer, Lung Cancer, Prenatal Chemical Exposures
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate. Jan 01, 2007

Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cancers: All
Problem Substances : Aspartame
[+]

Aspartame and saccharin led to overexpression of the key oncogene (h-Ras) and the downregulation of the tumor suppressor gene (P27) in all treated rats.May 31, 2015

Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):247-55. Epub 2015 May 26. PMID: 26015492
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Additional Keywords : Gene Expression, Tumor Suppressor Genes
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males. Jan 01, 2012

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Insulin Resistance
Problem Substances : Aspartame
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic
[+]

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.Jan 01, 1998

Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis.Jun 14, 2012

Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Article Published Date : Jun 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia, Insulin: Elevated, Insulin Resistance
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Diabetogenic, Endocrine Disruptor: Insulin Resistance
[+]

Aspartame induced a significant decrease in the mean placental weight and the mean thickness of both labyrinth and basal zones.Jun 30, 2019

Pubmed Data : Ann Anat. 2019 Jul ;224:133-141. Epub 2019 May 18. PMID: 31108189
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Diseases : Placental Insufficiency, Pregnancy Complications
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Aspartame induces brain oxidative stress and vascular congestion in the animal model. Mar 02, 2012

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, Brain: Vascular Congestion
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame influenced the gut microbial composition which could lead to the development of metabolic disease.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Metabolic Diseases, Obesity
Additional Keywords : Increased Risk, Microbiota
Problem Substances : Aspartame
[+]

Aspartame ingestion led to alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers.Aug 23, 2016

Pubmed Data : J Chem Neuroanat. 2016 Aug 24 ;78:42-56. Epub 2016 Aug 24. PMID: 27565676
Article Published Date : Aug 23, 2016
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame intake corresponding to common doses results in signs of neurotoxicity in rats. Jun 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2074-9. Epub 2008 Feb 8. PMID: 18343556
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Neurologic Disorders
Problem Substances : Aspartame
[+]

Aspartame is a multipotential carcinogenic agent even at doses well below the current acceptable daily intake. Mar 01, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Aspartame is associated with neurological dysfunction. Dec 01, 2007

Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame may induce redox and lipid imbalance in rats via mechanism that involves oxidative stress and depletion of glutathione-dependent system.Aug 05, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507
Article Published Date : Aug 05, 2015
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]

Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate. Jan 01, 2002

Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Formate
[+]

Aspartames break down product phenylalanine, can inhibit the protective effects of intestinal alkaline phosphatase.Nov 17, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Physiol Nutr Metab. 2016 Nov 18:1-7. Epub 2016 Nov 18. PMID: 27997218
Article Published Date : Nov 17, 2016
Study Type : Animal Study
Additional Links
Diseases : Insulin Resistance, Obesity
Additional Keywords : Artificial Sweeteners, aspartame, Insulin Resistance, obesity, Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
Adverse Pharmacological Actions : Obesogenic
[+]

Aspatame is associated with the creation of numerous cancers in rats. Sep 01, 2006

Pubmed Data : Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Bladder Cancer, Leukemia, Lymphoma, Renal Cancer, Schwannoma
Problem Substances : Aspartame
[+]

Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium.Sep 27, 2018

Pubmed Data : Metab Brain Dis. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30264280
Article Published Date : Sep 27, 2018
Study Type : Animal Study
Additional Links
Problem Substances : Acesulfame potassium , Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel.Aug 31, 2013

Pubmed Data : Arch Oral Biol. 2013 Sep ;58(9):1116-22. Epub 2013 Apr 28. PMID: 23631998
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Dental Caries
Problem Substances : Aspartame, Sucralose (aka Splenda), Sucrose
[+]

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Feb 1 ;11:701-707. Epub 2017 Feb 1. PMID: 28187322
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage
Problem Substances : Aspartame
[+]

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. Aug 31, 2012

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Excitotoxicity , Lipid Peroxidation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Exposure to very low doses of a mixture of chemicals induces genotoxic effects as well as monotonic cytotoxic effects in a tissue-dependent manner.Sep 11, 2019

