Paracetamol

Name	AC	CK
Acetaminophen (Tylenol) Toxicity	191	477
Prenatal Chemical Exposures	20	100
Liver Damage: Drug-Induced	50	99
Chemically-Induced Liver Damage	39	71
Oxidative Stress	28	53
Attention Deficit Disorder with Hyperactivity	6	42
Fever	2	30
Autism Spectrum Disorders	5	23
Inflammation	7	21
Hypersensitivity	1	20
Kidney Damage: Drug-Induced	9	18
Neurodevelopmental Disorders	2	11
Attention Deficit Hyperactivity Disorder	1	10
Cardiac Mortality	1	10
Children: Drug-Induced Toxicity	1	10
Common Cold	1	10
Febrile Seizures	1	10
Migraine Disorders	1	10
Rhinovirus Infection	1	10
Kidney Damage: Chemically-Induced	3	6
Lipid Peroxidation	3	6
Infertility: Female	2	4
Liver Damage	3	4
Alcohol Toxicity	1	2
Asthma	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
DNA damage	1	2
Fetal Origin of Adult Disease	1	2
Gastric Ulcer	1	2
Glutathione Deficiency	1	2
Ibuprofen Toxicity	1	2
Infertility: Male	1	2
Liver Disease	1	2
Lung Inflammation	1	2
Male Reproductive Development Abnormalities	1	2
Mitochondrial Dysfunction	1	2
Sexual Behavior	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Anemia	1	1
Autism	1	1
Endometrial Cancer	1	1
Endometrial Neoplasms	1	1
Liver Cancer	1	1
Neurodegenerative Diseases	1	1

Name	AC	CK
Immunosuppressive	1	10
Nephrotoxic	1	10
Neurotoxic	3	6
Cytotoxic	1	5
Immunotoxic	1	2
Genotoxic	1	1
Mutagenic	1	1
Necrotic	1	1

[+]

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

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Pubmed Data : Int Arch Allergy Immunol. 2018 ;176(2):106-114. Epub 2018 Apr 3. PMID: 29614487

Article Published Date : Dec 31, 2017

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Hypersensitivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

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Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499

Article Published Date : Jan 01, 2002

Study Type : Meta Analysis

Additional Links

Diseases : Fever

Problem Substances : Paracetamol, Tylenol

[+]

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Autism Open Access. 2016 Apr ;6(2). Epub 2016 Mar 28. PMID: 27695658

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Additional Keywords : Endocannabinoid System

Problem Substances : Acetaminophen, Paracetamol

[+]

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):69-76. PMID: 25464680

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Diseases : Migraine Disorders

Therapeutic Actions : Electroacupuncture

Additional Keywords : Therapeutic Action Superior to Drug Therapy

Problem Substances : Paracetamol

[+]

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

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Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Children: Drug-Induced Toxicity

Problem Substances : Diclofenac, Dipyrone, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

Adverse Pharmacological Actions : Nephrotoxic

[+]

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

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Pubmed Data : J Infect Dis. 1990 Dec ;162(6):1277-82. PMID: 2172402

Article Published Date : Nov 30, 1990

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Common Cold, Rhinovirus Infection

Additional Keywords : Increased Risk, Viral Shedding

Problem Substances : Acetaminophen, Aspirin , Ibuprofen, Paracetamol

Adverse Pharmacological Actions : Immunosuppressive

[+]

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

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Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Febrile Seizures, Fever

Problem Substances : Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol, Tylenol

[+]

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JAMA Pediatr. 2016 Oct 1 ;170(10):964-970. PMID: 27533796

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(9):e108210. Epub 2014 Sep 24. PMID: 25251831

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Diseases : Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Paracetamol, Tylenol

[+]

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

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Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):1998-2008. PMID: 27585674

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Sci. 2018 Jul 3 ;8(7). Epub 2018 Jul 3. PMID: 29970852

Article Published Date : Jul 02, 2018

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Hyperactivity Disorder, Prenatal Chemical Exposures

Additional Keywords : Increased Risk

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JAMA Pediatr. 2014 Apr ;168(4):313-20. PMID: 24566677

Article Published Date : Mar 31, 2014

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

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Pubmed Data : Epidemiology. 2016 Nov ;27(6):912-8. PMID: 27479646

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):2009-2017. PMID: 28031314

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation

Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity

Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2016 12 1 ;45(6):1987-1996. PMID: 27353198

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2013 Dec ;42(6):1702-13. Epub 2013 Oct 24. PMID: 24163279

Article Published Date : Nov 30, 2013

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Psychiatry. 2016 Mar ;77(3):e312-4. PMID: 27046315

Article Published Date : Feb 29, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

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Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646

Article Published Date : Jun 18, 2015

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Mesenchymal Stem Cells

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Cytotoxic

[+]

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

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Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

[+]

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178

Article Published Date : Jun 11, 2017

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

Article Published Date : Feb 29, 2020

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

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Pubmed Data : Drug Chem Toxicol. 2020 Feb 3:1-7. Epub 2020 Feb 3. PMID: 32013615

