Osteoporosis Drugs

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The Following are Sub-Topics of Osteoporosis Drugs

View the Evidence:
62 Abstracts with Osteoporosis Drugs Research

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42.4% of those who receive intravenous zoledronic acid experience adverse events of mild to moderate severity.Sep 01, 2010

Pubmed Data : J Clin Endocrinol Metab. 2010 Sep;95(9):4380-7. Epub 2010 Jun 16. PMID: 20554708
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates, Zoledronic Acid
[+]

A number of commonly used drugs interfere with the absorption of levothyroxine. Dec 01, 2009

Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism
Problem Substances : Antacids: Aluminium-Containing, Bile Acid Sequestrants, Calcium Carbonate, Ferrous Sulphate, Phosphate Binders, Proton-Pump Inhibitors, Raloxifene, Sucralfate
[+]

Alendronate use is associated with an increased risk for atrial fibrillation in women. Apr 28, 2008

Pubmed Data : Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID: 18443257
Article Published Date : Apr 28, 2008
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
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Bisphophonate use is associated with gastrointestinal toxicity and osteonecrosis.Dec 01, 2008

Pubmed Data : Curr Opin Endocrinol Diabetes Obes. 2008 Dec;15(6):508-13. PMID: 18971679
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
[+]

Bisphosphonate exposure was significantly associated with risk of atrial fibrillation serious adverse events in a meta-analysis of four trial datasets. Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(3):219-28. PMID: 19338379
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.Jan 01, 2010

Pubmed Data : Blood Purif. 2010;29(3):293-9. Epub 2010 Jan 21. PMID: 20090316
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Kidney Diseases, Kidney Failure: Chronic, Osteoporosis
Additional Keywords : Diseases that are Linked
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use in early breast cancer does not appeasr to reduce the number of fractures. Jan 08, 2010

Pubmed Data : Gynecol Oncol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061004
Article Published Date : Jan 08, 2010
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Breast Cancer
Problem Substances : Bisphosphonates
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Bisphosphonate use is associated with an increased risk of deep venous thromboembolism and pulmonary embolism.Oct 27, 2009

Pubmed Data : Osteoporos Int. 2009 Oct 27. Epub 2009 Oct 27. PMID: 19859641
Article Published Date : Oct 27, 2009
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates
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Bisphosphonate use is associated with osteonecrosis of the jaw. Sep 01, 2009

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):e1-8. Epub 2009 Jul 1. PMID: 19570696
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
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Bisphosphonate use may cause osteopetrosis.Oct 01, 2008

Pubmed Data : J Bone Miner Res. 2008 Oct;23(10):1698-707. PMID: 18505375
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteopetrosis
Problem Substances : Bisphosphonates, Pamidronate
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Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws. Nov 01, 2005

Pubmed Data : J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75. PMID: 16243172
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis, Osteopetrosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate, Zoledronic Acid
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Bisphosphonates used for osteoporosis in patients with cystic fibrosis increases bone mineral density without increasing bone quality/strength, while causing bone pain and flu-like symptoms. Jan 01, 2009

Pubmed Data : Cochrane Database Syst Rev. 2009(4):CD002010. Epub 2009 Oct 7. PMID: 19821288
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cystic Fibrosis, Osteoporosis
Problem Substances : Bisphosphonates
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Long-term oral bisphosphonate therapy may result in excessive suppression of bone turnover in postmenopausal osteoporotic patients. Aug 01, 2008

Pubmed Data : Climacteric. 2008 Aug;11(4):287-95. PMID: 18645694
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Additional Keywords : Turned to Stone
Problem Substances : Bisphosphonates
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Long-term use of bisphosphonates is assocated with low-energy femoral fractures. Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(9):775-85. PMID: 19670917
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Bisphosphonates
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Pill-induced esophageal injury is a common occurence.Aug 01, 2005

Pubmed Data : Endoscopy. 2005 Aug;37(8):740-4. PMID: 16032493
Article Published Date : Aug 01, 2005
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Bisphosphonates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Potassium Chloride
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Raloxifene enhances spontaneous microaggregation of platelets, associated with pathological thrombus (clot) formation. Jan 01, 2010

