Selective Serotonin Reuptake Inhibitors (SSRIs)

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31 Diseases Researched for Selective Serotonin Reuptake Inhibitors (SSRIs)
NameACCKFocus
Prenatal Chemical Exposures636Locked
Depression322Locked
Erectile Dysfunction213Locked
Fetal Origin of Adult Disease212Locked
Aneurysmal subarachnoid hemorrhage (SAH)110Locked
Bipolar Disorder110Locked
Birth Defects110Locked
Bleeding: Excessive110Locked
Cerebral Hemorrhage110Locked
Congenital Defects110Locked
Depressive Disorder110Locked
Elderly: Age Specific Diseases110Locked
Heart Defects: Congenital110Locked
Irritable Bowel Syndrome110Locked
Mortality: All-Cause110Locked
Obsessive-Compulsive Disorder110Locked
Restless Legs Syndrome110Locked
Sexual Dysfunction110Locked
Sexual Dysfunction: SSRI-induced110Locked
Suicidal Behavior110Locked
Vasospasm: Intracranial110Locked
Weight Gain: Drug-Induced110Locked
Aggression12Locked
Chemically-Induced Liver Damage12Locked
Diabetes Mellitus: Type 212Locked
Dyslipidemias12Locked
Female Reproductive Development Abnormalities12Locked
Lipopolysaccharide-Induced Toxicity12Locked
Memory Disorders: Drug-Induced12Locked
Metabolic Diseases12Locked
Metabolic Syndrome X12Locked
5 Adverse Pharmacological Actions Researched for Selective Serotonin Reuptake Inhibitors (SSRIs)
NameACCKFocus
Cardiotoxic110Locked
Hallucinogenic110Locked
Teratogenic110Locked
Neurotoxic12Locked
Immunotoxic11Locked

View the Evidence:
25 Abstracts with Selective Serotonin Reuptake Inhibitors (SSRIs) Research

[+]

Antidepressant use in a population aged 65 or older is associated with adverse outcomes including higher all cause mortality.Jan 01, 2011

Pubmed Data : BMJ. 2011 ;343:d4551. Epub 2011 Aug 2. PMID: 21810886
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Elderly: Age Specific Diseases, Mortality: All-Cause
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs), Tricyclic Antidepressant (TCA)
[+]

Antidepressants such as the SSRI paroxetine are associated with birth defects. Dec 01, 2006

Pubmed Data : Prescrire Int. 2006 Dec;15(86):222-3. PMID: 17167929
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Diseases : Birth Defects
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Duloxetine (Cymbalta) and escitalopram (Lexapro) are associated with weight-gain of 7% from baseline.Jun 01, 2007

Pubmed Data : Curr Med Res Opin. 2007 Jun;23(6):1303-18. Epub 2007 Apr 27. PMID: 17559729
Article Published Date : Jun 01, 2007
Study Type : Human Study
Additional Links
Diseases : Weight Gain: Drug-Induced
Problem Substances : Cymbalta, Lexapro, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

In people with unipolar depression, antidepressant treatment is associated with an increased risk of subsequent mania/bipolar disorder.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ Open. 2015;5(12):e008341. Epub 2015 Dec 14. PMID: 26667012
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Bipolar Disorder, Depression
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Initiation of SSRI therapy is associated with an increased risk of suicide during the first month of therapy compared with other antidepressants.Apr 30, 2006

Pubmed Data : Am J Psychiatry. 2006 May ;163(5):813-21. PMID: 16648321
Article Published Date : Apr 30, 2006
Study Type : Human Study
Additional Links
Diseases : Suicidal Behavior
Additional Keywords : Increased Risk
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Newborns exposed in utero to SSRIs, have a twofold higher risk of mild nonsyndromic heart defects than unexposed infants.Oct 01, 2009

Pubmed Data : Birth Defects Res A Clin Mol Teratol. 2009 Oct;85(10):837-41. PMID: 19691085
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Diseases : Heart Defects: Congenital, Prenatal Chemical Exposures
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
Adverse Pharmacological Actions : Teratogenic
[+]

Preinjury use of serotonin-modulating antidepressants led to an increased requirement of blood transfusions after solid organ injury.Oct 31, 2018

Pubmed Data : Am Surg. 2018 Nov 1 ;84(11):1727-1733. PMID: 30747624
Article Published Date : Oct 31, 2018
Study Type : Human Study
Additional Links
Diseases : Bleeding: Excessive
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Prenatal SSRI exposure was associated with increased rates of depression diagnoses in early adolescence.Apr 30, 2016

Pubmed Data : J Am Acad Child Adolesc Psychiatry. 2016 May ;55(5):359-66. Epub 2016 Mar 3. PMID: 27126849
Article Published Date : Apr 30, 2016
Study Type : Human Study
Additional Links
Diseases : Depression, Fetal Origin of Adult Disease, Prenatal Chemical Exposures
Additional Keywords : Increased Risk
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Rosa damascena oil improved sexual function in male patients suffering from both major depressive disorders and SSRI-induced sexual dysfunction.Jun 30, 2015

