Lovastatin

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73 Diseases Researched for Lovastatin
NameACCKFocus
Statin-Induced Pathologies46181Locked
High Cholesterol450Locked
Chemically-Induced Liver Damage634Locked
Myopathies524Locked
Drug-Induced Nutrient Depletion: Statin Drugs322Locked
Drug-Induced Toxicity 321Locked
Cancers: All120Locked
Coronary Artery Disease220Locked
Creatine Phosphokinase (CK): Elevated213Locked
Sleep Disorders213Locked
Cholesterol: Oxidation212Locked
Coenzyme Q10 Deficiency212Locked
Rhabdomyolysis412Locked
Cognitive Decline/Dysfunction211Locked
Mitochondrial Myopathies211Locked
Aldosterone levels: Low110Locked
Athletic Performance110Locked
Hormonal Perturbations: Dopamine Elevation110Locked
Hormonal Perturbations: Homovanillic acid (HVA) Elevations110Locked
Insomnia110Locked
Memory Disorders110Locked
Muscle Damage: Exercise-Induced110Locked
Muscle Soreness: Exercise-Induced110Locked
Muscle Stiffness: Exercise-Induced110Locked
Neuropsychological Dysfunction: Psychomotor Speed110Locked
Neurotoxicity610Locked
Oxidative Stress110Locked
Polyneuropathies110Locked
Psychological Well-Being110Locked
Birth Defects28Locked
Hepatitis26Locked
Hepatitis: Cholestatic26Locked
Peripheral Neuropathies26Locked
Prenatal Chemical Exposures26Locked
Abortion: Spontaneous15Locked
Heart Failure45Locked
Appetite Disorders: Loss/Lack of 13Locked
Brain Damage23Locked
Cholestasis13Locked
GGT13Locked
Hyperkalemia13Locked
Hyperthermia13Locked
Kidney Damage: Drug-Induced13Locked
Kidney Failure: Acute13Locked
Kidney Failure: Chronic13Locked
Lens Diseases23Locked
Lichenoid Dermatitis13Locked
Lipid Peroxidation13Locked
Mitochondrial Dysfunction 23Locked
Pancreatitis13Locked
Pregnancy: Environmental Exposures13Locked
Smell Disorders13Locked
Blood-Brain-Barrier Disorders12Locked
Death: Statin-Induced12Locked
Demyelinating Diseases22Locked
Eye Diseases12Locked
Immune Dysregulation: TH1/TH2 imbalance12Locked
Lens Damage12Locked
Liver Damage12Locked
Lung Diseases12Locked
Neurodegenerative Diseases12Locked
Skin Problems: Compromised Barrier Function12Locked
Thyroid Cancer12Locked
Aging11Locked
Cataract11Locked
Immune Disorders: Low Immune Function11Locked
Influenza A11Locked
Lens Opacities11Locked
Low Testosterone11Locked
Myasthenia Gravis11Locked
Neurologic Disorders11Locked
Ovarian Diseases11Locked
Ovulation Disorders11Locked
16 Adverse Pharmacological Actions Researched for Lovastatin
NameACCKFocus
Neurotoxic1552Locked
Myotoxicity729Locked
Cardiotoxic625Locked
Oxidant323Locked
Carcinogenic120Locked
Hepatotoxic719Locked
Cytotoxic514Locked
Endocrine Disruptor211Locked
Teratogenic39Locked
Nephrotoxic26Locked
Immunoreactive12Locked
Apoptotic11Locked
Cataractogenic11Locked
Embryotoxic11Locked
Endocrine Disruptor: Ovary11Locked
Immunosuppressive11Locked
Related Topics

Lovastatin is a Sub of the following Topic

View the Evidence:
68 Abstracts with Lovastatin Research

[+]

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All, Chemically-Induced Liver Damage, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Carcinogenic
[+]

Cholesterol lowering medications also alter measurable hormonal concentrations. Feb 01, 2004