Article Published Date : Feb 02, 2020

Study Type : Animal Study

Additional Links

Substances : Quercetin, Resveratrol

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Folia Morphol (Warsz). 2019 Mar 5. Epub 2019 Mar 5. PMID: 30835338

Article Published Date : Mar 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Thymoquinone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Acacia catechu

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

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Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

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Pubmed Data : Pharmacol Biochem Behav. 2018 Dec ;175:146-151. Epub 2018 Oct 22. PMID: 30359628

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Conventional Medicine Erodes Empathy

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

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Pubmed Data : Toxicol Sci. 2015 Dec 31. Epub 2015 Dec 31. PMID: 26721299

Article Published Date : Dec 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Mitochondrial Dysfunction

Problem Substances : Acetaminophen, Paracetamol

[+]

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.Aug 31, 2019

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Pubmed Data : J Food Biochem. 2019 Sep ;43(9):e12963. Epub 2019 Jul 2. PMID: 31489655

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : White Clover

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.Sep 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Food Drug Anal. 2017 Oct ;25(4):862-871. Epub 2016 Nov 5. PMID: 28987363

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2019 Apr 3. Epub 2019 Apr 3. PMID: 30944208

Article Published Date : Apr 02, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injuryApr 30, 2018

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Pubmed Data : Int J Biol Macromol. 2018 May ;111:1133-1139. Epub 2018 Feb 19. PMID: 29415408

Article Published Date : Apr 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

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Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160

Article Published Date : Apr 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.Feb 10, 2020

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Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 11:e22472. Epub 2020 Feb 11. PMID: 32048452

Article Published Date : Feb 10, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:549057. Epub 2020 Nov 20. PMID: 33658919

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:514. Epub 2020 Apr 24. PMID: 32425778

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, SIRT1 Activator

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.Mar 01, 2017

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Pubmed Data : Eur J Drug Metab Pharmacokinet. 2017 Mar 2. Epub 2017 Mar 2. PMID: 28255865

Article Published Date : Mar 01, 2017

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):27-35. Epub 2016 Jan 27. PMID: 27069723

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Papaya

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.Nov 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice.Jun 06, 2016

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Pubmed Data : Arch Biochem Biophys. 2016 Jun 7. Epub 2016 Jun 7. PMID: 27288086

Article Published Date : Jun 06, 2016

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Astragaloside IV attenuates acetaminophen-induced liver injuries in mice.Aug 13, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942

Article Published Date : Aug 13, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Curr Pharm Biotechnol. 2013 ;14(11):975-84. PMID: 24372242

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation

Pharmacological Actions : Antioxidants

Additional Keywords : Gene Expression Regulation, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Basil extract may act as a natural antioxidant to treat acetaminophen -induced acute hepato-renal toxicity when used as a post-treatment.Oct 11, 2018

Click here to read the entire abstract

Pubmed Data : J Complement Integr Med. 2018 Oct 12. Epub 2018 Oct 12. PMID: 30312166

Article Published Date : Oct 11, 2018

Study Type : Animal Study

Additional Links

Substances : Basil

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.Jun 30, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466

Article Published Date : Feb 01, 2000

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Paracetamol

[+]

Beta-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.Mar 17, 2019

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2019 Mar 18:1-8. Epub 2019 Mar 18. PMID: 30880499

Article Published Date : Mar 17, 2019

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Res Int. 2020 11 ;137:109461. Epub 2020 Jun 18. PMID: 33233135

Article Published Date : Jan 10, 2020

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895

Article Published Date : Nov 25, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

Click here to read the entire abstract

Pubmed Data : Turk J Med Sci. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33773522

Article Published Date : Mar 27, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Bitter Apple

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Paracetamol

[+]

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Article Published Date : Apr 20, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides, Panax Ginseng

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy

Problem Substances : Acetaminophen, Paracetamol

[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.Feb 23, 2016

Click here to read the entire abstract

Pubmed Data : Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26914515

Article Published Date : Feb 23, 2016

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Cytoprotective

Additional Keywords : Dose Response

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID: 28682524

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Apoptotic, Antioxidants, Chrysin, Hepatoprotective, Lipid Peroxidation

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Click here to read the entire abstract

Pubmed Data : Chem Res Toxicol. 2019 Nov 18 ;32(11):2329-2337. Epub 2019 Nov 1. PMID: 31625388

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935

Article Published Date : Jun 24, 2018

Study Type : Animal Study

Additional Links

Substances : Coconut Water

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Inflammation

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats.Jan 26, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Jan 27 ;6:19789. Epub 2016 Jan 27. PMID: 26813099

Article Published Date : Jan 26, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Infertility: Female, Prenatal Chemical Exposures, Transgenerational Epigenetic Modification

Problem Substances : Acetaminophen, Analgesic: Non-opioid, Indomethacin, Paracetamol

[+]

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID: 30772810

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Prophylactic Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

