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1 Diseases Researched for Lipitor
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View the Evidence:
107 Abstracts with Lipitor Research

[+]

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations. Sep 14, 2011

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated, Diabetes Insipidus, Diabetes Mellitus: Type 2, Elevated: ALT, Elevated: Creatinine Kinase, GGT
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acupuncture combined with administration of Lipitor is effective in improving primary hyperlipidemia in patients, which was superior to administration of just lipitor.Jan 31, 2015

Pubmed Data : Zhen Ci Yan Jiu. 2015 Feb ;40(1):61-4. PMID: 25845223
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Hyperlipidemia
Therapeutic Actions : Acupuncture, Integrative Medicine
Additional Keywords : Significant Treatment Outcome
Problem Substances : Lipitor
[+]

Although statin drugs decrease LDL cholesterol in end-stage kidney disease, their use does not lower morbidity or mortality.Aug 01, 2010

Pubmed Data : Pharmacotherapy. 2010 Aug;30(8):823-9. PMID: 20653359
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Hemodialysis, Kidney Diseases, Renal Failure: Chronic
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
[+]

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

Pubmed Data : Cell Biochem Funct. 2007 Jul-Aug;25(4):463-72. PMID: 16906597
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Diseases : Cardiomyopathy, Chemotherapy-Induced Toxicity
Additional Keywords : Drug Interaction
Problem Substances : Atorvastatin
[+]

Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patientsMar 23, 2010

Pubmed Data : J Am Coll Cardiol. 2010 Mar 23 ;55(12):1209-16. PMID: 20298928
Article Published Date : Mar 23, 2010
Study Type : Human Study
Additional Links
Diseases : High Cholesterol, Hyperglycemia, Insulin Resistance, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Insulin , Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance
[+]

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.Jun 01, 2004

Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Coenzyme Q10 Deficiency, Statin-Induced Pathologies, Stroke
Problem Substances : Atorvastatin
[+]

Atorvastatin may cause nightmares.Apr 22, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 2006 Apr 22 ;332(7547):950. PMID: 16627511
Article Published Date : Apr 22, 2006
Study Type : Human Study
Additional Links
Diseases : Nightmare, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.Jan 01, 2005

Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin treatment is not effective in reducing inflammation (C-reactive protein) or outcome in patients with type 2 diabetes on hemodialysis.Dec 01, 2008

Pubmed Data : Kidney Int. 2008 Dec;74(11):1461-7. Epub 2008 Sep 24. PMID: 18818679
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Hemodialysis, Inflammation
Problem Substances : Atorvastatin
[+]

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254
Article Published Date : Nov 15, 2004
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Coenzyme Q10 Deficiency, Heart Failure, Hypertension, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Antioxidants
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Pancreatitis, Statin-Induced Pathologies
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Cholesterol lowering medications also alter measurable hormonal concentrations. Feb 01, 2004

Pubmed Data : J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hormonal Perturbations: Dopamine Elevation, Hormonal Perturbations: Homovanillic acid (HVA) Elevations, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
[+]

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.May 01, 2007

Pubmed Data : Clin Pharmacol Ther. 2007 May ;81(5):650-3. Epub 2007 Feb 28. PMID: 17329991
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

Pubmed Data : Reprod Biol Endocrinol. 2014 Jul 12 ;12(1):65. Epub 2014 Jul 12. PMID: 25016482
Article Published Date : Jul 11, 2014
Study Type : Human Study
Additional Links
Diseases : Birth Defects, Infertility: Male, Sperm Count: Low, Sperm Quality: Low
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Teratogenic
[+]

Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.Jun 01, 2006

Pubmed Data : Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID: 16765141
Article Published Date : Jun 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

IGF1, IGF2 and IGFBP3 concentrations all decreased following atorvastatin therapy, which may be linked to its diabetogenic properties.Jan 17, 2013

Pubmed Data : Eur J Endocrinol. 2013 Jan 18. Epub 2013 Jan 18. PMID: 23333902
Article Published Date : Jan 17, 2013
Study Type : Human Study
Additional Links
Diseases : IGF2 and IGFBP3: Low, Insulin-Like Growth Factor (IGF): Low
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day increase in the incidence of hemorrhagic stroke.Aug 10, 2006

