Atorvastatin

Name	AC	CK
Statin-Induced Pathologies	69	338
Chemically-Induced Liver Damage	10	54
Diabetes Mellitus: Type 2	5	44
Myopathies	6	44
Coenzyme Q10 Deficiency	5	43
Drug-Induced Nutrient Depletion: Statin Drugs	7	30
Rhabdomyolysis	3	23
High Cholesterol	3	22
Pancreatitis	5	22
Mitochondrial Dysfunction	3	21
AST: Elevated	1	20
Cardiovascular Diseases	2	20
Diabetes Insipidus	1	20
Elevated: ALT	1	20
Elevated: Creatinine Kinase	1	20
GGT	1	20
Hemodialysis	2	20
Hypertension	2	20
Insulin Resistance	2	20
Oxidative Stress	5	20
Stroke	2	20
Vitamin D Deficiency	2	20
Hepatitis: Autoimmune	3	14
Hepatitis: Cholestatic	5	13
Cataract	2	12
Infertility: Male	2	12
Mitochondrial Myopathies	2	12
Hyperglycemia	2	11
Liver Damage	2	11
Liver Disease	2	11
Athletic Performance	1	10
Birth Defects	1	10
Blood Platelet Disorders	1	10
C-Reactive Protein	1	10
Cardiac Mortality	1	10
Cardiomyopathy	1	10
Chemotherapy-Induced Toxicity	1	10
Copper Deficiency	1	10
Coronary Artery Disease	1	10
DNA damage	2	10
Diabetes Mellitus: Type 2: Prevention	1	10
Dyslipidemias	1	10
Esophageal Cancer	1	10
Exercise-Induced Tissue Damage	1	10
Fibromyalgia	1	10
HIV Infections	1	10
Heart Failure	1	10
Hormonal Perturbations: Dopamine Elevation	1	10
Hormonal Perturbations: Homovanillic acid (HVA) Elevations	1	10
Hyperlipidemia	1	10
IGF2 and IGFBP3: Low	1	10
Immune Disorders: Low Immune Function	2	10
Infants: Low Birth Weight	1	10
Inflammation	1	10
Insulin-Like Growth Factor (IGF): Low	1	10
Intracerebral Hemorrhage	1	10
Kidney Damage: Drug-Induced	1	10
Kidney Diseases	1	10
Kidney Failure	1	10
Liver Failure: Drug Induced	1	10
Muscle Damage: Exercise-Induced	1	10
Muscle Soreness	1	10
Myalgias	1	10
Myocardial Infarction	1	10
Nightmare	1	10
Organ Transplantation: Heart	1	10
Premature Birth	1	10
Prenatal Chemical Exposures	1	10
Renal Failure: Chronic	1	10
Sepsis	1	10
Sperm Count: Low	1	10
Sperm Quality: Low	1	10
Testosterone: Too Low	1	10
Zinc Deficiency	1	10
Cholestasis	3	9
Drug-Induced Toxicity	3	8
Bile Duct Injury	2	6
Hepatitis	2	6
Multi-Organ Failure	2	6
Neuropathies	2	6
Brain Damage	2	4
Liver Damage: Drug-Induced	2	4
A1C	1	3
Alkaline Phosphatase: Elevated	1	3
Alopecia	1	3
Autoimmune Diseases	1	3
Bilirubin: Elevated	1	3
Blepharoptosis	1	3
Bullous Dermatosis	1	3
Cholangiolitis	1	3
Cognitive Decline/Dysfunction	2	3
Cystitis: Hemorrhagic	1	3
Diabetes: Glycation/A1C	1	3
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)	1	3
Eosinophilia	1	3
Gastric Ulcer	1	3
Gynecomastia	1	3
Hypotension	1	3
Hypothyroidism	1	3
Jaundice	1	3
Lactic Acidosis	1	3
Myositis	1	3
Myositis Migrans	1	3
Myositis: Focal	1	3
Paranoia	1	3
Peripheral Neuropathies	1	3
Polyneuropathies	1	3
Senile Paranoid Dementia	1	3
Skeletal Muscle Changes: Endoplasmic Reticulum Stress	1	3
Skeletal Muscle: Changes to MHC I expression	1	3
Systemic Lupus Erythematosus	1	3
Thrombocytopenia	1	3
Toxic Epidermal Necrolysis	1	3
Alcohol Toxicity	1	2
Anxiety Disorders	1	2
Diabetes Mellitus: Type 1	2	2
Drug Withdrawal Symptoms	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Endothelial Dysfunction	1	2
Gastrointestinal Diseases	1	2
Infertility	1	2
Infertility: Female	1	2
Lens Diseases	1	2
Myocardial Ischemia	1	2
NSAID-induced toxicity	1	2
Neurodegenerative Diseases	1	2
Pancreatic Diseases	1	2
Testicular Diseases	1	2
Colon Cancer	1	1
Congestive Heart Failure	1	1
Dementia	1	1
Lipid Peroxidation	1	1
Lung Diseases: Interstitial	1	1
Memory Disorders	1	1
Mineral Deficiencies: Selenium	1	1
Myasthenia Gravis	1	1
Neurotoxicity	1	1
Skeletal Muscle Changes: Ultrastructural Changes	1	1

