Cadmium

Name	AC	CK
Cadmium Poisoning	87	175
Breast Cancer	5	42
Cancers: All	2	40
Heavy Metal Toxicity	8	37
Oxidative Stress	20	37
Chemically-Induced Liver Damage	19	33
Autism Spectrum Disorders	4	32
Kidney Damage: Chemically-Induced	17	32
Lead Poisoning	4	22
Lung Cancer	1	20
Testicular Injury: Cadmium-Induced	9	17
Mercury Poisoning	4	15
Autism	2	12
Cardiovascular Disease: Prevention	1	10
Cardiovascular Diseases	1	10
Lipid Peroxidation	4	8
Multiple Sclerosis	2	6
Testicular Injury: Chemical/Metal Induced	3	6
Bisphenol Toxicity	3	4
Alzheimer's Disease	2	3
Brain Inflammation	2	3
Brain: Oxidative Stress	1	2
Diabetic Nephropathy	1	2
Dysbiosis	1	2
Hypothyroidism	1	2
Inflammation	1	2
Male Reproductive Development Abnormalities	1	2
Ovarian Diseases	1	2
Pesticide Toxicity	1	2
Cancers: Estrogen Responsive	1	1
Cardiovascular Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Diesel Exhaust Particle Toxicity	1	1
Drug Induced Toxicity: Cardiovascular Disease	1	1
Estrogen Dominance	1	1
Influenza	1	1
Kidney Damage	1	1
Neurodegenerative Diseases	1	1
Obesity	1	1
Thyroid Cancer	1	1
Tumors	1	1

Name	AC	CK
Neurotoxic	5	17
Estrogenic	2	11
Carcinogenic	1	10
Carcinogenic (suspected)	1	10
Cytotoxic	1	2
Genotoxic	1	2
Tumorigenic	1	1

Problem Substances : Cadmium

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"Increased levels of transition metals in breast cancer tissue."Nov 30, 2006

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Pubmed Data : Neuro Endocrinol Lett. 2006 Dec ;27 Suppl 1:36-9. PMID: 16804515

Article Published Date : Nov 30, 2006

Study Type : Human Study

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Diseases : Breast Cancer

Additional Keywords : Metalloestrogens

Problem Substances : Cadmium, Carbonyl Iron, Industrial Iron, Lead, Mercury

Adverse Pharmacological Actions : Carcinogenic (suspected)

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Arsenic, cadmium, lead, and mercury in sweat: a systematic review.Dec 31, 2011

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Pubmed Data : J Environ Public Health. 2012 ;2012:184745. Epub 2012 Feb 22. PMID: 22505948

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Pubmed Data : J Diet Suppl. 2018 Oct 9:1-12. Epub 2018 Oct 9. PMID: 30299203

Article Published Date : Oct 08, 2018

Study Type : Human In Vitro

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Substances : Piperine

Diseases : Cadmium Poisoning

Pharmacological Actions : Antioxidants

Problem Substances : Cadmium

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A tunisian radish extract reduced the harmful outcomes of commonly encountered toxicants like cadmium on the immune system and on overall host health status.Dec 31, 2014

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Pubmed Data : J Immunotoxicol. 2015 Jan-Mar;12(1):40-7. Epub 2014 Feb 14. PMID: 24524755

BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cellsNov 04, 2015

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Pubmed Data : Environ Toxicol. 2015 Nov 5. Epub 2015 Nov 5. PMID: 26537420

Article Published Date : Nov 04, 2015

Study Type : Animal Study

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Diseases : Bisphenol Toxicity, Cadmium Poisoning

Problem Substances : Bisphenol A , Cadmium

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Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity.Dec 31, 2020

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Pubmed Data : Food Chem Toxicol. 2019 Nov ;133:110751. Epub 2019 Aug 4. PMID: 31390532

Article Published Date : Oct 31, 2019

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Cadmium Poisoning

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

Problem Substances : Cadmium

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Chokeberry is a promising natural agent for skeletal protection under low-level and moderate chronic exposure to cadmium. May 24, 2017

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Pubmed Data : Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID: 28587093

Article Published Date : May 24, 2017

Study Type : Animal Study

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Substances : Chokeberry

Diseases : Cadmium Poisoning

Pharmacological Actions : Cytoprotective

Problem Substances : Cadmium

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Chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal.Apr 30, 2016

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Pubmed Data : Planta Med. 2016 May ;82(7):621-31. Epub 2016 Apr 20. PMID: 27096624