Pubmed Data : Osteoporos Int. 2010 Jan;21(1):189-93. Epub 2009 Apr 7. PMID: 19350338
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Clotting, Thrombosis
Problem Substances : Raloxifene
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Raloxifene increases the risk of fatal stroke in postmenopausal women. Jul 13, 2006

Pubmed Data : N Engl J Med. 2006 Jul 13;355(2):125-37. PMID: 16837676
Article Published Date : Jul 13, 2006
Study Type : Human Study
Additional Links
Diseases : Stroke, Thromboembolism
Problem Substances : Raloxifene
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Raloxifene increases the risk of venous thromboembolism and fatal stroke. Jan 01, 2009

Pubmed Data : Stroke. 2009 Jan;40(1):147-55. Epub 2008 Oct 23. PMID: 18948611
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Smoking
Problem Substances : Raloxifene
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Raloxifene induces changes in breast density. Jul 01, 2009

Pubmed Data : Menopause. 2009 Jul-Aug;16(4):785-91. PMID: 19322115
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Breast Diseases
Problem Substances : Raloxifene
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Raloxifene is associated with 75% increased risk of fatal stroke in women who score higher on the Framingham Stroke Risk Score. Aug 01, 2009

Pubmed Data : Am J Med. 2009 Aug;122(8):754-61. Epub 2009 Jun 18. PMID: 19540454
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Stroke
Problem Substances : Raloxifene
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Raloxifene is associated with a wide range of adverse side effects, including death from uknown cause. May 01, 2005

Pubmed Data : Osteoporos Int. 2005 May;16(5):490-500. Epub 2004 Aug 7. PMID: 15309382
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Diseases : Mortality: All-Cause
Problem Substances : Raloxifene
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Raloxifene is associated with double the risk of coronary artery disease. Jan 01, 2009

Pubmed Data : Climacteric. 2009;12 Suppl 1:108-11. PMID: 19811253
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease
Additional Keywords : Drug: Tamoxifen
Problem Substances : Raloxifene
Adverse Pharmacological Actions : Cardiotoxic
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Raloxifene therapy increases risk of deep venous thrombosis and pulmonary embolism. Feb 01, 2008

Pubmed Data : Thromb Haemost. 2008 Feb;99(2):338-42. PMID: 18278183
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Deep Vein Thrombosis, Pulmonary Embolism, Venous Thrombosis
Problem Substances : Raloxifene
Adverse Pharmacological Actions : Cardiotoxic
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Several cases of osteosarcoma induced by Forteo (teriparatide) have been identified. Jul 14, 2009

Pubmed Data : Osteoporos Int. 2009 Jul 14. Epub 2009 Jul 14. PMID: 19597911
Article Published Date : Jul 14, 2009
Study Type : Human Study
Additional Links
Diseases : Osteosarcoma
Problem Substances : Forteo
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Subtrochanteric stress fractures in patients on oral bisphosphonate therapy is an emerging problem. Oct 01, 2011

Pubmed Data : Acta Orthop Belg. 2011 Oct ;77(5):632-7. PMID: 22187839
Article Published Date : Oct 01, 2011
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Subtrochanteric stress fractures
Problem Substances : Bisphosphonates
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Tamoxifen and raloxifene adversely affect cognitive function in older women.Mar 01, 2010

Pubmed Data : J Womens Health (Larchmt). 2010 Mar ;19(3):371-9. PMID: 20136553
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Raloxifene, Tamoxifen
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The pathogenesis of bisphosphonate-related osteonecrosis of the jaw may be due to local tissue acidosis in the jaw.May 01, 2010

Pubmed Data : J Oral Maxillofac Surg. 2010 May;68(5):1158-61. PMID: 20138420
Article Published Date : May 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acidosis, Osteonecrosis
Additional Keywords : Diseases that are Linked
Problem Substances : Bisphosphonates
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The prolonged use of alendronate has been reported to be the cause of non-traumatic femoral shaft fracture. Dec 01, 2007

