Choline Chloride

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0 Abstracts with Choline Chloride Research

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Choline chloride is mass produced and is an important additive in feed especially for chickens where it accelerates growth. (Source: Wikipedia

The Material Safety Data Sheet says it "may act as an irritant." 

The following citations are sourced from the Hazardous Substance Data Bank via the National Libary of Medicine's TOXNET:

 

Non-Human Toxicity Excerpts:
/LABORATORY ANIMALS: Acute Exposure/ Given orally 2.8 g/kg to rats increased caudate nucleus choline acetyltransferase activity 27% after 8 hr & 28% after 24 hr.
[FERNSTROM MH, WURTMAN RJ; BRAIN RES 165(2) 358 (1979)] **PEER REVIEWED**


/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ ... Adult male rats were administered ip aqueous choline chloride (25 mg/rat, daily for 12 or 24 days). Administration of excess choline for 12 days did not significantly alter spermatogenesis. Administration for 24 days depleted pachytene spermatocytes until posttreatment day 5, while slight proliferation of spermatogonia was noted from day 5 onwards. By day 12, the tubules showed almost normal cellular associations. It is suggested that perhaps a prolonged administration of excess choline may prove to be toxic to male reproduction.
[Vachhrajani KD et al; Reprod Toxicol 7 (5): 477-81 (1993)] **PEER REVIEWED** PubMed Abstract

/LABORATORY ANIMALS: Neurotoxicity/ Oral admin of choline chloride to rats stimulated metabolism of dopamine in brain. Apparently, oral admin of choline augments central cholinergic function, possibly involving stimulation of rate of synthesis & release of acetylcholine.
[HAUBRICH DR, PFLUEGER AB; LIFE SCI 24(12) 1083 (1979)] **PEER REVIEWED**

/LABORATORY ANIMALS: Acute Exposure/ In rats, large single doses caused 4-fold elevations in acetylcholine content of adrenal & this result was followed by incr in tyrosine hydroxylase.
[WURTMAN RJ; PSYCHOPHARMACOL BULL 15(4) 70 (1979)] **PEER REVIEWED**

 

 

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