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Chokeberry

Diseases : Cadmium Poisoning , Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Osteoprotective

Additional Keywords : Plant Extracts

Problem Substances : Cadmium

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Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

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Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:3403264. Epub 2019 Nov 23. PMID: 31871545

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Chokeberry

Diseases : Cadmium Poisoning , Oxidative Stress

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Cadmium

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Cupric sulfate and cadmium have genotoxic and cytotoxic effects.Apr 01, 2005

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Pubmed Data : Food Chem Toxicol. 2005 Apr;43(4):569-74. PMID: 15721204

Article Published Date : Apr 01, 2005

Study Type : Animal Study

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Problem Substances : Cadmium, Cupric Sulfate

Adverse Pharmacological Actions : Cytotoxic, Genotoxic

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Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.May 16, 2017

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Pubmed Data : Neurotoxicology. 2017 May 17. Epub 2017 May 17. PMID: 28527659

Article Published Date : May 16, 2017

Study Type : Animal Study

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Substances : Curcumin

Diseases : Alzheimer's Disease, Cadmium Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor

Problem Substances : Cadmium

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Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice.Jan 04, 2022

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Pubmed Data : J Hazard Mater. 2022 03 5 ;425:127571. Epub 2021 Oct 24. PMID: 34986559

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Pubmed Data : J Toxicol. 2018 ;2018:4109491. Epub 2018 Oct 8. PMID: 30402094

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Ginger, Turmeric

Diseases : Cadmium Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Essential Oils

Problem Substances : Cadmium

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Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals.Apr 30, 2021

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Pubmed Data : Chemosphere. 2021 May ;270:128659. Epub 2020 Oct 19. PMID: 33757277

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Hibiscus sabdariffa extract protects against cadmium-induced ovarian toxicity.Dec 31, 2019

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Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2020 ;12(4):107-114. Epub 2020 Aug 25. PMID: 32934766

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Hibiscus sabdariffa

Diseases : Cadmium Poisoning , Ovarian Diseases

Pharmacological Actions : Cytoprotective

Problem Substances : Cadmium

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Honey bee colonies may have a weakened immune system in cadmium polluted areas, resulting in a decreased ability in dealing with pathogens.Oct 31, 2016

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Pubmed Data : Environ Pollut. 2016 Nov ;218:826-834. Epub 2016 Aug 12. PMID: 27528187

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Pubmed Data : J Oleo Sci. 2018 ;67(10):1339-1345. PMID: 30305562

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Aug 30. Epub 2021 Aug 30. PMID: 34458972

Article Published Date : Aug 29, 2021

Study Type : Animal Study

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Substances : Ashwagandha

Diseases : Cadmium Poisoning

Pharmacological Actions : Antioxidants, Immunomodulatory

Problem Substances : Cadmium

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Pubmed Data : Biol Trace Elem Res. 2020 Mar 9. Epub 2020 Mar 9. PMID: 32152873

Article Published Date : Mar 08, 2020

Study Type : Animal Study

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Substances : Dill

Diseases : Cadmium Poisoning , Oxidative Stress

Pharmacological Actions : Antioxidants

Problem Substances : Cadmium

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Protective effects of bromelain against cadmium-induced pulmonary intoxication.Jan 10, 2021

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Pubmed Data : Environ Toxicol. 2022 Apr ;37(4):720-729. Epub 2021 Dec 13. PMID: 34897960

Article Published Date : Mar 31, 2022

Study Type : Animal Study

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Substances : Puerarin

Diseases : Cadmium Poisoning , Oxidative Stress

Problem Substances : Cadmium

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Puerarin alleviates cadmium-induced rat neurocyte injury.Oct 28, 2022

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Pubmed Data : Ecotoxicol Environ Saf. 2022 Oct 29 ;247:114239. Epub 2022 Oct 29. PMID: 36326556

Article Published Date : Oct 28, 2022

Study Type : Animal Study

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Substances : Puerarin

Diseases : Cadmium Poisoning

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Cadmium

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Puerarin attenuates cadmium-iInduced neuronal injury via stimulating cadmium excretion, inhibiting oxidative stress and apoptosis.Jan 01, 2021

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Pubmed Data : Int J Mol Sci. 2018 Dec 10 ;19(12). Epub 2018 Dec 10. PMID: 30544760

Article Published Date : Dec 09, 2018

Study Type : Animal Study

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Substances : Royal Jelly

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Nrf2 activation

Problem Substances : Cadmium

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Royal jelly attenuates cadmium-induced nephrotoxicity in male mice.Apr 08, 2019

