Aspirin

Name	AC	CK
Aspirin-Induced Toxicity	26	99
Cardiovascular Diseases	7	71
Cardiac Mortality	6	60
Coronary Artery Disease	5	60
Gastric Ulcer	13	48
Drug-Induced Toxicity	4	34
Helicobacter Pylori Infection	3	32
Diabetes: Cardiovascular Illness	2	30
Hearing Loss	6	30
Myocardial Infarction	2	30
Stroke	3	30
Gastroduodenal Ulcer	3	22
Gastrointestinal Hemorrhage	3	21
Cerebral Aneurysm	2	20
Cerebral Ischemia	2	20
Coronary Stenting	2	20
Diabetes Mellitus: Type 2	1	20
Drug-Induced Toxicity: Gastrointestinal	2	20
Gastric Ulcers	1	20
Subarachnoid hemorrhage	2	20
Thromboembolism	1	20
Inflammation	5	17
Acetaminophen (Tylenol) Toxicity	2	12
Duodenal Ulcer	2	12
NSAID-induced toxicity	2	12
Anemia: Hemolytic	1	10
Aspirin-Exacerbated Respiratory Disease (AERD)	1	10
Bipolar Disorder	1	10
Brain Hemorrhage: Cerebral	1	10
Brain Injury: Traumatic	1	10
Brain Ischemia	1	10
Common Cold	1	10
Depression	1	10
Diverticular Disease	1	10
Diverticular Disease: Bleeding	1	10
Elderly: Age Specific Diseases	1	10
Encephalitis	1	10
Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient)	1	10
Glucosephosphate Dehydrogenase Deficiency	1	10
Heart Attack	1	10
Hemodialysis	1	10
Hepatitis	1	10
Hypoxia	1	10
Intracranial Hemmorhage	1	10
Intraocular Hemorrhage	1	10
Macular Degeneration	1	10
Mortality: All-Cause	1	10
Osteoporosis	1	10
Pain	1	10
Rhinovirus Infection	1	10
Tinnitus	5	9
Oxidative Stress	4	8
Kidney Damage: Drug-Induced	2	4
Wound Healing	2	4
Wound Healing: Delayed	2	4
Arthritis: Juvenile Rheumatoid	1	3
Esophageal Cancer	1	3
Rheumatoid Arthritis	1	3
Breast Cancer	1	2
Cancer Mortality	1	2
Chronic Pain	1	2
Cold and Flu: Infants & Children	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Fatty Acid Disorders/Imbalances: Arachidonic Acid	1	2
Febrile Seizures	1	2
Fever	1	2
Gastrointestinal Inflammation	1	2
Hyperglycemia	1	2
Hypoglycemia	1	2
Influenza	1	2
Influenza: Mortality	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Radiation-Induced Illness: Plutonium	1	2
Vitamin E Deficiency	1	2
Anemia	1	1
Drug-Induced Nutrient Depletion: Aspirin	1	1
Hypersensitivity	1	1
Immune Disorders: Low Immune Function	1	1
Reye Syndrome	1	1
Stroke: Prevention	1	1
Thrombosis	1	1
Vitamin C Deficiency	1	1

Name	AC	CK
Cardiotoxic	4	50
Ulcerogenic	3	22
Gastrotoxic	2	20
Bronchoconstriction	1	10
Hemolytic	1	10
Hemorrhagic	1	10
Immunosuppressive	1	10
Neurotoxic	5	10
Immunotoxic	1	1

[+]

Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Cardiovascular Diseases, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Problem Substances : Aspirin

[+]

long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women. Oct 16, 2007

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Pubmed Data : Ann Intern Med. 2007 Oct 16;147(8):525-33. PMID: 17938390

Article Published Date : Oct 16, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Thromboembolism

Problem Substances : Aspirin

[+]

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.Oct 19, 2010

Click here to read the entire abstract

Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85. PMID: 20946994

Article Published Date : Oct 19, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Myocardial Infarction

Problem Substances : Aspirin

Adverse Pharmacological Actions : Cardiotoxic

[+]

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.Mar 01, 2010

Click here to read the entire abstract

Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity , Hearing Loss

Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol

[+]

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Click here to read the entire abstract

Pubmed Data : J Gastroenterol Hepatol. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30408229

Article Published Date : Nov 07, 2018

Study Type : Meta Analysis

Additional Links

Diseases : Aspirin-Induced Toxicity , Gastric Ulcers, Helicobacter Pylori Infection

Additional Keywords : Increased Risk

Problem Substances : Aspirin

[+]

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

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Pubmed Data : J Infect Dis. 1990 Dec ;162(6):1277-82. PMID: 2172402

Article Published Date : Nov 30, 1990

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Common Cold, Rhinovirus Infection

Additional Keywords : Increased Risk, Viral Shedding

Problem Substances : Acetaminophen, Aspirin , Ibuprofen, Paracetamol

Adverse Pharmacological Actions : Immunosuppressive

[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Click here to read the entire abstract

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic

[+]

Antiplatelet therapy does not appear to improve outcome in patients with cerebral aneurysm (subarachnoid hemorrhage).Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Stroke. 2009 Jun;40(6):1969-72. Epub 2009 Apr 23. PMID: 19390079