Pubmed Data : J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hormonal Perturbations: Dopamine Elevation, Hormonal Perturbations: Homovanillic acid (HVA) Elevations, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
[+]

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy.May 14, 2002

Pubmed Data : Neurology. 2002 May 14 ;58(9):1333-7. PMID: 12011277
Article Published Date : May 14, 2002
Study Type : Human Study
Additional Links
Diseases : Polyneuropathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin decreases coenzyme Q levels associated with compromised cardiac function in humans.Nov 01, 1990

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4. PMID: 2247468
Article Published Date : Nov 01, 1990
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Lovastatin enhances the susceptibility of LDL cholesterol to oxidation.Jun 30, 1997

Pubmed Data : FEBS Lett. 1997 Jun 30;410(2-3):254-8. PMID: 9237640
Article Published Date : Jun 30, 1997
Study Type : Human Study
Additional Links
Diseases : Cholesterol: Oxidation, Coronary Artery Disease, High Cholesterol
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Oxidant
[+]

Lovastatin has an adverse effect on sleep efficiency and sleep stages.Dec 01, 1991

Pubmed Data : Clin Pharmacol Ther. 1991 Dec ;50(6):730-7. PMID: 1752118
Article Published Date : Dec 01, 1991
Study Type : Human Study
Additional Links
Diseases : Insomnia, Sleep Disorders
Problem Substances : Lovastatin
[+]

Lovastatin increases exercise-induced skeletal muscle injury in human subjects. Oct 01, 1997

Pubmed Data : Metabolism. 1997 Oct ;46(10):1206-10. PMID: 9322808
Article Published Date : Oct 01, 1997
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Creatine Phosphokinase (CK): Elevated, Muscle Damage: Exercise-Induced, Muscle Soreness: Exercise-Induced, Muscle Stiffness: Exercise-Induced, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Lovastatin may adversely affect neuropsychological tests of attention and psychomotor speed.May 01, 2000

Pubmed Data : Am J Med. 2000 May ;108(7):538-46. PMID: 10806282
Article Published Date : May 01, 2000
Study Type : Human Study
Additional Links
Diseases : Neuropsychological Dysfunction: Psychomotor Speed, Psychological Well-Being, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs impair mitochondrial function and decrease ubiquinone (coenzyme Q10) levels. Jan 01, 2009

Pubmed Data : Toxicol Mech Methods. 2009 Jan;19(1):44-50. PMID: 19778232
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
[+]

Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage. Mar 01, 1993

Pubmed Data : J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID: 8463436
Article Published Date : Mar 01, 1993
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , High Cholesterol, Myopathies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cytotoxic
[+]

Statin drugs show no cognitive or anti-amyloid benefits and may be associated with cognitive impairment.Jul 01, 2003

Pubmed Data : Pharmacotherapy. 2003 Jul ;23(7):871-80. PMID: 12885101
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Statin treatment results in significantly reduced serum levels of aldosterone. Sep 01, 1990

Pubmed Data : Clin Ther. 1990 Sep-Oct;12(5):410-20. PMID: 2268863
Article Published Date : Sep 01, 1990
Study Type : Human Study
Additional Links
Diseases : Aldosterone levels: Low, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Statin-induced muscle toxicity may be associated with altered oxidation of fatty acids. Feb 01, 2009

Pubmed Data : Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID: 19051066
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Myopathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. Jan 01, 1997

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Pharmacological Actions : Antioxidants
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
[+]

Lovastatin exhibits toxicity in human fetal brain cells.Jan 01, 1995

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017
Article Published Date : Jan 01, 1995
Study Type : Human In Vitro
Additional Links
Diseases : Abortion: Spontaneous, Birth Defects, Neurotoxicity, Prenatal Chemical Exposures
Pharmacological Actions : Antiproliferative
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic, Teratogenic
[+]

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

Pubmed Data : Gastroenterol Clin Biol. 1991 ;15(1):94-5. PMID: 2010080
Article Published Date : Jan 01, 1991
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Simvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

