Pravastatin

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54 Diseases Researched for Pravastatin
NameACCKFocus
Statin-Induced Pathologies28180Locked
Chemically-Induced Liver Damage443Locked
Cancers: All240Locked
Myopathies635Locked
High Cholesterol331Locked
Coenzyme Q10 Deficiency220Locked
Rhabdomyolysis316Locked
Drug-Induced Nutrient Depletion: Statin Drugs212Locked
Atherosclerosis110Locked
Blood Platelet Disorders110Locked
Cardiovascular Diseases110Locked
Cataract110Locked
Cognitive Decline/Dysfunction110Locked
DHEA: Low110Locked
Diabetes110Locked
Drug-Induced Toxicity 110Locked
Eczema110Locked
Esophageal Cancer110Locked
Fibromyalgia110Locked
Hyperlipidemia110Locked
Kidney Failure110Locked
Memory Disorders110Locked
Muscle Soreness110Locked
Myalgias110Locked
Organ Transplantation: Heart110Locked
Oxidative Stress110Locked
Polyneuropathies110Locked
Psoriasis110Locked
Sperm Quality: Low110Locked
Pancreatitis39Locked
Peripheral Neuropathies26Locked
Mitochondrial Dysfunction 24Locked
Myasthenia Gravis24Locked
A1C13Locked
Cholestasis13Locked
Diabetes Mellitus: Type 213Locked
Diabetes: Glycation/A1C13Locked
Eye Diseases23Locked
GGT13Locked
Gitelman's syndrome (False Presentation)13Locked
Headache: Altitude-Induced13Locked
Hepatitis: Cholestatic13Locked
Lens Damage23Locked
Lens Diseases23Locked
Lichenoid Dermatitis13Locked
Multiple Mononeuropathy13Locked
Muscle Disorders13Locked
Myositis13Locked
Myositis Migrans13Locked
Perioperative Care13Locked
Polymyositis13Locked
Aging12Locked
Liver Damage12Locked
Respiratory Diseases12Locked
8 Adverse Pharmacological Actions Researched for Pravastatin
NameACCKFocus
Carcinogenic240Locked
Myotoxicity731Locked
Hepatotoxic425Locked
Neurotoxic323Locked
Cytotoxic110Locked
Endocrine Disruptor110Locked
Oxidant110Locked
Diabetogenic25Locked
Related Topics

Pravastatin is a Sub of the following Topic

View the Evidence:
42 Abstracts with Pravastatin Research

[+]

Pravastatin therapy was associated with an increasing risk of cancer as age increases.Feb 27, 2007

Pubmed Data : CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
Article Published Date : Feb 27, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Carcinogenic
[+]

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All, Chemically-Induced Liver Damage, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Carcinogenic
[+]

Cholesterol-lowering drugs may contribute to skin disorders.Feb 01, 1995

Pubmed Data : Hautarzt. 1995 Feb ;46(2):76-80. PMID: 7706076
Article Published Date : Feb 01, 1995
Study Type : Human Study
Additional Links
Diseases : Eczema, Hyperlipidemia, Psoriasis, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Simvastatin, Statin Drugs
[+]

Cholesterol-lowering medications reduce DHEA-secretory responses and sperm motility. Sep 01, 1993

Pubmed Data : Metabolism. 1993 Sep ;42(9):1146-52. PMID: 8412767
Article Published Date : Sep 01, 1993
Study Type : Human Study
Additional Links
Diseases : DHEA: Low, Sperm Quality: Low, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy.May 14, 2002

Pubmed Data : Neurology. 2002 May 14 ;58(9):1333-7. PMID: 12011277
Article Published Date : May 14, 2002
Study Type : Human Study
Additional Links
Diseases : Polyneuropathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Low serum docosahexaenoic acid was associated with progression of coronary atherosclerosis in statin-treated patients with Diabetes mellitus.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cardiovasc Diabetol. 2014 ;13:13. Epub 2014 Jan 13. PMID: 24410834
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Atherosclerosis, Diabetes
Additional Keywords : Increased Risk
Problem Substances : Pravastatin , Statin Drugs
[+]