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cerebral Aneurysm, Subarachnoid hemorrhage

Problem Substances : Antiplatelet Drugs, Aspirin

[+]

Aspirin (Acetylsalicylic acid) may cause severe hemolytic anemia in some glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient) individuals. Jul 01, 1970

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Pubmed Data : J Clin Invest. 1970 Jul;49(7):1334-40. PMID: 5432368

Article Published Date : Jul 01, 1970

Study Type : Human Study

Additional Links

Diseases : Anemia: Hemolytic, Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient), Glucosephosphate Dehydrogenase Deficiency

Problem Substances : Aspirin

Adverse Pharmacological Actions : Hemolytic

[+]

Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

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Pubmed Data : Neurol Res. 1999 Jul;21(5):488-90. PMID: 10439430

Article Published Date : Jul 01, 1999

Study Type : Human Study

Additional Links

Diseases : Brain Ischemia, Cerebral Ischemia, Stroke

Problem Substances : Aspirin

[+]

Aspirin causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. Nov 01, 2009

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Pubmed Data : Curr Med Res Opin. 2009 Nov;25(11):2785-93. PMID: 19788350

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Diseases : Duodenal Ulcer, Gastric Ulcer, Gastroduodenal Ulcer

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Aspirin given after aneurysm treatment does not appreciably reduce the occurrence of delayed ischemic neurological deficit.Sep 01, 2006

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Pubmed Data : Stroke. 2006 Sep;37(9):2326-30. Epub 2006 Aug 3. PMID: 16888270

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Diseases : Cerebral Aneurysm, Cerebral Ischemia, Subarachnoid hemorrhage

Problem Substances : Aspirin

[+]

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

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Pubmed Data : Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9. PMID: 19672841

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Cardiovascular Diseases, Diabetes: Cardiovascular Illness

Problem Substances : Aspirin

[+]

Aspirin is a risk factor for colonic diverticular bleedingDec 24, 2012

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Pubmed Data : Korean J Gastroenterol. 2012 Dec 25 ;60(6):349-54. PMID: 23242017

Article Published Date : Dec 24, 2012

Study Type : Human Study

Additional Links

Diseases : Diverticular Disease, Diverticular Disease: Bleeding

Problem Substances : Aspirin

Adverse Pharmacological Actions : Hemorrhagic

[+]

Aspirin may contribute to the development of CD in a middle-aged to elderly populationSep 01, 2011

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Pubmed Data : Aliment Pharmacol Ther. 2011 Sep ;34(6):649-55. Epub 2011 Jul 26. PMID: 21790683

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Diseases : Elderly: Age Specific Diseases

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Aspirin treatment reduces ischemic strokes while increasing hemorrhagic stroke. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Curr Top Med Chem. 2009;9(14):1298-316. PMID: 19849660

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Stroke

Problem Substances : Aspirin

[+]

Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in the elderly.May 01, 1998

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Pubmed Data : Stroke. 1998 May;29(5):887-94. PMID: 9596230

Article Published Date : May 01, 1998

Study Type : Human Study

Additional Links

Diseases : Stroke

Problem Substances : Aspirin

[+]

Aspirin use was not found to lower the risk of heart attack or death from cardiovascular causes. Mar 31, 2005

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Pubmed Data : N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7. PMID: 15753114

Article Published Date : Mar 31, 2005

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Myocardial Infarction

Problem Substances : Aspirin

[+]

Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding. Mar 01, 2010

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Pubmed Data : Am J Med. 2010 Mar;123(3):250-8. PMID: 20193834

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Heart Attack

Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin

[+]

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

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Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798

Article Published Date : Aug 01, 1997

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate

Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic

[+]

Bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs has been observed and labeled as Aspirin-exacerbated respiratory disease (AERD. Jan 01, 2012

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Pubmed Data : J Allergy (Cairo). 2012 ;2012:794890. Epub 2011 Aug 7. PMID: 21837245

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Diseases : Aspirin-Exacerbated Respiratory Disease (AERD)

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Bronchoconstriction

[+]

Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.Apr 01, 2006

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Pubmed Data : J Invasive Cardiol. 2006 Apr;18(4):162-4. PMID: 16729401

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease, Coronary Stenting

Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin , Clopidogrel, Warfarin

[+]

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

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Pubmed Data : Pediatrics. 1987 Jun ;79(6):858-63. PMID: 3588140

Article Published Date : Jun 01, 1987

Study Type : Human Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Encephalitis, Hepatitis

Problem Substances : Aspirin

[+]

In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes.Jun 06, 2012

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Pubmed Data : JAMA. 2012 Jun 6 ;307(21):2286-94. PMID: 22706834.1

Article Published Date : Jun 06, 2012

Study Type : Human Study

Additional Links

Diseases : Brain Hemorrhage: Cerebral, Gastrointestinal Hemorrhage

Problem Substances : Aspirin

[+]

In healthy individuals using aspirin 80% experience small bowel mucosal injury. Jan 01, 2009

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Pubmed Data : Digestion. 2009;79(1):44-51. Epub 2009 Feb 26. PMID: 19246922

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Problem Substances : Aspirin

[+]

In patients undergoing percutaneous coronary intervention with drug-eluting stents the use of proton pump inhibitors was associated with a greater rate of major adverse cardiac events.Mar 15, 2010