Click here to read the entire abstract

Pubmed Data : J Biochem. 2020 Sep 24. Epub 2020 Sep 24. PMID: 32970799

Article Published Date : Sep 23, 2020

Study Type : Animal Study

Additional Links

Substances : Dandelion , NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Curcumin prevents paracetamol-induced liver mitochondrial alterations.Jan 14, 2016

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315

Article Published Date : Jan 14, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Click here to read the entire abstract

Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Dandelion , Polyphenols

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2015 Sep ;40(2):369-74. Epub 2015 Jul 4. PMID: 26233562

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Toxicol Res (Camb). 2019 Jan 1 ;8(1):67-76. Epub 2018 Oct 25. PMID: 30713662

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Diallyl sulfide

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum.Apr 13, 2017

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096

Article Published Date : Apr 13, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol.Mar 31, 2019

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2019 Apr 1 ;302:123-134. Epub 2019 Feb 19. PMID: 30794797

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Milk Thistle

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion.Jun 30, 1993

Click here to read the entire abstract

Pubmed Data : Xenobiotica. 1993 Jul ;23(7):809-19. PMID: 8237062

Article Published Date : Jun 30, 1993

Study Type : Animal Study

Additional Links

Substances : D-Limonene

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Glutathione Deficiency

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Eriodictyol may be used to treat acetaminophen-induced hepatotoxicity.Jan 04, 2017

Click here to read the entire abstract

Pubmed Data : Mol Pharm. 2017 09 5 ;14(9):2937-2951. Epub 2017 Jul 17. PMID: 28654297

Article Published Date : Jan 04, 2017

Study Type : Animal Study

Additional Links

Substances : Eriodictyol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats.Jul 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : An Acad Bras Cienc. 2018 Aug ;90(2 suppl 1):2347-2358. Epub 2018 Jun 25. PMID: 29947676

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Chamomile, Cumin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats.Apr 23, 2019

Click here to read the entire abstract

Pubmed Data : Arch Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020376

Article Published Date : Apr 23, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2017 Jan-Mar;13(49):108-113. PMID: 28216892

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Juniper

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Fermented ginseng was shown to possess hepatoprotective activity against paracetamol (APAP)-induced liver injury.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2015 Apr ;67(4):565-72. Epub 2014 Dec 10. PMID: 25495794

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Panax Ginseng

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Fisetin prevents acetaminophen-induced liver injury by promoting autophagy.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:162. Epub 2020 Feb 28. PMID: 32184730

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(2):e0170900. Epub 2017 Feb 24. PMID: 28234915

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Nov ;18(11):1187-97. Epub 2015 Jun 4. PMID: 26501381

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.Oct 19, 2019

Click here to read the entire abstract

Pubmed Data : Neurotoxicol Teratol. 2019 Oct 20 ;77:106838. Epub 2019 Oct 20. PMID: 31644948

Article Published Date : Oct 19, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Ginsenoside Rb1 exerts protective effects against acetaminophen-induced hepatotoxicity.Dec 01, 2019

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2019 Dec 2:1-17. Epub 2019 Dec 2. PMID: 31786947

Article Published Date : Dec 01, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis.Jan 03, 2019

Click here to read the entire abstract

Pubmed Data : J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002

Article Published Date : Jan 03, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 protects against acetaminophen-induced liver injury.Jul 16, 2018

Click here to read the entire abstract

Pubmed Data : Regul Toxicol Pharmacol. 2018 Jul 17 ;98:58-68. Epub 2018 Jul 17. PMID: 30030101

Article Published Date : Jul 16, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Mar 05, 2021

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2021 Mar 6 ;73(3):322-331. PMID: 33793882

Article Published Date : Mar 05, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Apr 01, 2018

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2018 Apr 2 ;59:21-30. Epub 2018 Apr 2. PMID: 29621733

Article Published Date : Apr 01, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg5 exerts a liver protection effect against acetaminophen-induced acute hepatotoxicity.Oct 24, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396

Article Published Date : Oct 24, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ginseng Res. 2019 Jan ;43(1):10-19. Epub 2017 Jul 25. PMID: 30662289

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury.Aug 15, 2021

Click here to read the entire abstract

Pubmed Data : Food Funct. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34397062

Article Published Date : Aug 15, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.May 09, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935

Article Published Date : May 09, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Glabridin attenuates paracetamol-induced liver injury.Jul 06, 2021

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Pubmed Data : Drug Chem Toxicol. 2021 Jul 7:1-9. Epub 2021 Jul 7. PMID: 34233566

Article Published Date : Jul 06, 2021

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity.Jan 29, 2017

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Pubmed Data : Exp Toxicol Pathol. 2017 Jan 30. Epub 2017 Jan 30. PMID: 28153389

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Gold (nanoparticles)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Goldenseal has hepatoprotective effects that ameliorate acetaminophen induced acute liver failure in rats.Sep 30, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2011 Oct ;3(4):250-5. PMID: 22224048

