Lipitor

Views 1296
Jump to
Abstracts Focused Research Topics
Your Token Count0

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
138 Diseases Researched for Lipitor
NameACCKFocus
Statin-Induced Pathologies69338Locked
Chemically-Induced Liver Damage1054Locked
Diabetes Mellitus: Type 2544Locked
Myopathies644Locked
Coenzyme Q10 Deficiency543Locked
Drug-Induced Nutrient Depletion: Statin Drugs730Locked
Rhabdomyolysis323Locked
High Cholesterol322Locked
Pancreatitis522Locked
Mitochondrial Dysfunction 321Locked
AST: Elevated120Locked
Cardiovascular Diseases220Locked
Diabetes Insipidus120Locked
Elevated: ALT120Locked
Elevated: Creatinine Kinase120Locked
GGT120Locked
Hemodialysis220Locked
Hyperlipidemia220Locked
Hypertension220Locked
Insulin Resistance220Locked
Oxidative Stress520Locked
Stroke220Locked
Vitamin D Deficiency220Locked
Hepatitis: Autoimmune 314Locked
Hepatitis: Cholestatic513Locked
Cataract212Locked
Infertility: Male212Locked
Mitochondrial Myopathies212Locked
Hyperglycemia211Locked
Liver Damage211Locked
Liver Disease211Locked
Athletic Performance110Locked
Birth Defects110Locked
Blood Platelet Disorders110Locked
C-Reactive Protein110Locked
Cardiac Mortality 110Locked
Cardiomyopathy110Locked
Chemotherapy-Induced Toxicity110Locked
Copper Deficiency110Locked
Coronary Artery Disease110Locked
DNA damage210Locked
Diabetes Mellitus: Type 2: Prevention110Locked
Dyslipidemias110Locked
Esophageal Cancer110Locked
Exercise-Induced Tissue Damage110Locked
Fibromyalgia110Locked
HIV Infections110Locked
Heart Failure110Locked
Hormonal Perturbations: Dopamine Elevation110Locked
Hormonal Perturbations: Homovanillic acid (HVA) Elevations110Locked
IGF2 and IGFBP3: Low110Locked
Immune Disorders: Low Immune Function210Locked
Infants: Low Birth Weight110Locked
Inflammation110Locked
Insulin-Like Growth Factor (IGF): Low110Locked
Intracerebral Hemorrhage110Locked
Kidney Damage: Drug-Induced110Locked
Kidney Diseases110Locked
Kidney Failure110Locked
Liver Failure: Drug Induced110Locked
Muscle Damage: Exercise-Induced110Locked
Muscle Soreness110Locked
Myalgias110Locked
Myocardial Infarction110Locked
Nightmare110Locked
Organ Transplantation: Heart110Locked
Premature Birth110Locked
Prenatal Chemical Exposures110Locked
Renal Failure: Chronic110Locked
Sepsis110Locked
Sperm Count: Low110Locked
Sperm Quality: Low110Locked
Testosterone: Too Low110Locked
Zinc Deficiency110Locked
Cholestasis39Locked
Drug-Induced Toxicity 38Locked
Bile Duct Injury26Locked
Hepatitis26Locked
Multi-Organ Failure26Locked
Neuropathies26Locked
Brain Damage24Locked
Liver Damage: Drug-Induced24Locked
A1C13Locked
Alkaline Phosphatase: Elevated13Locked
Alopecia13Locked
Autoimmune Diseases13Locked
Bilirubin: Elevated13Locked
Blepharoptosis13Locked
Bullous Dermatosis13Locked
Cholangiolitis13Locked
Cognitive Decline/Dysfunction23Locked
Cystitis: Hemorrhagic13Locked
Diabetes: Glycation/A1C13Locked
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)13Locked
Eosinophilia13Locked
Gastric Ulcer13Locked
Gynecomastia13Locked
Hypotension13Locked
Hypothyroidism13Locked
Jaundice13Locked
Lactic Acidosis13Locked
Myositis13Locked
Myositis Migrans13Locked
Myositis: Focal13Locked
Paranoia13Locked
Peripheral Neuropathies13Locked
Polyneuropathies13Locked
Senile Paranoid Dementia13Locked
Skeletal Muscle Changes: Endoplasmic Reticulum Stress13Locked
Skeletal Muscle: Changes to MHC I expression13Locked
Systemic Lupus Erythematosus13Locked
Thrombocytopenia13Locked
Toxic Epidermal Necrolysis13Locked
Alcohol Toxicity 12Locked
Anxiety Disorders12Locked
Diabetes Mellitus: Type 122Locked
Drug Withdrawal Symptoms12Locked
Drug-Induced Toxicity: Indomethacin12Locked
Endothelial Dysfunction12Locked
Gastrointestinal Diseases12Locked
Infertility12Locked
Infertility: Female12Locked
Lens Diseases12Locked
Myocardial Ischemia12Locked
NSAID-induced toxicity 12Locked
Neurodegenerative Diseases12Locked
Pancreatic Diseases12Locked
Testicular Diseases12Locked
Colon Cancer11Locked
Congestive Heart Failure11Locked
Dementia11Locked
Lipid Peroxidation11Locked
Lung Diseases: Interstitial11Locked
Memory Disorders11Locked
Mineral Deficiencies: Selenium11Locked
Myasthenia Gravis11Locked
Neurotoxicity11Locked
Skeletal Muscle Changes: Ultrastructural Changes11Locked
17 Adverse Pharmacological Actions Researched for Lipitor
NameACCKFocus
Hepatotoxic1380Locked
Myotoxicity940Locked
Endocrine Disruptor321Locked
Neurotoxic918Locked
Diabetogenic314Locked
Oxidant314Locked
Cardiotoxic313Locked
Immunotoxic313Locked
Teratogenic212Locked
Endocrine Disruptor: Insulin Resistance110Locked
Genotoxic210Locked
Nephrotoxic110Locked
Endocrine Disruptor: Thyroid13Locked
Ulcerogenic13Locked
Anxiogenic12Locked
Cataractogenic12Locked
Endocrine Disruptor: Pancreas12Locked

