Diclofenac

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15 Diseases Researched for Diclofenac
NameACCKFocus
Myocardial Infarction340Locked
Cardiac Mortality 230Locked
Cardiovascular Diseases230Locked
Coronary Artery Disease120Locked
Abortion: Spontaneous110Locked
Children: Drug-Induced Toxicity110Locked
Drug-Induced Toxicity 110Locked
Febrile Seizures110Locked
Fever110Locked
Heart Failure110Locked
Miscarriage110Locked
Gastric Ulcer12Locked
Inflammation12Locked
Lipid Peroxidation12Locked
Oxidative Stress12Locked
4 Adverse Pharmacological Actions Researched for Diclofenac
NameACCKFocus
Cardiotoxic120Locked
Nephrotoxic110Locked
Teratogenic110Locked
Irritant12Locked
Related Topics

Diclofenac is a Sub of the following Topic

View the Evidence:
49 Abstracts with Diclofenac Research

[+]

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.May 01, 2009

Pubmed Data : Circ Cardiovasc Qual Outcomes. 2009 May;2(3):155-63. Epub 2009 May 5. PMID: 20031832
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality , Cardiovascular Diseases, Coronary Artery Disease, Myocardial Infarction
Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib
Adverse Pharmacological Actions : Cardiotoxic
[+]

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Children: Drug-Induced Toxicity
Problem Substances : Diclofenac, Dipyrone, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol
Adverse Pharmacological Actions : Nephrotoxic
[+]

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Febrile Seizures, Fever
Problem Substances : Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol, Tylenol
[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation
Problem Substances : Diclofenac
[+]

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Pubmed Data : Am J Emerg Med. 2015 Jun ;33(6):749-53. Epub 2015 Feb 25. PMID: 25827597
Article Published Date : May 31, 2015
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Renal Colic
Therapeutic Actions : Acupuncture
Problem Substances : Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Curcumin treatment is safe and superior to drug therapy in patients with active RA.Oct 31, 2012

Article Published Date : Oct 31, 2012
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Rheumatoid Arthritis
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Green tea extract might be an adjunctive treatment for pain and the betterment of knee joint function in adults with osteoarthritis.Dec 17, 2016

Pubmed Data : Clin Nutr. 2016 Dec 18. Epub 2016 Dec 18. PMID: 28038881
Article Published Date : Dec 17, 2016
Study Type : Human Study
Additional Links
Substances : Green Tea
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Analgesics
Problem Substances : Diclofenac
[+]

N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.Nov 18, 2015

Pubmed Data : Planta Med. 2015 Nov 19. Epub 2015 Nov 19. PMID: 26584456
Article Published Date : Nov 18, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Mastalgia
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

NSAIDs are associated with an increased risk of myocardial infarction and death. Feb 01, 2009

Pubmed Data : Clin Pharmacol Ther. 2009 Feb;85(2):190-7. Epub 2008 Nov 5. PMID: 18987620
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Cardiovascular Diseases, Myocardial Infarction
Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib
[+]

NSAIDs are frequently used in patients with heart failure and are associated with increased risk of death and cardiovascular morbidity.Jan 26, 2009

Pubmed Data : Arch Intern Med. 2009 Jan 26;169(2):141-9. PMID: 19171810
Article Published Date : Jan 26, 2009
Study Type : Human Study
Additional Links
Diseases : Heart Failure, Myocardial Infarction
Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib
[+]

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation
Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity
Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol
[+]

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage. Jan 01, 2011

Pubmed Data : BMJ. 2011 ;343:d5769. Epub 2011 Sep 9. PMID: 21908536
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Abortion: Spontaneous, Drug-Induced Toxicity , Miscarriage
Pharmacological Actions : Teratogens
Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib
Adverse Pharmacological Actions : Teratogenic
[+]

Thymus daenensis gel improves osteoarthritis symptoms in patients equal and without significant difference than diclofenac.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2019 Jun ;9(2):9. Epub 2019 May 24. PMID: 31124455
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Thyme
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

Topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee osteoarthritis pain.Nov 30, 2019

Pubmed Data : Complement Ther Med. 2019 Dec ;47:102183. Epub 2019 Aug 22. PMID: 31780006
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Substances : Sesame oil: topical, Sesame Seed Oil
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

Pubmed Data : Eur Heart J Cardiovasc Pharmacother. 2016 Dec 26. Epub 2016 Dec 26. PMID: 28025218
Article Published Date : Dec 25, 2016
Study Type : Human Study
Additional Links
Diseases : Cardiac Arrest, NSAID-induced toxicity
Additional Keywords : Increased Risk
Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib
Adverse Pharmacological Actions : Cardiotoxic
[+]

