Pravastatin

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54 Diseases Researched for Pravastatin
NameACCKFocus
Statin-Induced Pathologies28180Locked
Chemically-Induced Liver Damage443Locked
Cancers: All240Locked
Myopathies635Locked
High Cholesterol331Locked
Coenzyme Q10 Deficiency220Locked
Rhabdomyolysis316Locked
Drug-Induced Nutrient Depletion: Statin Drugs212Locked
Atherosclerosis110Locked
Blood Platelet Disorders110Locked
Cardiovascular Diseases110Locked
Cataract110Locked
Cognitive Decline/Dysfunction110Locked
DHEA: Low110Locked
Diabetes110Locked
Drug-Induced Toxicity 110Locked
Eczema110Locked
Esophageal Cancer110Locked
Fibromyalgia110Locked
Hyperlipidemia110Locked
Kidney Failure110Locked
Memory Disorders110Locked
Muscle Soreness110Locked
Myalgias110Locked
Organ Transplantation: Heart110Locked
Oxidative Stress110Locked
Polyneuropathies110Locked
Psoriasis110Locked
Sperm Quality: Low110Locked
Pancreatitis39Locked
Peripheral Neuropathies26Locked
Mitochondrial Dysfunction 24Locked
Myasthenia Gravis24Locked
A1C13Locked
Cholestasis13Locked
Diabetes Mellitus: Type 213Locked
Diabetes: Glycation/A1C13Locked
Eye Diseases23Locked
GGT13Locked
Gitelman's syndrome (False Presentation)13Locked
Headache: Altitude-Induced13Locked
Hepatitis: Cholestatic13Locked
Lens Damage23Locked
Lens Diseases23Locked
Lichenoid Dermatitis13Locked
Multiple Mononeuropathy13Locked
Muscle Disorders13Locked
Myositis13Locked
Myositis Migrans13Locked
Perioperative Care13Locked
Polymyositis13Locked
Aging12Locked
Liver Damage12Locked
Respiratory Diseases12Locked
8 Adverse Pharmacological Actions Researched for Pravastatin
NameACCKFocus
Carcinogenic240Locked
Myotoxicity731Locked
Hepatotoxic425Locked
Neurotoxic323Locked
Cytotoxic110Locked
Endocrine Disruptor110Locked
Oxidant110Locked
Diabetogenic25Locked
Related Topics

Pravastatin is a Sub of the following Topic

View the Evidence:
42 Abstracts with Pravastatin Research

[+]

Pravastatin therapy was associated with an increasing risk of cancer as age increases.Feb 27, 2007

Pubmed Data : CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
Article Published Date : Feb 27, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Carcinogenic
[+]

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All, Chemically-Induced Liver Damage, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Carcinogenic
[+]

Cholesterol-lowering drugs may contribute to skin disorders.Feb 01, 1995

Pubmed Data : Hautarzt. 1995 Feb ;46(2):76-80. PMID: 7706076
Article Published Date : Feb 01, 1995
Study Type : Human Study
Additional Links
Diseases : Eczema, Hyperlipidemia, Psoriasis, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Simvastatin, Statin Drugs
[+]

Cholesterol-lowering medications reduce DHEA-secretory responses and sperm motility. Sep 01, 1993

Pubmed Data : Metabolism. 1993 Sep ;42(9):1146-52. PMID: 8412767
Article Published Date : Sep 01, 1993
Study Type : Human Study
Additional Links
Diseases : DHEA: Low, Sperm Quality: Low, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy.May 14, 2002

Pubmed Data : Neurology. 2002 May 14 ;58(9):1333-7. PMID: 12011277
Article Published Date : May 14, 2002
Study Type : Human Study
Additional Links
Diseases : Polyneuropathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Low serum docosahexaenoic acid was associated with progression of coronary atherosclerosis in statin-treated patients with Diabetes mellitus.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cardiovasc Diabetol. 2014 ;13:13. Epub 2014 Jan 13. PMID: 24410834
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Atherosclerosis, Diabetes
Additional Keywords : Increased Risk
Problem Substances : Pravastatin , Statin Drugs
[+]

