Cyclophosphamide

Name	AC	CK
Chemotherapy-Induced Toxicity: Cyclophosphamide	18	36
Liver Damage: Drug-Induced	3	6
Brain Injury: Hippocampal Damage	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Cognitive Decline/Dysfunction	1	2
Cystitis	1	2
Kidney Damage: Chemically-Induced	1	2
Liver Cancer	1	2
Oxidative Stress	1	2

Name	AC	CK	Focus
Neurotoxic	1	2

[+]

"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."Feb 14, 2012

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22338017

Article Published Date : Feb 14, 2012

Study Type : Animal Study

Additional Links

Diseases : Brain Injury: Hippocampal Damage, Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin, Cognitive Decline/Dysfunction

Additional Keywords : Drug: Doxorubicin

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Cyclophosphamide, Doxorubicin

Adverse Pharmacological Actions : Neurotoxic

[+]

Alleviative effects of astragaloside IV on cyclophosphamide-induced oxidative damage and immunosuppression.Nov 07, 2022

Click here to read the entire abstract

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2022 Nov 8:109503. Epub 2022 Nov 8. PMID: 36368505

Article Published Date : Nov 07, 2022

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Immunomodulatory, Nrf2 activation

Problem Substances : Cyclophosphamide

[+]

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury.Dec 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Res Food Sci. 2024 ;8:100734. Epub 2024 Apr 17. PMID: 38708102

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Cyclophosphamide

[+]

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Apr 22 ;182:101-9. Epub 2016 Feb 10. PMID: 26875643

Article Published Date : Apr 21, 2016

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Fertility Agents: Male

Additional Keywords : Plant Extracts

Problem Substances : Cyclophosphamide

[+]

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2018 Apr 6 ;215:191-198. Epub 2018 Jan 9. PMID: 29325915

Article Published Date : Apr 05, 2018

Study Type : Animal Study

Additional Links

Substances : Purslane

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antispasmodic, Immunomodulatory

Problem Substances : Cyclophosphamide

[+]

Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.Jun 03, 2016

Click here to read the entire abstract

Pubmed Data : Lipids. 2016 Jun 4. Epub 2016 Jun 4. PMID: 27262314

Article Published Date : Jun 03, 2016

Study Type : Animal Study

Additional Links

Substances : Apricot Kernel

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Problem Substances : Cyclophosphamide

[+]

Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency.Aug 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2023 Sep ;153(1):46-54. Epub 2023 Jul 13. PMID: 37524454

Article Published Date : Aug 31, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

Problem Substances : Cyclophosphamide

[+]

Chrysin has a protective effect against cyclophosphamide -induced hepatorenal toxicity.Oct 15, 2019

Click here to read the entire abstract

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31620822

Article Published Date : Oct 15, 2019

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Cyclophosphamide

[+]

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Click here to read the entire abstract

Pubmed Data : Rom J Physiol. 1999 Jul-Dec;36(3-4):205-18. PMID: 11797936

Article Published Date : Jun 30, 1999

Study Type : Animal Study

Additional Links

Substances : Water: Deuterium Depleted

Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemotherapeutic, Immunostimulatory, Radioprotective

Problem Substances : Cyclophosphamide

[+]

Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury.Oct 23, 2021

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2021 Oct 24. Epub 2021 Oct 24. PMID: 34689333

Article Published Date : Oct 23, 2021

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cyclophosphamide, Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Cyclophosphamide

[+]

Naringin prevents cyclophosphamide-induced hepatotoxicity.May 13, 2021

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2021 May 14 ;153:112266. Epub 2021 May 14. PMID: 33992719

Article Published Date : May 13, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective

Problem Substances : Cyclophosphamide

[+]

Omega-3 fatty acids modulate cyclophosphamide induced markers of immunosuppression and oxidative stress in pigs.Feb 24, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2019 Feb 25 ;9(1):2684. Epub 2019 Feb 25. PMID: 30804435

Article Published Date : Feb 24, 2019

Study Type : Animal Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Immunomodulatory

Problem Substances : Cyclophosphamide

[+]

Panax ginseng is superior to vitamin E as a hepatoprotector against cyclophosphamide-induced liver damage.Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2019 Oct ;46:95-102. Epub 2019 Aug 7. PMID: 31519295

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Panax Ginseng, Vitamin E

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents

Problem Substances : Cyclophosphamide

[+]

Polysaccharides from hemp seed protect against cyclophosphamide-induced intestinal oxidative damage. Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:1813798. Epub 2020 Aug 25. PMID: 32908623

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Hemp Seed

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Polysaccharides

Problem Substances : Cyclophosphamide

[+]

Sesamin's therapeutic actions on cyclophosphamide-induced hepatotoxicity.Dec 06, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicines. 2023 Dec 7 ;11(12). Epub 2023 Dec 7. PMID: 38137459

Article Published Date : Dec 06, 2023

Study Type : Animal Study

Additional Links

Substances : Sesamin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Cyclophosphamide

[+]

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):730-6. Epub 2015 May 23. PMID: 26141759

Article Published Date : Jul 14, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Buckwheat

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemoprotective Agents, Tumor Suppressor Protein p53 Upregulation

Problem Substances : Cyclophosphamide

[+]

The effect of acetylcysteine on renal function in experimental models of cyclophosphamide-and ifosfamide-induced cystitis. Sep 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Urol. 2020 Oct ;14(3):150-162. Epub 2020 Oct 13. PMID: 33224008

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Cytoprotective, Renoprotective

Problem Substances : Cyclophosphamide

[+]

The effects of naringin on different cyclophosphamide-induced organ toxicities.Jul 09, 2019

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31292874

Article Published Date : Jul 09, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents

Problem Substances : Cyclophosphamide

[+]

Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : J Adv Pharm Technol Res. 2017 Apr-Jun;8(2):73-79. PMID: 28516060

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cytoprotective

Problem Substances : Cyclophosphamide

Cyclophosphamide jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 19 Abstracts with Cyclophosphamide Research

Limited to Members Only

Currently Available Sorting Options

"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."Feb 14, 2012

Alleviative effects of astragaloside IV on cyclophosphamide-induced oxidative damage and immunosuppression.Nov 07, 2022

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury.Dec 31, 2023

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.Jun 03, 2016

Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency.Aug 31, 2023

Chrysin has a protective effect against cyclophosphamide -induced hepatorenal toxicity.Oct 15, 2019

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury.Oct 23, 2021

Naringin prevents cyclophosphamide-induced hepatotoxicity.May 13, 2021

Omega-3 fatty acids modulate cyclophosphamide induced markers of immunosuppression and oxidative stress in pigs.Feb 24, 2019

Panax ginseng is superior to vitamin E as a hepatoprotector against cyclophosphamide-induced liver damage.Sep 30, 2019

Polysaccharides from hemp seed protect against cyclophosphamide-induced intestinal oxidative damage. Dec 31, 2019

Sesamin's therapeutic actions on cyclophosphamide-induced hepatotoxicity.Dec 06, 2023

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

The effect of acetylcysteine on renal function in experimental models of cyclophosphamide-and ifosfamide-induced cystitis. Sep 30, 2020

The effects of naringin on different cyclophosphamide-induced organ toxicities.Jul 09, 2019

Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.Mar 31, 2017

Print Options

Cyclophosphamide

View the Evidence:
19 Abstracts with Cyclophosphamide Research