Allicin modulates diclofenac sodium induced hepatonephro toxicity.Nov 22, 2019

Pubmed Data : Environ Toxicol Pharmacol. 2019 Nov 23 ;74:103306. Epub 2019 Nov 23. PMID: 31812117
Article Published Date : Nov 22, 2019
Study Type : Animal Study
Additional Links
Substances : Allicin
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Diclofenac
[+]

Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury.Jul 31, 2019

Pubmed Data : J Food Biochem. 2019 Aug ;43(8):e12950. Epub 2019 Jun 18. PMID: 31368551
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Diclofenac
[+]

An oil-based Dill extract used topically was found to be significantly more effective than Diclofenac-gel.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2012 ;11(4):1169-74. PMID: 24250550
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Dill
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts, Plant Oils, Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Anthropogenic contaminants of high concern: Existence in water resources and their adverse effects.Nov 09, 2019

Pubmed Data : Sci Total Environ. 2019 Nov 10 ;690:1068-1088. Epub 2019 Jul 6. PMID: 31470472
Article Published Date : Nov 09, 2019
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Fate of Pharmacueticals, Public Drinking Water, Water Pollution
Problem Substances : Acetaminophen, Diclofenac, Ibuprofen, Naproxen, Ofloxacin, Pesticides, Ranitidine, Triclosan
[+]

Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.Jan 31, 2019

Pubmed Data : J Food Biochem. 2019 Feb ;43(2):e12704. Epub 2018 Oct 28. PMID: 31353658
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Berberine protects against diclofenac sodium-induced testicular impairment.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2022 Jun ;25(6):767-774. PMID: 35949309
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Problem Substances : Diclofenac
[+]

Berberine was found to be an effective agent in the attenuation of diclofenac-induced acute kidney injury.Jul 31, 2019

Pubmed Data : J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S83-S87. PMID: 31603884
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Diclofenac
[+]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Pubmed Data : Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895
Article Published Date : Nov 25, 2019
Study Type : Animal Study
Additional Links
Substances : Betanin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Diclofenac, Paracetamol
[+]

Carvacrol exerts anti-inflammatory, anti-oxidative stress and hepatoprotective effects against diclofenac-induced liver injury.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Prev Med. 2023 ;14:61. Epub 2023 May 27. PMID: 37351047
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress.Nov 06, 2022

Pubmed Data : Mol Biol Rep. 2022 Nov 7. Epub 2022 Nov 7. PMID: 36344803
Article Published Date : Nov 06, 2022
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Diclofenac
[+]

Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.Oct 24, 2019

Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258
Article Published Date : Oct 24, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin, Selenium
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Hepatoprotective effect of Woodfordia fruticosa flowers on diclofenac sodium induced liver toxicity.Apr 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2011 May ;4(5):342-6. Epub 2011 Jun 22. PMID: 21771673
Article Published Date : Apr 30, 2011
Study Type : Animal Study
Additional Links
Substances : Woodfordia fruticosa
Diseases : Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Diclofenac
[+]

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

Pubmed Data : Appl Physiol Nutr Metab. 2018 Sep ;43(9):956-968. Epub 2018 May 30. PMID: 29847737
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Renoprotective
Problem Substances : Diclofenac
[+]

L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Aug ;23(8):1035-1044. PMID: 32952950
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : L-Carnitine
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Diclofenac
[+]

Luteolin may be a promising lead for the treatment of drug-induced gastroenteropathy.Aug 04, 2020

Pubmed Data : Drug Chem Toxicol. 2020 Aug 5:1-13. Epub 2020 Aug 5. PMID: 32757682
Article Published Date : Aug 04, 2020
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Fluoride Toxicity
Pharmacological Actions : Gastroprotective
Additional Keywords : Synergistic Toxicity
Problem Substances : Diclofenac, Sodium Fluoride
Adverse Pharmacological Actions : Gastrotoxic
[+]

Melatonin supplementation could prevent the adverse effects of diclofenac sodium.Sep 11, 2015

Pubmed Data : Ren Fail. 2015 Sep 12:1-5. Epub 2015 Sep 12. PMID: 26365794
Article Published Date : Sep 11, 2015
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Kidney Damage
Pharmacological Actions : Hepatoprotective
Problem Substances : Diclofenac
[+]

Naringin and hesperidin counteract diclofenac-induced hepatotoxicity.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9990091. Epub 2021 Aug 11. PMID: 34422219
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Hesperidin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.Jun 30, 2015