Article Published Date : Sep 30, 2011

Study Type : Animal Study

Additional Links

Substances : Goldenseal

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice.Jun 30, 2018

Click here to read the entire abstract

Pubmed Data : J Hepatol. 2018 Jul ;69(1):51-59. Epub 2018 Mar 8. PMID: 29524531

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Additional Keywords : Microbiota

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Access Maced J Med Sci. 2019 Feb 28 ;7(4):536-542. Epub 2019 Feb 27. PMID: 30894908

Article Published Date : Feb 27, 2019

Study Type : Animal Study

Additional Links

Substances : Passion Flower

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2011 Dec ;49(12):3367-73. Epub 2011 Sep 29. PMID: 21983487

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Andrographis

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity of yellow chinese chive against acetaminophen-induced acute liver injury.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2020 ;66(4):357-363. PMID: 32863309

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Chives

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective and antioxidant potential of Pycnogenol in acetaminophen-induced hepatotoxicity in rats.Dec 15, 2018

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2018 Dec 16. Epub 2018 Dec 16. PMID: 30556209

Article Published Date : Dec 15, 2018

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of allicin against acetaminophen-induced liver injury.Feb 09, 2020

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 10:e22470. Epub 2020 Feb 10. PMID: 32040233

Article Published Date : Feb 09, 2020

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

Click here to read the entire abstract

Pubmed Data : J Immunoassay Immunochem. 2019 Nov 18:1-13. Epub 2019 Nov 18. PMID: 31739724

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury.Mar 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Res. 2021 Apr ;37(2):261-275. Epub 2020 Sep 7. PMID: 33868982

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Gotu Kola

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury.Nov 19, 2019

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31758991

Article Published Date : Nov 19, 2019

Study Type : Animal Study

Additional Links

Substances : Phellinus Linteus

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

Article Published Date : Jul 14, 2018

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects of zerumbone against paracetamol-induced acute hepatotoxicity.Feb 28, 2018

Click here to read the entire abstract

Pubmed Data : Malays J Med Sci. 2018 Mar ;25(2):64-71. Epub 2018 Apr 27. PMID: 30918456

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Zerumbone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine), Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Honokiol alleviates acetaminophen-induced hepatotoxicity.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Life Sci. 2019 Aug 1 ;230:97-103. Epub 2019 May 24. PMID: 31129139

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Honokiol

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.Apr 13, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4195-209. PMID: 25892869

Article Published Date : Apr 13, 2015

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Sep 30, 2013

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2013 Oct ;32(10):1107-16. Epub 2013 Aug 7. PMID: 23925941

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

In vivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris LMar 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ayurveda Integr Med. 2020 Mar 31. Epub 2020 Mar 31. PMID: 32241633

Article Published Date : Mar 30, 2020

Study Type : Animal Study

Additional Links

Substances : Prunella vulgaris

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Inhibitory activity of black mulberry extract against testicular, liver and kidney toxicity induced by paracetamol.Jan 24, 2020

Click here to read the entire abstract

Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015

Article Published Date : Jan 24, 2020

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : FASEB J. 2019 Jan ;33(1):339-357. Epub 2018 Jul 6. PMID: 29979629

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Male Reproductive Development Abnormalities

Additional Keywords : Transgenerational Epigenetic Modification

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Intrauterine exposure to paracetamol at levels commonly observed in pregnant women may block primordial germ cell proliferation.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2016 Mar ;150(1):178-89. Epub 2016 Jan 5. PMID: 26732887

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Isoquercitrin could be a potential hepatoprotective agent.Apr 30, 2016

Click here to read the entire abstract

Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:147. Epub 2018 Mar 23. PMID: 29628888

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599

Article Published Date : Jan 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carotenoids, Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Antioxidants, CAROTENOIDS, Hepatoprotective, Liver Damage: Drug-Induced, lycopene, Matrix metalloproteinase-2 (MMP-2) inhibitor, oxidative stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Inflammatory Agents, Hepatoprotective, Liver Damage: Drug-Induced, lycopene

Problem Substances : Acetaminophen, Paracetamol

[+]

Mangiferin ameliorates acetaminophen-induced hepatotoxicity.Jun 14, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128

Article Published Date : Jun 14, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Melilotus officinali has strong hepatoprotective activity against paracetamol and carbon tetrachloride induced hepatotoxicity.Apr 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):903-909. PMID: 29513960

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Yellow Sweet Clover (Melilotus officinalis)

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Methylsulfonylmethane pre-treatment could alleviate hepatic injury induced by acetaminophen intoxication.Jul 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2013 Aug ;16(8):896-900. PMID: 24106592

Article Published Date : Jul 31, 2013

Study Type : Animal Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Moringa oleifera leaf extracts shielded kidneys from acetaminophen toxicity through enhancement of the endogenous antioxidant system.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534

Article Published Date : Feb 24, 2019

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Hepatol. 2020 Sep 27 ;12(9):596-618. PMID: 33033567

Article Published Date : Sep 26, 2020

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin, NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Naringin treatment reduced histological alteration induced by APAP in the liver and kidney.Apr 05, 2016