Pubmed Data : Hong Kong Med J. 2007 Dec;13(6):485-9. PMID: 18057440
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
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Treatment with proton pump inhibitors increases the rate of subsequent treatment with anti-osteoporotic drugs.Jul 01, 2010

Pubmed Data : Pharmacoepidemiol Drug Saf. 2010 Jul;19(7):763-9. PMID: 20582909
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Osteoporosis
Additional Keywords : Downward Spiral of Drug Treatment
Problem Substances : Bisphosphonates
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Use of intravenous bisphosphanates can lead to bisphosphonate-induced necrosis of Jaw (BINJ) which may mimic malignancy or metastasis. Jan 11, 2010

Pubmed Data : Eur J Surg Oncol. 2010 Jan 11. Epub 2010 Jan 11. PMID: 20071132
Article Published Date : Jan 11, 2010
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
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Zoledronic acid may cause renal toxicity in 37.7% of patients with multiple myeloma. Jan 01, 2010

Pubmed Data : J Cancer Res Ther. 2010 Jan-Mar;6(1):31-5. PMID: 20479544
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Kidney Damage, Multiple Myeloma
Problem Substances : Zoledronic Acid
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Zolendronic acid has been associated with hand ostearthritis and arthralgia. Nov 21, 2009

Pubmed Data : Osteoporos Int. 2009 Nov 21. Epub 2009 Nov 21. PMID: 19936866
Article Published Date : Nov 21, 2009
Study Type : Human Study
Additional Links
Problem Substances : Zoledronic Acid
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Zolendronic acid results in renal impairment in 23,8% of the prostate cancer patients it is administered to.Mar 15, 2007

Pubmed Data : Cancer. 2007 Mar 15;109(6):1090-6. PMID: 17311345
Article Published Date : Mar 15, 2007
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced, Prostate Cancer
Problem Substances : Bisphosphonates, Zoledronic Acid
Adverse Pharmacological Actions : Nephrotoxic
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A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.Jan 01, 2009

Pubmed Data : Nippon Jinzo Gakkai Shi. 2009;51(5):557-62. PMID: 19715164
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced
Additional Keywords : Drug: Doxorubicin
Problem Substances : Bisphosphonates, Dexamethasone, Zoledronic Acid
Adverse Pharmacological Actions : Nephrotoxic
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Jaw avascular osteonecrosis after treatment of multiple myeloma with zoledronate has been reported.Jan 01, 2008

Pubmed Data : J Plast Reconstr Aesthet Surg. 2008;61(1):99-106. Epub 2006 Sep 12. PMID: 18068658
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates, Zoledronic Acid
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Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid has been reported.Oct 01, 2010

Pubmed Data : Hormones (Athens). 2010 Oct;9(4):338-42. PMID: 21112866
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Hypocalcemia
Problem Substances : Zoledronic Acid
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Raloxifene may be associated with accelerated platelet aggregation and subclinical thrombus (clot) formation. Jan 01, 2008

Pubmed Data : Intern Med. 2008;47(17):1523-8. Epub 2008 Sep 1. PMID: 18758128
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Thrombosis
Problem Substances : Raloxifene
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Bisphosphonates do not improve bone material characteristics such as tissue strength, elastic modulus, and cortical toughness in an animal model of osteoporosis. Nov 26, 2009

Pubmed Data : Bone. 2009 Nov 26. PMID: 19931661
Article Published Date : Nov 26, 2009
Study Type : Animal Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Bisphosphonates
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Forteo (recombinant human PTH) is associated with abnormal bone architecture and unwoard biomechanical properties in rats. Sep 01, 2002

Pubmed Data : Endocrinology. 2002 Sep;143(9):3230-42. PMID: 12193534
Article Published Date : Sep 01, 2002
Study Type : Animal Study
Additional Links
Problem Substances : Forteo
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Forteo (teriparatide) is associated with bone cancer in rats. Jul 01, 2004

Pubmed Data : Toxicol Pathol. 2004 Jul-Aug;32(4):426-38. PMID: 15204966
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Osteosarcoma
Problem Substances : Forteo
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Forteo is associated with bone cancer in rats. May 01, 2002