Pubmed Data : J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PMID: 26720998
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Allodynia, Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity.Jun 03, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Jun 4 ;152:113225. Epub 2022 Jun 4. PMID: 35671584
Article Published Date : Jun 03, 2022
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Diclofenac
[+]

Pre-treatment with olive leaf extract improved the haematological parameters and minimised the adverse effects induced by diclofenac.Apr 19, 2018

Pubmed Data : Appl Physiol Nutr Metab. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29677459
Article Published Date : Apr 19, 2018
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Diclofenac
[+]

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Feb ;6(2):e03330. Epub 2020 Feb 1. PMID: 32025584
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Hepatoprotective, Postaglandin PGE2 downregulation
Problem Substances : Diclofenac
[+]

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption.Aug 04, 2019

Pubmed Data : Biomarkers. 2019 Aug 5:1-7. Epub 2019 Aug 5. PMID: 31305161
Article Published Date : Aug 04, 2019
Study Type : Animal Study
Additional Links
Substances : Betanin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Acetaminophen, Diclofenac, Paracetamol
[+]

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Pubmed Data : Shock. 2008 Oct ;30(4):456-62. PMID: 18277948
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Gastric Ulcer, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase Inhibitors, Gastroprotective
Problem Substances : Diclofenac
Adverse Pharmacological Actions : Irritant
[+]

Spirulina fusiformis had hepato-renal and gastroprotective activity against Diclofenac-induced toxicity.Jan 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jan 13 ;88:11-18. Epub 2017 Jan 13. PMID: 28092840
Article Published Date : Jan 12, 2017
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Gastric Ulcer
Pharmacological Actions : Gastroprotective, Hepatoprotective, Renoprotective
Problem Substances : Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

The effects of ellagic acid on the prevention of peritoneal adhesion were found to be stronger than diclofenac sodium.Aug 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Surg. 2014 Sep-Oct;99(5):543-50. PMID: 25216418
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Surgery: Abdominal
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

These findings revealed that virgin coconut oil has potential benefits to prevent diclofenac-induced nephrotoxic damage. Apr 30, 2020

Pubmed Data : Avicenna J Phytomed. 2020 May-Jun;10(3):316-324. PMID: 32523886
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Coconut Oil
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Diclofenac
[+]

These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Pharm Res. 2016 Mar ;39(3):421-8. Epub 2016 Jan 30. PMID: 26832325
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

These results suggest that MSE could be a promising gastroprotective herbal medicine.Jan 31, 2013

Pubmed Data : Immunopharmacol Immunotoxicol. 2013 Feb ;35(1):126-32. Epub 2012 Aug 14. PMID: 22889079
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : Gac
Diseases : Helicobacter Pylori Infection, Wound Healing
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Diclofenac
[+]

Thymoquinone could ameliorate gastrointestinal and renal toxicity induced by high dose diclofenac treatment.Jun 19, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jun 20 ;118:795-804. Epub 2018 Jun 20. PMID: 29935248
Article Published Date : Jun 19, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : NSAID-induced toxicity
Pharmacological Actions : Gastroprotective
Problem Substances : Diclofenac
[+]

Vitamin C and vitamin E might play an important role in reducing oxidative stress and kidney damage induced by diclofenac sodium.Sep 21, 2016

Pubmed Data : Biomed Pharmacother. 2016 Sep 22 ;84:314-322. Epub 2016 Sep 22. PMID: 27665477
Article Published Date : Sep 21, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Diclofenac
[+]

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

Pubmed Data : J Pharm Pharmacol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31922618
Article Published Date : Jan 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid, Curcumin, EGCG (Epigallocatechin gallate), Gallic Acid, Naringenin , Piperine, Polyphenols, Quercetin, Rutin, Silymarin
Diseases : Drug-Induced Toxicity: Gastrointestinal, Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Antioxidants, Gastroprotective
Problem Substances : Diclofenac, Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Neuroprotective effects of chrysin on diclofenac-induced apoptosis in SH-SY5Y cells.Feb 09, 2020

Pubmed Data : Neurochem Res. 2020 Feb 10. Epub 2020 Feb 10. PMID: 32040722
Article Published Date : Feb 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Problem Substances : Diclofenac
Adverse Pharmacological Actions : Neurotoxic

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Turmeric Extract Puts Drugs For Knee Osteoarthritis To Shame
Written by Sayer Ji, Founder
Millions take anti-inflammatory drugs every day for arthritis and related conditions, but are completely unaware that far safer, and at least as effective, natural alternative already exist -- and are as easily accessible and inexpensive as the spices found in your kitchen cupboard.

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