Pubmed Data : N Engl J Med. 2006 Aug 10 ;355(6):549-59. PMID: 16899775
Article Published Date : Aug 10, 2006
Study Type : Human Study
Additional Links
Diseases : Intracerebral Hemorrhage
Problem Substances : Atorvastatin, Statin Drugs
[+]

In patients with vitamin D insufficiency atorvastatin led to impaired insulin sensitivity.Sep 25, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cardiol. 2016 Sep 26. Epub 2016 Aug 26. PMID: 27717074
Article Published Date : Sep 25, 2016
Study Type : Human Study
Additional Links
Diseases : Insulin Resistance, Statin-Induced Pathologies, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469
Article Published Date : Aug 31, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Liver Damage, Liver Disease, Liver Failure: Drug Induced, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Prenatal exposure to statin drugs results in reduced gestational age at birth and lower birth weight. Oct 01, 2008

Pubmed Data : Reprod Toxicol. 2008 Oct;26(2):175-7. Epub 2008 Jul 1. PMID: 18640262
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Infants: Low Birth Weight, Premature Birth, Prenatal Chemical Exposures
Problem Substances : Atorvastatin, Statin Drugs
[+]

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA)Dec 31, 2003

Pubmed Data : Drugs. 2004 ;64 Suppl 2:43-60. PMID: 15765890
Article Published Date : Dec 31, 2003
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Hypertension, Myocardial Infarction
Problem Substances : Atorvastatin, Statin Drugs
[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]

Statin drugs alter platelet function. Dec 01, 2002

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Diseases : Blood Platelet Disorders
Pharmacological Actions : Nitric Oxide Inhibitor
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

Pubmed Data : Clin Pharmacol Ther. 2005 Jul;78(1):60-8. PMID: 16003294
Article Published Date : Jul 01, 2005
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Statin therapy is associated with 14% increased risk of type 2 diabetes.Dec 16, 2012

Pubmed Data : Diabetes Care. 2012 Dec 17. Epub 2012 Dec 17. PMID: 23248196
Article Published Date : Dec 16, 2012
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Statin therapy is associated with decreased serum levels of zinc and copper.Jan 01, 2005

Pubmed Data : J Trace Elem Med Biol. 2005;19(1):61-7. PMID: 16240674
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Copper Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Hyperlipidemia, Statin-Induced Pathologies, Zinc Deficiency
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
[+]

Statin therapy is associated with lower total testosterone in men with type 2 diabetes. Apr 01, 2009

Pubmed Data : Diabetes Care. 2009 Apr ;32(4):541-6. Epub 2008 Dec 29. PMID: 19114614
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies, Testosterone: Too Low
Additional Keywords : Sex Hormone-Binding Globulin
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia.Jul 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2016 Jul 15. Epub 2016 Jul 15. PMID: 27429121
Article Published Date : Jul 14, 2016
Study Type : Animal Study, Human Study
Additional Links
Diseases : Dyslipidemias, Statin-Induced Pathologies
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Rosuvastatin, Simvastatin, Statin Drugs
[+]

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Drug-Induced Nutrient Depletion: Statin Drugs, Exercise-Induced Tissue Damage, Muscle Damage: Exercise-Induced
Pharmacological Actions : Proteasome Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan ;98(1):51-4. PMID: 16433891
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

The statin drug atorvastatin increases the risk of hemorrhagic stroke. Jun 10, 2008

Pubmed Data : Neurology. 2008 Jun 10;70(24 Pt 2):2364-70. Epub 2007 Dec 12. PMID: 18077795
Article Published Date : Jun 10, 2008
Study Type : Human Study
Additional Links
Diseases : Stroke
Problem Substances : Atorvastatin
[+]

The statin drug atorvastatin is found in very high concentrations in intensive patients with sepsis.Apr 01, 2009

Pubmed Data : Intensive Care Med. 2009 Apr;35(4):717-21. Epub 2008 Nov 26. PMID: 19034423
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Sepsis
Problem Substances : Atorvastatin, Statin Drugs
[+]