Name	AC	CK
Hepatotoxic	13	80
Myotoxicity	9	40
Endocrine Disruptor	3	21
Neurotoxic	9	18
Diabetogenic	3	14
Oxidant	3	14
Cardiotoxic	3	13
Immunotoxic	3	13
Teratogenic	2	12
Endocrine Disruptor: Insulin Resistance	1	10
Genotoxic	2	10
Nephrotoxic	1	10
Endocrine Disruptor: Thyroid	1	3
Ulcerogenic	1	3
Anxiogenic	1	2
Cataractogenic	1	2
Endocrine Disruptor: Pancreas	1	2

[+]

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations. Sep 14, 2011

Click here to read the entire abstract

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996

Article Published Date : Sep 14, 2011

Study Type : Meta Analysis

Additional Links

Diseases : AST: Elevated, Diabetes Insipidus, Diabetes Mellitus: Type 2, Elevated: ALT, Elevated: Creatinine Kinase, GGT

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Although statin drugs decrease LDL cholesterol in end-stage kidney disease, their use does not lower morbidity or mortality.Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2010 Aug;30(8):823-9. PMID: 20653359

Article Published Date : Aug 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Hemodialysis, Kidney Diseases, Renal Failure: Chronic

Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs

[+]

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

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Pubmed Data : Cell Biochem Funct. 2007 Jul-Aug;25(4):463-72. PMID: 16906597

Article Published Date : Jul 01, 2007

Study Type : Human Study

Additional Links

Diseases : Cardiomyopathy, Chemotherapy-Induced Toxicity

Additional Keywords : Drug Interaction

Problem Substances : Atorvastatin

[+]

Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patientsMar 23, 2010

Click here to read the entire abstract

Pubmed Data : J Am Coll Cardiol. 2010 Mar 23 ;55(12):1209-16. PMID: 20298928

Article Published Date : Mar 23, 2010

Study Type : Human Study

Additional Links

Diseases : High Cholesterol, Hyperglycemia, Insulin Resistance, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Insulin , Statin Drugs

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance

[+]

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.Jun 01, 2004

Click here to read the entire abstract

Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526

Article Published Date : Jun 01, 2004

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Coenzyme Q10 Deficiency, Statin-Induced Pathologies, Stroke

Problem Substances : Atorvastatin

[+]

Atorvastatin may cause nightmares.Apr 22, 2006

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMJ. 2006 Apr 22 ;332(7547):950. PMID: 16627511

Article Published Date : Apr 22, 2006

Study Type : Human Study

Additional Links

Diseases : Nightmare, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.Jan 01, 2005

Click here to read the entire abstract

Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, High Cholesterol, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Atorvastatin treatment is not effective in reducing inflammation (C-reactive protein) or outcome in patients with type 2 diabetes on hemodialysis.Dec 01, 2008

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Pubmed Data : Kidney Int. 2008 Dec;74(11):1461-7. Epub 2008 Sep 24. PMID: 18818679

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Hemodialysis, Inflammation

Problem Substances : Atorvastatin

[+]

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

Click here to read the entire abstract

Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254

Article Published Date : Nov 15, 2004

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Coenzyme Q10 Deficiency, Heart Failure, Hypertension, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents, Antioxidants

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic

[+]

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

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Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Pancreatitis, Statin-Induced Pathologies

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

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Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804

Article Published Date : Aug 01, 2003

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Cholesterol lowering medications also alter measurable hormonal concentrations. Feb 01, 2004

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Diseases : Hormonal Perturbations: Dopamine Elevation, Hormonal Perturbations: Homovanillic acid (HVA) Elevations, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Lovastatin, Statin Drugs

[+]

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.May 01, 2007

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Pubmed Data : Clin Pharmacol Ther. 2007 May ;81(5):650-3. Epub 2007 Feb 28. PMID: 17329991

Article Published Date : May 01, 2007

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Dysfunction , Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

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Pubmed Data : Reprod Biol Endocrinol. 2014 Jul 12 ;12(1):65. Epub 2014 Jul 12. PMID: 25016482

Article Published Date : Jul 11, 2014

Study Type : Human Study

Additional Links

Diseases : Birth Defects, Infertility: Male, Sperm Count: Low, Sperm Quality: Low

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Teratogenic

[+]

Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.Jun 01, 2006

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Pubmed Data : Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID: 16765141

Article Published Date : Jun 01, 2006

Study Type : Human Study

Additional Links

Diseases : Myopathies, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Myotoxicity

[+]

IGF1, IGF2 and IGFBP3 concentrations all decreased following atorvastatin therapy, which may be linked to its diabetogenic properties.Jan 17, 2013

