Diclofenac

Name	AC	CK
Myocardial Infarction	3	40
Cardiac Mortality	2	30
Cardiovascular Diseases	2	30
Coronary Artery Disease	1	20
Abortion: Spontaneous	1	10
Children: Drug-Induced Toxicity	1	10
Drug-Induced Toxicity	1	10
Febrile Seizures	1	10
Fever	1	10
Heart Failure	1	10
Miscarriage	1	10
Gastric Ulcer	1	2
Inflammation	1	2
Lipid Peroxidation	1	2
Oxidative Stress	1	2

Name	AC	CK
Cardiotoxic	1	20
Nephrotoxic	1	10
Teratogenic	1	10
Irritant	1	2

[+]

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Children: Drug-Induced Toxicity

Problem Substances : Diclofenac, Dipyrone, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

Adverse Pharmacological Actions : Nephrotoxic

[+]

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Febrile Seizures, Fever

Problem Substances : Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol, Tylenol

[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation

Problem Substances : Diclofenac

[+]

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Am J Emerg Med. 2015 Jun ;33(6):749-53. Epub 2015 Feb 25. PMID: 25827597

Article Published Date : May 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Renal Colic

Therapeutic Actions : Acupuncture

Problem Substances : Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Curcumin treatment is safe and superior to drug therapy in patients with active RA.Oct 31, 2012

Click here to read the entire abstract

Article Published Date : Oct 31, 2012

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Rheumatoid Arthritis

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

[+]

Green tea extract might be an adjunctive treatment for pain and the betterment of knee joint function in adults with osteoarthritis.Dec 17, 2016

Click here to read the entire abstract

Pubmed Data : Clin Nutr. 2016 Dec 18. Epub 2016 Dec 18. PMID: 28038881

Article Published Date : Dec 17, 2016

Study Type : Human Study

Additional Links

Substances : Green Tea

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Analgesics

Problem Substances : Diclofenac

[+]

N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.Nov 18, 2015

Click here to read the entire abstract

Pubmed Data : Planta Med. 2015 Nov 19. Epub 2015 Nov 19. PMID: 26584456

Article Published Date : Nov 18, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Mastalgia

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Diclofenac

[+]

NSAIDs are associated with an increased risk of myocardial infarction and death. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 2009 Feb;85(2):190-7. Epub 2008 Nov 5. PMID: 18987620

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Cardiovascular Diseases, Myocardial Infarction

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

[+]

NSAIDs are frequently used in patients with heart failure and are associated with increased risk of death and cardiovascular morbidity.Jan 26, 2009

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2009 Jan 26;169(2):141-9. PMID: 19171810

Article Published Date : Jan 26, 2009

Study Type : Human Study

Additional Links

Diseases : Heart Failure, Myocardial Infarction

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

[+]

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation

Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity

Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d5769. Epub 2011 Sep 9. PMID: 21908536

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Drug-Induced Toxicity , Miscarriage

Pharmacological Actions : Teratogens

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

Adverse Pharmacological Actions : Teratogenic

[+]

Thymus daenensis gel improves osteoarthritis symptoms in patients equal and without significant difference than diclofenac.May 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicine (Taipei). 2019 Jun ;9(2):9. Epub 2019 May 24. PMID: 31124455

Article Published Date : May 31, 2019

Study Type : Human Study

Additional Links

Substances : Thyme

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Diclofenac

[+]

Topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee osteoarthritis pain.Nov 30, 2019

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2019 Dec ;47:102183. Epub 2019 Aug 22. PMID: 31780006

Article Published Date : Nov 30, 2019

Study Type : Human Study

Additional Links

Substances : Sesame oil: topical, Sesame Seed Oil

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Diclofenac

[+]

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

Click here to read the entire abstract

Pubmed Data : Eur Heart J Cardiovasc Pharmacother. 2016 Dec 26. Epub 2016 Dec 26. PMID: 28025218