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Pubmed Data : Am J Cardiol. 2010 Mar 15;105(6):833-8. PMID: 20211327

Article Published Date : Mar 15, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Cardiovascular Diseases, Coronary Stenting

Problem Substances : Aspirin

Adverse Pharmacological Actions : Cardiotoxic

[+]

Lactobacillus complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.May 08, 2022

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Pubmed Data : Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Article Published Date : May 08, 2022

Study Type : Human Study

Additional Links

Substances : Enterococcus faecium, Lactobacillus rhamnosus

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

Low-dose aspirin has been linked to gastroduodenal ulcer. Nov 20, 2009

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Pubmed Data : Dig Dis Sci. 2009 Nov 20. Epub 2009 Nov 20. PMID: 19936921

Article Published Date : Nov 20, 2009

Study Type : Human Study

Additional Links

Diseases : Gastroduodenal Ulcer

Problem Substances : Aspirin

[+]

N-acetylcysteine could be associated with a reduction in depressive symptoms.Dec 03, 2018

Click here to read the entire abstract

Pubmed Data : J Clin Psychiatry. 2018 Dec 4 ;80(1). Epub 2018 Dec 4. PMID: 30549489

Article Published Date : Dec 03, 2018

Study Type : Human Study

Additional Links

Substances : Cysteine (see N-Acetylcysteine)

Diseases : Bipolar Disorder, Depression

Pharmacological Actions : Antidepressive Agents

Problem Substances : Aspirin

[+]

Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality.Feb 15, 2003

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Pubmed Data : Lancet. 2003 Feb 15;361(9357):573-4. PMID: 12598144

Article Published Date : Feb 15, 2003

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Cardiovascular Diseases, Mortality: All-Cause

Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Cardiotoxic

[+]

Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection.Oct 28, 2011

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2011 Oct 28 ;17(40):4509-16. PMID: 22110282

Article Published Date : Oct 28, 2011

Study Type : Human Study

Additional Links

Diseases : Helicobacter Pylori Infection

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Patients with recurrent urticaria and angio-edema show significant improvement when they refrain from using aspirin, benzoates and azo dyes. Jul 01, 1976

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Pubmed Data : Br J Dermatol. 1976 Jul;95(1):19-24. PMID: 952737

Article Published Date : Jul 01, 1976

Study Type : Human Study

Additional Links

Problem Substances : Aspirin , Azo Dyes, Food Colorings, Sodium Benzoate

[+]

Pill-induced esophageal injury is a common occurence.Aug 01, 2005

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Pubmed Data : Endoscopy. 2005 Aug;37(8):740-4. PMID: 16032493

Article Published Date : Aug 01, 2005

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Bisphosphonates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Potassium Chloride

[+]

Preoperative use of aspirin plus clopidogrel is associated with an increased risk of infection after coronary artery bypass surgery. Apr 27, 2009

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Pubmed Data : Arch Intern Med. 2009 Apr 27;169(8):788-96. PMID: 19398691

Article Published Date : Apr 27, 2009

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease

Problem Substances : Aspirin , Clopidogrel

[+]

Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. Apr 15, 1999

Click here to read the entire abstract

Pubmed Data : Am J Cardiol. 1999 Apr 15;83(8):1147-51. PMID: 10215274

Article Published Date : Apr 15, 1999

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Coronary Artery Disease

Problem Substances : Aspirin

Adverse Pharmacological Actions : Cardiotoxic

[+]

Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Stroke. 2006 Jan;37(1):129-33. Epub 2005 Dec 1. PMID: 16322483

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Salicylic acid, a non-steroidal anti-inflammatory drug, is present in fruits and vegetables and is found in higher concentrations in vegetarians than non-vegetarians.Jun 30, 2001

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Pathol. 2001 Jul ;54(7):553-5. PMID: 11429429

Article Published Date : Jun 30, 2001

Study Type : Human Study

Additional Links

Substances : Salicylic acid

Diseases : Inflammation, Pain

Therapeutic Actions : Dietary Modification: Vegetarian

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.Jan 14, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2011 Jan 14 ;17(2):226-30. PMID: 21245996

Article Published Date : Jan 14, 2011

Study Type : Human Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Gastrointestinal Hemorrhage, NSAID-induced toxicity

Pharmacological Actions : Anti-Ulcer Agents

Problem Substances : Aspirin

[+]

The evidence is not clear that aspirin is effective in the primary prevention of major cardiovascular events in people with diabetes. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : BMJ. 2009;339:b4531. Epub 2009 Nov 6. PMID: 19897665

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Problem Substances : Aspirin

[+]

The risks of aspirin therapy may outweigh the benefits for primary prevention of cardiovascular disease. Feb 01, 2010

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Pubmed Data : Evid Based Med. 2010 Feb;15(1):31-3. PMID: 20176886

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases

Problem Substances : Aspirin

[+]

The severity of gastric mucosal injury produced by aspirin was significantly greater in the morning compared to the evening.Dec 31, 1986

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Pubmed Data : Chronobiol Int. 1987 ;4(1):111-6. PMID: 3677213