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Pubmed Data : Eur J Endocrinol. 2013 Jan 18. Epub 2013 Jan 18. PMID: 23333902

Article Published Date : Jan 17, 2013

Study Type : Human Study

Additional Links

Diseases : IGF2 and IGFBP3: Low, Insulin-Like Growth Factor (IGF): Low

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Endocrine Disruptor

[+]

In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day increase in the incidence of hemorrhagic stroke.Aug 10, 2006

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Pubmed Data : N Engl J Med. 2006 Aug 10 ;355(6):549-59. PMID: 16899775

Article Published Date : Aug 10, 2006

Study Type : Human Study

Additional Links

Diseases : Intracerebral Hemorrhage

Problem Substances : Atorvastatin, Statin Drugs

[+]

In patients with vitamin D insufficiency atorvastatin led to impaired insulin sensitivity.Sep 25, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Cardiol. 2016 Sep 26. Epub 2016 Aug 26. PMID: 27717074

Article Published Date : Sep 25, 2016

Study Type : Human Study

Additional Links

Diseases : Insulin Resistance, Statin-Induced Pathologies, Vitamin D Deficiency

Additional Keywords : Risk Factors

Problem Substances : Atorvastatin, Statin Drugs

[+]

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

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Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469

Article Published Date : Aug 31, 2011

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Liver Damage, Liver Disease, Liver Failure: Drug Induced, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Prenatal exposure to statin drugs results in reduced gestational age at birth and lower birth weight. Oct 01, 2008

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Pubmed Data : Reprod Toxicol. 2008 Oct;26(2):175-7. Epub 2008 Jul 1. PMID: 18640262

Article Published Date : Oct 01, 2008

Study Type : Human Study

Additional Links

Diseases : Infants: Low Birth Weight, Premature Birth, Prenatal Chemical Exposures

Problem Substances : Atorvastatin, Statin Drugs

[+]

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA)Dec 31, 2003

Click here to read the entire abstract

Pubmed Data : Drugs. 2004 ;64 Suppl 2:43-60. PMID: 15765890

Article Published Date : Dec 31, 2003

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease, Hypertension, Myocardial Infarction

Problem Substances : Atorvastatin, Statin Drugs

[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Pravastatin , Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity

[+]

Statin drugs alter platelet function. Dec 01, 2002

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Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449

Article Published Date : Dec 01, 2002

Study Type : Human Study

Additional Links

Diseases : Blood Platelet Disorders

Pharmacological Actions : Nitric Oxide Inhibitor

Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Simvastatin, Statin Drugs

[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

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Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Diseases : Myopathies, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 2005 Jul;78(1):60-8. PMID: 16003294

Article Published Date : Jul 01, 2005

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

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Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128

Article Published Date : Jan 01, 2002

Study Type : Human Study

Additional Links

Diseases : Oxidative Stress

Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Oxidant

[+]

Statin therapy is associated with 14% increased risk of type 2 diabetes.Dec 16, 2012

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2012 Dec 17. Epub 2012 Dec 17. PMID: 23248196

Article Published Date : Dec 16, 2012

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Diabetogenic

[+]

Statin therapy is associated with decreased serum levels of zinc and copper.Jan 01, 2005

Click here to read the entire abstract

Pubmed Data : J Trace Elem Med Biol. 2005;19(1):61-7. PMID: 16240674

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Diseases : Copper Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Hyperlipidemia, Statin-Induced Pathologies, Zinc Deficiency

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

[+]

Statin therapy is associated with lower total testosterone in men with type 2 diabetes. Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2009 Apr ;32(4):541-6. Epub 2008 Dec 29. PMID: 19114614

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Diseases : Statin-Induced Pathologies, Testosterone: Too Low

Additional Keywords : Sex Hormone-Binding Globulin

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Endocrine Disruptor

[+]

Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia.Jul 14, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Physiol Res. 2016 Jul 15. Epub 2016 Jul 15. PMID: 27429121

Article Published Date : Jul 14, 2016

Study Type : Animal Study, Human Study

Additional Links

Diseases : Dyslipidemias, Statin-Induced Pathologies

Additional Keywords : Risk Factors

Problem Substances : Atorvastatin, Rosuvastatin, Simvastatin, Statin Drugs

[+]

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs

[+]

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Click here to read the entire abstract

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050

Article Published Date : Dec 01, 2005

Study Type : Human Study

Additional Links

Diseases : Athletic Performance, Drug-Induced Nutrient Depletion: Statin Drugs, Exercise-Induced Tissue Damage, Muscle Damage: Exercise-Induced

Pharmacological Actions : Proteasome Inhibitors

Problem Substances : Atorvastatin, Statin Drugs

[+]

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan ;98(1):51-4. PMID: 16433891

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Fibromyalgia, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs

[+]

The statin drug atorvastatin increases the risk of hemorrhagic stroke. Jun 10, 2008