Article Published Date : Dec 25, 2016

Study Type : Human Study

Additional Links

Diseases : Cardiac Arrest, NSAID-induced toxicity

Additional Keywords : Increased Risk

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

Adverse Pharmacological Actions : Cardiotoxic

[+]

Allicin modulates diclofenac sodium induced hepatonephro toxicity.Nov 22, 2019

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2019 Nov 23 ;74:103306. Epub 2019 Nov 23. PMID: 31812117

Article Published Date : Nov 22, 2019

Study Type : Animal Study

Additional Links

Substances : Allicin

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Diclofenac

[+]

Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Aug ;43(8):e12950. Epub 2019 Jun 18. PMID: 31368551

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Diclofenac

[+]

An oil-based Dill extract used topically was found to be significantly more effective than Diclofenac-gel.Dec 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Pharm Res. 2012 ;11(4):1169-74. PMID: 24250550

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Dill

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts, Plant Oils, Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

[+]

Anthropogenic contaminants of high concern: Existence in water resources and their adverse effects.Nov 09, 2019

Click here to read the entire abstract

Pubmed Data : Sci Total Environ. 2019 Nov 10 ;690:1068-1088. Epub 2019 Jul 6. PMID: 31470472

Article Published Date : Nov 09, 2019

Study Type : Environmental

Additional Links

Additional Keywords : Environmental Fate of Pharmacueticals, Public Drinking Water, Water Pollution

Problem Substances : Acetaminophen, Diclofenac, Ibuprofen, Naproxen, Ofloxacin, Pesticides, Ranitidine, Triclosan

[+]

Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Feb ;43(2):e12704. Epub 2018 Oct 28. PMID: 31353658

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Berberine protects against diclofenac sodium-induced testicular impairment.May 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2022 Jun ;25(6):767-774. PMID: 35949309

Article Published Date : May 31, 2022

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Diclofenac

[+]

Berberine was found to be an effective agent in the attenuation of diclofenac-induced acute kidney injury.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S83-S87. PMID: 31603884

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Diclofenac

[+]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895

Article Published Date : Nov 25, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress.Nov 06, 2022

Click here to read the entire abstract

Pubmed Data : Mol Biol Rep. 2022 Nov 7. Epub 2022 Nov 7. PMID: 36344803

Article Published Date : Nov 06, 2022

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.Oct 24, 2019

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Selenium

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Hepatoprotective effect of Woodfordia fruticosa flowers on diclofenac sodium induced liver toxicity.Apr 30, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2011 May ;4(5):342-6. Epub 2011 Jun 22. PMID: 21771673

Article Published Date : Apr 30, 2011

Study Type : Animal Study

Additional Links

Substances : Woodfordia fruticosa

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Diclofenac

[+]

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : Appl Physiol Nutr Metab. 2018 Sep ;43(9):956-968. Epub 2018 May 30. PMID: 29847737

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Kidney Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Renoprotective

Problem Substances : Diclofenac

[+]

L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2020 Aug ;23(8):1035-1044. PMID: 32952950

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : L-Carnitine

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Luteolin may be a promising lead for the treatment of drug-induced gastroenteropathy.Aug 04, 2020

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2020 Aug 5:1-13. Epub 2020 Aug 5. PMID: 32757682

Article Published Date : Aug 04, 2020

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Fluoride Toxicity

Pharmacological Actions : Gastroprotective

Additional Keywords : Synergistic Toxicity

Problem Substances : Diclofenac, Sodium Fluoride

Adverse Pharmacological Actions : Gastrotoxic

[+]

Melatonin supplementation could prevent the adverse effects of diclofenac sodium.Sep 11, 2015

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2015 Sep 12:1-5. Epub 2015 Sep 12. PMID: 26365794

Article Published Date : Sep 11, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Kidney Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Diclofenac

[+]