Article Published Date : Dec 31, 1986

Study Type : Human Study

Additional Links

Additional Keywords : Circadian Rhythm

Problem Substances : Aspirin

[+]

The use of a combination of clopidogrel and aspirin after coronary artery bypass surgery is associated with adverse events. Dec 01, 2001

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Pubmed Data : Crit Care Med. 2001 Dec;29(12):2271-5. PMID: 11801823

Article Published Date : Dec 01, 2001

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease

Problem Substances : Aspirin , Clopidogrel

[+]

There is an association between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration.Jun 01, 2000

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Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2000 Jun;238(6):482-5. PMID: 10943671

Article Published Date : Jun 01, 2000

Study Type : Human Study

Additional Links

Diseases : Intraocular Hemorrhage, Macular Degeneration

Problem Substances : Anticoagulants, Aspirin

[+]

There is high mortality rate associated with aspirin or clopidogrel or both in elderly patients who have head trauma resulting in intracranial hemmorhage. Oct 01, 2008

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Pubmed Data : J Trauma. 2008 Oct;65(4):785-8. PMID: 18849791

Article Published Date : Oct 01, 2008

Study Type : Human Study

Additional Links

Diseases : Brain Injury: Traumatic, Intracranial Hemmorhage

Problem Substances : Aspirin , Clopidogrel

[+]

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

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Pubmed Data : Eur J Clin Invest. 1999 May;29(5):438-44. PMID: 10354201

Article Published Date : May 01, 1999

Study Type : Human Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Hypoxia

Problem Substances : Aspirin

[+]

Warfarin, aspirin, or clopidogrel prescription is associated with higher mortality among hemodialysis patients.Apr 01, 2009

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Pubmed Data : J Am Soc Nephrol. 2009 Apr;20(4):872-81. Epub 2009 Mar 18. PMID: 19297555

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hemodialysis

Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin , Clopidogrel, Thrombolytics, Warfarin

[+]

Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries.Dec 31, 2016

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Pubmed Data : Digestion. 2017 ;95(1):49-54. Epub 2017 Jan 5. PMID: 28052291

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Lactobacillus gasseri, Yoghurt

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

Problem Substances : Aspirin

[+]

"Esophageal mucosal lesion with low-dose aspirin and prasugrel mimics malignancy: a case report."Sep 21, 2011

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2011 Sep 21 ;17(35):4048-51. PMID: 22046096

Article Published Date : Sep 21, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Esophageal Cancer

Pharmacological Actions : Platelet Aggregation Inhibitors

Additional Keywords : Misdiagnosis Of Malignancy

Problem Substances : Aspirin

[+]

Hearing loss due to aspirin has been reported.Feb 01, 2009

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Pubmed Data : Ther Drug Monit. 2009 Feb;31(1):1-2. PMID: 19155962

Article Published Date : Feb 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity , Hearing Loss

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Neurotoxic

[+]

[Long-term remission induced by measles infection and followed by immunosuppressive therapy in a case of refractory juvenile rheumatoid arthritis].Feb 29, 1988

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Pubmed Data : Pediatr Med Chir. 1988 Mar-Apr;10(2):191-3. PMID: 3174483

Article Published Date : Feb 29, 1988

Study Type : Human: Case Report

Additional Links

Diseases : Arthritis: Juvenile Rheumatoid, Rheumatoid Arthritis

Additional Keywords : Health Benefits of Measles Infection

Problem Substances : Aspirin

[+]

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."Aug 01, 2011

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Pubmed Data : J Physiol Pharmacol. 2011 Aug ;62(4):491-6. PMID: 22100851

Article Published Date : Aug 01, 2011

Study Type : Animal Study

Additional Links

Substances : Phosphatidylcholine

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

"Female But Not Male Mice Show Delayed Cutaneous Wound Healing By Aspirin Administration."Dec 13, 2012

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Pubmed Data : Clin Exp Pharmacol Physiol. 2012 Dec 14. Epub 2012 Dec 14. PMID: 23240590

Article Published Date : Dec 13, 2012

Study Type : Animal Study

Additional Links

Diseases : Wound Healing, Wound Healing: Delayed

Problem Substances : Aspirin

[+]

An ethanolic extract of curcuma longa ointment containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.Feb 28, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2015 Mar-Apr;47(2):160-6. PMID: 25878374

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Turmeric

Diseases : Wound Healing, Wound Healing: Delayed

Problem Substances : Aspirin

[+]

Antihyperglycemic and antinociceptive activity evaluation of 'khoyer' prepared from boiling the wood of Acacia catechu in water.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Afr J Tradit Complement Altern Med. 2013 ;10(4):1-5. Epub 2013 May 16. PMID: 24146493

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Acacia catechu

Diseases : Chronic Pain, Hyperglycemia

Pharmacological Actions : Analgesics, Hypoglycemic Agents

Additional Keywords : Phytotherapy

Problem Substances : Aspirin

[+]

Antipyretics increase influenza-associated mortality.Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Aspirin-Induced Toxicity , Influenza, Influenza: Mortality

Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID: 29397336

Article Published Date : Mar 31, 2018

Study Type : Animal Study

Additional Links

Substances : Artesunate

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Aspirin

[+]

