Perfluorooctanoic acid (PFOA)

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13 Diseases Researched for Perfluorooctanoic acid (PFOA)
NameACCKFocus
Perfluorinated Compound Toxicity830Locked
Chemically-Induced Liver Damage416Locked
Hyperlipidemia110Locked
Hyperuricemia110Locked
Prenatal Chemical Exposures110Locked
Oxidative Stress46Locked
Endometrial Cancer12Locked
Fatty Liver12Locked
Infertility12Locked
Bisphenol Toxicity11Locked
Breast Cancer: Chemically-Induced11Locked
Inflammation11Locked
Microplastic Toxicity11Locked
5 Adverse Pharmacological Actions Researched for Perfluorooctanoic acid (PFOA)
NameACCKFocus
Hepatotoxic110Locked
Carcinogen12Locked
Gastrotoxic11Locked
Immunotoxic11Locked
Inflammatory11Locked
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Perfluorooctanoic acid (PFOA) is a Sub of the following Topic

View the Evidence:
19 Abstracts with Perfluorooctanoic acid (PFOA) Research

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Higher serum levels of PFOA were associated with a higher prevalence of hyperuricemia.Feb 01, 2010

Pubmed Data : Environ Health Perspect. 2010 Feb;118(2):229-33. PMID: 20123605
Article Published Date : Feb 01, 2010
Study Type : Human Study
Additional Links
Diseases : Hyperuricemia
Problem Substances : Perfluorooctanoic acid (PFOA)
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Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2016 Aug ;124(8):1227-33. Epub 2016 Mar 15. PMID: 26978841
Article Published Date : Jul 31, 2016
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctanoic acid (PFOA)
Adverse Pharmacological Actions : Hepatotoxic
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Prenatal exposure to perfluoroalkyl substances led to a tendency toward increased birth weight in girls and reduced in boys.Jul 11, 2016

Pubmed Data : Reprod Toxicol. 2016 Jul 12. Epub 2016 Jul 12. PMID: 27421581
Article Published Date : Jul 11, 2016
Study Type : Human Study
Additional Links
Diseases : Perfluorinated Compound Toxicity, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Endocrine Disrupting Chemicals (EDCs), Perfluorinated compounds, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)
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There is an association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults.Nov 15, 2009

Pubmed Data : Am J Epidemiol. 2009 Nov 15;170(10):1268-78. Epub 2009 Oct 21. PMID: 19846564
Article Published Date : Nov 15, 2009
Study Type : Human Study
Additional Links
Diseases : Hyperlipidemia
Problem Substances : Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)
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Gastrodin attenuates perfluorooctanoic acid-induced liver injury.Jan 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2021 12 ;12(2):11546-11556. PMID: 34866532
Article Published Date : Jan 11, 2021
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective
Problem Substances : Perfluorooctanoic acid (PFOA)
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Oxidative stress and PUFA alteration might help explain the sperm injury and male reproductive dysfunction induced by PFOA exposure.Aug 31, 2016

Pubmed Data : Chemosphere. 2016 Sep ;158:143-53. Epub 2016 Jun 1. PMID: 27262104
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Infertility, Oxidative Stress, Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctanoic acid (PFOA)
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Perfluorooctanoic acid (PFOA), used in the production of non-stick surface compounds, may contribute to metabolic disorders by altering mitochondrial biogenesis.Oct 01, 2009

Pubmed Data : Toxicology. 2009 Oct 1;264(1-2):10-5. Epub 2009 Jul 16. PMID: 19616056
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Problem Substances : Nonstick cookware, Perfluorooctanoic acid (PFOA)
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Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid.Jun 30, 2021

Pubmed Data : Wei Sheng Yan Jiu. 2021 Jul ;50(4):609-614. PMID: 34311832
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Perfluorooctanoic acid (PFOA)
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These results indicate that PFOA is a carcinogen that promotes endometrial cancer cell migration and invasion.Aug 28, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Aug 29. Epub 2016 Aug 29. PMID: 27589685
Article Published Date : Aug 28, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Increased Risk
Problem Substances : Perfluorooctanoic acid (PFOA)
Adverse Pharmacological Actions : Carcinogen
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These results suggests the potential of PFOA to cause inflammation response in liver.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Apr 1 ;6:23963. Epub 2016 Apr 1. PMID: 27032815
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctanoic acid (PFOA)
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This study clearly demonstrates that soil contamination of PFOA can lead to adverse effects on soil health.Jun 30, 2016