View the Evidence:
107 Abstracts with Lipitor Research

[+]

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations. Sep 14, 2011

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated, Diabetes Insipidus, Diabetes Mellitus: Type 2, Elevated: ALT, Elevated: Creatinine Kinase, GGT
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acupuncture combined with administration of Lipitor is effective in improving primary hyperlipidemia in patients, which was superior to administration of just lipitor.Jan 31, 2015

Pubmed Data : Zhen Ci Yan Jiu. 2015 Feb ;40(1):61-4. PMID: 25845223
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Hyperlipidemia
Therapeutic Actions : Acupuncture, Integrative Medicine
Additional Keywords : Significant Treatment Outcome
Problem Substances : Lipitor
[+]

Although statin drugs decrease LDL cholesterol in end-stage kidney disease, their use does not lower morbidity or mortality.Aug 01, 2010

Pubmed Data : Pharmacotherapy. 2010 Aug;30(8):823-9. PMID: 20653359
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Hemodialysis, Kidney Diseases, Renal Failure: Chronic
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
[+]

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

Pubmed Data : Cell Biochem Funct. 2007 Jul-Aug;25(4):463-72. PMID: 16906597
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Diseases : Cardiomyopathy, Chemotherapy-Induced Toxicity
Additional Keywords : Drug Interaction
Problem Substances : Atorvastatin
[+]

Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patientsMar 23, 2010

Pubmed Data : J Am Coll Cardiol. 2010 Mar 23 ;55(12):1209-16. PMID: 20298928
Article Published Date : Mar 23, 2010
Study Type : Human Study
Additional Links
Diseases : High Cholesterol, Hyperglycemia, Insulin Resistance, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Insulin , Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance
[+]

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.Jun 01, 2004

Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Coenzyme Q10 Deficiency, Statin-Induced Pathologies, Stroke
Problem Substances : Atorvastatin
[+]