Aspirin (Acetylsalicylic acid) does not prevent arachidonic acid induced cardiac mortality in an animal model.Sep 01, 1980

Click here to read the entire abstract

Pubmed Data : Biull Eksp Biol Med. 1980 Sep;90(9):276-9. PMID: 7426725

Article Published Date : Sep 01, 1980

Study Type : Animal Study

Additional Links

Diseases : Fatty Acid Disorders/Imbalances: Arachidonic Acid

Problem Substances : Aspirin

[+]

Aspirin causes permanent reductions in neural activity in the cochlea and auditory brainstem response.Jun 14, 2010

Click here to read the entire abstract

Pubmed Data : Hear Res. 2010 Jun 14;265(1-2):63-9. Epub 2010 Mar 6. PMID: 20214971

Article Published Date : Jun 14, 2010

Study Type : Animal Study

Additional Links

Diseases : Hearing Loss, Tinnitus

Problem Substances : Aspirin

Adverse Pharmacological Actions : Neurotoxic

[+]

Aspirin chemically modifies human hemoglobin through acetylation.Jul 01, 1975

Click here to read the entire abstract

Pubmed Data : J Clin Invest. 1975 Jul;56(1):201-7. PMID: 237937

Article Published Date : Jul 01, 1975

Study Type : Animal Study

Additional Links

Problem Substances : Aspirin

[+]

Aspirin may be contraindicated in children with febrile illness because it causes gastrointestinal bleeding.Sep 01, 1989

Click here to read the entire abstract

Pubmed Data : Taiwan Yi Xue Hui Za Zhi. 1989 Sep;88(9):869-73. PMID: 2621427

Article Published Date : Sep 01, 1989

Study Type : Animal Study

Additional Links

Diseases : Cold and Flu: Infants & Children , Febrile Seizures, Fever

Problem Substances : Aspirin

[+]

Aspirin may exacerbate the adverse effects of vitamin E deficiency.Oct 01, 1980

Click here to read the entire abstract

Pubmed Data : J Nutr. 1980 Oct;110(10):1958-64. PMID: 7420204

Article Published Date : Oct 01, 1980

Study Type : Animal Study

Additional Links

Diseases : Vitamin E Deficiency

Problem Substances : Aspirin

[+]

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Gastroprotective, Superoxide Dismutase Up-regulation

Problem Substances : Aspirin

[+]

Basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers.Aug 14, 2018

Click here to read the entire abstract

Pubmed Data : Food Funct. 2018 Aug 15 ;9(8):4457-4468. PMID: 30073231

Article Published Date : Aug 14, 2018

Study Type : Animal Study

Additional Links

Substances : Basil

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastroprotective, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aspirin

[+]

Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin.Jan 05, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Metab (Lond). 2021 Jan 6 ;18(1):4. Epub 2021 Jan 6. PMID: 33407626

Article Published Date : Jan 05, 2021

Study Type : Animal Study

Additional Links

Substances : Goji

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.Mar 02, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 Mar 3 ;14:81. Epub 2014 Mar 3. PMID: 24589018

Article Published Date : Mar 02, 2014

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Aspirin-Induced Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Aspirin

[+]

Dual anti-platelet therapy might pose a hazard when applied to a patient with undiagnosed and untreated malignant cancer prone to undergo vascular mimicry.Apr 02, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2018 Apr 3 ;9(25):17810-17824. Epub 2018 Apr 3. PMID: 29707148

Article Published Date : Apr 02, 2018

Study Type : Animal Study

Additional Links

Diseases : Breast Cancer, Cancer Mortality

Additional Keywords : Increased Risk, Molecular Mimicry

Problem Substances : Aspirin , Clopidogrel

[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Aspirin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Gastric mucosal protection by aegle marmelos against gastric mucosal damage.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Saudi J Gastroenterol. 2015 Jan-Feb;21(1):35-42. PMID: 25672237

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bael

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Gastroprotective

Additional Keywords : Plant Extracts

Problem Substances : Aspirin

[+]

High doses of salicylate (aspirin) increase the gain of the central auditory system, presumably by down-regulating GABA-mediated inhibition, leading to an exaggerated acoustic startle response.Mar 03, 2009

Click here to read the entire abstract

Pubmed Data : Neuroscience. 2009 Mar 3;159(1):325-34. Epub 2008 Dec 24. PMID: 19154777

Article Published Date : Mar 03, 2009

Study Type : Animal Study

Additional Links

Diseases : Tinnitus

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.Feb 13, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2014 Feb 14 ;20(6):1614-22. PMID: 24587639

Article Published Date : Feb 13, 2014

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Aspirin-Induced Toxicity , Gastrointestinal Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aspirin

[+]

Long-term administration of salicylate (aspirin) may adversely effect presin levels resulting in tinnitus.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Int J Audiol. 2009 Jan;48(1):18-23. PMID: 19173110

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Hearing Loss, Tinnitus

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Neurotoxic

[+]

Nigella Sativa extract has shown protective effects on kidneys against aspirin-induced damage.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : J Ayub Med Coll Abbottabad. 2021 Jan-Mar;33(1):39-43. PMID: 33774952

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Aspirin

[+]

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.Sep 30, 2018

Click here to read the entire abstract

Pubmed Data : J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Aspirin

[+]