Pubmed Data : Toxicol Lett. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31521832
Article Published Date : Sep 11, 2019
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Inflammation
Additional Keywords : Increased Risk, Synergistic Toxicity
Problem Substances : Aspartame, Bisphenol A , Glyphosate, Parabens, Sodium Benzoate
Adverse Pharmacological Actions : Genotoxic
[+]

Increased dopaminergic degeneration and complications with chronic aspartame consumption and more injury in male groups.Nov 01, 2017

Pubmed Data : Arch Physiol Biochem. 2017 Nov 2:1-8. Epub 2017 Nov 2. PMID: 29096532
Article Published Date : Nov 01, 2017
Study Type : Animal Study
Additional Links
Diseases : Parkinson's Disease
Problem Substances : Aspartame
[+]

Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model.Jan 31, 2021

Pubmed Data : Environ Toxicol. 2021 Feb ;36(2):223-237. Epub 2020 Sep 20. PMID: 32951320
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Aspartame
[+]

Life-span exposure to low doses of aspartame beginning during prenatal life increases leukemia and lymphoma rates in rats.Sep 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver.Jun 01, 2011

Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : ALT: Elevated, AST: Elevated, Chemically-Induced Liver Damage, Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Oxidant
[+]

Long-term aspartame administration leads to fibrosis, inflammasome activation, and gluconeogenesis impairment in the liver.Jan 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biology (Basel). 2021 Jan 22 ;10(2). Epub 2021 Jan 22. PMID: 33499218
Article Published Date : Jan 21, 2021
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fibrosis, Inflammation
Problem Substances : Aspartame
[+]

Long-term soft drink and aspartame intake induces hepatic damage.Apr 18, 2017

Pubmed Data : Nutr Res. 2017 Apr 19. Epub 2017 Apr 19. PMID: 28465000
Article Published Date : Apr 18, 2017
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Hyperglycemia
Additional Keywords : Increased Risk
Problem Substances : Aspartame, High Fructose Corn Syrup, Sugar Sweetened Beverages
[+]

N-acetyl-L-cysteine and folic acid can ameliorate the toxic effect of aspartame on the rat's cerebral cortex.Apr 30, 2018

Pubmed Data : Ultrastruct Pathol. 2018 May-Jun;42(3):228-245. Epub 2018 Feb 26. PMID: 29482444
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Folate, Folic Acid , NAC (N-acetyl-L-cysteine)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]

Omega-3 has neuroprotective effects against aspartame-induced neuronal and astrocytic degeneration.Dec 19, 2016

Pubmed Data : Anat Rec (Hoboken). 2016 Dec 20. Epub 2016 Dec 20. PMID: 27998013
Article Published Date : Dec 19, 2016
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

Oral aspartame significantly altered behaviour, anti-oxidant status and morphology of the hippocampus in mice.Dec 30, 2016

Pubmed Data : Neurobiol Learn Mem. 2016 Dec 31 ;139:76-88. Epub 2016 Dec 31. PMID: 28049023
Article Published Date : Dec 30, 2016
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Pimpinella anisum oil displays a protective action against aspartame neurotoxicity.Apr 30, 2014

Pubmed Data : Ultrastruct Pathol. 2014 May ;38(3):224-36. Epub 2014 Mar 31. PMID: 24684500
Article Published Date : Apr 30, 2014
Study Type : Animal Study
Additional Links
Substances : Anise
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Essential Oils
Problem Substances : Aspartame
[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Jun 18, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067
Article Published Date : Jun 18, 2013
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prediabetes
Problem Substances : Aspartame, Monosodium Glutamate (MSG), Trans Fatty Acids
Adverse Pharmacological Actions : Diabetogenic
[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Dec 31, 1969

Study Type : Animal Study
Additional Links
Diseases : Abdominal Obesity (Midsection Fat), Diabetes, Obesity, Overweight
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Diabetogenic, Obesogenic
[+]

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.Oct 18, 2012

Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Article Published Date : Oct 18, 2012
Study Type : Animal Study
Additional Links
Diseases : Appetite Disorders, Obesity, Overweight
Problem Substances : Aspartame, Saccharin
[+]

Seaweed Sargassum vulgare is a promising functional food ingredient to minimize aspartame-associated toxicity.Jul 22, 2020