Click here to read the entire abstract

Pubmed Data : Neurology. 2008 Jun 10;70(24 Pt 2):2364-70. Epub 2007 Dec 12. PMID: 18077795

Article Published Date : Jun 10, 2008

Study Type : Human Study

Additional Links

Diseases : Stroke

Problem Substances : Atorvastatin

[+]

The statin drug atorvastatin is found in very high concentrations in intensive patients with sepsis.Apr 01, 2009

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Pubmed Data : Intensive Care Med. 2009 Apr;35(4):717-21. Epub 2008 Nov 26. PMID: 19034423

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Diseases : Sepsis

Problem Substances : Atorvastatin, Statin Drugs

[+]

There is a dose-response relationship in statin-induced rhabdomyolysis.Mar 01, 2011

Click here to read the entire abstract

Pubmed Data : Can J Cardiol. 2011 Mar-Apr;27(2):146-51. PMID: 21459261

Article Published Date : Mar 01, 2011

Study Type : Human Study

Additional Links

Diseases : Kidney Damage: Drug-Induced, Rhabdomyolysis, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Nephrotoxic

[+]

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Cataract, Chemically-Induced Liver Damage, Esophageal Cancer, Kidney Failure, Myopathies, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Rosuvastatin, Simvastatin, Statin Drugs

[+]

Vitamin D deficiency was significantly associated with a statin-induced myalgia among HIV-infected patients.Jan 03, 2017

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Pubmed Data : AIDS. 2017 Jan 4. Epub 2017 Jan 4. PMID: 28060020

Article Published Date : Jan 03, 2017

Study Type : Human Study

Additional Links

Diseases : HIV Infections, Statin-Induced Pathologies, Vitamin D Deficiency

Additional Keywords : Risk Factors

Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs

[+]

Atorvastatin exhibits immunotoxic and genotoxic properties - Article 2. Jan 01, 2008

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Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jan ;43(1):78-85. PMID: 18161561

Article Published Date : Jan 01, 2008

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage, Immune Disorders: Low Immune Function, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Genotoxic, Immunotoxic

[+]

Atorvastatin exhibits immunotoxic and genotoxic properties. Aug 15, 2008

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 15 ;231(1):85-93. Epub 2008 Apr 8. PMID: 18485436

Article Published Date : Aug 15, 2008

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage, Immune Disorders: Low Immune Function, Oxidative Stress, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Genotoxic, Immunotoxic

[+]

A case of atorvastatin-induced pancreatitis has been reported.Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629

Article Published Date : Oct 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Pancreatitis

Problem Substances : Atorvastatin, Statin Drugs

[+]

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

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Pubmed Data : Clin Drug Investig. 2010 ;30(3):205-9. PMID: 20155993

Article Published Date : Jan 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Alkaline Phosphatase: Elevated, Bile Duct Injury, Bilirubin: Elevated, Cholangiolitis, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626

Article Published Date : Jan 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Click here to read the entire abstract

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732

Article Published Date : Jun 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Pravastatin , Statin Drugs

Adverse Pharmacological Actions : Diabetogenic

[+]

Acute pancreatitis associated with atorvastatine therapy has been reported. Apr 01, 2000

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterol Clin Biol. 2000 Apr ;24(4):471-2. PMID: 10844297

Article Published Date : Apr 01, 2000

Study Type : Human: Case Report

Additional Links

Diseases : Pancreatitis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Acute pancreatitis associated with combined lisinopril and atorvastatin therapy has been reported. Jan 01, 2005

Click here to read the entire abstract

Pubmed Data : Dig Dis. 2005 ;23(1):92-4. PMID: 15920330

Article Published Date : Jan 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Pancreatitis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents

Problem Substances : Atorvastatin, Lisinopril

[+]

Alopecia associated with atorvastatin has been reported. Aug 01, 2002

Click here to read the entire abstract

Pubmed Data : Am J Med. 2002 Aug 1 ;113(2):171. PMID: 12133763

Article Published Date : Aug 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Alopecia, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578

Article Published Date : Jul 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Bile Duct Injury, Chemically-Induced Liver Damage, Cholestasis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Atorvastatin induced multiple organ failure has been reported.May 01, 2010

Click here to read the entire abstract

Pubmed Data : J La State Med Soc. 2010 May-Jun;162(3):159-60. PMID: 20666169

Article Published Date : May 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Multi-Organ Failure, Statin-Induced Pathologies

Pharmacological Actions : Calcium Channel Blockers

Additional Keywords : Drug Synergy

Problem Substances : Atorvastatin, Statin Drugs

[+]

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 1999 Aug 9-23;159(15):1811-2. PMID: 10448788

Article Published Date : Aug 09, 1999

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Atorvastatin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Ann Dermatol Venereol. 2009 Jan ;136(1):50-3. Epub 2008 Nov 28. PMID: 19171231

Article Published Date : Jan 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Atorvastatin-induced hemorrhagic cystitis has been reported.Mar 01, 2009