Atorvastatin may cause nightmares.Apr 22, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 2006 Apr 22 ;332(7547):950. PMID: 16627511
Article Published Date : Apr 22, 2006
Study Type : Human Study
Additional Links
Diseases : Nightmare, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.Jan 01, 2005

Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin treatment is not effective in reducing inflammation (C-reactive protein) or outcome in patients with type 2 diabetes on hemodialysis.Dec 01, 2008

Pubmed Data : Kidney Int. 2008 Dec;74(11):1461-7. Epub 2008 Sep 24. PMID: 18818679
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Hemodialysis, Inflammation
Problem Substances : Atorvastatin
[+]

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254
Article Published Date : Nov 15, 2004
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Coenzyme Q10 Deficiency, Heart Failure, Hypertension, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Antioxidants
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Pancreatitis, Statin-Induced Pathologies
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Cholesterol lowering medications also alter measurable hormonal concentrations. Feb 01, 2004

Pubmed Data : J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hormonal Perturbations: Dopamine Elevation, Hormonal Perturbations: Homovanillic acid (HVA) Elevations, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
[+]

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.May 01, 2007

Pubmed Data : Clin Pharmacol Ther. 2007 May ;81(5):650-3. Epub 2007 Feb 28. PMID: 17329991
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

Pubmed Data : Reprod Biol Endocrinol. 2014 Jul 12 ;12(1):65. Epub 2014 Jul 12. PMID: 25016482
Article Published Date : Jul 11, 2014
Study Type : Human Study
Additional Links
Diseases : Birth Defects, Infertility: Male, Sperm Count: Low, Sperm Quality: Low
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Teratogenic
[+]

Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.Jun 01, 2006

Pubmed Data : Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID: 16765141
Article Published Date : Jun 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

IGF1, IGF2 and IGFBP3 concentrations all decreased following atorvastatin therapy, which may be linked to its diabetogenic properties.Jan 17, 2013

Pubmed Data : Eur J Endocrinol. 2013 Jan 18. Epub 2013 Jan 18. PMID: 23333902
Article Published Date : Jan 17, 2013
Study Type : Human Study
Additional Links
Diseases : IGF2 and IGFBP3: Low, Insulin-Like Growth Factor (IGF): Low
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day increase in the incidence of hemorrhagic stroke.Aug 10, 2006

Pubmed Data : N Engl J Med. 2006 Aug 10 ;355(6):549-59. PMID: 16899775
Article Published Date : Aug 10, 2006
Study Type : Human Study
Additional Links
Diseases : Intracerebral Hemorrhage
Problem Substances : Atorvastatin, Statin Drugs
[+]

In patients with vitamin D insufficiency atorvastatin led to impaired insulin sensitivity.Sep 25, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cardiol. 2016 Sep 26. Epub 2016 Aug 26. PMID: 27717074
Article Published Date : Sep 25, 2016
Study Type : Human Study
Additional Links
Diseases : Insulin Resistance, Statin-Induced Pathologies, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469
Article Published Date : Aug 31, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Liver Damage, Liver Disease, Liver Failure: Drug Induced, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Prenatal exposure to statin drugs results in reduced gestational age at birth and lower birth weight. Oct 01, 2008

Pubmed Data : Reprod Toxicol. 2008 Oct;26(2):175-7. Epub 2008 Jul 1. PMID: 18640262
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Infants: Low Birth Weight, Premature Birth, Prenatal Chemical Exposures
Problem Substances : Atorvastatin, Statin Drugs
[+]

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA)Dec 31, 2003

Pubmed Data : Drugs. 2004 ;64 Suppl 2:43-60. PMID: 15765890
Article Published Date : Dec 31, 2003
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Hypertension, Myocardial Infarction
Problem Substances : Atorvastatin, Statin Drugs
[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]

Statin drugs alter platelet function. Dec 01, 2002

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Diseases : Blood Platelet Disorders
Pharmacological Actions : Nitric Oxide Inhibitor
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