There is a dose-response relationship in statin-induced rhabdomyolysis.Mar 01, 2011

Pubmed Data : Can J Cardiol. 2011 Mar-Apr;27(2):146-51. PMID: 21459261
Article Published Date : Mar 01, 2011
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Nephrotoxic
[+]

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Cataract, Chemically-Induced Liver Damage, Esophageal Cancer, Kidney Failure, Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Rosuvastatin, Simvastatin, Statin Drugs
[+]

Vitamin D deficiency was significantly associated with a statin-induced myalgia among HIV-infected patients.Jan 03, 2017

Pubmed Data : AIDS. 2017 Jan 4. Epub 2017 Jan 4. PMID: 28060020
Article Published Date : Jan 03, 2017
Study Type : Human Study
Additional Links
Diseases : HIV Infections, Statin-Induced Pathologies, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
[+]

Atorvastatin exhibits immunotoxic and genotoxic properties - Article 2. Jan 01, 2008

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jan ;43(1):78-85. PMID: 18161561
Article Published Date : Jan 01, 2008
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Immune Disorders: Low Immune Function, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Genotoxic, Immunotoxic
[+]

Atorvastatin exhibits immunotoxic and genotoxic properties. Aug 15, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 15 ;231(1):85-93. Epub 2008 Apr 8. PMID: 18485436
Article Published Date : Aug 15, 2008
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Immune Disorders: Low Immune Function, Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Genotoxic, Immunotoxic
[+]

A case of atorvastatin-induced pancreatitis has been reported.Oct 01, 2010

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Pancreatitis
Problem Substances : Atorvastatin, Statin Drugs
[+]

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

Pubmed Data : Clin Drug Investig. 2010 ;30(3):205-9. PMID: 20155993
Article Published Date : Jan 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Alkaline Phosphatase: Elevated, Bile Duct Injury, Bilirubin: Elevated, Cholangiolitis, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626
Article Published Date : Jan 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
Article Published Date : Jun 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Acute pancreatitis associated with atorvastatine therapy has been reported. Apr 01, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Clin Biol. 2000 Apr ;24(4):471-2. PMID: 10844297
Article Published Date : Apr 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Acute pancreatitis associated with combined lisinopril and atorvastatin therapy has been reported. Jan 01, 2005

Pubmed Data : Dig Dis. 2005 ;23(1):92-4. PMID: 15920330
Article Published Date : Jan 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents
Problem Substances : Atorvastatin, Lisinopril
[+]

Alopecia associated with atorvastatin has been reported. Aug 01, 2002

Pubmed Data : Am J Med. 2002 Aug 1 ;113(2):171. PMID: 12133763
Article Published Date : Aug 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Alopecia, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578
Article Published Date : Jul 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Bile Duct Injury, Chemically-Induced Liver Damage, Cholestasis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin induced multiple organ failure has been reported.May 01, 2010

Pubmed Data : J La State Med Soc. 2010 May-Jun;162(3):159-60. PMID: 20666169
Article Published Date : May 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Multi-Organ Failure, Statin-Induced Pathologies
Pharmacological Actions : Calcium Channel Blockers
Additional Keywords : Drug Synergy
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Pubmed Data : Arch Intern Med. 1999 Aug 9-23;159(15):1811-2. PMID: 10448788
Article Published Date : Aug 09, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported.Jan 01, 2009

Pubmed Data : Ann Dermatol Venereol. 2009 Jan ;136(1):50-3. Epub 2008 Nov 28. PMID: 19171231
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced hemorrhagic cystitis has been reported.Mar 01, 2009

Pubmed Data : Urology. 2009 Mar ;73(3):681.e5-6. Epub 2008 May 12. PMID: 18468659
Article Published Date : Mar 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Cystitis: Hemorrhagic, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced polyneuropathy has been reported. Nov 04, 2003

Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471
Article Published Date : Nov 04, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies, Polyneuropathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Pubmed Data : World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID: 15918210
Article Published Date : May 28, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Gastric Ulcer, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Atorvastatin-induced severe thrombocytopenia.Oct 17, 1998