Pubmed Data : Int J Environ Health Res. 2020 Jul 23:1-20. Epub 2020 Jul 23. PMID: 32705899
Article Published Date : Jul 22, 2020
Study Type : Animal Study
Additional Links
Substances : Seaweed
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspartame
[+]

Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.Feb 14, 2017

Pubmed Data : Pathophysiology. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28254270
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]

Subchronic intake of aspartame and soft drink significantly disrupted the brain energy production.Jun 27, 2017

Pubmed Data : Metab Brain Dis. 2017 Jun 28. Epub 2017 Jun 28. PMID: 28660358
Article Published Date : Jun 27, 2017
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

There was a significant decrease in sperm function of aspartame treated animals.Apr 26, 2017

Pubmed Data : Int J Impot Res. 2017 Apr 27. Epub 2017 Apr 27. PMID: 28446800
Article Published Date : Apr 26, 2017
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Aspartame
[+]

These findings demonstrate that aspartame metabolites could be a contributing factor for the development of oxidative stress in the brain.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Apr ;26(2):903-916. Epub 2017 Dec 6. PMID: 29567262
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

These findings suggest that long-term consumption of aspartame leads to hyperglycemia and hyperlipidemia, as well as to oxidative stress in erythrocytes.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biosci. 2014 Dec ;39(5):859-66. PMID: 25431414
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia, Hyperlipidemia, Lipid Peroxidation, Oxidative Stress
Additional Keywords : Increased Risk
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]

These results reveal that the aspartame molecule is inherently amyloidogenic.May 27, 2019

Pubmed Data : ACS Nano. 2019 May 28 ;13(5):6033-6049. Epub 2019 May 6. PMID: 31021591
Article Published Date : May 27, 2019
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

This study describes the fate of artificial sweeteners, including the fraction found in SPM and in sludge, in addition to the aqueous portion of wastewater in WWTPs.Dec 01, 2014

Pubmed Data : Environ Sci Technol. 2014 Dec 2 ;48(23):13668-74. Epub 2014 Nov 14. PMID: 25365516
Article Published Date : Dec 01, 2014
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollutant
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Vitamin E could ameliorate some of aspartames induced memory impairments and cortical cells loss in mPFC.Nov 20, 2017

Pubmed Data : Acta Histochem. 2017 Nov 21. Epub 2017 Nov 21. PMID: 29169694
Article Published Date : Nov 20, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.Mar 01, 2006

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity, Excitotoxicity , Neurodevelopmental Disorders
Additional Keywords : Drug-Plant-Vitamin Synergies
Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver. Mar 01, 2010

Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282
Article Published Date : Mar 01, 2010
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

Aspartame is broken down into formaldehyde in various tissues and may contribute to migraines. May 01, 2008

Pubmed Data : Dermatitis. 2008 May-Jun;19(3):E10-1. PMID: 18627677
Article Published Date : May 01, 2008
Study Type : Commentary
Additional Links
Diseases : Migraine Disorders
Problem Substances : Aspartame
[+]

Aspartame may be associated with certain mental disorders, compromised learning and emotional functioning. Apr 01, 2008

Pubmed Data : Eur J Clin Nutr. 2008 Apr;62(4):451-62. Epub 2007 Aug 8. PMID: 17684524
Article Published Date : Apr 01, 2008
Study Type : Review
Additional Links
Diseases : Emotional Disorders, Learning disorders, Mental Disorders
Problem Substances : Aspartame
[+]

Aspartame may be responsible for adverse neurobehavioral health outcomes.Feb 14, 2017

Pubmed Data : Nutr Neurosci. 2017 Feb 15:1-11. Epub 2017 Feb 15. PMID: 28198207
Article Published Date : Feb 14, 2017
Study Type : Review
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspartame metabolites have an adverse effect on human red blood cell enzyme activity. Jan 01, 2006

Pubmed Data : Pharmacol Res. 2006 Jan;53(1):1-5. Epub 2005 Aug 29. PMID: 16129618
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame
[+]