Pubmed Data : Clin Pharmacol Ther. 2005 Jul;78(1):60-8. PMID: 16003294
Article Published Date : Jul 01, 2005
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Statin therapy is associated with 14% increased risk of type 2 diabetes.Dec 16, 2012

Pubmed Data : Diabetes Care. 2012 Dec 17. Epub 2012 Dec 17. PMID: 23248196
Article Published Date : Dec 16, 2012
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Statin therapy is associated with decreased serum levels of zinc and copper.Jan 01, 2005

Pubmed Data : J Trace Elem Med Biol. 2005;19(1):61-7. PMID: 16240674
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Copper Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Hyperlipidemia, Statin-Induced Pathologies, Zinc Deficiency
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
[+]

Statin therapy is associated with lower total testosterone in men with type 2 diabetes. Apr 01, 2009

Pubmed Data : Diabetes Care. 2009 Apr ;32(4):541-6. Epub 2008 Dec 29. PMID: 19114614
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies, Testosterone: Too Low
Additional Keywords : Sex Hormone-Binding Globulin
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia.Jul 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2016 Jul 15. Epub 2016 Jul 15. PMID: 27429121
Article Published Date : Jul 14, 2016
Study Type : Animal Study, Human Study
Additional Links
Diseases : Dyslipidemias, Statin-Induced Pathologies
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Rosuvastatin, Simvastatin, Statin Drugs
[+]

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Drug-Induced Nutrient Depletion: Statin Drugs, Exercise-Induced Tissue Damage, Muscle Damage: Exercise-Induced
Pharmacological Actions : Proteasome Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan ;98(1):51-4. PMID: 16433891
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

The statin drug atorvastatin increases the risk of hemorrhagic stroke. Jun 10, 2008

Pubmed Data : Neurology. 2008 Jun 10;70(24 Pt 2):2364-70. Epub 2007 Dec 12. PMID: 18077795
Article Published Date : Jun 10, 2008
Study Type : Human Study
Additional Links
Diseases : Stroke
Problem Substances : Atorvastatin
[+]

The statin drug atorvastatin is found in very high concentrations in intensive patients with sepsis.Apr 01, 2009

Pubmed Data : Intensive Care Med. 2009 Apr;35(4):717-21. Epub 2008 Nov 26. PMID: 19034423
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Sepsis
Problem Substances : Atorvastatin, Statin Drugs
[+]

There is a dose-response relationship in statin-induced rhabdomyolysis.Mar 01, 2011

Pubmed Data : Can J Cardiol. 2011 Mar-Apr;27(2):146-51. PMID: 21459261
Article Published Date : Mar 01, 2011
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Nephrotoxic
[+]

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Cataract, Chemically-Induced Liver Damage, Esophageal Cancer, Kidney Failure, Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Rosuvastatin, Simvastatin, Statin Drugs
[+]

Vitamin D deficiency was significantly associated with a statin-induced myalgia among HIV-infected patients.Jan 03, 2017

Pubmed Data : AIDS. 2017 Jan 4. Epub 2017 Jan 4. PMID: 28060020
Article Published Date : Jan 03, 2017
Study Type : Human Study
Additional Links
Diseases : HIV Infections, Statin-Induced Pathologies, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
[+]

Atorvastatin exhibits immunotoxic and genotoxic properties - Article 2. Jan 01, 2008

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jan ;43(1):78-85. PMID: 18161561
Article Published Date : Jan 01, 2008
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Immune Disorders: Low Immune Function, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Genotoxic, Immunotoxic
[+]

Atorvastatin exhibits immunotoxic and genotoxic properties. Aug 15, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 15 ;231(1):85-93. Epub 2008 Apr 8. PMID: 18485436
Article Published Date : Aug 15, 2008
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Immune Disorders: Low Immune Function, Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Genotoxic, Immunotoxic
[+]

A case of atorvastatin-induced pancreatitis has been reported.Oct 01, 2010

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Pancreatitis
Problem Substances : Atorvastatin, Statin Drugs
[+]