Pubmed Data : Environ Monit Assess. Jul 2016;188(7):424. Epub 2016 Jun 21. PMID: 27329475
Article Published Date : Jun 30, 2016
Study Type : Environmental
Additional Links
Diseases : Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctanoic acid (PFOA)
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This study showed that textiles could be a significant direct and indirect source of PFOS and PFOA exposure for both humans and the environment.Dec 31, 2015

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 ;51(6):472-7. Epub 2016 Feb 11. PMID: 26864911
Article Published Date : Dec 31, 2015
Study Type : Environmental
Additional Links
Diseases : Perfluorinated Compound Toxicity
Additional Keywords : Environmental Pollutant, Perfluorinated Compound Toxicity, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA), PFOA, PFOS, Risk Factors, Toxins
Problem Substances : Perfluorinated compounds, Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)
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Vitamin C protects the spleen against PFOA-induced immunotoxicity.Mar 19, 2023

Pubmed Data : Sci Total Environ. 2023 Mar 20 ;865:161266. Epub 2022 Dec 30. PMID: 36592905
Article Published Date : Mar 19, 2023
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fatty Liver
Pharmacological Actions : Immunomodulatory
Problem Substances : Perfluorooctanoic acid (PFOA)
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A ternary mixture of common chemicals perturbs benign human breast epithelial cells more than the same chemicals do individually.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Sci. 2018 Sep 1 ;165(1):131-144. PMID: 29846718
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Breast Cancer: Chemically-Induced
Additional Keywords : Synergistic Toxicity
Problem Substances : Bisphenol A , Parabens, Perfluorooctanoic acid (PFOA)
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Blueberry anthocyanin alleviate perfluorooctanoic acid-induced toxicity.Jan 31, 2019

Pubmed Data : Environ Pollut. 2019 Feb ;245:957-964. Epub 2018 Nov 28. PMID: 30682752
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Problem Substances : Perfluorooctanoic acid (PFOA)
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Effects of co-exposure to microplastics and perfluorooctanoic acid on the Caco-2 cells.Jul 31, 2025

Pubmed Data : Toxicology. 2025 Aug ;515:154152. Epub 2025 Apr 11. PMID: 40220582
Article Published Date : Jul 31, 2025
Study Type : In Vitro Study
Additional Links
Diseases : Microplastic Toxicity, Oxidative Stress
Problem Substances : Nano Plastic-and Micro-Particles, Perfluorooctanoic acid (PFOA)
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Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS.Feb 28, 2022

Pubmed Data : Chemosphere. 2022 Mar ;291(Pt 2):132892. Epub 2021 Nov 12. PMID: 34780734
Article Published Date : Feb 28, 2022
Study Type : Review
Additional Links
Diseases : Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctane sulfonate (PFOS), Perfluorooctanoic acid (PFOA)
Adverse Pharmacological Actions : Immunotoxic
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Impacts of PFOS, PFOA and their alternatives on the gut, intestinal barriers and gut-organ axis.Jul 31, 2024

Pubmed Data : Chemosphere. 2024 Aug ;361:142461. Epub 2024 May 27. PMID: 38810808
Article Published Date : Jul 31, 2024
Study Type : Review
Additional Links
Diseases : Perfluorinated Compound Toxicity
Problem Substances : Perfluorooctanoic acid (PFOA)
Adverse Pharmacological Actions : Gastrotoxic
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The present data indicate that PFOA aggravated FcɛRI-mediated mast cell degranulation and allergic symptoms.Sep 28, 2016

Pubmed Data : J Appl Toxicol. 2016 Sep 29. Epub 2016 Sep 29. PMID: 27682001
Article Published Date : Sep 28, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Inflammation
Problem Substances : Perfluorooctanoic acid (PFOA)
Adverse Pharmacological Actions : Inflammatory

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