Click here to read the entire abstract

Pubmed Data : Urology. 2009 Mar ;73(3):681.e5-6. Epub 2008 May 12. PMID: 18468659

Article Published Date : Mar 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Cystitis: Hemorrhagic, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Atorvastatin-induced polyneuropathy has been reported. Nov 04, 2003

Click here to read the entire abstract

Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471

Article Published Date : Nov 04, 2003

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies, Polyneuropathies, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Neurotoxic

[+]

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID: 15918210

Article Published Date : May 28, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Gastric Ulcer, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Atorvastatin-induced severe thrombocytopenia.Oct 17, 1998

Click here to read the entire abstract

Pubmed Data : Lancet. 1998 Oct 17 ;352(9136):1284. PMID: 9788465

Article Published Date : Oct 17, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Statin-Induced Pathologies, Thrombocytopenia

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

[+]

Autoimmune hepatitis triggered by statins has been reported. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : J Clin Gastroenterol. 2006 Sep ;40(8):757-61. PMID: 16940892

Article Published Date : Sep 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Hepatitis: Autoimmune

Problem Substances : Atorvastatin, Simvastatin

Adverse Pharmacological Actions : Hepatotoxic, Immunotoxic

[+]

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Isr Med Assoc J. 2009 Jul ;11(7):440-1. PMID: 19911499

Article Published Date : Jul 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Autoimmune Diseases, Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Jaundice

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe has been reported. Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Ann Clin Biochem. 2005 Sep ;42(Pt 5):402-4. PMID: 16168199

Article Published Date : Sep 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity , Hepatitis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Drug Interaction

Problem Substances : Atorvastatin

[+]

Gynecomastia may be associated with atorvastatin therapy.Aug 01, 2006

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2006 Aug ;26(8):1165-8. PMID: 16863492

Article Published Date : Aug 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Gynecomastia, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

[+]

Hypotension and eosinophilia with atorvastatin has been reported. Aug 01, 2005

Click here to read the entire abstract

Pubmed Data : Pharm World Sci. 2005 Aug ;27(4):279-80. PMID: 16228623

Article Published Date : Aug 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Eosinophilia, Hypotension, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Hypothyroidism misdiagnosed as statin intolerance has been reported.Jul 07, 2009

Click here to read the entire abstract

Pubmed Data : Ann Intern Med. 2009 Jul 7 ;151(1):72. PMID: 19581652

Article Published Date : Jul 07, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Hypothyroidism, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Misdiagnosed Conditions

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid

[+]

Linear IgA bullous dermatosis induced by atorvastatin has been observed. Apr 01, 2001

Click here to read the entire abstract

Pubmed Data : J Am Acad Dermatol. 2001 Apr ;44(4):689-92. PMID: 11260550

Article Published Date : Apr 01, 2001

Study Type : Human: Case Report

Additional Links

Diseases : Bullous Dermatosis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Multiorgan failure induced by atorvastatin has been reported.Sep 01, 2002

Click here to read the entire abstract

Pubmed Data : Am J Med. 2002 Sep ;113(4):348-9. PMID: 12361829

Article Published Date : Sep 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Multi-Organ Failure, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Paranoia is one of the symptoms associated with statin therapy.Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Geriatr Pharmacother. 2008 Mar ;6(1):28-32. PMID: 18396246

Article Published Date : Mar 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Paranoia, Senile Paranoid Dementia, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Click here to read the entire abstract

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841

Article Published Date : Jul 01, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Rhabdomyolysis with atorvastatin and fusidic acid has been reported. Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : Postgrad Med J. 2008 Jun ;84(992):325-7. PMID: 18644925

Article Published Date : Jun 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity , Rhabdomyolysis, Statin-Induced Pathologies

Pharmacological Actions : Anti-Bacterial Agents

Problem Substances : Atorvastatin, Fusidic acid, Statin Drugs

[+]

Statin drug induced lupus-like syndrome concomitant with a severe autoimmune hepatitis has been reported. Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : Lupus. 2003 ;12(5):409-12. PMID: 12765306

Article Published Date : Jan 01, 2003

Study Type : Human: Case Report

Additional Links

Diseases : Hepatitis, Systemic Lupus Erythematosus

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Statin induced pancreatitis has been reported. Nov 01, 2004

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JOP. 2004 Nov ;5(6):502-4. Epub 2004 Nov 10. PMID: 15536291

Article Published Date : Nov 01, 2004

Study Type : Human: Case Report

Additional Links

Diseases : Pancreatitis, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Lovastatin, Rosuvastatin, Simvastatin, Statin Drugs

[+]

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported. Aug 01, 2005

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Care. 2005 Aug ;28(8):2082. PMID: 16043768

Article Published Date : Aug 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Statin precipitated lactic acidosis has been reported. Sep 01, 2004

Click here to read the entire abstract

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664

Article Published Date : Sep 01, 2004

Study Type : Human: Case Report

Additional Links

Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Lactic Acidosis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.Feb 01, 2007