Pubmed Data : Lancet. 1998 Oct 17 ;352(9136):1284. PMID: 9788465
Article Published Date : Oct 17, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Statin-Induced Pathologies, Thrombocytopenia
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Autoimmune hepatitis triggered by statins has been reported. Sep 01, 2006

Pubmed Data : J Clin Gastroenterol. 2006 Sep ;40(8):757-61. PMID: 16940892
Article Published Date : Sep 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Autoimmune
Problem Substances : Atorvastatin, Simvastatin
Adverse Pharmacological Actions : Hepatotoxic, Immunotoxic
[+]

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Isr Med Assoc J. 2009 Jul ;11(7):440-1. PMID: 19911499
Article Published Date : Jul 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Autoimmune Diseases, Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Jaundice
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe has been reported. Sep 01, 2005

Pubmed Data : Ann Clin Biochem. 2005 Sep ;42(Pt 5):402-4. PMID: 16168199
Article Published Date : Sep 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Hepatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Drug Interaction
Problem Substances : Atorvastatin
[+]

Gynecomastia may be associated with atorvastatin therapy.Aug 01, 2006

Pubmed Data : Pharmacotherapy. 2006 Aug ;26(8):1165-8. PMID: 16863492
Article Published Date : Aug 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Gynecomastia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Hypotension and eosinophilia with atorvastatin has been reported. Aug 01, 2005

Pubmed Data : Pharm World Sci. 2005 Aug ;27(4):279-80. PMID: 16228623
Article Published Date : Aug 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Eosinophilia, Hypotension, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Hypothyroidism misdiagnosed as statin intolerance has been reported.Jul 07, 2009

Pubmed Data : Ann Intern Med. 2009 Jul 7 ;151(1):72. PMID: 19581652
Article Published Date : Jul 07, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Hypothyroidism, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Misdiagnosed Conditions
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid
[+]

Linear IgA bullous dermatosis induced by atorvastatin has been observed. Apr 01, 2001

Pubmed Data : J Am Acad Dermatol. 2001 Apr ;44(4):689-92. PMID: 11260550
Article Published Date : Apr 01, 2001
Study Type : Human: Case Report
Additional Links
Diseases : Bullous Dermatosis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Multiorgan failure induced by atorvastatin has been reported.Sep 01, 2002

Pubmed Data : Am J Med. 2002 Sep ;113(4):348-9. PMID: 12361829
Article Published Date : Sep 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Multi-Organ Failure, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Paranoia is one of the symptoms associated with statin therapy.Mar 01, 2008

Pubmed Data : Am J Geriatr Pharmacother. 2008 Mar ;6(1):28-32. PMID: 18396246
Article Published Date : Mar 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Paranoia, Senile Paranoid Dementia, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Rhabdomyolysis with atorvastatin and fusidic acid has been reported. Jun 01, 2008

Pubmed Data : Postgrad Med J. 2008 Jun ;84(992):325-7. PMID: 18644925
Article Published Date : Jun 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anti-Bacterial Agents
Problem Substances : Atorvastatin, Fusidic acid, Statin Drugs
[+]

Statin drug induced lupus-like syndrome concomitant with a severe autoimmune hepatitis has been reported. Jan 01, 2003

Pubmed Data : Lupus. 2003 ;12(5):409-12. PMID: 12765306
Article Published Date : Jan 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis, Systemic Lupus Erythematosus
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Statin induced pancreatitis has been reported. Nov 01, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JOP. 2004 Nov ;5(6):502-4. Epub 2004 Nov 10. PMID: 15536291
Article Published Date : Nov 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Rosuvastatin, Simvastatin, Statin Drugs
[+]

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported. Aug 01, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Care. 2005 Aug ;28(8):2082. PMID: 16043768
Article Published Date : Aug 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin precipitated lactic acidosis has been reported. Sep 01, 2004

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Lactic Acidosis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.Feb 01, 2007

Pubmed Data : Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID: 17241784
Article Published Date : Feb 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Skeletal Muscle Changes: Endoplasmic Reticulum Stress, Statin-Induced Pathologies
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myositis migrans has been reported. Nov 30, 2002