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

Pubmed Data : Clin Drug Investig. 2010 ;30(3):205-9. PMID: 20155993
Article Published Date : Jan 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Alkaline Phosphatase: Elevated, Bile Duct Injury, Bilirubin: Elevated, Cholangiolitis, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626
Article Published Date : Jan 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
Article Published Date : Jun 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Acute pancreatitis associated with atorvastatine therapy has been reported. Apr 01, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Clin Biol. 2000 Apr ;24(4):471-2. PMID: 10844297
Article Published Date : Apr 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Acute pancreatitis associated with combined lisinopril and atorvastatin therapy has been reported. Jan 01, 2005

Pubmed Data : Dig Dis. 2005 ;23(1):92-4. PMID: 15920330
Article Published Date : Jan 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents
Problem Substances : Atorvastatin, Lisinopril
[+]

Alopecia associated with atorvastatin has been reported. Aug 01, 2002

Pubmed Data : Am J Med. 2002 Aug 1 ;113(2):171. PMID: 12133763
Article Published Date : Aug 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Alopecia, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578
Article Published Date : Jul 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Bile Duct Injury, Chemically-Induced Liver Damage, Cholestasis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin induced multiple organ failure has been reported.May 01, 2010

Pubmed Data : J La State Med Soc. 2010 May-Jun;162(3):159-60. PMID: 20666169
Article Published Date : May 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Multi-Organ Failure, Statin-Induced Pathologies
Pharmacological Actions : Calcium Channel Blockers
Additional Keywords : Drug Synergy
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Pubmed Data : Arch Intern Med. 1999 Aug 9-23;159(15):1811-2. PMID: 10448788
Article Published Date : Aug 09, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported.Jan 01, 2009

Pubmed Data : Ann Dermatol Venereol. 2009 Jan ;136(1):50-3. Epub 2008 Nov 28. PMID: 19171231
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced hemorrhagic cystitis has been reported.Mar 01, 2009

Pubmed Data : Urology. 2009 Mar ;73(3):681.e5-6. Epub 2008 May 12. PMID: 18468659
Article Published Date : Mar 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Cystitis: Hemorrhagic, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin-induced polyneuropathy has been reported. Nov 04, 2003

Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471
Article Published Date : Nov 04, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies, Polyneuropathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Pubmed Data : World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID: 15918210
Article Published Date : May 28, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Gastric Ulcer, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Atorvastatin-induced severe thrombocytopenia.Oct 17, 1998

Pubmed Data : Lancet. 1998 Oct 17 ;352(9136):1284. PMID: 9788465
Article Published Date : Oct 17, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Statin-Induced Pathologies, Thrombocytopenia
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Autoimmune hepatitis triggered by statins has been reported. Sep 01, 2006

Pubmed Data : J Clin Gastroenterol. 2006 Sep ;40(8):757-61. PMID: 16940892
Article Published Date : Sep 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Autoimmune
Problem Substances : Atorvastatin, Simvastatin
Adverse Pharmacological Actions : Hepatotoxic, Immunotoxic
[+]

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Isr Med Assoc J. 2009 Jul ;11(7):440-1. PMID: 19911499
Article Published Date : Jul 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Autoimmune Diseases, Chemically-Induced Liver Damage, Hepatitis: Cholestatic, Jaundice
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe has been reported. Sep 01, 2005

Pubmed Data : Ann Clin Biochem. 2005 Sep ;42(Pt 5):402-4. PMID: 16168199
Article Published Date : Sep 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Hepatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Drug Interaction
Problem Substances : Atorvastatin
[+]

Gynecomastia may be associated with atorvastatin therapy.Aug 01, 2006

Pubmed Data : Pharmacotherapy. 2006 Aug ;26(8):1165-8. PMID: 16863492
Article Published Date : Aug 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Gynecomastia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Hypotension and eosinophilia with atorvastatin has been reported. Aug 01, 2005

