Benzo(a)pyrene

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6 Diseases Researched for Benzo(a)pyrene
NameACCKFocus
Lung Cancer612Locked
Lung Cancer: Prevention510Locked
Benzo[a]pyrene-induced Toxicity 12Locked
Carcinoma: Non-Small-Cell Lung12Locked
Cervical Cancer12Locked
Chemically-Induced Liver Damage12Locked
1 Adverse Pharmacological Actions Researched for Benzo(a)pyrene
NameACCKFocus
Carcinogenic12Locked

View the Evidence:
57 Abstracts with Benzo(a)pyrene Research

[+]

These findings support the assumption that Xanthohumol has anti-carcinogenic properties in humans.Dec 05, 2016

Pubmed Data : Cancer Prev Res (Phila). 2016 Dec 6. Epub 2016 Dec 6. PMID: 27923802
Article Published Date : Dec 05, 2016
Study Type : Human Study
Additional Links
Substances : Xanthohumol
Diseases : Cancers: All, DNA damage, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents
Problem Substances : Benzo(a)pyrene, N-nitrosodimethylamine
[+]

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

Pubmed Data : Chem Biol Interact. 2019 Apr 18 ;307:1-7. Epub 2019 Apr 18. PMID: 31004597
Article Published Date : Apr 17, 2019
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Benzo(a)pyrene
[+]

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

Pubmed Data : Food Chem Toxicol. 2020 Jun 5 ;142:111483. Epub 2020 Jun 5. PMID: 32512025
Article Published Date : Jun 04, 2020
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Benzo[a]pyrene-induced Toxicity , Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Problem Substances : Benzo(a)pyrene
[+]

Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer.Dec 31, 2018

Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(3):239-251. PMID: 31679311
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
Problem Substances : Benzo(a)pyrene
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Antineoplaston A10 has a chempreventive effect on benzo(a)pyrene-induced pulmonary neoplasia.Jan 01, 1987

Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:51-5. PMID: 3569016
Article Published Date : Jan 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive
Problem Substances : Benzo(a)pyrene
Adverse Pharmacological Actions : Carcinogenic
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Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
Problem Substances : Benzo(a)pyrene
[+]

Astragaloside-IV has potential as an intervention in the formation of abdominal aortic aneurysm.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:496. Epub 2018 May 22. PMID: 29872394
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Aortic Aneurysm
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
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Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Pubmed Data : Mol Carcinog. 2013 Sep ;52(9):686-91. Epub 2012 Mar 27. PMID: 22456940
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Beet, Betaine
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive
Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate
Problem Substances : Benzo(a)pyrene, Vinyl Carbamate
[+]

Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.Dec 31, 2016

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117735572. Epub 2017 Jan 1. PMID: 29019276
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Benzo[a]pyrene-induced Toxicity , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
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Curcumin and resveratrol effectively prevent benzo(a)pyrene induced testicular germ cell apoptosis and restore male reproductive health.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:245. Epub 2016 Aug 8. PMID: 27551266
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin, Resveratrol
Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 Ratio: Decrease
Additional Keywords : Natural Substance Synergy
Problem Substances : Benzo(a)pyrene
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Curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene-induced lung injury.Feb 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Feb 7 ;25(3). Epub 2020 Feb 7. PMID: 32046055
Article Published Date : Feb 06, 2020
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Benzo(a)pyrene
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Daily intake of thymoquione after and before or during exposure to B(a)P significantly reduced the rates of chromosomal aberrations and damaged cells.Dec 31, 2006

Pubmed Data : Food Chem Toxicol. 2007 Jan ;45(1):88-92. Epub 2006 Aug 30. PMID: 17011106
Article Published Date : Dec 31, 2006
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antimutagenic Agents, Genoprotective
Problem Substances : Benzo(a)pyrene
[+]