Pubmed Data : Dig Dis Sci. 1994 Sep ;39(9):2032-3. PMID: 8082513
Article Published Date : Sep 01, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, GGT, Hepatitis: Cholestatic, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly has been reported. Jun 30, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : N Engl J Med. 2005 Jun 30 ;352(26):2759. PMID: 15987932
Article Published Date : Jun 30, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Birth Defects, Pregnancy: Environmental Exposures, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Teratogenic
[+]

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Pubmed Data : Gastroenterol Hepatol. 1998 Mar ;21(3):127-8. PMID: 9607293
Article Published Date : Mar 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Hyperkalemia during treatment with a statin drug has been reported. May 04, 1989

Pubmed Data : N Engl J Med. 1989 May 4 ;320(18):1219-20. PMID: 2710198
Article Published Date : May 04, 1989
Study Type : Human: Case Report
Additional Links
Diseases : Hyperkalemia
Problem Substances : Lovastatin
[+]

Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy has been reported. Nov 01, 2000

Pubmed Data : Atherosclerosis. 2000 Nov ;153(1):255-6. PMID: 11058722
Article Published Date : Nov 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated, Lipid Peroxidation, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Lichenoid drug eruption with fluvastatin and lovastatin has been reported. Jan 01, 2004

Pubmed Data : Acta Derm Venereol. 2004 ;84(3):229-30. PMID: 15202842
Article Published Date : Jan 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Lichenoid Dermatitis, Statin-Induced Pathologies
Problem Substances : Fluvastatin, Lovastatin
[+]

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Pubmed Data : Jpn Heart J. 1997 Jul ;38(4):541-5. PMID: 9350151
Article Published Date : Jul 01, 1997
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Kidney Failure: Acute, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Nephrotoxic
[+]

Lovastatin-induced acute cholestatic hepatitis has been reported. Feb 24, 1995

Pubmed Data : Dtsch Med Wochenschr. 1995 Feb 24 ;120(8):252-6. PMID: 7867482
Article Published Date : Feb 24, 1995
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Cholestatic, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Lovastatin-induced acute rhabdomyolysis has been reported.Apr 01, 1990

Pubmed Data : Postgrad Med J. 1990 Apr ;66(774):294-6. PMID: 2385552
Article Published Date : Apr 01, 1990
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Lovastatin
[+]

Lovastatin-induced cholestasis has been reported. Feb 01, 1993

Pubmed Data : CMAJ. 1993 Feb 1 ;148(3):374. PMID: 8439902
Article Published Date : Feb 01, 1993
Study Type : Human: Case Report
Additional Links
Diseases : Cholestasis, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Lovastatin-induced smell disorders have been reported. Sep 01, 1992

Pubmed Data : Laryngorhinootologie. 1992 Sep ;71(9):483-4. PMID: 1388478
Article Published Date : Sep 01, 1992
Study Type : Human: Case Report
Additional Links
Diseases : Smell Disorders
Problem Substances : Lovastatin
[+]

Peripheral neuropathy associated with simvastatin has been reported.May 01, 1995

Pubmed Data : J Neurol Neurosurg Psychiatry. 1995 May ;58(5):625-8. PMID: 7745415
Article Published Date : May 01, 1995
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Simvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Recurrent hyperthermia due to lovastatin has been reported. Oct 01, 1994

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : West J Med. 1994 Oct ;161(4):427-8. PMID: 7817565
Article Published Date : Oct 01, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Hyperthermia, Statin-Induced Pathologies
Problem Substances : Lovastatin
[+]

Rhabdomyolysis secondary to lovastatin therapy has been reported. Dec 01, 1990

Pubmed Data : Clin Chem. 1990 Dec ;36(12):2145-7. PMID: 2253372
Article Published Date : Dec 01, 1990
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Sleep disturbance and appetite loss after lovastatin.Apr 16, 1994