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2016 Apr 6:1-14. Epub 2016 Apr 6. PMID: 27050864

Article Published Date : Apr 05, 2016

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective, MicroRNA modulator, Renoprotective

Problem Substances : Paracetamol

[+]

Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4916519. Epub 2019 May 13. PMID: 31214269

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Tongkat Ali

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nephroprotective property of Trifolium repens leaf extract against paracetamol-induced kidney damage.Nov 30, 2020

Click here to read the entire abstract

Pubmed Data : 3 Biotech. 2020 Dec ;10(12):541. Epub 2020 Nov 19. PMID: 33240744

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : White Clover

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nicotinamide improves NAD + levels to protect against acetaminophen-induced acute liver injury in mice.May 04, 2021

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2021 May 5:9603271211014573. Epub 2021 May 5. PMID: 33949241

Article Published Date : May 04, 2021

Study Type : Animal Study

Additional Links

Substances : Nicotinamide

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Paracetamol

[+]

Nigella sativa has a significant nephroprotective activity on paracetamol-induced nephrotoxicity.Mar 08, 2016

Click here to read the entire abstract

Pubmed Data : Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID: 26956915

Article Published Date : Mar 08, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137

Article Published Date : Nov 26, 2019

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Non-toxic dose of acetaminophen has the potential to increase carbon tetrachloride-induced liver damage and oxidative stress.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2017 ;40(9):1590-1594. PMID: 28867745

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent acute liver failure.Oct 03, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Oct 4 ;8(10). Epub 2016 Oct 4. PMID: 27782042

Article Published Date : Oct 03, 2016

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Ozone showed beneficial effects on acetaminophen hepatotoxicity at a statistically significant level.Nov 12, 2017

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2017 Nov 13 ;70(2):340-345. Epub 2017 Nov 13. PMID: 29477043

Article Published Date : Nov 12, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Therapeutic Actions : Ozone Therapy

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

P. leschenaultii leaves extract protects the liver from paracetamol induced hepatic damage.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:1114-1121. Epub 2017 Feb 10. PMID: 28192885

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Passion Flower

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Paracetamol

[+]

P. major extracts attenuate the inflammatory reaction following APAP-induced liver injury. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:347861. Epub 2015 Aug 2. PMID: 26300946

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Plantago major

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Sci. 2014 Mar ;138(1):139-47. Epub 2013 Dec 21. PMID: 24361869

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Polysaccharides from dandelion root have hepatoprotective effects.Aug 24, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Aug 25 ;22(9). Epub 2017 Aug 25. PMID: 28841174

Article Published Date : Aug 24, 2017

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Pomegranate juice might have a preventive effect in paracetamol-induced acute liver damage.May 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk Pediatri Ars. 2016 Jun ;51(2):72-8. Epub 2016 Jun 1. PMID: 27489463

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Potentiation of gastric toxicity of ibuprofen by paracetamol.Jun 30, 1991

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 1991 Jul ;43(7):520-1. PMID: 1682470

Article Published Date : Jun 30, 1991

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Gastric Ulcer, Ibuprofen Toxicity

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Pre-treatment with cinnamon provide potential therapeutic applications in acute liver and kidney injury induced by acetaminophen.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2285-2292. Epub 2018 Nov 28. PMID: 30551486

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal and postnatal paracetamol exposure results in modulation of cerebellar neurotransmission with changes concerning mainly 5-HIAA and MHPG levels.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Prenatal exposure to acetaminophen may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming.Jul 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Reproduction. 2017 Aug ;154(2):145-152. Epub 2017 May 30. PMID: 28559473

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Sexual Behavior

Problem Substances : Acetaminophen, Paracetamol

[+]

Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Life. 2015 ;8(Spec Iss 4):270-274. PMID: 28316743

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Zataria multiflora

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Propolis significantly prevented paracetamol induced renal, hepatic and hematological toxicity.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res Pract. 2018 Dec ;12(6):535-540. Epub 2018 Nov 23. PMID: 30515282

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect and mechanism of action of diallyl disulfide against acetaminophen-induced acute hepatotoxicity.Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):28-37. Epub 2017 Aug 25. PMID: 28847761

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2019 Jan ;26(1):240-249. Epub 2018 Nov 3. PMID: 30392171

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption.Aug 04, 2019

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2019 Aug 5:1-7. Epub 2019 Aug 5. PMID: 31305161

Article Published Date : Aug 04, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.Sep 04, 2019

Click here to read the entire abstract

Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711

Article Published Date : Sep 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.Apr 30, 1992

Click here to read the entire abstract

Pubmed Data : Zhongguo Yao Li Xue Bao. 1992 May ;13(3):209-12. PMID: 1442100

Article Published Date : Apr 30, 1992

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity.Oct 31, 2018

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2018 Nov ;121:131-139. Epub 2018 Aug 24. PMID: 30149109

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : P-Coumaric Acid

Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Protracted use of acetaminophen (1 week) may suppress fetal testosterone production, which could have adverse consequences.May 19, 2015

