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8 Diseases Researched for Metformin
NameACCKFocus
Diabetes Mellitus: Type 2541Locked
Cardiac Mortality 330Locked
Diabetes: Cardiovascular Illness220Locked
Cancers: All110Locked
Cardiovascular Diseases110Locked
Coronary Artery Disease110Locked
Hypothyroidism12Locked
Vitamin B 12 Deficiency11Locked
1 Adverse Pharmacological Actions Researched for Metformin
NameACCKFocus
Endocrine Disruptor: Thyroid12Locked

View the Evidence:
25 Abstracts with Metformin Research

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he effect of metformin on some cardiovascular outcomes was not significantly better than the non-metformin therapy or DPP-4i in T2DM patients based on observational studieDec 31, 2021

Pubmed Data : Front Cardiovasc Med. 2022 ;9:944902. Epub 2022 Sep 23. PMID: 36211585
Article Published Date : Dec 31, 2021
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Disease, Diabetes Mellitus: Type 2, Heart Failure, Stroke
Problem Substances : Metformin
[+]

Drug use is associated with lower plasma magnesium levels in geriatric outpatients.Dec 05, 2018

Pubmed Data : Clin Nutr. 2018 Dec 6. Epub 2018 Dec 6. PMID: 30581015
Article Published Date : Dec 05, 2018
Study Type : Human Study
Additional Links
Diseases : Magnesium Deficiency
Additional Keywords : Increased Risk
Problem Substances : Metformin , Proton-Pump Inhibitors, Statin Drugs
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Even short-term treatment with metformin causes a decrease in serum cobalamin folic acid and increase in homocysteine.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):631-637. PMID: 27730072
Article Published Date : Aug 31, 2016
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Folate and Folic Acid, Homocysteine: Elevated
Additional Keywords : Risk Factors
Problem Substances : Metformin
[+]

Hyperglycemia and metformin use are associated With B vitamin deficiency and cognitive dysfunction in older adults.Sep 30, 2019

Pubmed Data : J Clin Endocrinol Metab. 2019 Oct 1 ;104(10):4837-4847. PMID: 30920623
Article Published Date : Sep 30, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
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In patients with type 2 diabetes, long-term metformin treatment and smoking are associated with higher chances of developing vitamin B12 deficiency.Aug 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2017 Aug 18 ;9(8):e1577. Epub 2017 Aug 18. PMID: 29057189
Article Published Date : Aug 17, 2017
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
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Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. Jan 01, 1985

Pubmed Data : Horm Metab Res Suppl. 1985;15:105-11. PMID: 3935560
Article Published Date : Jan 01, 1985
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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Metformin reduces insulin doses in type 1 diabetes, but does not reduce the rate of glycated hemoglobin (HbA 1c), nor is it clear whether the benefit is sustained beyone 1 year or has any benefit to cardiovascular or other key clinical outcomes. Jan 08, 2010

Pubmed Data : Diabetologia. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20057994
Article Published Date : Jan 08, 2010
Study Type : Human Study
Additional Links
Problem Substances : Metformin
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Metformin users randomized to aspirin had greater risk of cancer mortality.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JNCI Cancer Spectr. 2023 Mar 1 ;7(2). PMID: 36857596
Article Published Date : Feb 28, 2023
Study Type : Human Study
Additional Links
Diseases : Cancer Mortality, Diabetes Mellitus: Type 2
Additional Keywords : Increased Risk
Problem Substances : Aspirin , Metformin
[+]

Metformin-induced changes of the gut microbiota in healthy young men.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetologia. 2019 06 ;62(6):1024-1035. Epub 2019 Mar 23. PMID: 30904939
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Drug Induced Toxicity: Metformin, Dysbiosis
Additional Keywords : Increased Risk
Problem Substances : Metformin
[+]

NAC can be used as a substitute for insulin-sensitizing agent in treatment of polycystic ovarian syndrome.Jan 31, 2019

Pubmed Data : J Obstet Gynaecol India. 2019 Feb ;69(1):77-81. Epub 2018 May 28. PMID: 30814814
Article Published Date : Jan 31, 2019
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Insulin Sensitizers
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Patients with type 2 diabetes who use sulfonylureas or insulin have an increased risk for cancer-related mortality. Feb 01, 2006

Pubmed Data : Diabetes Care. 2006 Feb;29(2):254-8. PMID: 16443869
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Cancers: All, Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Glipizide, Glyburide, Insulin , Metformin , Sulfonylureas
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The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sultan Qaboos Univ Med J. 2020 Feb ;20(1):e90-e94. Epub 2020 Mar 9. PMID: 32190375
Article Published Date : Jan 31, 2020
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
[+]