Pubmed Data : Toxicol Pathol. 2002 May-Jun;30(3):312-21. PMID: 12051548
Article Published Date : May 01, 2002
Study Type : Animal Study
Additional Links
Diseases : Osteosarcoma
Problem Substances : Forteo
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Prolonged use of bisphophonates may lead to excess mineralization, resulting in microcracks that interfere with bone quality/strength. Jan 01, 2007

Pubmed Data : Joint Bone Spine. 2007 Jan;74(1):39-47. Epub 2006 Nov 28. PMID: 17196423
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Risedronate
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The combination of CS plus metronomic ZOL demonstrated significant antitumor, anti-metastatic and anti-osteolytic effects against breast cancerMay 19, 2015

Pubmed Data : Oncol Rep. 2015 May 20. Epub 2015 May 20. PMID: 25998578
Article Published Date : May 19, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Zoledronic Acid
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Zolendronic acid causes oxidative stress in the rabbit liver.Nov 01, 2010

Pubmed Data : Transplant Proc. 2010 Nov;42(9):3820-2. PMID: 21094863
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage
Problem Substances : Zoledronic Acid
Adverse Pharmacological Actions : Hepatotoxic, Oxidant
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"Bisphosphonate stimulation of osteoblasts and osteoblastic metastasis as a mechanism of hypocalcaemia."Dec 27, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Hypotheses. 2011 Dec 27. Epub 2011 Dec 27. PMID: 22206806
Article Published Date : Dec 27, 2011
Study Type : Commentary
Additional Links
Diseases : Cancer Metastasis, Prostate Cancer, Prostate Cancer: Bone Metastatic
Problem Substances : Bisphosphonates
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Bisphosphonates are associated with a wide range of adverse health effects.Apr 01, 2009

Pubmed Data : Hormones (Athens). 2009 Apr-Jun;8(2):96-110. PMID: 19570737
Article Published Date : Apr 01, 2009
Study Type : Review
Additional Links
Diseases : Osteopenia, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Ibandronate, Risedronate, Zoledronic Acid
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Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts - Article 2.Mar 01, 2008

Pubmed Data : Calcif Tissue Int. 2008 Mar;82(3):191-201. Epub 2008 Feb 8. PMID: 18259679
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate (trade name Aredia)
Adverse Pharmacological Actions : Cytotoxic
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Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts.Jul 01, 2008

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):5-13. Epub 2008 May 27. PMID: 18504149
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Zoledronic Acid
Adverse Pharmacological Actions : Cytotoxic
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Bisphosphonates inhibit oral mucosal cell wound healing.May 01, 2008

Pubmed Data : J Oral Maxillofac Surg. 2008 May;66(5):839-47. PMID: 18423269
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Periodontal Wound Healing
Problem Substances : Bisphosphonates, Pamidronate
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Bisphosphonates may induce conjunctival irritation.Jan 01, 2007

Pubmed Data : Bull Soc Belge Ophtalmol. 2007(304):155-78. PMID: 17718241
Article Published Date : Jan 01, 2007
Study Type : Commentary
Additional Links
Diseases : Conjunctival Diseases, Conjunctivitis, Dry Eye Syndromes
Problem Substances : Bisphosphonates
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Bisphosphonates may induce gastrointestinal damage through the inhibition of the mevalonate pathway.Oct 01, 2001

Pubmed Data : Bone. 2001 Oct;29(4):336-43. PMID: 11595616
Article Published Date : Oct 01, 2001
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastrointestinal Diseases
Additional Keywords : Mevalonate Pathway Inhibition
Problem Substances : Bisphosphonates
Adverse Pharmacological Actions : Apoptotic
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Bisphosphonates may interfere with mevalonate pathway enzymes. Jan 01, 2000

Pubmed Data : Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. PMID: 10620343
Article Published Date : Jan 01, 2000
Study Type : In Vitro Study
Additional Links
Diseases : Mevalonate Pathway Enzyme Disorders
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate, Risedronate
Adverse Pharmacological Actions : Mevalonate Pathway Enzyme Inhibitors
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Bisphosphonates may result in skeletal harm when combined with anti-remodeling therapy. Aug 01, 2008

