Benzo(a)pyrene

Name	AC	CK
Benzo[a]pyrene-induced Toxicity	82	131
Lung Cancer	27	49
DNA damage	12	25
Oxidative Stress	8	15
Lung Cancer: Prevention	7	13
Cancers: All	2	11
Liver Cancer	2	11
Lipid Peroxidation	5	10
Chemically-Induced Liver Damage	5	9
Microplastic Toxicity	5	9
Inflammation	5	8
Breast Cancer	4	5
Aging	2	4
Cervical Cancer	3	4
Kidney Damage: Chemically-Induced	2	4
Lung Injury: Acute	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Air Pollution Linked Toxicity	2	2
Aortic Aneurysm	1	2
Carcinoma: Non-Small-Cell Lung	1	2
Colon Cancer	1	2
Colorectal Cancer	1	2
Female Reproductive Development Abnormalities	1	2
Gastric Cancer	1	2
Gastrointestinal Inflammation	1	2
Infertility: Female	1	2
Lung Damage	1	2
Prenatal Chemical Exposures	1	2
Skin Cancer: Prevention	1	2
Smoking	2	2
Alcohol Toxicity	1	1
Aluminum Toxicity	1	1
Arsenic Poisoning	1	1
Autism	1	1
Bisphenol Toxicity	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Human Papillomavirus (HPV)	1	1
Nicotine/Tobacco Toxicity	1	1
Oral Cancer	1	1
Stomach Cancer	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Carcinogenic	1	2
Apoptotic	1	1
Neurotoxic	1	1

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Pubmed Data : J Biochem Mol Toxicol. 2022 Mar 25:e23053. Epub 2022 Mar 25. PMID: 35332611

Article Published Date : Mar 24, 2022

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Pubmed Data : Mol Carcinog. 2013 Sep ;52(9):686-91. Epub 2012 Mar 27. PMID: 22456940

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:245. Epub 2016 Aug 8. PMID: 27551266

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Curcumin, Resveratrol

Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 Ratio: Decrease

Additional Keywords : Natural Substance Synergy

Problem Substances : Benzo(a)pyrene

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Curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene-induced lung injury.Feb 06, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Drug Chem Toxicol. 2022 Jul 31:1-9. Epub 2022 Jul 31. PMID: 35912572

Article Published Date : Jul 30, 2022

Study Type : Animal Study

Additional Links

Diseases : Benzo[a]pyrene-induced Toxicity , Infertility: Female

Problem Substances : Benzo(a)pyrene

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Microplastics can also transfer POPs not only via ingestion, but also by simple attachment to epithelia.Mar 31, 2018

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Pubmed Data : Environ Pollut. 2018 Apr ;235:918-930. Epub 2018 Feb 21. PMID: 29751397

Article Published Date : Mar 31, 2018

Study Type : Animal Study

Additional Links

Additional Keywords : Microplastic, Persistent Organic Pollutant

Problem Substances : Benzo(a)pyrene, Persistent organic pollutants (POPs)

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MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo(a)pyrene.May 31, 2022

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Pubmed Data : Free Radic Biol Med. 2022 Jun ;186:53-65. Epub 2022 May 10. PMID: 35561843

Article Published Date : May 31, 2022

Study Type : Animal Study

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Substances : Isoflavones

Diseases : Benzo[a]pyrene-induced Toxicity , Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Benzo(a)pyrene

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Nano curcumin may be an effective therapeutic modality for cervical cancer.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 ;6:20051. Epub 2016 Feb 3. PMID: 26837852

Pubmed Data : Aquat Toxicol. 2023 Mar ;256:106430. Epub 2023 Feb 18. PMID: 36812700

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Diseases : Benzo[a]pyrene-induced Toxicity , Microplastic Toxicity

Additional Keywords : Synergistic Toxicity

Problem Substances : Benzo(a)pyrene

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Pomegranate fruit extract significantly inhibits lung tumorigenesis in A/J mice.Mar 31, 2007

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Pubmed Data : Cancer Res. 2007 Apr 1 ;67(7):3475-82. Epub 2007 Mar 27. PMID: 17389758

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Pubmed Data : Asian Pac J Cancer Prev. 2010 ;11(5):1355-8. PMID: 21198292

Article Published Date : Dec 31, 2009

Study Type : Animal Study

Additional Links

Substances : Prunella vulgaris

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Benzo(a)pyrene

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Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.Dec 31, 2013

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Pubmed Data : Biomed Res Int. 2014 ;2014:467465. Epub 2014 May 14. PMID: 24949451

Article Published Date : Dec 31, 2013

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Pubmed Data : Food Chem Toxicol. 2017 Jan ;99:182-189. Epub 2016 Nov 9. PMID: 27836749

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Pubmed Data : J Inflamm Res. 2020 ;13:1075-1087. Epub 2020 Dec 8. PMID: 33324084