Deguelin appears to be a promising new preventive agent for lung cancer.Nov 30, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neoplasia. 2005 Dec ;7(12):1053-7. PMID: 16354587
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Deguelin, Silibinin
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Chemopreventive
Problem Substances : Benzo(a)pyrene
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Dietary hydrolyzed jujube extract can reduce benzo(a)pyrene-induced lung inflammation.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Aug 1 ;9(8). Epub 2020 Aug 1. PMID: 32752184
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
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Folic acid was found to reduce the mutagenicity and genotoxicity induced by benzo(a)pyrene.Dec 31, 2015

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2016 ;62(1):26-31. PMID: 27117848
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Folic Acid
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, Genoprotective, Hepatoprotective
Problem Substances : Benzo(a)pyrene
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Hesperetin possesses a potential chemopreventive activity against Benzo[a]pyrene induced lung cancer.Dec 04, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 5 ;242:345-52. Epub 2015 Nov 4. PMID: 26546711
Article Published Date : Dec 04, 2015
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Lipid Peroxidation, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Chemopreventive, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Benzo(a)pyrene
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Lycopene ameliorated benzo[a]pyrene-caused testicular damage via inhibiting oxidative stress and apoptosis.Oct 31, 2019

Pubmed Data : Toxicology. 2019 Nov 1 ;427:152301. Epub 2019 Sep 27. PMID: 31568845
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Benzo[a]pyrene-induced Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Problem Substances : Benzo(a)pyrene
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Maternal benzo[a]pyrene exposure compromised offspring oocyte maturation and quality.Dec 20, 2019

Pubmed Data : Reprod Toxicol. 2019 Dec 21. Epub 2019 Dec 21. PMID: 31874190
Article Published Date : Dec 20, 2019
Study Type : Animal Study
Additional Links
Diseases : Benzo[a]pyrene-induced Toxicity , Female Reproductive Development Abnormalities, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Benzo(a)pyrene
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Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity.Apr 30, 2017

Pubmed Data : Environ Toxicol. 2017 May ;32(5):1566-1577. Epub 2016 Dec 29. PMID: 28032951
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Acacia catechu
Diseases : Benzo[a]pyrene-induced Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
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Microplastics can also transfer POPs not only via ingestion, but also by simple attachment to epithelia.Mar 31, 2018

Pubmed Data : Environ Pollut. 2018 Apr ;235:918-930. Epub 2018 Feb 21. PMID: 29751397
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Additional Keywords : Microplastic, Persistent Organic Pollutant
Problem Substances : Benzo(a)pyrene, Persistent organic pollutants (POPs)
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Nano curcumin may be an effective therapeutic modality for cervical cancer.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:20051. Epub 2016 Feb 3. PMID: 26837852
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator
Additional Keywords : E6 Oncoprotein
Problem Substances : Benzo(a)pyrene
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Polymeric black tea polyphenols have chemopreventive effect through inhibition of inflammation, cellular proliferation and induction of apoptosis.Jul 04, 2016

Pubmed Data : Mol Carcinog. 2016 Jul 5. Epub 2016 Jul 5. PMID: 27377358
Article Published Date : Jul 04, 2016
Study Type : Animal Study
Additional Links
Substances : Black Tea
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive
Problem Substances : Benzo(a)pyrene
[+]

Pomegranate fruit extract significantly inhibits lung tumorigenesis in A/J mice.Mar 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 2007 Apr 1 ;67(7):3475-82. Epub 2007 Mar 27. PMID: 17389758
Article Published Date : Mar 31, 2007
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, NF-kappaB Inhibitor
Additional Keywords : Anticarcinogenic Agents, Chemopreventive, lung cancer, NF-kappaB Inhibitor, Phytotherapy, Plant Extracts, pomegranate
Problem Substances : Benzo(a)pyrene
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Protective effect of Diosmin against benzo(a)pyrene-induced lung injury.Feb 14, 2020

Pubmed Data : Environ Toxicol. 2020 Feb 15. Epub 2020 Feb 15. PMID: 32061149
Article Published Date : Feb 14, 2020
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
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Protective effects of green and white tea against benzo(a)pyrene induced oxidative stress and DNA damage in murine model.Dec 31, 2011