Pubmed Data : Lancet. 1994 Apr 16 ;343(8903):973. PMID: 7909021
Article Published Date : Apr 16, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Appetite Disorders: Loss/Lack of , Sleep Disorders
Problem Substances : Lovastatin
[+]

Statin induced pancreatitis has been reported. Nov 01, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JOP. 2004 Nov ;5(6):502-4. Epub 2004 Nov 10. PMID: 15536291
Article Published Date : Nov 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Lovastatin, Rosuvastatin, Simvastatin, Statin Drugs
[+]

Terminal renal failure in lovastatin therapy with pre-existing chronic renal insufficiency has been reported.Jan 01, 1996

Pubmed Data : Wien Klin Wochenschr. 1996 ;108(11):334-7. PMID: 8767987
Article Published Date : Jan 01, 1996
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced, Kidney Failure: Chronic, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Nephrotoxic
[+]

High lovastatin doses combined with hypercholesterolemic diet induce liver damage and are lethal to the mouse.Jan 01, 1999

Pubmed Data : Life Sci. 1999 ;64(23):2155-61. PMID: 10372657
Article Published Date : Jan 01, 1999
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Death: Statin-Induced, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Long-term treatmetn of animals with statin drugs result in the inhibition of cholesterol synthesis in the lens.Aug 01, 1991

Pubmed Data : Exp Eye Res. 1991 Aug ;53(2):179-86. PMID: 1915674
Article Published Date : Aug 01, 1991
Study Type : Animal Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Lovastatin alters the immunological balance towards a Th2 dominant state.Nov 29, 2002

Pubmed Data : Neurosci Lett. 2002 Nov 29 ;333(3):167-70. PMID: 12429374
Article Published Date : Nov 29, 2002
Study Type : Animal Study
Additional Links
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Interleukin-10 downregulation, Interleukin-6 Downregulation
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Immunoreactive
[+]

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.Jul 06, 1994

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Lovastatin has the potential of causing muscle damage.Sep 01, 1993

Pubmed Data : J Neuropathol Exp Neurol. 1993 Sep ;52(5):542-9. PMID: 8360706
Article Published Date : Sep 01, 1993
Study Type : Animal Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Some statin drugs are may cause neurological problems due to their ability to cross the blood-brain barrier. Feb 01, 1994

Pubmed Data : Pharm Res. 1994 Feb ;11(2):305-11. PMID: 8165193
Article Published Date : Feb 01, 1994
Study Type : Animal Study
Additional Links
Diseases : Blood-Brain-Barrier Disorders, Statin-Induced Pathologies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs alter the composition of surfactant in the adult lung. Jan 01, 1997

Pubmed Data : Am J Physiol. 1997 Jan ;272(1 Pt 1):L106-14. PMID: 9038909
Article Published Date : Jan 01, 1997
Study Type : Animal Study
Additional Links
Diseases : Lung Diseases
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Simvastatin
[+]

Statin drugs exhibit neurotoxicity in an animal neuronal cell line. Sep 01, 2011

Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Sep ;15(9):985-91. PMID: 22013720
Article Published Date : Sep 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Neurodegenerative Diseases, Statin-Induced Pathologies
Pharmacological Actions : Antiproliferative
Problem Substances : Atorvastatin, Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs may enhance respiratory impairment of liver mitochondria under pathophysiological conditions, such as ischemia.Aug 03, 1994

Pubmed Data : Eur J Pharmacol. 1994 Aug 3 ;270(4):365-9. PMID: 7805787
Article Published Date : Aug 03, 1994
Study Type : Animal Study
Additional Links
Diseases : Liver Damage, Mitochondrial Dysfunction
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Statin drugs, when applied topically, adversely affect skin barrier function. Nov 01, 1990

Pubmed Data : J Clin Invest. 1990 Nov ;86(5):1738-45. PMID: 2243142
Article Published Date : Nov 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Skin Problems: Compromised Barrier Function
Problem Substances : Lovastatin, Statin Drugs
[+]

Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat.Dec 31, 1990

Pubmed Data : Toxicol Pathol. 1991 ;19(3):197-205. PMID: 1780636
Article Published Date : Dec 31, 1990
Study Type : Animal Study
Additional Links
Diseases : Thyroid Cancer
Problem Substances : Lovastatin, Simvastatin, Statin Drugs, Thyroxine
[+]

The statin drug lovastatin reduces the antioxidant capacity of LDL, indicating it may increase the oxidation of LDL cholesterol. Jun 01, 1999

Pubmed Data : Arterioscler Thromb Vasc Biol. 1999 Jun;19(6):1541-8. PMID: 10364087
Article Published Date : Jun 01, 1999
Study Type : Animal Study
Additional Links
Diseases : Cholesterol: Oxidation
Problem Substances : Lovastatin, Statin Drugs
[+]

Lovastatin exhibits neurotoxic properties.Oct 01, 1995

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443
Article Published Date : Oct 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival. Feb 01, 2001

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870
Article Published Date : Feb 01, 2001
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin induces neuronal cell death. Jun 01, 1999

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836
Article Published Date : Jun 01, 1999
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage, Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin induces the formation of abnormal myelin-like membrane sheets in primary oligodendrocytes. Mar 01, 2009

Pubmed Data : Glia. 2009 Mar;57(4):402-13. PMID: 18814266
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases
Problem Substances : Lovastatin
[+]

Lovastatin inhibits testosterone production in testicular cells.Sep 01, 1990

Pubmed Data : Exp Clin Endocrinol. 1990 Sep ;96(1):15-24. PMID: 2279522
Article Published Date : Sep 01, 1990
Study Type : In Vitro Study
Additional Links
Diseases : Low Testosterone, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Lovastatin may adversely affect myelin formation and the remyelination process. Apr 01, 1994

Pubmed Data : J Neurochem. 1994 Apr ;62(4):1539-45. PMID: 8133281
Article Published Date : Apr 01, 1994
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases, Statin-Induced Pathologies
Additional Keywords : Remyelination
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death.Dec 15, 2003

Pubmed Data : Toxicol Appl Pharmacol. 2003 Dec 15 ;193(3):346-55. PMID: 14678744
Article Published Date : Dec 15, 2003
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in neurons.Sep 01, 2010

Pubmed Data : Neurobiol Aging. 2010 Sep ;31(9):1543-53. Epub 2008 Oct 31. PMID: 18951667
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Aging, Cognitive Decline/Dysfunction, Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs can act directly on mitochondria either in vivo or in vitro inducing permeability transition, which is a process involved in cell death.Feb 15, 2006

Pubmed Data : Toxicology. 2006 Feb 15 ;219(1-3):124-32. Epub 2005 Dec 15. PMID: 16343726
Article Published Date : Feb 15, 2006
Study Type : Review
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cytotoxic
[+]

Statin drugs decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells.Mar 01, 2005

Pubmed Data : Biol Reprod. 2005 Mar ;72(3):538-45. Epub 2004 Sep 22. PMID: 15385411
Article Published Date : Mar 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Ovarian Diseases, Ovulation Disorders, Statin-Induced Pathologies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Apoptotic, Endocrine Disruptor: Ovary
[+]

Statin drugs exhibit myotoxicity. Mar 01, 1995

Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Article Published Date : Mar 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs may contribute to lens opacities.Jan 01, 1990

Pubmed Data : Exp Eye Res. 1990 Jan ;50(1):65-78. PMID: 2307197
Article Published Date : Jan 01, 1990
Study Type : Review
Additional Links
Diseases : Cataract, Lens Diseases, Lens Opacities
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cataractogenic
[+]

Statin drugs may intefere with neurological function in the brain by inhibiting cholesterol biosynthesis and synaptic transmission.Sep 07, 2011

Pubmed Data : J Neurochem. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899539
Article Published Date : Sep 07, 2011
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity , Neurologic Disorders, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs may interfere with the immune cell function. Nov 01, 1991

