Oseltamivir (trade name Tamiflu)

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29 Diseases Researched for Oseltamivir (trade name Tamiflu)
NameACCKFocus
Influenza993Locked
Drug-Induced Toxicity 858Locked
Influenza A442Locked
Childhood Infections330Locked
Swine Flu Associated Virus230Locked
Psychiatric Disorders427Locked
Childhood Chemical Exposures120Locked
Childhood Cognitive Disorders120Locked
Infant Infections120Locked
Influenza B 120Locked
Lyell syndrome120Locked
Meningitis: Drug-Induced120Locked
Pneumonia: Drug-Induced120Locked
Avian Influenza110Locked
H1N1 Infection110Locked
H3N2 Infection 110Locked
Vaccine-induced Toxicity 110Locked
Acute Angle Closure Glaucoma (AACG)13Locked
Depression13Locked
Myopia13Locked
Stevens-Johnson Syndrome13Locked
Toxic Epidermal Necrolysis13Locked
Infant Chemical Exposures12Locked
Inflammation12Locked
Lipopolysaccharide-Induced Toxicity12Locked
Delirium: Drug-Induced11Locked
Hallucinations11Locked
Parasuicide11Locked
Suicidal Behavior11Locked
1 Adverse Pharmacological Actions Researched for Oseltamivir (trade name Tamiflu)
NameACCKFocus
Neurotoxic759Locked
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View the Evidence:
33 Abstracts with Oseltamivir (trade name Tamiflu) Research

[+]

2014 Cochrane: a dose-response effect on psychiatric events. In trials of prevention in adults one person was harmed for every 94 treated. Apr 09, 2014

Pubmed Data : Cochrane Database Syst Rev. 2014 Apr 10(4):CD008965. Epub 2014 Apr 10. PMID: 24718923
Article Published Date : Apr 09, 2014
Study Type : Meta Analysis
Additional Links
Pharmacological Actions : Antiviral Agents, Enzyme Inhibitors
Additional Keywords : Randomized Controlled Trials As Topic
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir for treatment of influenza in infants less than one year results in complications in 54% of the patients with the most serious of which were meningitis in 1 infant (1%), pneumonia in 9 (6%), and otitis media in 2 (1%)Jun 01, 2010

Pubmed Data : Pediatr Infect Dis J. 2010 Jun;29(6):495-8. PMID: 20035245
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity , Infant Infections, Influenza, Meningitis: Drug-Induced, Pneumonia: Drug-Induced
Additional Keywords : Iatrogenic Disease
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

Oseltamivir has been reported to cause neuropsychiatric disorders in children and may be particularly dangerous to infants.Oct 01, 2006

Pubmed Data : Prescrire Int. 2006 Oct;15(85):182-3. PMID: 17128526
Article Published Date : Oct 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Childhood Chemical Exposures, Childhood Cognitive Disorders, Lyell syndrome, Psychiatric Disorders
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus has been reported.Jul 01, 2010

Pubmed Data : Emerg Infect Dis. 2010 Jul;16(7):1068-75. PMID: 20587176
Article Published Date : Jul 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Swine Flu Associated Virus
Additional Keywords : Drug Resistant Pathogens
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

The data is inconclusive as to whether or not neuraminidase inhibitors are effective at preventing and treating influenza in healthy adults.Oct 01, 2010

Pubmed Data : Health Technol Assess. 2010 Oct;14(46):355-458. PMID: 20945587
Article Published Date : Oct 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Influenza, Influenza A, Influenza B
Problem Substances : Neuraminidase inhibitors , Oseltamivir (trade name Tamiflu), Zanamivir
[+]

Adverse drug effects following oseltamivir mass treatment and prophylaxis in a school outbreak of 2009 pandemic influenza A(H1N1) in June 2009, Sheffield, United Kingdom has been reported. May 13, 2010

Pubmed Data : Euro Surveill. 2010 May 13;15(19):pii/19565. Epub 2010 May 13. PMID: 20483106
Article Published Date : May 13, 2010
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Swine Flu Associated Virus
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Echinaforce Hotdrink is as effective as oseltamivir in the early treatment of confirmed influenza virus infections with a reduced risk of complications and adverse events.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:66-72. Epub 2015 Apr 20. PMID: 26265958
Article Published Date : Nov 30, 2015
Study Type : Human Study
Additional Links
Substances : Echinacea
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
Additional Keywords : Risk Reduction, Superiority of Natural Substances versus Drugs
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir had no significant effect on mortality in patients with influenza.Dec 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Infect Dis. 2017 Dec 20 ;17(1):785. Epub 2017 Dec 20. PMID: 29262784
Article Published Date : Dec 19, 2017
Study Type : Human Study
Additional Links
Diseases : Influenza
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir is not sufficiently effective or safe for the prevention of influenza in children.Feb 01, 2007