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Pubmed Data : Minerva Gastroenterol Dietol. 1992 Jan-Mar;38(1):41-4. PMID: 1520752
Article Published Date : Jan 01, 1992
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Statin-Induced Pathologies
Problem Substances : Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]

Statin drugs alter platelet function. Dec 01, 2002

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Diseases : Blood Platelet Disorders
Pharmacological Actions : Nitric Oxide Inhibitor
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage. Mar 01, 1993

Pubmed Data : J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID: 8463436
Article Published Date : Mar 01, 1993
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , High Cholesterol, Myopathies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cytotoxic
[+]

Statin drugs show no cognitive or anti-amyloid benefits and may be associated with cognitive impairment.Jul 01, 2003

Pubmed Data : Pharmacotherapy. 2003 Jul ;23(7):871-80. PMID: 12885101
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin therapy appears to be associated with increased oxidation injury.Jan 01, 2002

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Atorvastatin, Fluvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Oxidant
[+]

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.Jan 01, 2006

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan ;98(1):51-4. PMID: 16433891
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. Jan 01, 1997

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Pharmacological Actions : Antioxidants
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
[+]

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Cataract, Chemically-Induced Liver Damage, Esophageal Cancer, Kidney Failure, Myopathies, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Fluvastatin, Pravastatin , Rosuvastatin, Simvastatin, Statin Drugs
[+]

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Pubmed Data : Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223
Article Published Date : May 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage, Cholestasis, GGT, Hepatitis: Cholestatic, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Acute onset and worsening of diabetes concurrent with administration of statins has been reported. Jun 01, 2005

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
Article Published Date : Jun 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Acute pancreatitis due to pravastatin therapy has been reported. May 01, 2003

Pubmed Data : JOP. 2003 May ;4(3):129-32. PMID: 12743419
Article Published Date : May 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin has been reported.Jan 01, 2007

Pubmed Data : Clin Ther. 2007 Jan ;29(1):172-6. PMID: 17379057
Article Published Date : Jan 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Cholesterol-lowering drugs may increase the risk of periooperative mortality. Sep 01, 2002

Pubmed Data : Cardiovasc Drugs Ther. 2002 Sep ;16(5):471-5. PMID: 12652117
Article Published Date : Sep 01, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Perioperative Care, Rhabdomyolysis, Statin-Induced Pathologies
Anti Therapeutic Actions : Surgical Procedures
Problem Substances : Cholesterol Lowering Drugs, Pravastatin , Statin Drugs
[+]

Gitelman's syndrome presenting as intolerance to statin therapy has been reported. May 01, 2005

Pubmed Data : Ann Clin Biochem. 2005 May ;42(Pt 3):232-3. PMID: 15949161
Article Published Date : May 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Gitelman's syndrome (False Presentation), Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Multiple mononeuropathy caused by treatment with pravastatin has been reporeted. Dec 01, 2006

Pubmed Data : Rev Neurol. 2006 Dec 1-15;43(11):659-61. PMID: 17133326
Article Published Date : Dec 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Multiple Mononeuropathy, Peripheral Neuropathies
Problem Substances : Pravastatin , Statin Drugs
[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Pravastatin may contribute to altitude-induced migraine headaches. Jun 01, 1998

Pubmed Data : Aviat Space Environ Med. 1998 Jun ;69(6):603-6. PMID: 9641408
Article Published Date : Jun 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Headache: Altitude-Induced
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Pravastatin, as a potential cause for acute pancreatitis, has been reported. Nov 21, 2006

Pubmed Data : World J Gastroenterol. 2006 Nov 21 ;12(43):7055-7. PMID: 17109506
Article Published Date : Nov 21, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Pravastatin-associated myopathy has been reported. May 01, 1995

Pubmed Data : Recenti Prog Med. 1995 May ;86(5):198-200. PMID: 7604176
Article Published Date : May 01, 1995
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-associated polymyositis has been reported. Jan 01, 2004

Pubmed Data : Rinsho Shinkeigaku. 2004 Jan ;44(1):25-7. PMID: 15199734
Article Published Date : Jan 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Muscle Disorders, Polymyositis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-induced lichenoid drug eruption has been reported. Feb 01, 2006