Pubmed Data : Nutr Cancer. 2012 ;64(2):300-6. Epub 2012 Jan 13. PMID: 22243054
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Green Tea, White Tea
Diseases : DNA damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Genoprotective
Problem Substances : Benzo(a)pyrene
[+]

Prunella vulgaris has potential as a lung cancer chemopreventive agent.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2010 ;11(5):1355-8. PMID: 21198292
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Prunella vulgaris
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Benzo(a)pyrene
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Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:467465. Epub 2014 May 14. PMID: 24949451
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
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The combination of pterostilbene and lupeol was more effective in prevention of skin cancer as compared to either of the phytochemical alone.Dec 31, 2016

Pubmed Data : Food Chem Toxicol. 2017 Jan ;99:182-189. Epub 2016 Nov 9. PMID: 27836749
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol, Pterostilbene
Diseases : Skin Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Natural Substance Synergy
Problem Substances : Benzo(a)pyrene
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The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer.Aug 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2013 Sep ;16(3):11-22. PMID: 25780671
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Benzo(a)pyrene
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The present study thus recommends the usefulness of white tea extract in mitigating benzo(a)pyrene induced hepatic dysfunctions.May 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jun ;116(Pt B):281-291. Epub 2018 Apr 21. PMID: 29684493
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), White Tea
Diseases : Benzo[a]pyrene-induced Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Benzo(a)pyrene
[+]

The western diet enhances benzo(a)pyrene-induced colon tumorigenesis in animals.May 16, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 May 17 ;7(20):28947-60. PMID: 26959117
Article Published Date : May 16, 2016
Study Type : Animal Study
Additional Links
Diseases : Colon Cancer
Additional Keywords : Increased Risk
Anti Therapeutic Actions : Western Diet
Problem Substances : Benzo(a)pyrene
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These findings confirm the chemopreventive potential of chrysin against benzo(a)pyrene induced lung cancer in Swiss albino mice.Mar 31, 2016

Pubmed Data : Pharmacol Rep. 2016 Apr ;68(2):310-8. Epub 2015 Sep 6. PMID: 26922533
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
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These findings confirm the chemopreventive potential of luteolin against benzo(a)pyrene induced lung carcinogenesis.Jun 05, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jun 6 ;82:568-577. Epub 2016 Jun 6. PMID: 27470398
Article Published Date : Jun 05, 2016
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive
Problem Substances : Benzo(a)pyrene
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These findings substantiate the chemopreventive potential of naringenin against chemically induced lung cancer in mice.Dec 03, 2015

Pubmed Data : Int Immunopharmacol. 2015 Dec 4 ;30:102-110. Epub 2015 Dec 4. PMID: 26655880
Article Published Date : Dec 03, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
Problem Substances : Benzo(a)pyrene
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This study illustrates the multifaceted efficacy of curcumin in preventing lung cancer.Nov 11, 2015

Pubmed Data : Biofactors. 2015 Nov 12 ;41(6):431-42. Epub 2015 Dec 8. PMID: 26643788
Article Published Date : Nov 11, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Problem Substances : Benzo(a)pyrene
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White tea - A cost effective alternative to EGCG in fight against benzo(a)pyrene (BaP) induced lung toxicity.Aug 31, 2019

Pubmed Data : Food Chem Toxicol. 2019 Sep ;131:110551. Epub 2019 Jun 1. PMID: 31163217
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : White Tea
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer, Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
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A review of curcumin as a multifaceted compound against human papilloma virus infection and cervical cancersNov 28, 2016

Pubmed Data : Biofactors. 2016 Nov 29. Epub 2016 Nov 29. PMID: 27896883
Article Published Date : Nov 28, 2016
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer, Human Papillomavirus (HPV)
Pharmacological Actions : Anticarcinogenic Agents, Antiviral Agents, Chemopreventive
Problem Substances : Benzo(a)pyrene
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Abundance and sources of Benzo[a]pyrene and other PAHs in ambient air in Hong KongJul 04, 2020