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Pubmed Data : Minerva Gastroenterol Dietol. 1992 Jan-Mar;38(1):41-4. PMID: 1520752
Article Published Date : Jan 01, 1992
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Statin-Induced Pathologies
Problem Substances : Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]

Statin drugs alter platelet function. Dec 01, 2002

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Diseases : Blood Platelet Disorders
Pharmacological Actions : Nitric Oxide Inhibitor
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage. Mar 01, 1993

Pubmed Data : J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID: 8463436
Article Published Date : Mar 01, 1993
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , High Cholesterol, Myopathies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cytotoxic
[+]

Statin drugs show no cognitive or anti-amyloid benefits and may be associated with cognitive impairment.Jul 01, 2003

Pubmed Data : Pharmacotherapy. 2003 Jul ;23(7):871-80. PMID: 12885101
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan ;98(1):51-4. PMID: 16433891
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. Jan 01, 1997

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Pharmacological Actions : Antioxidants
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
[+]

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Cataract, Chemically-Induced Liver Damage, Esophageal Cancer, Kidney Failure, Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Rosuvastatin, Simvastatin, Statin Drugs
[+]

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Pubmed Data : Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223
Article Published Date : May 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Cholestasis, GGT, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
Article Published Date : Jun 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Acute pancreatitis due to pravastatin therapy has been reported. May 01, 2003

Pubmed Data : JOP. 2003 May ;4(3):129-32. PMID: 12743419
Article Published Date : May 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin has been reported.Jan 01, 2007

Pubmed Data : Clin Ther. 2007 Jan ;29(1):172-6. PMID: 17379057
Article Published Date : Jan 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Cholesterol-lowering drugs may increase the risk of periooperative mortality. Sep 01, 2002

Pubmed Data : Cardiovasc Drugs Ther. 2002 Sep ;16(5):471-5. PMID: 12652117
Article Published Date : Sep 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Perioperative Care, Rhabdomyolysis, Statin-Induced Pathologies
Anti Therapeutic Actions : Surgical Procedures
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Statin Drugs
[+]

Gitelman's syndrome presenting as intolerance to statin therapy has been reported. May 01, 2005

Pubmed Data : Ann Clin Biochem. 2005 May ;42(Pt 3):232-3. PMID: 15949161
Article Published Date : May 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Gitelman's syndrome (False Presentation), Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Multiple mononeuropathy caused by treatment with pravastatin has been reporeted. Dec 01, 2006

Pubmed Data : Rev Neurol. 2006 Dec 1-15;43(11):659-61. PMID: 17133326
Article Published Date : Dec 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Multiple Mononeuropathy, Peripheral Neuropathies
Problem Substances : Pravastatin , Statin Drugs
[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Pravastatin may contribute to altitude-induced migraine headaches. Jun 01, 1998

Pubmed Data : Aviat Space Environ Med. 1998 Jun ;69(6):603-6. PMID: 9641408
Article Published Date : Jun 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Headache: Altitude-Induced
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Pravastatin, as a potential cause for acute pancreatitis, has been reported. Nov 21, 2006

Pubmed Data : World J Gastroenterol. 2006 Nov 21 ;12(43):7055-7. PMID: 17109506
Article Published Date : Nov 21, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Pravastatin-associated myopathy has been reported. May 01, 1995

Pubmed Data : Recenti Prog Med. 1995 May ;86(5):198-200. PMID: 7604176
Article Published Date : May 01, 1995
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-associated polymyositis has been reported. Jan 01, 2004

Pubmed Data : Rinsho Shinkeigaku. 2004 Jan ;44(1):25-7. PMID: 15199734
Article Published Date : Jan 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Muscle Disorders, Polymyositis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-induced lichenoid drug eruption has been reported. Feb 01, 2006