Pubmed Data : Pharm World Sci. 2005 Aug ;27(4):279-80. PMID: 16228623
Article Published Date : Aug 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Eosinophilia, Hypotension, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Hypothyroidism misdiagnosed as statin intolerance has been reported.Jul 07, 2009

Pubmed Data : Ann Intern Med. 2009 Jul 7 ;151(1):72. PMID: 19581652
Article Published Date : Jul 07, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Hypothyroidism, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Misdiagnosed Conditions
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid
[+]

Linear IgA bullous dermatosis induced by atorvastatin has been observed. Apr 01, 2001

Pubmed Data : J Am Acad Dermatol. 2001 Apr ;44(4):689-92. PMID: 11260550
Article Published Date : Apr 01, 2001
Study Type : Human: Case Report
Additional Links
Diseases : Bullous Dermatosis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Multiorgan failure induced by atorvastatin has been reported.Sep 01, 2002

Pubmed Data : Am J Med. 2002 Sep ;113(4):348-9. PMID: 12361829
Article Published Date : Sep 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Multi-Organ Failure, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Paranoia is one of the symptoms associated with statin therapy.Mar 01, 2008

Pubmed Data : Am J Geriatr Pharmacother. 2008 Mar ;6(1):28-32. PMID: 18396246
Article Published Date : Mar 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Paranoia, Senile Paranoid Dementia, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Rhabdomyolysis with atorvastatin and fusidic acid has been reported. Jun 01, 2008

Pubmed Data : Postgrad Med J. 2008 Jun ;84(992):325-7. PMID: 18644925
Article Published Date : Jun 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anti-Bacterial Agents
Problem Substances : Atorvastatin, Fusidic acid, Statin Drugs
[+]

Statin drug induced lupus-like syndrome concomitant with a severe autoimmune hepatitis has been reported. Jan 01, 2003

Pubmed Data : Lupus. 2003 ;12(5):409-12. PMID: 12765306
Article Published Date : Jan 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis, Systemic Lupus Erythematosus
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Statin induced pancreatitis has been reported. Nov 01, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JOP. 2004 Nov ;5(6):502-4. Epub 2004 Nov 10. PMID: 15536291
Article Published Date : Nov 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Rosuvastatin, Simvastatin, Statin Drugs
[+]

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported. Aug 01, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Care. 2005 Aug ;28(8):2082. PMID: 16043768
Article Published Date : Aug 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin precipitated lactic acidosis has been reported. Sep 01, 2004

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Lactic Acidosis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.Feb 01, 2007

Pubmed Data : Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID: 17241784
Article Published Date : Feb 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Skeletal Muscle Changes: Endoplasmic Reticulum Stress, Statin-Induced Pathologies
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myositis migrans has been reported. Nov 30, 2002

Pubmed Data : Wien Klin Wochenschr. 2002 Nov 30 ;114(21-22):943-4. PMID: 12528328
Article Published Date : Nov 30, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Myositis, Myositis Migrans, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin
[+]

Toxic epidermal necrolysis from atorvastatin has been reported.May 27, 1998

Pubmed Data : JAMA. 1998 May 27 ;279(20):1613-4. PMID: 9613909
Article Published Date : May 27, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Toxic Epidermal Necrolysis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Unilateral blepharoptosis is an unrecognized side effect of statin treatment.May 01, 2006

Pubmed Data : Ophthal Plast Reconstr Surg. 2006 May-Jun;22(3):222-4. PMID: 16714939
Article Published Date : May 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Blepharoptosis, Myositis: Focal, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Statin Drugs
[+]

Alcohol and atorvastatin interact to adversely affect intestinal villi structure.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):38-43. PMID: 16146046
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity , Gastrointestinal Diseases, Statin-Induced Pathologies
Additional Keywords : Toxic Substance Synergy
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atorvastatin contributes to cataract formation in the white rat.Jan 01, 2002

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2002 ;57(2):165-71. PMID: 12898835
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Diseases : Cataract, Lens Diseases
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cataractogenic
[+]

Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia.Jul 01, 2008

Pubmed Data : J Card Surg. 2008 Jul-Aug;23(4):312-20. PMID: 18598320
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Endothelial Dysfunction, High Cholesterol, Oxidative Stress
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Atorvastatin may contribute to hepatopathy through suppressing oxidized and reduce coenzyme q10 and mitochondrial function in the liver. Apr 20, 2012

Pubmed Data : Physiol Res. 2012 Apr 20 ;61(2):185-93. Epub 2012 Jan 31. PMID: 22292717
Article Published Date : Apr 20, 2012
Study Type : Animal Study
Additional Links
Diseases : Liver Damage: Drug-Induced, Statin-Induced Pathologies
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Atorvastatin treatment reduces exercise capacities in rats and exacerbates metabolic perturbations and oxidative stress in skeletal muscle.Aug 18, 2011

Pubmed Data : J Appl Physiol. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21852406
Article Published Date : Aug 18, 2011
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

High doses of atorvastatin modifies the secretory process in the exocrine portion of the pancreas.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Pancreatic Diseases
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor: Pancreas
[+]

In this animal study statin withdrawal was associated with a deleterious rebound phenomenon with increased risk of thrombotic vascular events.Apr 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2013 May ;71:1-8. Epub 2013 Feb 18. PMID: 23428346
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Diseases : Drug Withdrawal Symptoms
Additional Keywords : Risk Factors
Problem Substances : Atorvastatin, Statin Drugs
[+]

Lipophilic statin drugs are associated with impaired skeletal muscle mitochondria.Oct 01, 2006

Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 17013560
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Cerivastatin, Fluvastatin, Simvastatin, Statin Drugs
[+]

Lipophilic statin drugs worsen myocardial ischemia in dogs. Feb 01, 2000

Pubmed Data : J Cardiovasc Pharmacol. 2000 Feb ;35(2):256-62. PMID: 10672858
Article Published Date : Feb 01, 2000
Study Type : Animal Study
Additional Links
Diseases : Myocardial Ischemia
Additional Keywords : Lipophilic Stains
Problem Substances : Atorvastatin, Fluvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Low dose treatment with statins can induce mild but significant anxiety in guinea pigs.Nov 12, 2011

Pubmed Data : Eur J Pharmacol. 2011 Nov 12. Epub 2011 Nov 12. PMID: 22115894
Article Published Date : Nov 12, 2011
Study Type : Animal Study
Additional Links
Diseases : Anxiety Disorders
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Anxiogenic
[+]

Post treatment thymoquinone may reverse oxidative stress injury in rat liver produced by atorvastatin.Oct 01, 2017

Pubmed Data : Can J Physiol Pharmacol. 2017 Oct 2. Epub 2017 Oct 2. PMID: 28968507
Article Published Date : Oct 01, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Hepatoprotective
Problem Substances : Atorvastatin
[+]

Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats.Dec 31, 1997

Pubmed Data : Toxicol Sci. 1998 Jan ;41(1):88-99. PMID: 9520344
Article Published Date : Dec 31, 1997
Study Type : Animal Study
Additional Links
Diseases : Infertility, Infertility: Female, Infertility: Male
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Teratogenic
[+]

Quercetin is able to ameliorate statin-drug induced skeletal muscle myopathy in an animal model. Jul 20, 2011

Pubmed Data : Eur Heart J. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21775390
Article Published Date : Jul 20, 2011
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Drug-Induced Toxicity , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain. Jul 08, 2011

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754
Article Published Date : Jul 08, 2011
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model.Jul 01, 1996

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188
Article Published Date : Jul 01, 1996
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Liver Damage: Drug-Induced, Statin-Induced Pathologies, Testicular Diseases
Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity, Neurotoxic
[+]

Statin drugs exhibit neurotoxicity in an animal neuronal cell line. Sep 01, 2011

Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Sep ;15(9):985-91. PMID: 22013720
Article Published Date : Sep 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Neurodegenerative Diseases, Statin-Induced Pathologies
Pharmacological Actions : Antiproliferative
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