Pubmed Data : Prescrire Int. 2007 Feb;16(87):9-11. PMID: 17323516
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Diseases : Childhood Infections, Influenza, Vaccine-induced Toxicity
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir resistance during treatment of influenza A (H5N1) infection has been reported.Dec 22, 2005

Pubmed Data : N Engl J Med. 2005 Dec 22;353(25):2667-72. PMID: 16371632
Article Published Date : Dec 22, 2005
Study Type : Human Study
Additional Links
Diseases : Avian Influenza, Influenza A
Additional Keywords : Drug Resistant Pathogens
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Prophylactic oseltamivir treatment in children resulted in 51% experiencing adverse reactions.Jul 30, 2009

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19285. Epub 2009 Jul 30. PMID: 19643061
Article Published Date : Jul 30, 2009
Study Type : Human Study
Additional Links
Diseases : Childhood Infections, Drug-Induced Toxicity , Influenza
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

The administration of oral maoto granules to healthy adults with seasonal influenza was well tolerated and associated with equivalent clinical and virological efficacy to oseltamivir or zanamivir.Jul 31, 2012

Pubmed Data : J Infect Chemother. 2012 Aug ;18(4):534-43. Epub 2012 Feb 16. PMID: 22350323
Article Published Date : Jul 31, 2012
Study Type : Human Study
Additional Links
Substances : Apricot Kernel, Cinnamon, Ephedra sinica (Ma Huang)
Diseases : H1N1 Infection, H3N2 Infection , Influenza, Influenza A
Pharmacological Actions : Antiviral Agents, Enzyme Inhibitors
Additional Keywords : Cytokine Modulation, Maoto Granules, Natural Substances Versus Drugs
Problem Substances : Oseltamivir (trade name Tamiflu), Zanamivir
[+]

The prophylactic use of oseltamivir in children results in side effects including high rates of gastrointestinal and neuropsychiatric reactions.Jul 30, 2009

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19287. Epub 2009 Jul 30. PMID: 19643062
Article Published Date : Jul 30, 2009
Study Type : Human Study
Additional Links
Diseases : Childhood Infections, Drug-Induced Toxicity
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

A case of bilateral acute angle closure glaucoma after one dose of oseltamivir.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ophthalmic Vis Res. 2017 Oct-Dec;12(4):434-436. PMID: 29090056
Article Published Date : Sep 30, 2017
Study Type : Human: Case Report
Additional Links
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir.Aug 04, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Neurol. 2015 Aug 5 ;15:130. Epub 2015 Aug 5. PMID: 26242979
Article Published Date : Aug 04, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Psychiatric Disorders
Additional Keywords : Gene Expression, Oseltamivir (trade name Tamiflu), psychiatric disorders
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

Oseltamivir (tamiflu) induced depressive episode in a female adolescent.Nov 30, 2010

Pubmed Data : Psychiatry Investig. 2010 Dec ;7(4):302-4. Epub 2010 Nov 11. PMID: 21253416
Article Published Date : Nov 30, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Depression
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir (Tamiflu)-induced bilateral acute angle closure glaucoma and transient myopia.Nov 30, 2014

Pubmed Data : Indian J Ophthalmol. 2014 Dec ;62(12):1165-7. PMID: 23571265
Article Published Date : Nov 30, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Acute Angle Closure Glaucoma (AACG), Myopia
Pharmacological Actions : Antiviral Agents
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir induced Stevens-Johnson syndrome/toxic epidermal necrolysis-case reportApr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2019 May ;98(19):e15553. PMID: 31083216
Article Published Date : Apr 30, 2019
Study Type : Human: Case Report
Additional Links
Diseases : Stevens-Johnson Syndrome
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Oseltamivir-resistance to pandemic (H1N1) 2009 influenza has been reported in a severely ill patient.Feb 01, 2010