Click here to read the entire abstract

Pubmed Data : Sci Transl Med. 2015 May 20 ;7(288):288ra80. PMID: 25995226

Article Published Date : May 19, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Fetal Origin of Adult Disease

Problem Substances : Acetaminophen, Paracetamol

[+]

Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2019 Jan ;123:536-545. Epub 2018 Dec 10. PMID: 30543896

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Pterostilbene reduces acetaminophen-induced liver injury.Sep 19, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2018 Sep 20 ;49(5):1943-1958. Epub 2018 Sep 20. PMID: 30235447

Article Published Date : Sep 19, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Quercitrin attenuates acetaminophen induced liver damage by the activation of defensive genes and the inhibition of pro-inflammatory genes.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID: 27428996

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Toona sinensis

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator

Problem Substances : Acetaminophen, Paracetamol

[+]

Reduced sperm count was seen at a dose level reflecting human therapeutic exposure to paracetamol. Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Endocr Connect. 2018 Jan ;7(1):139-148. Epub 2017 Dec 4. PMID: 29203468

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Male

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Endocrine Disruptors, Paracetamol

[+]

Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury.Jun 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2019 Jul ;140(3):248-254. Epub 2019 Jul 24. PMID: 31400930

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Schisandra

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Seaweed could be a beneficial dietary supplement to attenuate nephrotoxicity and hepatotoxicity.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2019 Aug ;26(24):25301-25311. Epub 2019 Jun 29. PMID: 31256398

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Seaweed

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin, Kidney Damage: Chemically-Induced

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation.Feb 24, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Feb 25 ;112:108704. Epub 2019 Feb 25. PMID: 30818140

Article Published Date : Feb 24, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Sinomenine attenuates acetaminophen-induced acute liver injury. Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2020 ;14:2393-2403. Epub 2020 Jun 17. PMID: 32606606

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sinomenine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID: 25818464

Article Published Date : May 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.May 31, 2016

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2016 Jun 1 ;23(6):589-96. Epub 2016 Mar 22. PMID: 27161400

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

The administration of pelargonidin protects against acetaminophen-induced hepatotoxicity.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Biochimie. 2020 Jan ;168:10-16. Epub 2019 Oct 25. PMID: 31669604

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Anthocyanins

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The present study demonstrated that American ginseng berry pretreatment protected liver cells against acetaminophen-induced hepatotoxicity.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:128-138. Epub 2018 Oct 2. PMID: 30466610

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Ginseng (American)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

The present study demonstrates paeonol has a protective ability against acetaminophen-induced hepatotoxicity.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(5):e0154375. Epub 2016 May 4. PMID: 27144271

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

The receptacle and stem extracts of artichoke were found to exert higher protective activity on liver and kidney damage induced by paracetamol.Feb 29, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Mar 1 ;249:112458. Epub 2019 Dec 4. PMID: 31809787

Article Published Date : Feb 29, 2020

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Thearubigins protected against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice possibly through their antioxidant activity.Aug 02, 2015

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2015 Aug 3:1-9. Epub 2015 Aug 3. PMID: 26234406

Article Published Date : Aug 02, 2015

Study Type : Animal Study

Additional Links

Substances : Black Tea

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Dose Response

Problem Substances : Acetaminophen, Paracetamol

[+]

These findings provide a novel potential mechanism for hepatotoxicity caused by combined alcohol and acetaminophen exposure.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(8):e0160982. Epub 2016 Aug 11. PMID: 27513663

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Alcohol Toxicity , Chemically-Induced Liver Damage

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

These findings support that boswellic acid is a potent hepato-protective agent.May 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicine (Taipei). 2017 Jun ;7(2):13. Epub 2017 Jun 14. PMID: 28612711

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Frankincense

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

These results demonstrate a possible protective potential of silver nanoparticles on renal toxicity induced by acetaminophen.Jun 30, 2020

Click here to read the entire abstract

Pubmed Data : Toxicol Res (Camb). 2020 Jul ;9(4):406-412. Epub 2020 Jun 17. PMID: 32905110

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : Silver (nanoparticles)

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

These results indicate that fisetin prevented acetaminophen -induced hepatotoxicity.Apr 30, 2019

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2019 May ;58:152865. Epub 2019 Feb 19. PMID: 30831465

Article Published Date : Apr 30, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

These results offer support for vitamin C and its potential use as protective treatment in cases of chronic paracetamol overdose.Aug 02, 2017

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28771433

Article Published Date : Aug 02, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

These results show that infusion from B. orellana barks is hepatoprotective against acetaminophen-induced toxicity.Jun 30, 2020

Click here to read the entire abstract

Pubmed Data : Avicenna J Phytomed. 2020 Jul-Aug;10(4):428-439. PMID: 32850299

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : Achiote

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.Sep 13, 1993

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 1993 Sep 14 ;46(6):1081-5. PMID: 8216352