Pubmed Data : Am J Physiol. 1991 Nov ;261(5 Pt 1):C780-6. PMID: 1659206
Article Published Date : Nov 01, 1991
Study Type : In Vitro Study
Additional Links
Diseases : Immune Disorders: Low Immune Function, Statin-Induced Pathologies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
[+]

Statin drugs may reduce T cell responses associated with inhibiting influenza A virus. Jan 01, 2010

Pubmed Data : Cell Immunol. 2010 ;264(1):71-7. Epub 2010 May 4. PMID: 20483407
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Influenza A, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Immunosuppressive
[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782
Article Published Date : Dec 14, 2004
Study Type : Review
Additional Links
Diseases : Myasthenia Gravis
Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

statin-induced inhibition of protein synthesis is an underlying mechanism for statin-induced cardiomyocyte cell death.Jan 01, 2007

Pubmed Data : Cardiovasc Toxicol. 2007 ;7(1):1-9. PMID: 17646677
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells. Apr 01, 1986

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306
Article Published Date : Apr 01, 1986
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

The myotoxicity of statin drugs may be due to the inhibition of the geranylgeranylation of low-molecular-weight proteins in the muscle cells.Jul 01, 1997

Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The statin drug lovastatin induces concentration-dependent cell death in cardiomyoctyes.Jan 01, 2008

Pubmed Data : Pharmacology. 2008 ;82(1):74-82. Epub 2008 May 27. PMID: 18504415
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

Warfarin and lovastatin exhibit embryotoxic potential.Aug 01, 2010

Pubmed Data : Reprod Toxicol. 2010 Aug;30(1):121-30. Epub 2010 May 20. PMID: 20493250
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Prenatal Chemical Exposures
Problem Substances : Lovastatin, Warfarin
Adverse Pharmacological Actions : Embryotoxic, Teratogenic

Lovastatin Related Articles

FAIL: Merck's Statin Drug Found No Better Than Coconut Water
Written by Sayer Ji, Founder
In a 2008 study published in the journal Food Chemistry & Toxicology titled, "Comparative evaluation of the hypolipidemic effects of coconut water and lovastatin in rats fed fat-cholesterol enriched diet," the beverage coconut water was as effective as Merck's original cholesterol-lowering drug in positively modulating blood lipid levels in rats.
Sugarcane Extract Superior to Cholesterol-Lowering Drugs?
Written by Sayer Ji, Founder
There is a little known natural extract of plant waxes known as policosanol, extractable from sugar cane, yams, and beeswax, which has been giving some of the more profitable drugs on the market a biomedical beating since it was first investigated in clinical trials by the Cubans in the 1990's.
Statins Raise Diabetes Risk by 48% for Postmenopausal Women
Written by Margie King, Health Coach
More and more women are being prescribed cholesterol-lowering statins and some doctors are even recommending the drugs be added to the water supply or dispensed at the McDonald’s drive-thru windows. However, postmenopausal women using statins may be increasing their risk of diabetes according to a study published by the Archives of Internal Medicine.
New Documentary Exposes the Over-Prescription of Statins
Written by Justin Smith
An estimated 40 million people take a statin to lower their cholesterol levels. These are one of the most widely prescribed medications in history and, of course, one of the most profitable.
Cracking the Cholesterol Myth: How Statins Harm The Body and Mind
Written by Kelly Brogan, M.D.
The chemical war against cholesterol has been based on statistical deception and the active covering up of over 300 adverse health effects they are known to produce.
Statin Drugs Linked to Arthritis, Heart Trouble and More
Written by Sayer Ji, Founder
Research revealing the broad spectrum toxicity of statin drugs continues to accumulate unabated. Adding to a growing body of clinical evidence that they may cause over 300 adverse health effects, a new study reveals that these cholesterol-lowering drugs may be contributing to an epidemic of arthritis and autoimmunity in exposed populations, as well.

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