Pubmed Data : Wien Klin Wochenschr. 2002 Nov 30 ;114(21-22):943-4. PMID: 12528328
Article Published Date : Nov 30, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Myositis, Myositis Migrans, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin
[+]

Toxic epidermal necrolysis from atorvastatin has been reported.May 27, 1998

Pubmed Data : JAMA. 1998 May 27 ;279(20):1613-4. PMID: 9613909
Article Published Date : May 27, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Toxic Epidermal Necrolysis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Unilateral blepharoptosis is an unrecognized side effect of statin treatment.May 01, 2006

Pubmed Data : Ophthal Plast Reconstr Surg. 2006 May-Jun;22(3):222-4. PMID: 16714939
Article Published Date : May 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Blepharoptosis, Myositis: Focal, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Alcohol and atorvastatin interact to adversely affect intestinal villi structure.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):38-43. PMID: 16146046
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity , Gastrointestinal Diseases, Statin-Induced Pathologies
Additional Keywords : Toxic Substance Synergy
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin contributes to cataract formation in the white rat.Jan 01, 2002

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2002 ;57(2):165-71. PMID: 12898835
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Diseases : Cataract, Lens Diseases
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cataractogenic
[+]

Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia.Jul 01, 2008

Pubmed Data : J Card Surg. 2008 Jul-Aug;23(4):312-20. PMID: 18598320
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Endothelial Dysfunction, High Cholesterol, Oxidative Stress
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Atorvastatin may contribute to hepatopathy through suppressing oxidized and reduce coenzyme q10 and mitochondrial function in the liver. Apr 20, 2012

Pubmed Data : Physiol Res. 2012 Apr 20 ;61(2):185-93. Epub 2012 Jan 31. PMID: 22292717
Article Published Date : Apr 20, 2012
Study Type : Animal Study
Additional Links
Diseases : Liver Damage: Drug-Induced, Statin-Induced Pathologies
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin treatment reduces exercise capacities in rats and exacerbates metabolic perturbations and oxidative stress in skeletal muscle.Aug 18, 2011

Pubmed Data : J Appl Physiol. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21852406
Article Published Date : Aug 18, 2011
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

High doses of atorvastatin modifies the secretory process in the exocrine portion of the pancreas.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Pancreatic Diseases
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Pancreas
[+]

In this animal study statin withdrawal was associated with a deleterious rebound phenomenon with increased risk of thrombotic vascular events.Apr 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2013 May ;71:1-8. Epub 2013 Feb 18. PMID: 23428346
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Diseases : Drug Withdrawal Symptoms
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Lipophilic statin drugs are associated with impaired skeletal muscle mitochondria.Oct 01, 2006

Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 17013560
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Cerivastatin, Fluvastatin, Simvastatin, Statin Drugs
[+]

Lipophilic statin drugs worsen myocardial ischemia in dogs. Feb 01, 2000

Pubmed Data : J Cardiovasc Pharmacol. 2000 Feb ;35(2):256-62. PMID: 10672858
Article Published Date : Feb 01, 2000
Study Type : Animal Study
Additional Links
Diseases : Myocardial Ischemia
Additional Keywords : Lipophilic Stains
Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Low dose treatment with statins can induce mild but significant anxiety in guinea pigs.Nov 12, 2011

Pubmed Data : Eur J Pharmacol. 2011 Nov 12. Epub 2011 Nov 12. PMID: 22115894
Article Published Date : Nov 12, 2011
Study Type : Animal Study
Additional Links
Diseases : Anxiety Disorders
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Anxiogenic
[+]

Post treatment thymoquinone may reverse oxidative stress injury in rat liver produced by atorvastatin.Oct 01, 2017

Pubmed Data : Can J Physiol Pharmacol. 2017 Oct 2. Epub 2017 Oct 2. PMID: 28968507
Article Published Date : Oct 01, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Hepatoprotective
Problem Substances : Atorvastatin
[+]

Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats.Dec 31, 1997

Pubmed Data : Toxicol Sci. 1998 Jan ;41(1):88-99. PMID: 9520344
Article Published Date : Dec 31, 1997
Study Type : Animal Study
Additional Links
Diseases : Infertility, Infertility: Female, Infertility: Male
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Teratogenic
[+]