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Diallyl sulfide

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive

Problem Substances : Benzo(a)pyrene

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The western diet enhances benzo(a)pyrene-induced colon tumorigenesis in animals.May 16, 2016

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Pubmed Data : Theriogenology. 2022 Mar 1 ;180:72-81. Epub 2021 Dec 17. PMID: 34953351

Article Published Date : Feb 28, 2022

Study Type : In Vitro Study

Additional Links

Substances : Paeoniflorin

Diseases : Benzo[a]pyrene-induced Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Benzo(a)pyrene

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Phlorotannins-rich extract that could be deeper investigated as a cancer chemopreventive agent to block B[a]P-mediated carcinogenesis.Jan 13, 2021

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Pubmed Data : Mar Drugs. 2021 Jan 14 ;19(1). Epub 2021 Jan 14. PMID: 33466689

Article Published Date : Jan 13, 2021

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan, Seaweed: Brown

Diseases : Benzo[a]pyrene-induced Toxicity

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Problem Substances : Benzo(a)pyrene

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Protective effect of the hydrophilic extract of Polypodium leucotomos, fernblock®, against the synergistic action of UVA radiation and benzo[a]pyrene pollutant.Nov 03, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Nov 4 ;11(11). Epub 2022 Nov 4. PMID: 36358556

Article Published Date : Nov 03, 2022

Study Type : In Vitro Study

Additional Links

Substances : Polypodium leucotomos

Diseases : Benzo[a]pyrene-induced Toxicity , Ultraviolet Radiation Induced Damage

Pharmacological Actions : Antioxidants, Photoprotective

Additional Keywords : Synergistic Toxicity

Problem Substances : Benzo(a)pyrene

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Protective effects of myricetin on benzo[a]pyrene-induced 8-hydroxy-2′-deoxyguanosine and BPDE-DNA adduct.May 20, 2020

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Pubmed Data : Oncotarget. 2016 Nov 25. Epub 2016 Nov 25. PMID: 27901495

Article Published Date : Nov 24, 2016

Study Type : In Vitro Study, Review

Additional Links

Substances : Vitamin B-6, Vitamin C

Diseases : Air Pollution Linked Toxicity, Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : DNA Methylation, Hypomethylation

Problem Substances : Benzo(a)pyrene

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Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells.Jul 28, 2023

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Pubmed Data : Environ Toxicol. 2023 Jul 29. Epub 2023 Jul 29. PMID: 37515497

Article Published Date : Jul 28, 2023

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage

Pharmacological Actions : Antioxidants, Genoprotective

Problem Substances : Benzo(a)pyrene

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View the Evidence: 109 Abstracts with Benzo(a)pyrene Research

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These findings support the assumption that Xanthohumol has anti-carcinogenic properties in humans.Dec 05, 2016

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

Ameliorative potential of synbiotic combination of Lactobacillus sp. and polyphenols against Benzo[a]pyrene-induced toxicity in Caco-2 cell line.Dec 12, 2023

Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer.Dec 31, 2018

Anticancer effect of Limonin against benzo(a)pyrene-induced lung carcinogenesis.Nov 30, 2019

Antineoplaston A10 has a chempreventive effect on benzo(a)pyrene-induced pulmonary neoplasia.Jan 01, 1987

Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer.Dec 31, 2021

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Astragaloside-IV has potential as an intervention in the formation of abdominal aortic aneurysm.Dec 31, 2017

Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice.Mar 24, 2022

Benzo(a)pyrene exposure in early life suppresses spermatogenesis.Apr 30, 2023

Benzo[a]pyrene-induces multigenerational changes in gene expression, behavior, and DNA methylation.Jun 14, 2023

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.Dec 31, 2016

Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis.Aug 02, 2022

Combined exposure of polystyrene microplastics and benzo[a]pyrene.May 03, 2024

Compound effect and mechanism of oxidative damage induced by nanoplastics and benzo [a] pyrene.Oct 14, 2023

Curcumin and resveratrol effectively prevent benzo(a)pyrene induced testicular germ cell apoptosis and restore male reproductive health.Dec 31, 2015

Curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene-induced lung injury.Feb 06, 2020

Daily intake of thymoquione after and before or during exposure to B(a)P significantly reduced the rates of chromosomal aberrations and damaged cells.Dec 31, 2006

Deguelin appears to be a promising new preventive agent for lung cancer.Nov 30, 2005

Dietary hydrolyzed jujube extract can reduce benzo(a)pyrene-induced lung inflammation.Jul 31, 2020

Dietary inclusion of Kolaviron could exert protective effects against renal toxicity resulting from B[a]P exposure.Mar 31, 2015

Evaluation of anti-cancer and anti-oxidative potential of Syzygium Cumini against benzo[a]pyrene (BaP) induced gastric carcinogenesis.Dec 31, 2009