Click here to read the entire abstract

Pubmed Data : Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID: 17241784

Article Published Date : Feb 01, 2007

Study Type : Human: Case Report

Additional Links

Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Skeletal Muscle Changes: Endoplasmic Reticulum Stress, Statin-Induced Pathologies

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Statin-induced myositis migrans has been reported. Nov 30, 2002

Click here to read the entire abstract

Pubmed Data : Wien Klin Wochenschr. 2002 Nov 30 ;114(21-22):943-4. PMID: 12528328

Article Published Date : Nov 30, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Myositis, Myositis Migrans, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Pravastatin , Simvastatin

[+]

Toxic epidermal necrolysis from atorvastatin has been reported.May 27, 1998

Click here to read the entire abstract

Pubmed Data : JAMA. 1998 May 27 ;279(20):1613-4. PMID: 9613909

Article Published Date : May 27, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Toxic Epidermal Necrolysis

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

[+]

Unilateral blepharoptosis is an unrecognized side effect of statin treatment.May 01, 2006

Click here to read the entire abstract

Pubmed Data : Ophthal Plast Reconstr Surg. 2006 May-Jun;22(3):222-4. PMID: 16714939

Article Published Date : May 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Blepharoptosis, Myositis: Focal, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

[+]

Alcohol and atorvastatin interact to adversely affect intestinal villi structure.Jan 01, 2004

Click here to read the entire abstract

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):38-43. PMID: 16146046

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Alcohol Toxicity , Gastrointestinal Diseases, Statin-Induced Pathologies

Additional Keywords : Toxic Substance Synergy

Problem Substances : Atorvastatin, Statin Drugs

[+]

Anti-hyperlipidemic effect of fucoidan fractions prepared from Iceland brown Algae Ascophyllum nodosum.Aug 25, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2023 Aug 26 ;21(9). Epub 2023 Aug 26. PMID: 37755081

Article Published Date : Aug 25, 2023

Study Type : Animal Study

Additional Links

Substances : Fucoidan, Seaweed: Brown

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Atorvastatin

[+]

Atorvastatin contributes to cataract formation in the white rat.Jan 01, 2002

Click here to read the entire abstract

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2002 ;57(2):165-71. PMID: 12898835

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Cataract, Lens Diseases

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Cataractogenic

[+]

Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia.Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : J Card Surg. 2008 Jul-Aug;23(4):312-20. PMID: 18598320

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Endothelial Dysfunction, High Cholesterol, Oxidative Stress

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Oxidant

[+]

Atorvastatin may contribute to hepatopathy through suppressing oxidized and reduce coenzyme q10 and mitochondrial function in the liver. Apr 20, 2012

Click here to read the entire abstract

Pubmed Data : Physiol Res. 2012 Apr 20 ;61(2):185-93. Epub 2012 Jan 31. PMID: 22292717

Article Published Date : Apr 20, 2012

Study Type : Animal Study

Additional Links

Diseases : Liver Damage: Drug-Induced, Statin-Induced Pathologies

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Atorvastatin treatment reduces exercise capacities in rats and exacerbates metabolic perturbations and oxidative stress in skeletal muscle.Aug 18, 2011

Click here to read the entire abstract

Pubmed Data : J Appl Physiol. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21852406

Article Published Date : Aug 18, 2011

Study Type : Animal Study

Additional Links

Diseases : Oxidative Stress, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Oxidant

[+]

High doses of atorvastatin modifies the secretory process in the exocrine portion of the pancreas.Jan 01, 2004

Click here to read the entire abstract

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Pancreatic Diseases

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Endocrine Disruptor: Pancreas

[+]

In this animal study statin withdrawal was associated with a deleterious rebound phenomenon with increased risk of thrombotic vascular events.Apr 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacol Res. 2013 May ;71:1-8. Epub 2013 Feb 18. PMID: 23428346

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Diseases : Drug Withdrawal Symptoms

Additional Keywords : Risk Factors

Problem Substances : Atorvastatin, Statin Drugs

[+]

Lipophilic statin drugs are associated with impaired skeletal muscle mitochondria.Oct 01, 2006

Click here to read the entire abstract

Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 17013560

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Cerivastatin, Fluvastatin, Simvastatin, Statin Drugs

[+]

Lipophilic statin drugs worsen myocardial ischemia in dogs. Feb 01, 2000

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 2000 Feb ;35(2):256-62. PMID: 10672858

Article Published Date : Feb 01, 2000

Study Type : Animal Study

Additional Links

Diseases : Myocardial Ischemia

Additional Keywords : Lipophilic Stains

Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic

[+]

Low dose treatment with statins can induce mild but significant anxiety in guinea pigs.Nov 12, 2011

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2011 Nov 12. Epub 2011 Nov 12. PMID: 22115894

Article Published Date : Nov 12, 2011

Study Type : Animal Study

Additional Links

Diseases : Anxiety Disorders

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Anxiogenic

[+]