The prevalence of vitamin B12 deficiency was significantly high in diabetics, especially the metformin-treated patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : SAGE Open Med. 2019 ;7:2050312119853433. Epub 2019 May 23. PMID: 31205703
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
Problem Substances : Metformin
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There is a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combination than in those taking only sulphonylurea.May 01, 2000

Pubmed Data : Diabetologia. 2000 May;43(5):558-60. PMID: 10855529
Article Published Date : May 01, 2000
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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There was a significant decrease in the serum anti-Mullerian hormone level after administration of cinnamon.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Hum Reprod Sci. 2017 Jan-Mar;10(1):31-36. PMID: 28479753
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Cinnamon
Diseases : Polycystic Ovary Syndrome
Additional Keywords : cinnamon, Metformin, Polycystic Ovary Syndrome
Problem Substances : Metformin
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Tight glycaemic control may be hazardous in older people with type 2 diabetes when achieved with pharmacotherapy with metformin, insulin or sulphonylureas.Nov 30, 2018

Pubmed Data : Diabetes Obes Metab. 2018 Dec ;20(12):2852-2859. Epub 2018 Aug 10. PMID: 30003670
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
Problem Substances : Metformin
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Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

Pubmed Data : Cardiology. 1999;91(3):195-202. PMID: 10516414
Article Published Date : Jan 01, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2
Additional Keywords : Drug: Metformin
Problem Substances : Metformin , Sulfonylureas
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Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment.Dec 31, 2019

Pubmed Data : Pan Afr Med J. 2020 ;37:280. Epub 2020 Nov 26. PMID: 33598094
Article Published Date : Dec 31, 2019
Study Type : Human: Case Report
Additional Links
Diseases : Anemia, Vitamin B 12 Deficiency
Problem Substances : Metformin
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Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.Mar 15, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 Mar 16. Epub 2020 Mar 16. PMID: 32180335
Article Published Date : Mar 15, 2020
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Drug Induced Toxicity: Metformin
Pharmacological Actions : Hepatoprotective
Problem Substances : Metformin
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Grape seed proanthocyanidins is superior to metformin to promote insulin signaling in rats fed high calorie diet.Sep 11, 2013

Pubmed Data : J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID: 24026800
Article Published Date : Sep 11, 2013
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Blood Sugar Problems, Diabetes Mellitus: Type 2, Hyperglycemia, Hyperinsulinism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Metformin exhibits toxicity in animals when given in high doses. Jan 11, 2010

Pubmed Data : Toxicol Appl Pharmacol. 2010 Jan 11. Epub 2010 Jan 11. PMID: 20004680
Article Published Date : Jan 11, 2010
Study Type : Animal Study
Additional Links
Problem Substances : Metformin
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Metformin may contribute to hypothyroidism.Aug 01, 2009

Pubmed Data : Phytother Res. 2009 Aug;23(8):1140-5. PMID: 19170137
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Hypothyroidism
Additional Keywords : Drug: Metformin, Plant Extracts
Problem Substances : Metformin
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid
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These results showed that hypoglycemic effects of MOLE might be mediated through the stimulation of insulin release leading to enhanced glucose uptake and glycogen synthesis.Jun 26, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26124050
Article Published Date : Jun 26, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetes Mellitus: Type 2, Hypoglycemia
Pharmacological Actions : Anticholesteremic Agents, Hypoglycemic Agents, Insulin-releasing
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Phenformin and metformin cause vitamin B12 malabsorption in 33% of cases. Jan 01, 1985

Pubmed Data : Horm Metab Res Suppl. 1985;15:111-5. PMID: 3865878
Article Published Date : Jan 01, 1985
Study Type : Commentary
Additional Links
Diseases : Diabetes Mellitus: Type 2, Vitamin B 12 Deficiency
Problem Substances : Metformin , Phenformin
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Residues of metformin may lead to the formation of disinfection by-products during chlorine disinfection.Jul 31, 2015

Pubmed Data : Water Res. 2015 Aug 1 ;79:104-18. Epub 2015 Apr 27. PMID: 25973582
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Chlorinated Water, Chlorine, Disinfection by-products: In Drinking Water, Environmental Fate of Pharmacueticals, Hypoglycemic Agents, Metformin
Problem Substances : Chlorinated Water, Chlorine, Disinfection by-products: In Drinking Water, Metformin

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