Perfluorooctanoic acid (PFOA)

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11 Diseases Researched for Perfluorooctanoic acid (PFOA)

Name	AC	CK
Perfluorinated Compound Toxicity	6	28
Chemically-Induced Liver Damage	3	14
Hyperlipidemia	1	10
Hyperuricemia	1	10
Prenatal Chemical Exposures	1	10
Oxidative Stress	2	3
Endometrial Cancer	1	2
Infertility	1	2
Bisphenol Toxicity	1	1
Breast Cancer: Chemically-Induced	1	1
Inflammation	1	1

3 Adverse Pharmacological Actions Researched for Perfluorooctanoic acid (PFOA)

Name	AC	CK
Hepatotoxic	1	10
Carcinogen	1	2
Inflammatory	1	1

Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Perfluorooctanoic acid (PFOA) Research

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Higher serum levels of PFOA were associated with a higher prevalence of hyperuricemia.Feb 01, 2010

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Pubmed Data : Environ Health Perspect. 2010 Feb;118(2):229-33. PMID: 20123605

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperuricemia

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2016 Aug ;124(8):1227-33. Epub 2016 Mar 15. PMID: 26978841

Article Published Date : Jul 31, 2016

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Perfluorinated Compound Toxicity

Problem Substances : Perfluorooctanoic acid (PFOA)

Adverse Pharmacological Actions : Hepatotoxic

[+]

Prenatal exposure to perfluoroalkyl substances led to a tendency toward increased birth weight in girls and reduced in boys.Jul 11, 2016

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Pubmed Data : Reprod Toxicol. 2016 Jul 12. Epub 2016 Jul 12. PMID: 27421581

Article Published Date : Jul 11, 2016

Study Type : Human Study

Additional Links

Diseases : Perfluorinated Compound Toxicity, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Endocrine Disrupting Chemicals (EDCs), Perfluorinated compounds, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)

[+]

There is an association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults.Nov 15, 2009

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Pubmed Data : Am J Epidemiol. 2009 Nov 15;170(10):1268-78. Epub 2009 Oct 21. PMID: 19846564

Article Published Date : Nov 15, 2009

Study Type : Human Study

Additional Links

Diseases : Hyperlipidemia

Problem Substances : Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)

[+]

Oxidative stress and PUFA alteration might help explain the sperm injury and male reproductive dysfunction induced by PFOA exposure.Aug 31, 2016

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Pubmed Data : Chemosphere. 2016 Sep ;158:143-53. Epub 2016 Jun 1. PMID: 27262104

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Infertility, Oxidative Stress, Perfluorinated Compound Toxicity

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

Perfluorooctanoic acid (PFOA), used in the production of non-stick surface compounds, may contribute to metabolic disorders by altering mitochondrial biogenesis.Oct 01, 2009

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Pubmed Data : Toxicology. 2009 Oct 1;264(1-2):10-5. Epub 2009 Jul 16. PMID: 19616056

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Problem Substances : Nonstick cookware, Perfluorooctanoic acid (PFOA)

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Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid.Jun 30, 2021

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Pubmed Data : Wei Sheng Yan Jiu. 2021 Jul ;50(4):609-614. PMID: 34311832

Article Published Date : Jun 30, 2021

Study Type : Animal Study

Additional Links

Substances : Rutin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

These results indicate that PFOA is a carcinogen that promotes endometrial cancer cell migration and invasion.Aug 28, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Aug 29. Epub 2016 Aug 29. PMID: 27589685

Article Published Date : Aug 28, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Endometrial Cancer

Additional Keywords : Increased Risk

Problem Substances : Perfluorooctanoic acid (PFOA)

Adverse Pharmacological Actions : Carcinogen

[+]

These results suggests the potential of PFOA to cause inflammation response in liver.Mar 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Apr 1 ;6:23963. Epub 2016 Apr 1. PMID: 27032815

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Perfluorinated Compound Toxicity

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

This study clearly demonstrates that soil contamination of PFOA can lead to adverse effects on soil health.Jun 30, 2016