Pubmed Data : Chemosphere. 2020 Jul 5 ;259:127518. Epub 2020 Jul 5. PMID: 32650173
Article Published Date : Jul 04, 2020
Study Type : Review
Additional Links
Diseases : Air Pollution Linked Toxicity, Benzo[a]pyrene-induced Toxicity
Additional Keywords : Risk Factors
Problem Substances : Benzo(a)pyrene, Polycyclic aromatic hydrocarbon
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Aluminum and benzo[a]pyrene co-operate to induce neuronal apoptosis in vitro.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Sci. 2015 Jun ;40(3):365-73. PMID: 25971159
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Aluminum Toxicity , Benzo[a]pyrene-induced Toxicity
Additional Keywords : Synergistic Toxicity
Problem Substances : Aluminum, Benzo(a)pyrene
Adverse Pharmacological Actions : Apoptotic, Neurotoxic
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Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis.Feb 12, 2020

Pubmed Data : Environ Int. 2020 Feb 13 ;137:105560. Epub 2020 Feb 13. PMID: 32062438
Article Published Date : Feb 12, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Arsenic Poisoning, Benzo[a]pyrene-induced Toxicity , Lung Cancer
Additional Keywords : Cancer Stem Cells, Synergistic Toxicity
Problem Substances : Arsenic, Benzo(a)pyrene
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Autism genes are selectively targeted by environmental pollutants.Oct 26, 2016

Pubmed Data : Neurochem Int. 2016 Oct 27. Epub 2016 Oct 27. PMID: 27984170
Article Published Date : Oct 26, 2016
Study Type : Review
Additional Links
Diseases : Autism
Additional Keywords : Gene Expression
Problem Substances : Acetaminophen, Benzo(a)pyrene, Bisphenol A , Heavy Metals, Pesticides, Phthalates
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Bacopa monnieri inhibits apoptosis and senescence through mitophagy in human astrocytes. Apr 22, 2020

Pubmed Data : Food Chem Toxicol. 2020 Apr 23:111367. Epub 2020 Apr 23. PMID: 32335210
Article Published Date : Apr 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bacopa
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Problem Substances : Benzo(a)pyrene
[+]

Bacopa monnieri-induced protective autophagy which inhibited Benzo[a]pyrene-mediated apoptosis.Jul 18, 2016

Pubmed Data : Phytother Res. 2016 Jul 19. Epub 2016 Jul 19. PMID: 27432245
Article Published Date : Jul 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bacopa
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Cytoprotective
Problem Substances : Benzo(a)pyrene
[+]

Bisphenol A prevents the maintenance of stem cell features prompted by bone morphogenetic protein 4. Oct 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2016 Oct 14. Epub 2016 Aug 14. PMID: 27740625
Article Published Date : Oct 13, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Adult Stem Cells
Problem Substances : Benzo(a)pyrene, Bisphenol A
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Cytoprotective effect of 20S-Rg3 on benzo[a]pyrene-induced DNA damage.Dec 31, 2011

Pubmed Data : Drug Metab Dispos. 2012 Jan ;40(1):120-9. Epub 2011 Sep 28. PMID: 21956953
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
Problem Substances : Benzo(a)pyrene
[+]

Cytoprotective effect of a functional antipollutant blend through reducing B[a] P-induced intracellular oxidative stress and UVA exposure.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Biol. 2018 ;42(5):453-462. Epub 2018 Oct 25. PMID: 30930629
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elderberry, Pomegranate, Sour Cherry, Wheat Protein
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene.Nov 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Dec ;77:105980. Epub 2019 Nov 4. PMID: 31699670
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Benzo[a]pyrene-induced Toxicity , Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents
Additional Keywords : Dose Response
Problem Substances : Benzo(a)pyrene
[+]