Pubmed Data : Med J Aust. 2010 Feb 1;192(3):166-8. PMID: 20121687
Article Published Date : Feb 01, 2010
Study Type : Human: Case Report
Additional Links
Additional Keywords : Drug Resistant Pathogens
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Severe, delayed-onset neuropsychiatric symptoms after administration of high-dose oseltamivir has been reported in a critically ill patient.Apr 01, 2010

Pubmed Data : Clin Infect Dis. 2010 Apr 1;50(7):e47-9. PMID: 20192728
Article Published Date : Apr 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Psychiatric Disorders
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

Toxic epidermal necrolysis after treatment with oseltamivir has been reported.Jun 01, 2010

Pubmed Data : Arch Argent Pediatr. 2010 Jun;108(3):e76-8. PMID: 20544126
Article Published Date : Jun 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Toxic Epidermal Necrolysis
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

"Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats."Dec 31, 2011

Pubmed Data : J Toxicol Sci. 2012 ;37(6):1217-23. PMID: 23208436
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Animal research on Tamiflu shows that the infant brain absorbs it more readily than those who are older. This may explain why neuropsychiatric side effects of oseltamivir occur in young patients.May 19, 2011

Pubmed Data : Neurosci Lett. 2011 May 20 ;495(3):187-91. Epub 2011 Apr 2. PMID: 21443926
Article Published Date : May 19, 2011
Study Type : Animal Study
Additional Links
Diseases : Infant Chemical Exposures
Pharmacological Actions : Antiviral Agents
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Biodistribution and metabolism of the anti-influenza drug [11C]oseltamivir and its active metabolite [11C]Ro 64-0802 in mice.Dec 31, 2008

Pubmed Data : Nucl Med Biol. 2009 Jan ;36(1):47-55. PMID: 19181268
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Pharmacological Actions : Antiviral Agents
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dairy Sci. 2019 Nov ;102(11):9559-9569. Epub 2019 Sep 5. PMID: 31495632
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lactobacillus delbrueckii Subsp
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents, Enzyme Inhibitors, Immunomodulatory
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Lipopolysaccharide-induced inflammation in mice increases the penetration of oseltamivir and its active metabolite into the brain. Oct 01, 2009

Pubmed Data : J Pharm Pharmacol. 2009 Oct;61(10):1397-400. PMID: 19814874
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.Mar 31, 2007

Pubmed Data : Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):349-54. PMID: 17624247
Article Published Date : Mar 31, 2007
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

These results suggest that oseltamivir in the brain induces hypothermia through activation of dopamine D2 receptors.Dec 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2017 Dec 15. Epub 2017 Dec 15. PMID: 29292053
Article Published Date : Dec 14, 2017
Study Type : Animal Study
Additional Links
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Anti-influenza activity of a Bacillus subtilis probiotic strain.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antimicrob Agents Chemother. 2017 07 ;61(7). Epub 2017 Jun 27. PMID: 28416546
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bacillus subtilis
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Cases of early deterioration leading to death have been reported to occur as a result of oseltamivir use.Dec 31, 2010

Pubmed Data : Int J Risk Saf Med. 2011 ;23(4):201-15. PMID: 22156085
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity
Pharmacological Actions : Antiviral Agents
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Neuropsychiatric disorders have been reported in connection with oseltamivir use. Oct 01, 2007

Pubmed Data : Prescrire Int. 2007 Oct;16(91):200. PMID: 17926837
Article Published Date : Oct 01, 2007
Study Type : Commentary
Additional Links
Diseases : Delirium: Drug-Induced, Drug-Induced Toxicity , Hallucinations, Parasuicide, Psychiatric Disorders, Suicidal Behavior
Problem Substances : Oseltamivir (trade name Tamiflu)
Adverse Pharmacological Actions : Neurotoxic
[+]

Oseltamivir may lead to sudden‐onset type reactions such as sudden death from respiratory arrest.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Neurol Scand. 2017 Feb ;135(2):148-160. Epub 2016 Jun 30. PMID: 27364959
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Additional Keywords : Adverse Events, Oseltamivir (trade name Tamiflu)
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

The Tamiflu saga continues: will our conduct change after the publication of the latest systematic review on benefits and harms of oseltamivir?May 19, 2014

Pubmed Data : Medwave. 2014 May 20 ;14(4):e5953. Epub 2014 May 20. PMID: 25383799
Article Published Date : May 19, 2014
Study Type : Commentary
Additional Links
Pharmacological Actions : Antiviral Agents
Problem Substances : Oseltamivir (trade name Tamiflu)

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