Experimental and theoretical insights on chemopreventive effect of the liposomal thymoquinone against benzo[ a]pyrene-induced lung cancer.Dec 31, 2021

Folic acid was found to reduce the mutagenicity and genotoxicity induced by benzo(a)pyrene.Dec 31, 2015

Green sweet potato leaves increase Nrf2-mediated antioxidant activity and facilitate benzo[ a]pyrene metabolism in the liver.Jun 30, 2022

Hesperetin possesses a potential chemopreventive activity against Benzo[a]pyrene induced lung cancer.Dec 04, 2015

Immunomodulatory effect of Myrtenol on benzo (a) pyrene-induced lung cancer in Swiss albino mice.Dec 31, 2023

Kolaviron protects against benzo[a]pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats.Aug 31, 2015

Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.Jul 30, 2022

Lycopene ameliorated benzo[a]pyrene-caused testicular damage via inhibiting oxidative stress and apoptosis.Oct 31, 2019

Maternal benzo[a]pyrene exposure compromised offspring oocyte maturation and quality.Dec 20, 2019

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity.Apr 30, 2017

Microplastics can also transfer POPs not only via ingestion, but also by simple attachment to epithelia.Mar 31, 2018

MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo(a)pyrene.May 31, 2022

Nano curcumin may be an effective therapeutic modality for cervical cancer.Dec 31, 2015

Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways.Mar 31, 2021

Polymeric black tea polyphenols have chemopreventive effect through inhibition of inflammation, cellular proliferation and induction of apoptosis.Jul 04, 2016

Polystyrene microplastics alleviate adverse effects of benzo[a]pyrene on tissues and cells of the marine mussel, Mytilus galloprovincialis.Feb 28, 2023

Pomegranate fruit extract significantly inhibits lung tumorigenesis in A/J mice.Mar 31, 2007

Protective effect of Diosmin against benzo(a)pyrene-induced lung injury.Feb 14, 2020

Protective effects of green and white tea against benzo(a)pyrene induced oxidative stress and DNA damage in murine model.Dec 31, 2011

Protective effects of piceatannol on DNA damage in benzo[a]pyrene-induced human colon epithelial cells.May 16, 2023

Proteomic analysis of the protective effect of eriodictyol on benzo(a)pyrene-induced caco-2 cytotoxicity.Dec 31, 2021

Prunella vulgaris has potential as a lung cancer chemopreventive agent.Dec 31, 2009

Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.Dec 31, 2013

Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations.Aug 29, 2023

Short-term exposure to benzo(a)pyrene causes disruption of GnRH network in Zebrafish embryos.Apr 06, 2023

Synergy between nanoplastics and benzo[a]pyrene promotes senescence.Oct 09, 2024

Tangeretin supplementation mitigates the aging toxicity induced by dietary benzo[a]pyrene exposure.Aug 27, 2023

Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway.Jun 30, 2021

The combination of pterostilbene and lupeol was more effective in prevention of skin cancer as compared to either of the phytochemical alone.Dec 31, 2016

The effect of melatonin on benzo(a)pyrene-induced renal toxicity.Apr 30, 2023

The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.Dec 31, 2022

The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer.Aug 31, 2013

The present study thus recommends the usefulness of white tea extract in mitigating benzo(a)pyrene induced hepatic dysfunctions.May 31, 2018

The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene.Mar 19, 2023

The results of the present study support the potential chemopreventive effect of diallyl sulfide in the process of lung carcinogenesis.Dec 31, 2019

The western diet enhances benzo(a)pyrene-induced colon tumorigenesis in animals.May 16, 2016

These findings confirm the chemopreventive potential of chrysin against benzo(a)pyrene induced lung cancer in Swiss albino mice.Mar 31, 2016

These findings confirm the chemopreventive potential of luteolin against benzo(a)pyrene induced lung carcinogenesis.Jun 05, 2016

These findings substantiate the chemopreventive potential of naringenin against chemically induced lung cancer in mice.Dec 03, 2015

This study illustrates the multifaceted efficacy of curcumin in preventing lung cancer.Nov 11, 2015

Tinospora Cordifolia and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis.Oct 27, 2021

Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma.Sep 30, 2022

White tea - A cost effective alternative to EGCG in fight against benzo(a)pyrene (BaP) induced lung toxicity.Aug 31, 2019

A review of curcumin as a multifaceted compound against human papilloma virus infection and cervical cancersNov 28, 2016

Abundance and sources of Benzo[a]pyrene and other PAHs in ambient air in Hong KongJul 04, 2020

Aluminum and benzo[a]pyrene co-operate to induce neuronal apoptosis in vitro.May 31, 2015

Ameliorative effect of dandelion peptides on benzo(a)pyrene-induced oxidative stress and inflammation in human umbilical vein endothelial cells.Aug 07, 2022

Benzo(a)pyrene

View the Evidence:
109 Abstracts with Benzo(a)pyrene Research