Naringin and hesperidin counteract diclofenac-induced hepatotoxicity.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9990091. Epub 2021 Aug 11. PMID: 34422219

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Hesperidin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PMID: 26720998

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Diclofenac

[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Allodynia, Chronic Pain, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

[+]

Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity.Jun 03, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2022 Jun 4 ;152:113225. Epub 2022 Jun 4. PMID: 35671584

Article Published Date : Jun 03, 2022

Study Type : Animal Study

Additional Links

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Diclofenac

[+]

Pre-treatment with olive leaf extract improved the haematological parameters and minimised the adverse effects induced by diclofenac.Apr 19, 2018

Click here to read the entire abstract

Pubmed Data : Appl Physiol Nutr Metab. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29677459

Article Published Date : Apr 19, 2018

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats.Jan 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2020 Feb ;6(2):e03330. Epub 2020 Feb 1. PMID: 32025584

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Royal Jelly

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Hepatoprotective, Postaglandin PGE2 downregulation

Problem Substances : Diclofenac

[+]

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption.Aug 04, 2019

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2019 Aug 5:1-7. Epub 2019 Aug 5. PMID: 31305161

Article Published Date : Aug 04, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Click here to read the entire abstract

Pubmed Data : Shock. 2008 Oct ;30(4):456-62. PMID: 18277948

Article Published Date : Oct 01, 2008

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Gastric Ulcer, Inflammation, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase Inhibitors, Gastroprotective

Problem Substances : Diclofenac

Adverse Pharmacological Actions : Irritant

[+]

Spirulina fusiformis had hepato-renal and gastroprotective activity against Diclofenac-induced toxicity.Jan 12, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Jan 13 ;88:11-18. Epub 2017 Jan 13. PMID: 28092840

Article Published Date : Jan 12, 2017

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Gastric Ulcer

Pharmacological Actions : Gastroprotective, Hepatoprotective, Renoprotective

Problem Substances : Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

The effects of ellagic acid on the prevention of peritoneal adhesion were found to be stronger than diclofenac sodium.Aug 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int Surg. 2014 Sep-Oct;99(5):543-50. PMID: 25216418

Article Published Date : Aug 31, 2014

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Surgery: Abdominal

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

[+]

These findings revealed that virgin coconut oil has potential benefits to prevent diclofenac-induced nephrotoxic damage. Apr 30, 2020

Click here to read the entire abstract

Pubmed Data : Avicenna J Phytomed. 2020 May-Jun;10(3):316-324. PMID: 32523886

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Coconut Oil

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Diclofenac

[+]

These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Pharm Res. 2016 Mar ;39(3):421-8. Epub 2016 Jan 30. PMID: 26832325

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Tongkat Ali

Diseases : Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

[+]

These results suggest that MSE could be a promising gastroprotective herbal medicine.Jan 31, 2013

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2013 Feb ;35(1):126-32. Epub 2012 Aug 14. PMID: 22889079

Article Published Date : Jan 31, 2013

Study Type : Animal Study

Additional Links

Substances : Gac

Diseases : Helicobacter Pylori Infection, Wound Healing

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

Problem Substances : Diclofenac

[+]

Thymoquinone could ameliorate gastrointestinal and renal toxicity induced by high dose diclofenac treatment.Jun 19, 2018

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2018 Jun 20 ;118:795-804. Epub 2018 Jun 20. PMID: 29935248

Article Published Date : Jun 19, 2018

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : NSAID-induced toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Diclofenac

[+]

Vitamin C and vitamin E might play an important role in reducing oxidative stress and kidney damage induced by diclofenac sodium.Sep 21, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Sep 22 ;84:314-322. Epub 2016 Sep 22. PMID: 27665477

Article Published Date : Sep 21, 2016

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Diclofenac

[+]

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31922618

Article Published Date : Jan 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Curcumin, EGCG (Epigallocatechin gallate), Gallic Acid, Naringenin , Piperine, Polyphenols, Quercetin, Rutin, Silymarin