Post treatment thymoquinone may reverse oxidative stress injury in rat liver produced by atorvastatin.Oct 01, 2017

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2017 Oct 2. Epub 2017 Oct 2. PMID: 28968507

Article Published Date : Oct 01, 2017

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Statin-Induced Pathologies

Pharmacological Actions : Hepatoprotective

Problem Substances : Atorvastatin

[+]

Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats.Dec 31, 1997

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 1998 Jan ;41(1):88-99. PMID: 9520344

Article Published Date : Dec 31, 1997

Study Type : Animal Study

Additional Links

Diseases : Infertility, Infertility: Female, Infertility: Male

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Quercetin is able to ameliorate statin-drug induced skeletal muscle myopathy in an animal model. Jul 20, 2011

Click here to read the entire abstract

Pubmed Data : Eur Heart J. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21775390

Article Published Date : Jul 20, 2011

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Drug-Induced Toxicity , Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain. Jul 08, 2011

Click here to read the entire abstract

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754

Article Published Date : Jul 08, 2011

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model.Jul 01, 1996

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188

Article Published Date : Jul 01, 1996

Study Type : Animal Study

Additional Links

Diseases : Brain Damage, Liver Damage: Drug-Induced, Statin-Induced Pathologies, Testicular Diseases

Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity, Neurotoxic

[+]

Statin drugs exhibit neurotoxicity in an animal neuronal cell line. Sep 01, 2011

Click here to read the entire abstract

Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Sep ;15(9):985-91. PMID: 22013720

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Brain Damage, Neurodegenerative Diseases, Statin-Induced Pathologies

Pharmacological Actions : Antiproliferative

Problem Substances : Atorvastatin, Lovastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

The statin atorvastatin increase indomethacin-induced gastric injury model in rats.Sep 30, 2012

Click here to read the entire abstract

Pubmed Data : Turk J Gastroenterol. 2012 Oct ;23(5):456-62. PMID: 23161290

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Diseases : Drug-Induced Toxicity: Indomethacin, NSAID-induced toxicity

Problem Substances : Atorvastatin, Indomethacin, Statin Drugs

[+]

Atorvastatin appears to increase the risk of deteriorating blood sugar control. Jun 01, 2006

Click here to read the entire abstract

Pubmed Data : J Atheroscler Thromb. 2006 Jun ;13(3):123-9. PMID: 16835466

Article Published Date : Jun 01, 2006

Study Type : Review

Additional Links

Diseases : Diabetes Mellitus: Type 1, Hyperglycemia

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Endocrine Disruptor

[+]

Atorvastatin reduced the ATP levels in pancreas mitochondria.Aug 23, 2016

Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27553485

Article Published Date : Aug 23, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Diabetogenic

[+]

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983

Article Published Date : Jan 01, 2011

Study Type : Review

Additional Links

Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity

[+]

Cognitive impairment associated with statin drug use has been reported. Dec 01, 2003

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047

Article Published Date : Dec 01, 2003

Study Type : Review

Additional Links

Diseases : Cognitive Decline/Dysfunction, Dementia, Memory Disorders

Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Interstitial lung disease has been reported as a side effect of statins.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Therapie. 2006 Jan-Feb;61(1):57-67. PMID: 16792155

Article Published Date : Jan 01, 2006

Study Type : Review

Additional Links

Diseases : Lung Diseases: Interstitial, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

[+]

Review: Drug-induced liver injury associated with statins.Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Semin Liver Dis. 2009 Nov ;29(4):412-22. Epub 2009 Oct 13. PMID: 19826975

Article Published Date : Nov 01, 2009

Study Type : Review

Additional Links

Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Hepatitis: Cholestatic, Liver Damage, Liver Disease, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Statin toxicity is pleiotropic in nature. Mar 01, 2010

Click here to read the entire abstract

Pubmed Data : FEMS Yeast Res. 2010 Mar ;10(2):188-98. Epub 2009 Nov 3. PMID: 20002195

Article Published Date : Mar 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents, Apoptotic

Additional Keywords : Saccharomyces Cerevisiae

Problem Substances : Atorvastatin

[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Click here to read the entire abstract

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782

Article Published Date : Dec 14, 2004

Study Type : Review

Additional Links

Diseases : Myasthenia Gravis

Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs

[+]

Statin-induced liver injury may result from the suppression of selenoprotein expression.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511

Article Published Date : Jun 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Statin-Induced Pathologies

Additional Keywords : Statin-Selenium Deficiency

Problem Substances : Atorvastatin, Statin Drugs

[+]

Statin-induced myopathy occurs in between 10-15% of users.Feb 23, 2011

Click here to read the entire abstract

Pubmed Data : Expert Opin Drug Saf. 2011 Feb 23. Epub 2011 Feb 23. PMID: 21342078

Article Published Date : Feb 23, 2011

Study Type : Review

Additional Links

Diseases : Myopathies

Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Statins have been associated with cell death in primary neuronal culture.Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