Pubmed Data : Australas J Dermatol. 2006 Feb ;47(1):57-9. PMID: 16405486
Article Published Date : Feb 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Lichenoid Dermatitis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Recurrent acute pancreatitis during pravastatin-therapy has been reported. Jan 25, 2006

Pubmed Data : Praxis (Bern 1994). 2006 Jan 25 ;95(4):111-6. PMID: 16485606
Article Published Date : Jan 25, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Pancreatitis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin-associated myasthenia gravis has been reported.Mar 01, 2006

Pubmed Data : Medicine (Baltimore). 2006 Mar ;85(2):82-5. PMID: 16609346
Article Published Date : Mar 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Myasthenia Gravis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Simvastatin, Statin Drugs
[+]

Statin-induced myositis migrans has been reported. Nov 30, 2002

Pubmed Data : Wien Klin Wochenschr. 2002 Nov 30 ;114(21-22):943-4. PMID: 12528328
Article Published Date : Nov 30, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Myositis, Myositis Migrans, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin
[+]

Long-term treatmetn of animals with statin drugs result in the inhibition of cholesterol synthesis in the lens.Aug 01, 1991

Pubmed Data : Exp Eye Res. 1991 Aug ;53(2):179-86. PMID: 1915674
Article Published Date : Aug 01, 1991
Study Type : Animal Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

Pravastatin accelerates aging effect on diaphragm mitochondrial respiratory function in rats.Dec 01, 1998

Pubmed Data : Biochem Mol Biol Int. 1998 Dec ;46(5):923-31. PMID: 9861446
Article Published Date : Dec 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Aging, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Respiratory Diseases, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin drugs may enhance respiratory impairment of liver mitochondria under pathophysiological conditions, such as ischemia.Aug 03, 1994

Pubmed Data : Eur J Pharmacol. 1994 Aug 3 ;270(4):365-9. PMID: 7805787
Article Published Date : Aug 03, 1994
Study Type : Animal Study
Additional Links
Diseases : Liver Damage, Mitochondrial Dysfunction
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

These findings suggest that prolonged use of statins may have a diabetogenic effect. Feb 16, 2016

Pubmed Data : Toxicology. 2016 Feb 17 ;344-346:42-52. Epub 2016 Feb 10. PMID: 26875785
Article Published Date : Feb 16, 2016
Study Type : Animal Study
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Diabetogenic
[+]

Pravastatin may contribute to the pathology of eye diseases by inhibit cholesterol synthesis in the lens.Sep 01, 1989

Pubmed Data : J Lipid Res. 1989 Sep ;30(9):1411-20. PMID: 2513368
Article Published Date : Sep 01, 1989
Study Type : In Vitro Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Statin drugs exhibit myotoxicity. Mar 01, 1995

Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Article Published Date : Mar 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs have been demonstrated to increase the rate of breast cancer, hemorrhagic stroke and mortality from noncardiovascular causes including cancer and infections.Jan 01, 2007

Pubmed Data : Kardiologiia. 2007;47(11):75-85. PMID: 18260968
Article Published Date : Jan 01, 2007
Study Type : Review
Additional Links
Diseases : High Cholesterol
Problem Substances : Pravastatin , Statin Drugs
[+]

Statin-associated exacerbation of myasthenia gravis has been reported.Dec 14, 2004

Pubmed Data : Neurology. 2004 Dec 14 ;63(11):2188. PMID: 15596782
Article Published Date : Dec 14, 2004
Study Type : Review
Additional Links
Diseases : Myasthenia Gravis
Problem Substances : Atorvastatin, Lovastatin, Pravastatin , Simvastatin, Statin Drugs
[+]

The myotoxicity of statin drugs may be due to the inhibition of the geranylgeranylation of low-molecular-weight proteins in the muscle cells.Jul 01, 1997

Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity

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Statin Drugs Linked to Arthritis, Heart Trouble and More
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Research revealing the broad spectrum toxicity of statin drugs continues to accumulate unabated. Adding to a growing body of clinical evidence that they may cause over 300 adverse health effects, a new study reveals that these cholesterol-lowering drugs may be contributing to an epidemic of arthritis and autoimmunity in exposed populations, as well.
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Written by Kelly Brogan, M.D.
The chemical war against cholesterol has been based on statistical deception and the active covering up of over 300 adverse health effects they are known to produce.

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