Metformin

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8 Diseases Researched for Metformin
NameACCKFocus
Diabetes Mellitus: Type 2541Locked
Cardiac Mortality 330Locked
Diabetes: Cardiovascular Illness220Locked
Cancers: All110Locked
Cardiovascular Diseases110Locked
Coronary Artery Disease110Locked
Hypothyroidism12Locked
Vitamin B 12 Deficiency11Locked
1 Adverse Pharmacological Actions Researched for Metformin
NameACCKFocus
Endocrine Disruptor: Thyroid12Locked

View the Evidence:
23 Abstracts with Metformin Research

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he effect of metformin on some cardiovascular outcomes was not significantly better than the non-metformin therapy or DPP-4i in T2DM patients based on observational studieDec 31, 2021

Pubmed Data : Front Cardiovasc Med. 2022 ;9:944902. Epub 2022 Sep 23. PMID: 36211585
Article Published Date : Dec 31, 2021
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Disease, Diabetes Mellitus: Type 2, Heart Failure, Stroke
Problem Substances : Metformin
[+]

Drug use is associated with lower plasma magnesium levels in geriatric outpatients.Dec 05, 2018

Pubmed Data : Clin Nutr. 2018 Dec 6. Epub 2018 Dec 6. PMID: 30581015
Article Published Date : Dec 05, 2018
Study Type : Human Study
Additional Links
Diseases : Magnesium Deficiency
Additional Keywords : Increased Risk
Problem Substances : Metformin , Proton-Pump Inhibitors, Statin Drugs
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Even short-term treatment with metformin causes a decrease in serum cobalamin folic acid and increase in homocysteine.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):631-637. PMID: 27730072
Article Published Date : Aug 31, 2016
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Folate and Folic Acid, Homocysteine: Elevated
Additional Keywords : Risk Factors
Problem Substances : Metformin
[+]

Hyperglycemia and metformin use are associated With B vitamin deficiency and cognitive dysfunction in older adults.Sep 30, 2019

Pubmed Data : J Clin Endocrinol Metab. 2019 Oct 1 ;104(10):4837-4847. PMID: 30920623
Article Published Date : Sep 30, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
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In patients with type 2 diabetes, long-term metformin treatment and smoking are associated with higher chances of developing vitamin B12 deficiency.Aug 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2017 Aug 18 ;9(8):e1577. Epub 2017 Aug 18. PMID: 29057189
Article Published Date : Aug 17, 2017
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
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Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. Jan 01, 1985

Pubmed Data : Horm Metab Res Suppl. 1985;15:105-11. PMID: 3935560
Article Published Date : Jan 01, 1985
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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Metformin reduces insulin doses in type 1 diabetes, but does not reduce the rate of glycated hemoglobin (HbA 1c), nor is it clear whether the benefit is sustained beyone 1 year or has any benefit to cardiovascular or other key clinical outcomes. Jan 08, 2010

Pubmed Data : Diabetologia. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20057994
Article Published Date : Jan 08, 2010
Study Type : Human Study
Additional Links
Problem Substances : Metformin
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Metformin-induced changes of the gut microbiota in healthy young men.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetologia. 2019 06 ;62(6):1024-1035. Epub 2019 Mar 23. PMID: 30904939
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Drug Induced Toxicity: Metformin, Dysbiosis
Additional Keywords : Increased Risk
Problem Substances : Metformin
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NAC can be used as a substitute for insulin-sensitizing agent in treatment of polycystic ovarian syndrome.Jan 31, 2019

Pubmed Data : J Obstet Gynaecol India. 2019 Feb ;69(1):77-81. Epub 2018 May 28. PMID: 30814814
Article Published Date : Jan 31, 2019
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Insulin Sensitizers
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Patients with type 2 diabetes who use sulfonylureas or insulin have an increased risk for cancer-related mortality. Feb 01, 2006

Pubmed Data : Diabetes Care. 2006 Feb;29(2):254-8. PMID: 16443869
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Cancers: All, Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Glipizide, Glyburide, Insulin , Metformin , Sulfonylureas
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The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sultan Qaboos Univ Med J. 2020 Feb ;20(1):e90-e94. Epub 2020 Mar 9. PMID: 32190375
Article Published Date : Jan 31, 2020
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
[+]

The prevalence of vitamin B12 deficiency was significantly high in diabetics, especially the metformin-treated patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : SAGE Open Med. 2019 ;7:2050312119853433. Epub 2019 May 23. PMID: 31205703
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
[+]

There is a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combination than in those taking only sulphonylurea.May 01, 2000

Pubmed Data : Diabetologia. 2000 May;43(5):558-60. PMID: 10855529
Article Published Date : May 01, 2000
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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There was a significant decrease in the serum anti-Mullerian hormone level after administration of cinnamon.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Hum Reprod Sci. 2017 Jan-Mar;10(1):31-36. PMID: 28479753
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Cinnamon
Diseases : Polycystic Ovary Syndrome
Additional Keywords : cinnamon, Metformin, Polycystic Ovary Syndrome
Problem Substances : Metformin
[+]

Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

Pubmed Data : Cardiology. 1999;91(3):195-202. PMID: 10516414
Article Published Date : Jan 01, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment.Dec 31, 2019

Pubmed Data : Pan Afr Med J. 2020 ;37:280. Epub 2020 Nov 26. PMID: 33598094
Article Published Date : Dec 31, 2019
Study Type : Human: Case Report
Additional Links
Diseases : Anemia, Vitamin B 12 Deficiency
Problem Substances : Metformin
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Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.Mar 15, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 Mar 16. Epub 2020 Mar 16. PMID: 32180335
Article Published Date : Mar 15, 2020
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Drug Induced Toxicity: Metformin
Pharmacological Actions : Hepatoprotective
Problem Substances : Metformin
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Grape seed proanthocyanidins is superior to metformin to promote insulin signaling in rats fed high calorie diet.Sep 11, 2013

Pubmed Data : J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID: 24026800
Article Published Date : Sep 11, 2013
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Blood Sugar Problems, Diabetes Mellitus: Type 2, Hyperglycemia, Hyperinsulinism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Metformin exhibits toxicity in animals when given in high doses. Jan 11, 2010

Pubmed Data : Toxicol Appl Pharmacol. 2010 Jan 11. Epub 2010 Jan 11. PMID: 20004680
Article Published Date : Jan 11, 2010
Study Type : Animal Study
Additional Links
Problem Substances : Metformin
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Metformin may contribute to hypothyroidism.Aug 01, 2009

Pubmed Data : Phytother Res. 2009 Aug;23(8):1140-5. PMID: 19170137
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Hypothyroidism
Additional Keywords : Drug: Metformin, Plant Extracts
Problem Substances : Metformin
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid
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These results showed that hypoglycemic effects of MOLE might be mediated through the stimulation of insulin release leading to enhanced glucose uptake and glycogen synthesis.Jun 26, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26124050
Article Published Date : Jun 26, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetes Mellitus: Type 2, Hypoglycemia
Pharmacological Actions : Anticholesteremic Agents, Hypoglycemic Agents, Insulin-releasing
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Phenformin and metformin cause vitamin B12 malabsorption in 33% of cases. Jan 01, 1985

Pubmed Data : Horm Metab Res Suppl. 1985;15:111-5. PMID: 3865878
Article Published Date : Jan 01, 1985
Study Type : Commentary
Additional Links
Diseases : Diabetes Mellitus: Type 2, Vitamin B 12 Deficiency
Problem Substances : Metformin , Phenformin
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Residues of metformin may lead to the formation of disinfection by-products during chlorine disinfection.Jul 31, 2015

Pubmed Data : Water Res. 2015 Aug 1 ;79:104-18. Epub 2015 Apr 27. PMID: 25973582
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Chlorinated Water, Chlorine, Disinfection by-products: In Drinking Water, Environmental Fate of Pharmacueticals, Hypoglycemic Agents, Metformin
Problem Substances : Chlorinated Water, Chlorine, Disinfection by-products: In Drinking Water, Metformin

Metformin Related Articles

Please Stay Away from These Drugs for Type 2 Diabetes
Written by Dr. Michael Murray
The research is quite clear – oral medications to treat type 2 diabetes do not alter the long-term progression of the disease. While these drugs can be quite effective in the short term, several different types are associated with increased all cause mortality and in particular an increased risk for dying due to cardiovascular disease.
Insulin Doubles Death Rate in Type 2 Diabetics: Study
Written by Heidi Stevenson
A new study clearly documents that the standard treatment for type 2 diabetes is a killer, resulting in more than double the deaths. The treatment justification has always been based on irrelevant criteria - just as it is with most pharmaceutical treatments.
Aging Is Officially A Disease
Written by Jennie Ann Freiman MD
The search for eternal life isn’t new, but how far we’ve come from the Holy Grail, the Fountain of Youth and the hidden valley of Shangri-La, is truly a sign of the times. Today, the crossroads meet between the natural tendency to find an easy way out, and the seductive promise of profits. The quest is on for how to put longevity in a pill.
Lipid Lowering Effects of Black Seed
Written by Dr. Ali Hassan, MD
There are a number of trials which have shown black seed oil (Nigella sativa) has a beneficial effect on blood lipids, reducing cholesterol and low density lipoprotein and increasing beneficial high density low density lipoprotein
Why All Diabetics Should Know About Turmeric
Written by Sayer Ji, Founder
Many diabetics already know about the benefits of a low-glycemic diet and regular exercise, but why haven't they heard about turmeric, one of the world's most extensively researched anti-diabetic plants?
Is the Solution for Diabetes a Humble Root?
Written by Sayer Ji, Founder
Billions are spent annually and still there is no conventional cure for diabetes. Or is there a cheap, safe and freely available solution already growing beneath our feet?
The Dangers of GMO Insulin for Type 2 Diabetics No One Talks About
Written by GreenMedInfo Research Group
A growing body of concerning research indicates that conventional medicine's standard of care for type 2 diabetes, including synthetic insulin and oral anti-diabetic drugs, may actually increase morbidity and mortality. On the other hand, recently validated traditional approaches relying on plant-based medicines may greatly mitigate the global diabetes epidemic.

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