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Diseases : Neurotoxicity, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin.Jan 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1985-1992. Epub 2017 Nov 23. PMID: 29399200

Article Published Date : Jan 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Atorvastatin

[+]

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.Jan 01, 2004

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Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045

Article Published Date : Jan 01, 2004

Study Type : In Vitro Study

Additional Links

Diseases : Skeletal Muscle Changes: Ultrastructural Changes, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity, Neurotoxic

[+]

This systematic review suggests that there is an association between atorvastatin treatment and new onset diabetes mellitus.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Endocrinol. 2018 ;2018:8380192. Epub 2018 Oct 22. PMID: 30425742

Article Published Date : Dec 31, 2017

Study Type : Review

Additional Links

Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Statin-Induced Pathologies

Additional Keywords : Increased Risk

Problem Substances : Atorvastatin

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View the Evidence: 107 Abstracts with Atorvastatin Research

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Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations. Sep 14, 2011

Although statin drugs decrease LDL cholesterol in end-stage kidney disease, their use does not lower morbidity or mortality.Aug 01, 2010

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patientsMar 23, 2010

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.Jun 01, 2004

Atorvastatin may cause nightmares.Apr 22, 2006

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.Jan 01, 2005

Atorvastatin treatment is not effective in reducing inflammation (C-reactive protein) or outcome in patients with type 2 diabetes on hemodialysis.Dec 01, 2008

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Cholesterol lowering medications also alter measurable hormonal concentrations. Feb 01, 2004

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.May 01, 2007

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.Jun 01, 2006

IGF1, IGF2 and IGFBP3 concentrations all decreased following atorvastatin therapy, which may be linked to its diabetogenic properties.Jan 17, 2013

In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day increase in the incidence of hemorrhagic stroke.Aug 10, 2006

In patients with vitamin D insufficiency atorvastatin led to impaired insulin sensitivity.Sep 25, 2016

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

Prenatal exposure to statin drugs results in reduced gestational age at birth and lower birth weight. Oct 01, 2008

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA)Dec 31, 2003

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Statin drugs alter platelet function. Dec 01, 2002

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Statin therapy is associated with 14% increased risk of type 2 diabetes.Dec 16, 2012

Statin therapy is associated with decreased serum levels of zinc and copper.Jan 01, 2005

Statin therapy is associated with lower total testosterone in men with type 2 diabetes. Apr 01, 2009

Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia.Jul 14, 2016

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

The statin drug atorvastatin increases the risk of hemorrhagic stroke. Jun 10, 2008

The statin drug atorvastatin is found in very high concentrations in intensive patients with sepsis.Apr 01, 2009

There is a dose-response relationship in statin-induced rhabdomyolysis.Mar 01, 2011

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Vitamin D deficiency was significantly associated with a statin-induced myalgia among HIV-infected patients.Jan 03, 2017

Atorvastatin exhibits immunotoxic and genotoxic properties - Article 2. Jan 01, 2008

Atorvastatin exhibits immunotoxic and genotoxic properties. Aug 15, 2008

A case of atorvastatin-induced pancreatitis has been reported.Oct 01, 2010

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Acute pancreatitis associated with atorvastatine therapy has been reported. Apr 01, 2000

Acute pancreatitis associated with combined lisinopril and atorvastatin therapy has been reported. Jan 01, 2005

Alopecia associated with atorvastatin has been reported. Aug 01, 2002

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin induced multiple organ failure has been reported.May 01, 2010

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Atorvastatin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported.Jan 01, 2009

Atorvastatin-induced hemorrhagic cystitis has been reported.Mar 01, 2009

Atorvastatin-induced polyneuropathy has been reported. Nov 04, 2003

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Atorvastatin-induced severe thrombocytopenia.Oct 17, 1998

Autoimmune hepatitis triggered by statins has been reported. Sep 01, 2006

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe has been reported. Sep 01, 2005

Gynecomastia may be associated with atorvastatin therapy.Aug 01, 2006

Hypotension and eosinophilia with atorvastatin has been reported. Aug 01, 2005

Hypothyroidism misdiagnosed as statin intolerance has been reported.Jul 07, 2009

Linear IgA bullous dermatosis induced by atorvastatin has been observed. Apr 01, 2001

Multiorgan failure induced by atorvastatin has been reported.Sep 01, 2002

Paranoia is one of the symptoms associated with statin therapy.Mar 01, 2008

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Rhabdomyolysis with atorvastatin and fusidic acid has been reported. Jun 01, 2008

Statin drug induced lupus-like syndrome concomitant with a severe autoimmune hepatitis has been reported. Jan 01, 2003

Statin induced pancreatitis has been reported. Nov 01, 2004

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported. Aug 01, 2005

Statin precipitated lactic acidosis has been reported. Sep 01, 2004

Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.Feb 01, 2007

Statin-induced myositis migrans has been reported. Nov 30, 2002

Atorvastatin

View the Evidence:
107 Abstracts with Atorvastatin Research