Aspartame significantly down-regulates mRNA expression of tumor suppressor gene p53 and apoptotic gene bax in the cancer cells.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2016 Jul ;23(4):503-6. Epub 2015 Jun 15. PMID: 27298583
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Cervical Cancer
Additional Keywords : Disease Progression, Risk Factors
Problem Substances : Aspartame
[+]

Aspartame, Acesulfame potassium and Saccharin have potential genotoxicity. Jan 01, 2008

Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Acesulfame potassium , Aspartame, Saccharin
[+]

Based on an animal study which showed aspartame contains cancer the FDA should reevaluate its position on aspartame being safe under all conditions. Oct 01, 2007

Pubmed Data : Int J Occup Environ Health. 2007 Oct-Dec;13(4):446-8. PMID: 18085058
Article Published Date : Oct 01, 2007
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

EFSA's toxicological assessment of aspartame: was it even-handedly trying to identify possible unreliable positives and unreliable negatives?Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Public Health. 2019 ;77:34. Epub 2019 Jul 15. PMID: 31338189
Article Published Date : Dec 31, 2018
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]

Formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxic effects on rat thymus cells. Jan 01, 2003

Pubmed Data : J Pharmacol Sci. 2003 Jan;91(1):83-6. PMID: 12686735
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Methanol
[+]

Long term consumption of artificial sweeteners might accelerate atherosclerosis and aging. May 01, 2011

Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Aging, Atherosclerosis
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Long-term consumption of aspartame led to a dose-dependent increased production of free radicals in renal tissues as well as kidney injury.Sep 30, 2017

Pubmed Data : Iran J Kidney Dis. 2017 Oct ;11(5):339-343. PMID: 29038387
Article Published Date : Sep 30, 2017
Study Type : Review
Additional Links
Substances : aspartame
Diseases : Kidney Diseases
Additional Keywords : aspartame, Kidney Diseases
Problem Substances : Aspartame
Adverse Pharmacological Actions : Hepatotoxic, Renotoxic
[+]

Measuring artificial sweeteners toxicity using a bioluminescent bacterial panel.Sep 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 25 ;23(10). Epub 2018 Sep 25. PMID: 30257473
Article Published Date : Sep 24, 2018
Study Type : In Vitro Study
Additional Links
Additional Keywords : Microbiome
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Sucralose (aka Splenda)
[+]

Omega-3 fatty acids may be a therapeutic agent to reduce the aspartame induced biochemical and morphological alterations in normal renal cells.Sep 06, 2017

Pubmed Data : Biofactors. 2017 Sep 7. Epub 2017 Sep 7. PMID: 28881099
Article Published Date : Sep 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : DNA damage
Pharmacological Actions : Renoprotective
Problem Substances : Aspartame
[+]

Sucralose and sodium saccharin seemed to elicit the greatest degree of DNA fragmentation of all the sweeteners tested in all the cell lines used.Dec 31, 2014

Pubmed Data : Drug Chem Toxicol. 2015 ;38(3):318-27. Epub 2014 Oct 15. PMID: 25317478
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Colon Cancer, DNA damage
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sodium Cyclamate
[+]

Sucralose, aspartame and saccharin have been shown to disrupt the balance and diversity of gut microbiota.Apr 13, 2016

Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Article Published Date : Apr 13, 2016
Study Type : Bacterial
Additional Links
Diseases : Dysbiosis, Metabolic Diseases
Additional Keywords : Microbiota, Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

The consumption of aspartame is associated with higher serum levels of a benzene metabolite associated with blood disorders and leukemia. Jan 01, 2006

Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134
Article Published Date : Jan 01, 2006
Study Type : Commentary
Additional Links
Diseases : Hematologic Diseases, Leukemia
Problem Substances : Aspartame, Benzene
[+]

This review provides evidence that raise concerns that aspartame may exacerbate T2D and add to the global burden of disease.May 30, 2017

Pubmed Data : Curr Diabetes Rev. 2017 May 31. Epub 2017 May 31. PMID: 28571543
Article Published Date : May 30, 2017
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]

Toxic effects of aspartame metabolites on astrocytes and neurons.Dec 31, 2012

Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Diseases : Brain Cancer, Glioma, Medulloblastoma, Meningioma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic

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