Pubmed Data : J Clin Endocrinol Metab. 2008 Aug;93(8):2948-52. Epub 2008 Jun 3. PMID: 18522980
Article Published Date : Aug 01, 2008
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates
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Etidronate increases bone density without reducing non-vertebral fractures.Jan 01, 2006

Pubmed Data : Cochrane Database Syst Rev. 2006(1):CD003376. Epub 2007 Jul 18. PMID: 17636719
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Bone Fractures, Osteoporosis
Problem Substances : Bisphosphonates, Etidronate
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Intravenous bisphosphonate use may cause culmulative toxicity, including some level of renal dysfunction.Jan 01, 2006

Pubmed Data : Support Cancer Ther. 2006 Jan 1;3(2):77-83. PMID: 18632443
Article Published Date : Jan 01, 2006
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates, Reclast
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Long-term alendronate is associated with spontaneous femoral shaft fracture. Sep 01, 2009

Pubmed Data : Age Ageing. 2009 Sep;38(5):625-6. Epub 2009 Jun 25. PMID: 19556326
Article Published Date : Sep 01, 2009
Study Type : Commentary
Additional Links
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
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Long-term bisphosphonate therapy may result in atypical insufficiency facture of the tibia. Feb 02, 2010

Pubmed Data : J Clin Rheumatol. 2010 Feb 2. Epub 2010 Feb 2. PMID: 20130483
Article Published Date : Feb 02, 2010
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates
[+]

Potential chemotherapeutic effects of diosgenin on PE/CA-PJ15 oral squamous cancer cell line.Sep 30, 2017

Pubmed Data : Arch Oral Biol. 2017 Oct ;82:141-146. Epub 2017 Jun 19. PMID: 28641180
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Diosgenin, EGCG (Epigallocatechin gallate)
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive
Problem Substances : Zoledronic Acid
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The mechanism behind bisphosphonate's supposedly therapeutic activity in bone may also underlie the mechanism of nephrotoxicity.Jun 01, 2008

Pubmed Data : Toxicol In Vitro. 2008 Jun;22(4):899-909. Epub 2008 Jan 26. PMID: 18325729
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Kidney Damage, Kidney Damage: Drug-Induced
Problem Substances : Bisphosphonates, Ibandronate, Pamidronate, Zoledronic Acid
[+]

There is a signal that oral bisphosphonates may increase the risk of esophageal cancer.Feb 29, 2012

Pubmed Data : Ann Pharmacother. 2012 Mar ;46(3):419-23. Epub 2012 Feb 14. PMID: 22333262
Article Published Date : Feb 29, 2012
Study Type : Review
Additional Links
Diseases : Esophageal Cancer
Problem Substances : Bisphosphonates
[+]

Vitamin D status should be monitored in all cancer patients and treated by adequate vitamin D3 supplementation. Nov 30, 2015

Pubmed Data : Med Monatsschr Pharm. 2015 Dec ;38(12):512-6. PMID: 26837159
Article Published Date : Nov 30, 2015
Study Type : Commentary
Additional Links
Substances : Vitamin D
Diseases : Breast Cancer, Cachexia: Cancer, Cancers: All, Colon Cancer, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Aromatase Inhibitor Drugs, Bisphosphonates
[+]

Zolendronate is cytotoxic to human periodontal fibroblasts, which confirms its link to osteonecrosis. Jan 01, 2010

Pubmed Data : J Dent Res. 2010 Jan;89(1):40-5. PMID: 19948943
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Zoledronic Acid

Osteoporosis Drugs Related Articles

Industry-Sponsored Doctors: New Study Shows Depth of Commercial Influence
Written by Jefferey Jaxen
Professional education events are heavily sponsored by drug companies promoting their products as the solution. This widely used coercive and misinformation technique where drug benefits are exaggerated and side effects minimized was exposed in a recent BMJ Open study.

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