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Pubmed Data : Water Environ Res. 2018 Jun 1 ;90(6):554-562. Epub 2017 Oct 12. PMID: 29050549

Article Published Date : May 31, 2018

Study Type : Environmental

Additional Links

Substances : Guduchi

Additional Keywords : Bioremediation, Environmental Pollution

Problem Substances : Cadmium

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Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats.Feb 28, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Mar ;87:280-287. Epub 2017 Jan 4. PMID: 28063409

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Pubmed Data : Front Pharmacol. 2022 ;13:969892. Epub 2022 Aug 11. PMID: 36034823

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Quercetin

Diseases : Cadmium Poisoning

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Cadmium

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Alpha-mangostin protects PC12 cells against neurotoxicity induced by cadmium and arsenic.Nov 28, 2022

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Pubmed Data : Biol Trace Elem Res. 2022 Nov 29. Epub 2022 Nov 29. PMID: 36445559

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Pubmed Data : Environ Res. 2016 Oct 27 ;152:221-225. Epub 2016 Aug 27. PMID: 27810679

Article Published Date : Oct 26, 2016

Study Type : In Vitro Study

Additional Links

Additional Keywords : Risk Factors

Problem Substances : Cadmium, Electronic Cigarettes, Lead

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Effects of individual and combined toxicity of bisphenol A, dibutyl phthalate and cadmium on oxidative stress and genotoxicity in HepG 2 cells.Mar 27, 2017

Pubmed Data : J Clin Diagn Res. 2017 Apr ;11(4):CE01-CE04. Epub 2017 Apr 1. PMID: 28571135

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Pubmed Data : Saudi Med J. 2011 Aug ;32(8):797-805. PMID: 21858388

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Pubmed Data : J Neurochem. 2015 Jul 4. Epub 2015 Jul 4. PMID: 26146868

Article Published Date : Jul 03, 2015

Problem Substances : Cadmium

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Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage.Nov 30, 2001

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Pubmed Data : Curr Top Med Chem. 2001 Dec ;1(6):529-39. PMID: 11895129

Article Published Date : Nov 30, 2001

Study Type : Review

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Diseases : Heavy Metal Toxicity, Oxidative Stress

Problem Substances : Arsenic, Cadmium, Lead, Mercury

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View the Evidence: 207 Abstracts with Cadmium Research

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Low-level environmental exposure to cadmium is a risk factor for total cancer and lung cancer.Aug 31, 2015

This meta-analysis suggests that a high cadmium exposure may be a risk factor for breast cancer.Aug 05, 2015

This meta-analysis supports the findings of existing studies regarding the role of dietary cadmium intake in hormone-related cancer risk in Western countriesDec 31, 2012

"Increased levels of transition metals in breast cancer tissue."Nov 30, 2006

Arsenic, cadmium, lead, and mercury in sweat: a systematic review.Dec 31, 2011

Autism spectrum disorders in relation to distribution of hazardous air pollutants in the san francisco bay area.Aug 31, 2006

Dietary cadmium exposure increases the risk of postmenopausal breast cancer.Mar 15, 2012

Lowering blood cadmium levels could be beneficial in reducing the incident of cardiovascular disease and related mortality.Oct 29, 2015

Physical training produces a decrease in erythrocyte concentrations of cadmium and lead.Jul 28, 2019

Selenium attenuates the association of co-exposure to arsenic, cadmium, and lead with cognitive function.Dec 21, 2022

This data supports the historic evidence that heavy metals play a role in the development of ASD.Dec 31, 2011

This study demonstrates that children with autism have higher average levels of several toxic metals, and levels of several toxic metals are strongly associated with variations in the severity of autism.Feb 01, 2013

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

A case of multiple sclerosis improvement following removal of heavy metal intoxication has been reported.Mar 22, 2012

It is possible that a deficiency of micronutrients and a high burden of heavy metals play a role in the pathogenesis of multiple sclerosis.Aug 12, 2011

Puerarin alleviates cadmium-induced mitochondrial mass decrease.Dec 30, 2021

A tunisian radish extract reduced the harmful outcomes of commonly encountered toxicants like cadmium on the immune system and on overall host health status.Dec 31, 2014

Agaricus blazei Murill polysaccharides inhibited cadmium induced effects on chicken peripheral blood lymphocytes.Oct 31, 2017

Agaricus blazei polysaccharide has beneficial effects on cadmium toxicity on peripheral blood lymphocytes.Dec 31, 2017