Olive-derived hydroxytyrosol shows anti-inflammatory effect without gastric damage in rats.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2019 ;42(7):1120-1127. PMID: 31257288

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents

Problem Substances : Aspirin

[+]

Protective effect of essential oil from Citrus limon against aspirin-induced toxicity.Dec 18, 2018

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2018 Dec 19:960327118819044. Epub 2018 Dec 19. PMID: 30565488

Article Published Date : Dec 18, 2018

Study Type : Animal Study

Additional Links

Substances : Lemon

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Antioxidants, Cytoprotective, Gastroprotective

Additional Keywords : Essential Oils

Problem Substances : Aspirin

[+]

Protective effects of dried mature Citrus unshiu peel (Chenpi) and hesperidin on aspirin-induced oxidative damage.Feb 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Biochem Nutr. 2021 Mar ;68(2):149-155. Epub 2020 Oct 13. PMID: 33879966

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Satsuma

Diseases : Aspirin-Induced Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Aspirin

[+]

Royal jelly has potent anti-inflammatory effects compared to aspirin and it could be used in the treatment of inflammation.Jan 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Jundishapur J Nat Pharm Prod. 2015 Feb ;10(1):e22466. Epub 2015 Feb 20. PMID: 25866724

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Royal Jelly

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Aspirin

[+]

Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:314-321. Epub 2018 Nov 3. PMID: 30396089

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Gastroprotective, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aspirin

[+]

Spirulina supplements: an approach moderating aspirin persuaded histological and ultra-structural alterations in albino rats gastric mucosa.Mar 03, 2022

Click here to read the entire abstract

Pubmed Data : Ultrastruct Pathol. 2022 Mar 4 ;46(2):204-216. PMID: 35333148

Article Published Date : Mar 03, 2022

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Gastroprotective

Problem Substances : Aspirin

[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666

Article Published Date : Feb 05, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

The administration of aspirin increases the retention of plutonium 238 in the skeleton of rats.Apr 01, 1983

Click here to read the entire abstract

Pubmed Data : Radiat Res. 1983 Apr;94(1):89-96. PMID: 6856771

Article Published Date : Apr 01, 1983

Study Type : Animal Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Radiation-Induced Illness: Plutonium

Additional Keywords : Problem Substance Synergy

Problem Substances : Aspirin , Plutonium 238

[+]

The protective effect of Citrus limon essential oil on hepatotoxicity and nephrotoxicity induced by aspirin.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:1327-1334. Epub 2016 Aug 27. PMID: 27571876

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Lemon

Diseases : Aspirin-Induced Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Essential Oils

Problem Substances : Aspirin

[+]

There is evidence that aspirin causing tinnitus in the rat model.Feb 17, 2010

Click here to read the entire abstract

Pubmed Data : Neuroscience. 2010 Feb 17;165(4):1323-32. Epub 2009 Dec 1. PMID: 19958810

Article Published Date : Feb 17, 2010

Study Type : Animal Study

Additional Links

Diseases : Hearing Loss, Tinnitus

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Neurotoxic

[+]

Toxic-induced hypoglycemia in clinical practice.Jan 01, 2004

Click here to read the entire abstract

Pubmed Data : Rom J Intern Med. 2004;42(2):447-55. PMID: 15529635

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Hypoglycemia

Problem Substances : Anti-diabetic drugs, Aspirin , Beta Blockers, Ethanol

[+]

Zucchini has a protective effect against aspirin induced gastric and duodenal ulcer in rats. Sep 01, 2008

Click here to read the entire abstract

Pubmed Data : Indian J Exp Biol. 2008 Sep;46(9):639-45. PMID: 18949893

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Zucchini

Diseases : Aspirin-Induced Toxicity , Duodenal Ulcer, Gastric Ulcer, Gastroduodenal Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Additional Keywords : Plant Extracts

Problem Substances : Aspirin

[+]

"Acetylsalicylate and salicylates in foods."Mar 18, 1997

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 1997 Mar 19 ;114(1-2):163-4. PMID: 9103279

Article Published Date : Mar 18, 1997

Study Type : Review

Additional Links

Problem Substances : Aspirin

[+]

Aspirin can reduce the absorption of Vitamin C in the human body.Apr 12, 2020

Click here to read the entire abstract

Pubmed Data : Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 13 ;236:118356. Epub 2020 Apr 13. PMID: 32325408

Article Published Date : Apr 12, 2020

Study Type : In Vitro Study

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Aspirin, Vitamin C Deficiency

Additional Keywords : Risk Factors

Problem Substances : Aspirin

[+]

Aspirin causes gastric mucosal cell injury in vitro by reducing intracellular pH,Jan 01, 1993

Click here to read the entire abstract

Pubmed Data : J Clin Gastroenterol. 1993;17 Suppl 1:S1-4. PMID: 8283002

Article Published Date : Jan 01, 1993

Study Type : In Vitro Study

Additional Links

Problem Substances : Aspirin

[+]

Aspirin has been associated with a significant increase in mortality and antagonism of clot lysis in clinical and animal studies, respectively. Aug 01, 1997