Article Published Date : Sep 13, 1993

Study Type : Animal Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

This data provide strong evidence that prenatal acetaminophen interferes with maternal immune and endocrine adaptation to pregnancy.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Am J Pathol. 2015 Oct ;185(10):2805-18. Epub 2015 Aug 5. PMID: 26254283

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Additional Keywords : acetaminophen, Acetaminophen (Tylenol) Toxicity, Asthma, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Immunotoxic

[+]

Thymoquinone attenuates acetaminophen overdose-induced acute liver injury.Apr 10, 2019

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2019 Apr 11:1-18. Epub 2019 Apr 11. PMID: 30974967

Article Published Date : Apr 10, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Tormentic acid may be a potential therapeutic candidate for the prevention of acetaminophen induced liver injury.May 17, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID: 28524081

Article Published Date : May 17, 2017

Study Type : Animal Study

Additional Links

Substances : Loquat

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Toxic acetaminophen exposure induces distal lung ER stress, proinflammatory signalling, and emphysematous changes in the adult murine lung.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:7595126. Epub 2019 Nov 28. PMID: 31885815

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Lung Inflammation

Problem Substances : Acetaminophen, Paracetamol

[+]

Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity.Jun 26, 2019

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2019 Jun 27. Epub 2019 Jun 27. PMID: 31255668

Article Published Date : Jun 26, 2019

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Zataria multiflora and carvacrol have a powerful hepatoprotective effects.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacopuncture. 2018 Dec ;21(4):249-257. Epub 2018 Dec 31. PMID: 30652051

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Carvacrol, Zataria multiflora

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle.Dec 13, 2018

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Pubmed Data : Arch Toxicol. 2018 Dec 14. Epub 2018 Dec 14. PMID: 30552463

Article Published Date : Dec 13, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen hepatotoxicity is dominated by necrosis or programmed necrosis and does not involve relevant apoptosis.Jun 17, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Jun 18 ;118:709-718. Epub 2018 Jun 18. PMID: 29920288

Article Published Date : Jun 17, 2018

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Necrotic

[+]

Acetaminophen reduces empathy for other's physical and social pain.Apr 30, 2017

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Pubmed Data : J Neurophysiol. 2017 May 1 ;117(5):1844-1846. Epub 2016 Oct 5. PMID: 27707814

Article Published Date : Apr 30, 2017

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Conventional Medicine Erodes Empathy

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Amino Acids. 2018 Oct ;50(10):1377-1390. Epub 2018 Jul 5. PMID: 29978260

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Tryptophan

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Aged citrus peel (Chenpi) prevents acetaminophen-induced Hepatotoxicity by epigenetically regulating Nrf2 pathway.Dec 31, 2018

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Pubmed Data : Am J Chin Med. 2019 ;47(8):1833-1851. Epub 2019 Dec 3. PMID: 31795743

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.Oct 14, 2017

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Pubmed Data : Phytomedicine. 2017 Oct 15 ;34:59-66. Epub 2017 Aug 7. PMID: 28899510

Article Published Date : Oct 14, 2017

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Curcumin is a potential therapy for diseases where the deleterious effects of oxidative stress are due to aberrant Ca2+ entry mediated by TRPM2 channels. Nov 09, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Redox Biol. 2015 Nov 10 ;7:1-7. Epub 2015 Nov 10. PMID: 26609559

Article Published Date : Nov 09, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Liver Damage, Liver Damage: Drug-Induced, Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Hepatoprotective, Transient Receptor Potential Melastatin 2 Inhibition

Problem Substances : Acetaminophen, Paracetamol

[+]

Diallyl sulfide exhibited cytoprotective effects against acetaminophen toxicity. Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(12):e0145965. Epub 2015 Dec 29. PMID: 26714183

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Diallyl sulfide

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Cancer, Oxidative Stress

Pharmacological Actions : Chemopreventive, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Endocannabinoid system dysregulation from acetaminophen use may lead to autism spectrum disorder.Mar 24, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Mar 25 ;26(7). Epub 2021 Mar 25. PMID: 33805951

Article Published Date : Mar 24, 2021

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity.Jan 30, 2018

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Pubmed Data : Mol Med Rep. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29393462

Article Published Date : Jan 30, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Genetic association of single nucleotide polymorphisms with acetaminophen-induced hepatotoxicity.Sep 30, 2018

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Pubmed Data : J Pharmacol Exp Ther. 2018 Oct ;367(1):95-100. Epub 2018 Aug 3. PMID: 30076262

Article Published Date : Sep 30, 2018

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Korean red ginseng extract prevents acetaminophen -induced hepatotoxicity.Jul 31, 2013

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Pubmed Data : Liver Int. 2013 Aug ;33(7):1071-84. Epub 2013 Jun 10. PMID: 23750847

Article Published Date : Jul 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Lactobacillus fermentum postbiotic-induced autophagy as potential approach for treatment of acetaminophen hepatotoxicity.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2017 ;8:594. Epub 2017 Apr 6. PMID: 28428777