The statin atorvastatin increase indomethacin-induced gastric injury model in rats.Sep 30, 2012

Pubmed Data : Turk J Gastroenterol. 2012 Oct ;23(5):456-62. PMID: 23161290
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Toxicity: Indomethacin, NSAID-induced toxicity
Problem Substances : Atorvastatin, Indomethacin, Statin Drugs
[+]

Atorvastatin appears to increase the risk of deteriorating blood sugar control. Jun 01, 2006

Pubmed Data : J Atheroscler Thromb. 2006 Jun ;13(3):123-9. PMID: 16835466
Article Published Date : Jun 01, 2006
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 1, Hyperglycemia
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Atorvastatin reduced the ATP levels in pancreas mitochondria.Aug 23, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27553485
Article Published Date : Aug 23, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model. Jan 01, 2011

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Cognitive impairment associated with statin drug use has been reported. Dec 01, 2003

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047
Article Published Date : Dec 01, 2003
Study Type : Review
Additional Links
Diseases : Cognitive Decline/Dysfunction, Dementia, Memory Disorders
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Interstitial lung disease has been reported as a side effect of statins.Jan 01, 2006

Pubmed Data : Therapie. 2006 Jan-Feb;61(1):57-67. PMID: 16792155
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Lung Diseases: Interstitial, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

Review: Drug-induced liver injury associated with statins.Nov 01, 2009

Pubmed Data : Semin Liver Dis. 2009 Nov ;29(4):412-22. Epub 2009 Oct 13. PMID: 19826975
Article Published Date : Nov 01, 2009
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Hepatitis: Cholestatic, Liver Damage, Liver Disease, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Statin toxicity is pleiotropic in nature. Mar 01, 2010

Pubmed Data : FEMS Yeast Res. 2010 Mar ;10(2):188-98. Epub 2009 Nov 3. PMID: 20002195
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Additional Keywords : Saccharomyces Cerevisiae
Problem Substances : Atorvastatin
[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782
Article Published Date : Dec 14, 2004
Study Type : Review
Additional Links
Diseases : Myasthenia Gravis
Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin-induced liver injury may result from the suppression of selenoprotein expression.Jun 01, 2009

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statin-induced myopathy occurs in between 10-15% of users.Feb 23, 2011

Pubmed Data : Expert Opin Drug Saf. 2011 Feb 23. Epub 2011 Feb 23. PMID: 21342078
Article Published Date : Feb 23, 2011
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins have been associated with cell death in primary neuronal culture.Jan 01, 2007

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1985-1992. Epub 2017 Nov 23. PMID: 29399200
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Atorvastatin
[+]

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle Changes: Ultrastructural Changes, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]

This systematic review suggests that there is an association between atorvastatin treatment and new onset diabetes mellitus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Endocrinol. 2018 ;2018:8380192. Epub 2018 Oct 22. PMID: 30425742
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Statin-Induced Pathologies
Additional Keywords : Increased Risk
Problem Substances : Atorvastatin
[+]

Treatment with atorvastatin is associated with mitochondrial oxidative stress, which activates apoptosis and contributes to myopathy. Sep 27, 2015

Pubmed Data : Antioxid Redox Signal. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26414931
Article Published Date : Sep 27, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs

Lipitor Related Articles

Public Health SCANDAL: Sugar Industry Hid Science Linking Sugar to Heart Disease – Blamed Saturated Fats and Cholesterol
Written by Brian Shilhavy
Government Advice on Nutrition has Destroyed Countless Lives the Past Few Decades, Since the War on Fat Started in the 1970s
War on Coconut Oil: California Companies Attacked to try and Prevent the Sale of Coconut Oil
Written by Brian Shilhavy
Companies selling coconut oil in California are finding out the hard way that they cannot claim that coconut oil is “healthy” because the FDA does not allow such a claim, even if scientific studies back up this claim, along with hundreds of thousands of customer testimonials about the health benefits of coconut oil

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.