Click here to read the entire abstract

Pubmed Data : Exp Neurol. 1997 Aug;146(2):513-7. PMID: 9270062

Article Published Date : Aug 01, 1997

Study Type : Commentary

Additional Links

Diseases : Thrombosis

Problem Substances : Aspirin

[+]

Aspirin in combination with hydrogen peroxide causes hemolysis, in vitro. Sep 01, 1978

Click here to read the entire abstract

Pubmed Data : Pediatr Res. 1978 Sep;12(9):927-31. PMID: 714540

Article Published Date : Sep 01, 1978

Study Type : In Vitro Study

Additional Links

Problem Substances : Aspirin

[+]

Aspirin may inhibit lymphocyte function. Aug 01, 2008

Click here to read the entire abstract

Pubmed Data : Bosn J Basic Med Sci. 2008 Aug;8(3):210-3. PMID: 18816250

Article Published Date : Aug 01, 2008

Study Type : Commentary

Additional Links

Diseases : Immune Disorders: Low Immune Function

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Immunotoxic

[+]

Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation.Feb 20, 2022

Click here to read the entire abstract

Pubmed Data : Food Funct. 2022 Feb 21 ;13(4):2336-2353. Epub 2022 Feb 21. PMID: 35142767

Article Published Date : Feb 20, 2022

Study Type : In Vitro Study

Additional Links

Substances : Royal Jelly

Diseases : Brain Inflammation , Memory Disorders

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents, Gastroprotective, Interleukin-6 Downregulation, Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Aspirin

[+]

Gastric protective activities of fucoidan from brown alga Kjellmaniella crassifolia through the NF-κB signaling pathway.Jan 19, 2020

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2020 Jan 20. Epub 2020 Jan 20. PMID: 31972198

Article Published Date : Jan 19, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aspirin

[+]

HLA-related and other genetic markers involved in severe hypersensitivity reactions to aspirin and other drugsJul 31, 2010

Click here to read the entire abstract

Pubmed Data : Curr Opin Allergy Clin Immunol. 2010 Aug ;10(4):280-90. PMID: 20485159

Article Published Date : Jul 31, 2010

Study Type : Review

Additional Links

Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity , Hypersensitivity

Problem Substances : Allopurinol, Antibiotics, Aspirin

[+]

Long-term low-dose aspirin therapy may not be effective in preventing cardiovascular disease and may double the risk of gastrointestinal bleeding.Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Drug Ther Bull. 2009 Nov;47(11):122-5. PMID: 19887685

Article Published Date : Nov 01, 2009

Study Type : Commentary

Additional Links

Diseases : Cardiovascular Diseases, Gastrointestinal Hemorrhage

Problem Substances : Aspirin

[+]

Non-steroidal anti-inflammatory drugs exhibit direct cytotoxicity against erthyrocytes (red blood cells) in vitro in an acidic media. Dec 01, 2002

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2002 Dec;57(12):848-51. PMID: 12561250

Article Published Date : Dec 01, 2002

Study Type : In Vitro Study

Additional Links

Diseases : Anemia

Problem Substances : Aspirin , Ibuprofen, Indomethacin, Meloxicam, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.Mar 01, 1987

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 1987 Mar ;84(5):1417-20. PMID: 3103135

Article Published Date : Mar 01, 1987

Study Type : In Vitro Study

Additional Links

Substances : Salicylic acid

Diseases : Inflammation

Pharmacological Actions : Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Aspirin

[+]

Protective effects of essential oil of Citrus limon against aspirin-induced toxicity in IEC-6 cells.Apr 30, 2017

Click here to read the entire abstract

Pubmed Data : Appl Physiol Nutr Metab. 2017 May ;42(5):479-486. Epub 2016 Dec 15. PMID: 28177735

Article Published Date : Apr 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lemon

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Essential Oils

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

The active ingredient in aspirin is sodium salicyclate which induces degeneration of cochlea spiral ganglion neurons. This may explain why aspirin use has been associated wtih Reye's syndrome, tinnitus and hearing loss.Jun 16, 2010

Click here to read the entire abstract

Pubmed Data : Neuroscience. 2010 Jun 16;168(1):288-99. Epub 2010 Mar 15. PMID: 20298761

Article Published Date : Jun 16, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Hearing Loss, Reye Syndrome, Tinnitus

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Neurotoxic

[+]

The aqueous extracts of the leaves of Gymnema sylvestre possess anti ulcerogenic, Anti allergic, Anti stress, properties.Feb 21, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 Feb 22 ;14:70. Epub 2014 Feb 22. PMID: 24559073

Article Published Date : Feb 21, 2014

Study Type : In Vitro Study

Additional Links

Substances : Gymnema Sylvestre

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Aspirin

[+]

The combination of clopidogrel and aspirin may be harmful, compared with aspirin alone.Nov 01, 2007

Click here to read the entire abstract

Pubmed Data : Curr Treat Options Neurol. 2007 Nov;9(6):442-50. PMID: 18173943

Article Published Date : Nov 01, 2007

Study Type : Commentary

Additional Links

Diseases : Stroke: Prevention

Additional Keywords : Drug Interaction

Problem Substances : Aspirin , Clopidogrel

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Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women. Oct 16, 2007

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.Oct 19, 2010

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.Mar 01, 2010

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Antiplatelet therapy does not appear to improve outcome in patients with cerebral aneurysm (subarachnoid hemorrhage).Jun 01, 2009