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Pubmed Data : Environ Monit Assess. Jul 2016;188(7):424. Epub 2016 Jun 21. PMID: 27329475

Article Published Date : Jun 30, 2016

Study Type : Environmental

Additional Links

Diseases : Perfluorinated Compound Toxicity

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

This study showed that textiles could be a significant direct and indirect source of PFOS and PFOA exposure for both humans and the environment.Dec 31, 2015

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Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 ;51(6):472-7. Epub 2016 Feb 11. PMID: 26864911

Article Published Date : Dec 31, 2015

Study Type : Environmental

Additional Links

Diseases : Perfluorinated Compound Toxicity

Additional Keywords : Environmental Pollutant, Perfluorinated Compound Toxicity, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA), PFOA, PFOS, Risk Factors, Toxins

Problem Substances : Perfluorinated compounds, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)

[+]

A ternary mixture of common chemicals perturbs benign human breast epithelial cells more than the same chemicals do individually.Aug 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Sci. 2018 Sep 1 ;165(1):131-144. PMID: 29846718

Article Published Date : Aug 31, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Bisphenol Toxicity, Breast Cancer: Chemically-Induced

Additional Keywords : Synergistic Toxicity

Problem Substances : Bisphenol A , Parabens, Perfluorooctanoic acid (PFOA)

[+]

Blueberry anthocyanin alleviate perfluorooctanoic acid-induced toxicity.Jan 31, 2019

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Pubmed Data : Environ Pollut. 2019 Feb ;245:957-964. Epub 2018 Nov 28. PMID: 30682752

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Blueberry

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

Problem Substances : Perfluorooctanoic acid (PFOA)

[+]

The present data indicate that PFOA aggravated FcɛRI-mediated mast cell degranulation and allergic symptoms.Sep 28, 2016

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Pubmed Data : J Appl Toxicol. 2016 Sep 29. Epub 2016 Sep 29. PMID: 27682001

Article Published Date : Sep 28, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Inflammation

Problem Substances : Perfluorooctanoic acid (PFOA)

Adverse Pharmacological Actions : Inflammatory

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Perfluorooctanoic acid (PFOA) is a Sub of the following Topic

View the Evidence: 14 Abstracts with Perfluorooctanoic acid (PFOA) Research

Limited to Members Only

Currently Available Sorting Options

Higher serum levels of PFOA were associated with a higher prevalence of hyperuricemia.Feb 01, 2010

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Prenatal exposure to perfluoroalkyl substances led to a tendency toward increased birth weight in girls and reduced in boys.Jul 11, 2016

There is an association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults.Nov 15, 2009

Oxidative stress and PUFA alteration might help explain the sperm injury and male reproductive dysfunction induced by PFOA exposure.Aug 31, 2016

Perfluorooctanoic acid (PFOA), used in the production of non-stick surface compounds, may contribute to metabolic disorders by altering mitochondrial biogenesis.Oct 01, 2009

Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid.Jun 30, 2021

These results indicate that PFOA is a carcinogen that promotes endometrial cancer cell migration and invasion.Aug 28, 2016

These results suggests the potential of PFOA to cause inflammation response in liver.Mar 31, 2016

This study clearly demonstrates that soil contamination of PFOA can lead to adverse effects on soil health.Jun 30, 2016

This study showed that textiles could be a significant direct and indirect source of PFOS and PFOA exposure for both humans and the environment.Dec 31, 2015

A ternary mixture of common chemicals perturbs benign human breast epithelial cells more than the same chemicals do individually.Aug 31, 2018

Blueberry anthocyanin alleviate perfluorooctanoic acid-induced toxicity.Jan 31, 2019

The present data indicate that PFOA aggravated FcɛRI-mediated mast cell degranulation and allergic symptoms.Sep 28, 2016

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Perfluorooctanoic acid (PFOA)

View the Evidence:
14 Abstracts with Perfluorooctanoic acid (PFOA) Research