Alpha-lipoic acid attenuates cadmium- and lead-induced neurotoxicity.Mar 09, 2021

An extract of Fragaria ananassa had a protective effect against cadmium chloride toxicity upon the liver. Jan 21, 2017

Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier.May 21, 2018

Astaxanthin induces the expression of CatSper1 gene and protects sperms in toxicity induced by cadmium.Aug 17, 2021

Astilbin protects chicken peripheral blood lymphocytes from cadmium-induced necroptosis.Feb 29, 2020

BA may be an effective agent for the prevention and treatment of cadmium-induced diseases in humans.Dec 14, 2018

Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity.Jul 16, 2021

BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cellsNov 04, 2015

Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity.Dec 31, 2020

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders.Sep 30, 2020

CAPE seems to be effective agent and may be related to its potent antioxidant, anti-inflammatory properties and action as an Nrf2 activator.Aug 31, 2017

Cardiac toxicity of heavy metals cadmium and mercury and pharmacological intervention by vitamin C. May 20, 2020

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats.Oct 31, 2019

Chokeberry is a promising natural agent for skeletal protection under low-level and moderate chronic exposure to cadmium. May 24, 2017

Chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal.Apr 30, 2016

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Coenzyme Q10 and vitamin E have antioxidative and haematoprotective activity of against cadmium-induced oxidative stress.Dec 31, 2016

Consumption of anthocyanins can be protective against metal-induced male reproductive dysfunction.Jun 30, 2019

Consumption of aronia products may prevent oxidative/antioxidative imbalance induced by cadmium.Dec 31, 2018

Cupric sulfate and cadmium have genotoxic and cytotoxic effects.Apr 01, 2005

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.May 16, 2017

Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice.Jan 04, 2022

Dietary garlic powder has protective effects against cadmium-induced toxicity.Sep 01, 2017

Disruption of kidney metabolism in rats after subchronic combined exposure to low-dose cadmium and chlorpyrifos.Nov 29, 2018

Early-life exposure to low-dose cadmium accelerates diethylnitrosamine and diet-induced liver cancer.Dec 31, 2020

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals.Apr 30, 2021

Effects of quercetin on cadmium-induced toxicity in rat urine using metabonomics techniques.Dec 25, 2019

Extract from Aronia melanocarpa L. berries prevents cadmium-induced oxidative stress in the liver.Dec 20, 2018

Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.Dec 31, 2014

Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium-induced oxidative challenge, inflammation, and apoptosis.Oct 11, 2020

First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary.Nov 08, 2020

Galangin attenuates cadmium-evoked nephrotoxicity.Jun 30, 2022

Gallic and ascorbic acids supplementation alleviate cognitive deficits and neuropathological damage exerted by cadmium chloride.Aug 23, 2022

Ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.Jan 31, 2019

Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride.Aug 31, 2020

Grape juice concentrate protects rat liver against cadmium intoxication.Jun 30, 2016

Grape or apple juices have protective effects in bone tissue of rats exposed to cadmium.Mar 25, 2018

Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle.Sep 30, 2018

Hepatoprotective role of vitexin against cadmium-induced liver damage.Apr 10, 2022

Hibiscus sabdariffa extract protects against cadmium-induced ovarian toxicity.Dec 31, 2019

Honey bee colonies may have a weakened immune system in cadmium polluted areas, resulting in a decreased ability in dealing with pathogens.Oct 31, 2016

Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation.Jan 19, 2023

Honokiol showed beneficial effects on kidney injury caused by cadmium.Oct 09, 2022

Inhibitory activity of flaxseed oil against cadmium chloride induced liver and kidney damage.Dec 31, 2019

Isoliquiritigenin has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation.Nov 30, 2016

Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium.Nov 30, 2022

Low dose cadmium can cause dysbiosis of the gut microbiota. Feb 04, 2020

Metal ingestion produced two of the hallmark characteristics of autism: social avoidance and a male-oriented bias in prairie vole.Nov 12, 2010

N-Acetyl cysteine mitigates histopathological changes and inflammatory genes expressions in the liver of cadmium exposed rats.Nov 30, 2021

N-acetylcysteine reduces miR-146a and NF-κB p65 inflammatory signalling following cadmium hepatotoxicity.Jan 16, 2021

Naringenin possesses a remarkable alleviative effect against cadmium induced toxicity in albino mice.Dec 31, 2015

Cadmium

View the Evidence:
207 Abstracts with Cadmium Research