Quercetin is able to ameliorate statin-drug induced skeletal muscle myopathy in an animal model. Jul 20, 2011

Pubmed Data : Eur Heart J. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21775390
Article Published Date : Jul 20, 2011
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Drug-Induced Toxicity , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain. Jul 08, 2011

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754
Article Published Date : Jul 08, 2011
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model.Jul 01, 1996

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188
Article Published Date : Jul 01, 1996
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Liver Damage: Drug-Induced, Statin-Induced Pathologies, Testicular Diseases
Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity, Neurotoxic
[+]

Statin drugs exhibit neurotoxicity in an animal neuronal cell line. Sep 01, 2011

Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Sep ;15(9):985-91. PMID: 22013720
Article Published Date : Sep 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Neurodegenerative Diseases, Statin-Induced Pathologies
Pharmacological Actions : Antiproliferative
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

The statin atorvastatin increase indomethacin-induced gastric injury model in rats.Sep 30, 2012

Pubmed Data : Turk J Gastroenterol. 2012 Oct ;23(5):456-62. PMID: 23161290
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Toxicity: Indomethacin, NSAID-induced toxicity
Problem Substances : Atorvastatin, Indomethacin, Statin Drugs
[+]

Atorvastatin appears to increase the risk of deteriorating blood sugar control. Jun 01, 2006

Pubmed Data : J Atheroscler Thromb. 2006 Jun ;13(3):123-9. PMID: 16835466
Article Published Date : Jun 01, 2006
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 1, Hyperglycemia
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Atorvastatin reduced the ATP levels in pancreas mitochondria.Aug 23, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27553485
Article Published Date : Aug 23, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model. Jan 01, 2011

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Cognitive impairment associated with statin drug use has been reported. Dec 01, 2003

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047
Article Published Date : Dec 01, 2003
Study Type : Review
Additional Links
Diseases : Cognitive Decline/Dysfunction, Dementia, Memory Disorders
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Interstitial lung disease has been reported as a side effect of statins.Jan 01, 2006

Pubmed Data : Therapie. 2006 Jan-Feb;61(1):57-67. PMID: 16792155
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Lung Diseases: Interstitial, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Review: Drug-induced liver injury associated with statins.Nov 01, 2009

Pubmed Data : Semin Liver Dis. 2009 Nov ;29(4):412-22. Epub 2009 Oct 13. PMID: 19826975
Article Published Date : Nov 01, 2009
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Hepatitis: Cholestatic, Liver Damage, Liver Disease, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Statin toxicity is pleiotropic in nature. Mar 01, 2010

Pubmed Data : FEMS Yeast Res. 2010 Mar ;10(2):188-98. Epub 2009 Nov 3. PMID: 20002195
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Additional Keywords : Saccharomyces Cerevisiae
Problem Substances : Atorvastatin
[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782
Article Published Date : Dec 14, 2004
Study Type : Review
Additional Links
Diseases : Myasthenia Gravis
Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin-induced liver injury may result from the suppression of selenoprotein expression.Jun 01, 2009

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statin-induced myopathy occurs in between 10-15% of users.Feb 23, 2011

Pubmed Data : Expert Opin Drug Saf. 2011 Feb 23. Epub 2011 Feb 23. PMID: 21342078
Article Published Date : Feb 23, 2011
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins have been associated with cell death in primary neuronal culture.Jan 01, 2007

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1985-1992. Epub 2017 Nov 23. PMID: 29399200
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Atorvastatin
[+]

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle Changes: Ultrastructural Changes, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]

This systematic review suggests that there is an association between atorvastatin treatment and new onset diabetes mellitus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Endocrinol. 2018 ;2018:8380192. Epub 2018 Oct 22. PMID: 30425742
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Statin-Induced Pathologies
Additional Keywords : Increased Risk
Problem Substances : Atorvastatin
[+]

Treatment with atorvastatin is associated with mitochondrial oxidative stress, which activates apoptosis and contributes to myopathy. Sep 27, 2015

Pubmed Data : Antioxid Redox Signal. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26414931
Article Published Date : Sep 27, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs

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