Diseases : Drug-Induced Toxicity: Gastrointestinal, Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Diclofenac, Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Neuroprotective effects of chrysin on diclofenac-induced apoptosis in SH-SY5Y cells.Feb 09, 2020

Click here to read the entire abstract

Pubmed Data : Neurochem Res. 2020 Feb 10. Epub 2020 Feb 10. PMID: 32040722

Article Published Date : Feb 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Chrysin

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Problem Substances : Diclofenac

Adverse Pharmacological Actions : Neurotoxic

Diclofenac jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

Diclofenac is a Sub of the following Topic

View the Evidence: 48 Abstracts with Diclofenac Research

Limited to Members Only

Currently Available Sorting Options

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.May 01, 2009

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Curcumin treatment is safe and superior to drug therapy in patients with active RA.Oct 31, 2012

Green tea extract might be an adjunctive treatment for pain and the betterment of knee joint function in adults with osteoarthritis.Dec 17, 2016

N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.Nov 18, 2015

NSAIDs are associated with an increased risk of myocardial infarction and death. Feb 01, 2009

NSAIDs are frequently used in patients with heart failure and are associated with increased risk of death and cardiovascular morbidity.Jan 26, 2009

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage. Jan 01, 2011

Thymus daenensis gel improves osteoarthritis symptoms in patients equal and without significant difference than diclofenac.May 31, 2019

Topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee osteoarthritis pain.Nov 30, 2019

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

Allicin modulates diclofenac sodium induced hepatonephro toxicity.Nov 22, 2019

Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury.Jul 31, 2019

An oil-based Dill extract used topically was found to be significantly more effective than Diclofenac-gel.Dec 31, 2011

Anthropogenic contaminants of high concern: Existence in water resources and their adverse effects.Nov 09, 2019

Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.Jan 31, 2019

Berberine protects against diclofenac sodium-induced testicular impairment.May 31, 2022

Berberine was found to be an effective agent in the attenuation of diclofenac-induced acute kidney injury.Jul 31, 2019

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress.Nov 06, 2022

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.Oct 24, 2019

Hepatoprotective effect of Woodfordia fruticosa flowers on diclofenac sodium induced liver toxicity.Apr 30, 2011

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium.Jul 31, 2020

Luteolin may be a promising lead for the treatment of drug-induced gastroenteropathy.Aug 04, 2020

Melatonin supplementation could prevent the adverse effects of diclofenac sodium.Sep 11, 2015

Naringin and hesperidin counteract diclofenac-induced hepatotoxicity.Dec 31, 2020

Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.Jun 30, 2015

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity.Jun 03, 2022

Pre-treatment with olive leaf extract improved the haematological parameters and minimised the adverse effects induced by diclofenac.Apr 19, 2018

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats.Jan 31, 2020

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption.Aug 04, 2019

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Spirulina fusiformis had hepato-renal and gastroprotective activity against Diclofenac-induced toxicity.Jan 12, 2017

The effects of ellagic acid on the prevention of peritoneal adhesion were found to be stronger than diclofenac sodium.Aug 31, 2014

These findings revealed that virgin coconut oil has potential benefits to prevent diclofenac-induced nephrotoxic damage. Apr 30, 2020

These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.Feb 29, 2016

These results suggest that MSE could be a promising gastroprotective herbal medicine.Jan 31, 2013

Thymoquinone could ameliorate gastrointestinal and renal toxicity induced by high dose diclofenac treatment.Jun 19, 2018

Vitamin C and vitamin E might play an important role in reducing oxidative stress and kidney damage induced by diclofenac sodium.Sep 21, 2016

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

Neuroprotective effects of chrysin on diclofenac-induced apoptosis in SH-SY5Y cells.Feb 09, 2020

Diclofenac Related Articles

Print Options

Diclofenac

View the Evidence:
48 Abstracts with Diclofenac Research