Pubmed Data : Australas J Dermatol. 2006 Feb ;47(1):57-9. PMID: 16405486
Article Published Date : Feb 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Lichenoid Dermatitis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Recurrent acute pancreatitis during pravastatin-therapy has been reported. Jan 25, 2006

Pubmed Data : Praxis (Bern 1994). 2006 Jan 25 ;95(4):111-6. PMID: 16485606
Article Published Date : Jan 25, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin-associated myasthenia gravis has been reported.Mar 01, 2006

Pubmed Data : Medicine (Baltimore). 2006 Mar ;85(2):82-5. PMID: 16609346
Article Published Date : Mar 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Myasthenia Gravis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Simvastatin, Statin Drugs
[+]

Statin-induced myositis migrans has been reported. Nov 30, 2002

Pubmed Data : Wien Klin Wochenschr. 2002 Nov 30 ;114(21-22):943-4. PMID: 12528328
Article Published Date : Nov 30, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Myositis, Myositis Migrans, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin
[+]

Long-term treatmetn of animals with statin drugs result in the inhibition of cholesterol synthesis in the lens.Aug 01, 1991

Pubmed Data : Exp Eye Res. 1991 Aug ;53(2):179-86. PMID: 1915674
Article Published Date : Aug 01, 1991
Study Type : Animal Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Pravastatin accelerates aging effect on diaphragm mitochondrial respiratory function in rats.Dec 01, 1998

Pubmed Data : Biochem Mol Biol Int. 1998 Dec ;46(5):923-31. PMID: 9861446
Article Published Date : Dec 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Aging, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Respiratory Diseases, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin drugs may enhance respiratory impairment of liver mitochondria under pathophysiological conditions, such as ischemia.Aug 03, 1994

Pubmed Data : Eur J Pharmacol. 1994 Aug 3 ;270(4):365-9. PMID: 7805787
Article Published Date : Aug 03, 1994
Study Type : Animal Study
Additional Links
Diseases : Liver Damage, Mitochondrial Dysfunction
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

These findings suggest that prolonged use of statins may have a diabetogenic effect. Feb 16, 2016

Pubmed Data : Toxicology. 2016 Feb 17 ;344-346:42-52. Epub 2016 Feb 10. PMID: 26875785
Article Published Date : Feb 16, 2016
Study Type : Animal Study
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Pravastatin may contribute to the pathology of eye diseases by inhibit cholesterol synthesis in the lens.Sep 01, 1989

Pubmed Data : J Lipid Res. 1989 Sep ;30(9):1411-20. PMID: 2513368
Article Published Date : Sep 01, 1989
Study Type : In Vitro Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Statin drugs exhibit myotoxicity. Mar 01, 1995

Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Article Published Date : Mar 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs have been demonstrated to increase the rate of breast cancer, hemorrhagic stroke and mortality from noncardiovascular causes including cancer and infections.Jan 01, 2007

Pubmed Data : Kardiologiia. 2007;47(11):75-85. PMID: 18260968
Article Published Date : Jan 01, 2007
Study Type : Review
Additional Links
Diseases : High Cholesterol
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782
Article Published Date : Dec 14, 2004
Study Type : Review
Additional Links
Diseases : Myasthenia Gravis
Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

The myotoxicity of statin drugs may be due to the inhibition of the geranylgeranylation of low-molecular-weight proteins in the muscle cells.Jul 01, 1997

Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity

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An estimated 40 million people take a statin to lower their cholesterol levels. These are one of the most widely prescribed medications in history and, of course, one of the most profitable.
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There is a little known natural extract of plant waxes known as policosanol, extractable from sugar cane, yams, and beeswax, which has been giving some of the more profitable drugs on the market a biomedical beating since it was first investigated in clinical trials by the Cubans in the 1990's.

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