Hyperforin exhibits antigenotoxic activity on human and bacterial cells.Jan 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jan 21 ;22(1). Epub 2017 Jan 21. PMID: 28117734
Article Published Date : Jan 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hyperforin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, DNA damage
Pharmacological Actions : Antimutagenic Agents, Chemoprotective Agents
Problem Substances : Benzo(a)pyrene
[+]

Lemongrass essential oil offered protection against Benzo(a)pyrene induced oxidative stress and DNA damage.Nov 27, 2016

Pubmed Data : Toxicol Mech Methods. 2016 Nov 28:1-15. Epub 2016 Nov 28. PMID: 27894210
Article Published Date : Nov 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lemongrass: Essential Oil
Diseases : DNA damage, Lung Cancer: Prevention
Pharmacological Actions : Chemopreventive, Cryoprotective Agents
Problem Substances : Benzo(a)pyrene
[+]

Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes.Jan 31, 2020

Pubmed Data : J Cosmet Dermatol. 2020 Feb ;19(2):502-507. Epub 2019 May 28. PMID: 31135098
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lentinan
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-8 downregulation, Malondialdehyde Down-regulation
Problem Substances : Benzo(a)pyrene
[+]

Long-term exposure of early-transformed human mammary cells to low doses of benzo[a]pyrene and/or bisphenol A enhances their cancerous phenotype.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2020 ;10:712. Epub 2020 May 29. PMID: 32670863
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Benzo[a]pyrene-induced Toxicity , Bisphenol Toxicity, Breast Cancer
Additional Keywords : Risk Factors
Problem Substances : Benzo(a)pyrene, Bisphenol A
[+]

Protective effects of myricetin on benzo[a]pyrene-induced 8-hydroxy-2′-deoxyguanosine and BPDE-DNA adduct.May 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 May 21 ;9(5). Epub 2020 May 21. PMID: 32455619
Article Published Date : May 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antioxidants, Genoprotective
Problem Substances : Benzo(a)pyrene
[+]

The results support a role for dietary polyphenols in protecting against benzo[a]pyrene induced carcinogenesis.May 18, 2017

Pubmed Data : Food Chem Toxicol. 2017 May 19. Epub 2017 May 19. PMID: 28533128
Article Published Date : May 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
Problem Substances : Benzo(a)pyrene
[+]

These results provide evidence that xanthohumol displays anti-genotoxic activity in metabolically competent human cells.Aug 14, 2007

Pubmed Data : Mutat Res. 2007 Aug 15 ;632(1-2):1-8. Epub 2007 May 21. PMID: 17590382
Article Published Date : Aug 14, 2007
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage, Liver Cancer
Pharmacological Actions : Antimutagenic Agents, Chemopreventive
Problem Substances : Benzo(a)pyrene
[+]

This is first report demonstrating that e-cigarettes can potentiate the genotoxic effects of a tobacco smoke carcinogen.Jan 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2019 07 11 ;16(14). Epub 2019 Jul 11. PMID: 31373329
Article Published Date : Jan 10, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Benzo[a]pyrene-induced Toxicity , Nicotine/Tobacco Toxicity , Smoking
Additional Keywords : Increased Risk, Synergistic Toxicity
Problem Substances : Benzo(a)pyrene, Electronic Cigarettes
[+]

Thuja 30C ameliorates benzo(a)pyrene induced toxicity, stress and DNA damage in perfused lung cells.Oct 31, 2013

Pubmed Data : J Integr Med. 2013 Nov ;11(6):397-404. PMID: 24299603
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : DNA Repair Up-regulation, Genoprotective
Problem Substances : Benzo(a)pyrene
[+]

Vitamin C and B6 can reduce benzo(a)pyrene-induced DNA methylation alterations and may be used as chemopreventive agents.Nov 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 25. Epub 2016 Nov 25. PMID: 27901495
Article Published Date : Nov 24, 2016
Study Type : In Vitro Study, Review
Additional Links
Substances : Vitamin B-6, Vitamin C
Diseases : Air Pollution Linked Toxicity, Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : DNA Methylation, Hypomethylation
Problem Substances : Benzo(a)pyrene

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