Aspirin (Acetylsalicylic acid) may cause severe hemolytic anemia in some glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient) individuals. Jul 01, 1970

Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

Aspirin causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. Nov 01, 2009

Aspirin given after aneurysm treatment does not appreciably reduce the occurrence of delayed ischemic neurological deficit.Sep 01, 2006

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

Aspirin is a risk factor for colonic diverticular bleedingDec 24, 2012

Aspirin may contribute to the development of CD in a middle-aged to elderly populationSep 01, 2011

Aspirin treatment reduces ischemic strokes while increasing hemorrhagic stroke. Jan 01, 2009

Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in the elderly.May 01, 1998

Aspirin use was not found to lower the risk of heart attack or death from cardiovascular causes. Mar 31, 2005

Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding. Mar 01, 2010

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs has been observed and labeled as Aspirin-exacerbated respiratory disease (AERD. Jan 01, 2012

Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.Apr 01, 2006

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes.Jun 06, 2012

In healthy individuals using aspirin 80% experience small bowel mucosal injury. Jan 01, 2009

In patients undergoing percutaneous coronary intervention with drug-eluting stents the use of proton pump inhibitors was associated with a greater rate of major adverse cardiac events.Mar 15, 2010

Lactobacillus complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.May 08, 2022

Low-dose aspirin has been linked to gastroduodenal ulcer. Nov 20, 2009

N-acetylcysteine could be associated with a reduction in depressive symptoms.Dec 03, 2018

Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality.Feb 15, 2003

Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection.Oct 28, 2011

Patients with recurrent urticaria and angio-edema show significant improvement when they refrain from using aspirin, benzoates and azo dyes. Jul 01, 1976

Pill-induced esophageal injury is a common occurence.Aug 01, 2005

Preoperative use of aspirin plus clopidogrel is associated with an increased risk of infection after coronary artery bypass surgery. Apr 27, 2009

Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. Apr 15, 1999

Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death.Jan 01, 2006

Salicylic acid, a non-steroidal anti-inflammatory drug, is present in fruits and vegetables and is found in higher concentrations in vegetarians than non-vegetarians.Jun 30, 2001

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.Jan 14, 2011

The evidence is not clear that aspirin is effective in the primary prevention of major cardiovascular events in people with diabetes. Jan 01, 2009

The risks of aspirin therapy may outweigh the benefits for primary prevention of cardiovascular disease. Feb 01, 2010

The severity of gastric mucosal injury produced by aspirin was significantly greater in the morning compared to the evening.Dec 31, 1986

The use of a combination of clopidogrel and aspirin after coronary artery bypass surgery is associated with adverse events. Dec 01, 2001

There is an association between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration.Jun 01, 2000

There is high mortality rate associated with aspirin or clopidogrel or both in elderly patients who have head trauma resulting in intracranial hemmorhage. Oct 01, 2008

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

Warfarin, aspirin, or clopidogrel prescription is associated with higher mortality among hemodialysis patients.Apr 01, 2009

Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries.Dec 31, 2016

"Esophageal mucosal lesion with low-dose aspirin and prasugrel mimics malignancy: a case report."Sep 21, 2011

Hearing loss due to aspirin has been reported.Feb 01, 2009

[Long-term remission induced by measles infection and followed by immunosuppressive therapy in a case of refractory juvenile rheumatoid arthritis].Feb 29, 1988

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."Aug 01, 2011

"Female But Not Male Mice Show Delayed Cutaneous Wound Healing By Aspirin Administration."Dec 13, 2012

An ethanolic extract of curcuma longa ointment containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.Feb 28, 2015

Antihyperglycemic and antinociceptive activity evaluation of 'khoyer' prepared from boiling the wood of Acacia catechu in water.Dec 31, 2012

Antipyretics increase influenza-associated mortality.Oct 01, 2010

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

Aspirin (Acetylsalicylic acid) does not prevent arachidonic acid induced cardiac mortality in an animal model.Sep 01, 1980

Aspirin causes permanent reductions in neural activity in the cochlea and auditory brainstem response.Jun 14, 2010

Aspirin chemically modifies human hemoglobin through acetylation.Jul 01, 1975

Aspirin may be contraindicated in children with febrile illness because it causes gastrointestinal bleeding.Sep 01, 1989

Aspirin may exacerbate the adverse effects of vitamin E deficiency.Oct 01, 1980

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

Basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers.Aug 14, 2018

Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin.Jan 05, 2021

Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.Mar 02, 2014

Dual anti-platelet therapy might pose a hazard when applied to a patient with undiagnosed and untreated malignant cancer prone to undergo vascular mimicry.Apr 02, 2018

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Gastric mucosal protection by aegle marmelos against gastric mucosal damage.Dec 31, 2014

High doses of salicylate (aspirin) increase the gain of the central auditory system, presumably by down-regulating GABA-mediated inhibition, leading to an exaggerated acoustic startle response.Mar 03, 2009

Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.Feb 13, 2014

Long-term administration of salicylate (aspirin) may adversely effect presin levels resulting in tinnitus.Jan 01, 2009

Aspirin

View the Evidence:
101 Abstracts with Aspirin Research