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lactobacillus fermentum

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.Jun 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Redox Biol. 2018 Jul ;17:274-283. Epub 2018 Apr 22. PMID: 29753208

Article Published Date : Jun 30, 2018

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

N-acetylcysteine is recommended for all patients with acetaminophen-induced acute liver failure and it reduces mortality. Dec 31, 2017

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Pubmed Data : Clin Liver Dis. 2018 05 ;22(2):325-346. Epub 2018 Feb 9. PMID: 29605069

Article Published Date : Dec 31, 2017

Study Type : Review

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Non-steroidal anti-inflammatory drugs exhibit direct cytotoxicity against erthyrocytes (red blood cells) in vitro in an acidic media. Dec 01, 2002

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Pubmed Data : Pharmazie. 2002 Dec;57(12):848-51. PMID: 12561250

Article Published Date : Dec 01, 2002

Study Type : In Vitro Study

Additional Links

Diseases : Anemia

Problem Substances : Aspirin , Ibuprofen, Indomethacin, Meloxicam, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Shikonin may be a promising candidate against acetaminophen-induced liver injury.Dec 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Dec 29 ;24(1). Epub 2018 Dec 29. PMID: 30597971

Article Published Date : Dec 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Tamoxifen is genotoxic and carcinogenic to endometrial cells.May 01, 2004

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Pubmed Data : Drug Metab Rev. 2004 May;36(2):199-218. PMID: 15237851

Article Published Date : May 01, 2004

Study Type : In Vitro Study

Additional Links

Diseases : Endometrial Cancer, Endometrial Neoplasms

Additional Keywords : Drug: Tamoxifen

Problem Substances : Paracetamol

Adverse Pharmacological Actions : Genotoxic, Mutagenic

[+]

Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity.Aug 06, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Aug 7 ;130:110547. Epub 2020 Aug 7. PMID: 32777703

Article Published Date : Aug 06, 2020

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Tetrahydrocurcumin and octahydrocurcumin possess superior hepatic-protective effect against acetaminophen-induced liver injury.Dec 31, 2018

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Pubmed Data : Food Chem Toxicol. 2019 Jan ;123:349-362. Epub 2018 Nov 10. PMID: 30423402

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcuminoids, Tetrahydrocurcumin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Metabolites

Problem Substances : Acetaminophen, Paracetamol

[+]

The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.Mar 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2017 Apr ;45(2):407-438. Epub 2017 Mar 16. PMID: 28415925

Article Published Date : Mar 31, 2017

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

These nine studies suggest an increased risk of adverse neurodevelopmental outcomes following prenatal acetaminophen exposure.Apr 30, 2018

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Pubmed Data : Horm Behav. 2018 May ;101:125-147. Epub 2018 Feb 3. PMID: 29341895

Article Published Date : Apr 30, 2018

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorders, Neurodevelopmental Disorders, Prenatal Chemical Exposures

Additional Keywords : Increased Risk

Problem Substances : Acetaminophen, Paracetamol

[+]

Thymol and carvacrol protected against acetaminophen induced toxicity.Jan 21, 2016

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Pubmed Data : Hum Exp Toxicol. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801986

Article Published Date : Jan 21, 2016

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol, Thymol

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Dose Response

Problem Substances : Acetaminophen, Paracetamol

[+]

Total saponins from Rosa laevigata Michx fruit shows a significant protective effect against acetaminophen-induced liver damage.May 29, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 May 30 ;19(6):7189-206. Epub 2014 May 30. PMID: 24886943

Article Published Date : May 29, 2014

Study Type : In Vitro Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Use of acetaminophen during pregnancy and the risk of autism spectrum disorder in the offspring.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Psychiatry. 2016 Feb ;77(2):e152-4. PMID: 26930528

Article Published Date : Jan 31, 2016

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Use of paracetamol during pregnancy and child neurological development.Jul 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Dev Med Child Neurol. 2015 Aug ;57(8):718-24. Epub 2015 Apr 7. PMID: 25851072

Article Published Date : Jul 31, 2015

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

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View the Evidence: 212 Abstracts with Paracetamol Research

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Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.Aug 31, 2019

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.Sep 30, 2017

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injuryApr 30, 2018

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.Feb 10, 2020

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.Mar 01, 2017

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.Dec 31, 2015

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.Nov 30, 2015

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice.Jun 06, 2016

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

Astragaloside IV attenuates acetaminophen-induced liver injuries in mice.Aug 13, 2018

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.Dec 31, 2012

Basil extract may act as a natural antioxidant to treat acetaminophen -induced acute hepato-renal toxicity when used as a post-treatment.Oct 11, 2018

Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.Jun 30, 2018

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

Beta-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.Mar 17, 2019

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.Feb 23, 2016

Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.Oct 31, 2017

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats.Jan 26, 2016

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

Curcumin prevents paracetamol-induced liver mitochondrial alterations.Jan 14, 2016

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Aug 31, 2015

Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury.Dec 31, 2018

Paracetamol

View the Evidence:
212 Abstracts with Paracetamol Research