Pubmed Data : Pharmacopsychiatry. 2015 Jul ;48(4-5):156-63. Epub 2015 Jun 22. PMID: 26098128
Article Published Date : Jun 30, 2015
Study Type : Human Study
Additional Links
Substances : Rose
Diseases : Depressive Disorder, Sexual Dysfunction: SSRI-induced
Additional Keywords : Plant Extracts
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Selective serotonin reuptake inhibitor use may increase the risk of restless legs syndrome in male irritable bowel syndrome patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(8):e0220641. Epub 2019 Aug 1. PMID: 31369638
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Irritable Bowel Syndrome, Restless Legs Syndrome
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Selective Serotonin Reuptake Inhibitors (SSRIs) are associated with sexual dysfunction in 95.6% of women and 97.9% men.Mar 01, 2006

Pubmed Data : J Affect Disord. 2006 Mar;91(1):27-32. Epub 2006 Jan 20. PMID: 16430968
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Sexual Dysfunction
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Selective serotonin reuptake inhibitors and statin use increases the risk for vasospasm after subarachnoid hemorrhage.Mar 22, 2005

Pubmed Data : Neurology. 2005 Mar 22 ;64(6):1008-13. PMID: 15781818
Article Published Date : Mar 22, 2005
Study Type : Human Study
Additional Links
Diseases : Aneurysmal subarachnoid hemorrhage (SAH), Cerebral Hemorrhage, Vasospasm: Intracranial
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs), Statin Drugs
[+]

There is a risk of congenital heart disease in patients who are prenatally exposed to anti-depressant medications.May 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2019 May 15 ;11(5):e4673. Epub 2019 May 15. PMID: 31328065
Article Published Date : May 14, 2019
Study Type : Human Study
Additional Links
Diseases : Congenital Defects, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Antidepressants, Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
Adverse Pharmacological Actions : Cardiotoxic
[+]

W. somnifera extract may be beneficial as a safe and effective adjunct to SSRIs in the treatment of OCD.Jul 31, 2016

Pubmed Data : Complement Ther Med. 2016 Aug ;27:25-9. Epub 2016 Apr 9. PMID: 27515872
Article Published Date : Jul 31, 2016
Study Type : Human Study
Additional Links
Substances : Ashwagandha
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Plant Extracts
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Zolpidem-associated hallucinations may be stimulated or amplified by the use of serotonin reuptake inhibitors.Jan 01, 1998

Pubmed Data : J Toxicol Clin Toxicol. 1998;36(3):195-203. PMID: 9656974
Article Published Date : Jan 01, 1998
Study Type : Human Study
Additional Links
Additional Keywords : Drug-Plant-Vitamin Synergies
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs), Zolpidem (trade name Ambien)
Adverse Pharmacological Actions : Hallucinogenic
[+]

Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors has been reported. Jan 01, 2008

Pubmed Data : J Sex Med. 2008 Jan;5(1):227-33. PMID: 18173768
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Erectile Dysfunction
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Alterations in the development of serotonergic pathways following prenatal exposure to SSRIs are associated with changes in social and maternal behavior throughout life.Sep 03, 2015

Pubmed Data : Dev Psychobiol. 2015 Sep 4. Epub 2015 Sep 4. PMID: 26336834
Article Published Date : Sep 03, 2015
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Prenatal Epigenetic Programming
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Citalopram induced depressive-like behaviour in the offspring of control mothers in this rat study. Jan 31, 2016

Pubmed Data : Eur J Neurosci. 2016 Feb ;43(4):590-600. Epub 2016 Jan 13. PMID: 26669896
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Depression
Additional Keywords : Transgenerational Epigenetic Modification
Anti Therapeutic Actions : Prenatal Stress
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
Adverse Pharmacological Actions : Neurotoxic
[+]

Fetal and neonatal exposure to Fluoxetine results in evidence of increased adiposity, fatty liver and abnormal glycemic control.May 14, 2015

Pubmed Data : Toxicol Appl Pharmacol. 2015 May 15 ;285(1):32-40. Epub 2015 Mar 12. PMID: 25771129
Article Published Date : May 14, 2015
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Diabetes Mellitus: Type 2, Dyslipidemias, Metabolic Diseases, Metabolic Syndrome X
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Genes that regulate serotonin signalling and action in the ovary are altered in prenatally fluoxetine exposed offspring.Sep 30, 2015

Pubmed Data : Reprod Sci. 2015 Oct ;22(10):1297-311. Epub 2015 Mar 29. PMID: 25824009
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Female Reproductive Development Abnormalities, Fetal Origin of Adult Disease
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Prenatal modulations of the serotonergic system had lasting implications for host response to an immune challenge.Jul 14, 2015

Pubmed Data : J Neuroimmunol. 2015 Jul 15 ;284:49-56. Epub 2015 May 8. PMID: 26025058
Article Published Date : Jul 14, 2015
Study Type : Animal Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Prenatal Chemical Exposures
Additional Keywords : Transgenerational Epigenetic Modification
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Brain. 2019 04 1 ;12(1):29. Epub 2019 Apr 1. PMID: 30935412
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Memory Disorders: Drug-Induced, Prenatal Chemical Exposures
Problem Substances : Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

The results in the current study indicate that developmental SSRI exposure causes long-lasting behavioural effects in fish.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicology. 2018 Jan ;27(1):12-22. Epub 2017 Oct 23. PMID: 29058178
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Aggression
Additional Keywords : Aggression, Environmental Fate of Pharmacueticals, Environmental Pollution, Risk Factors
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Antidepressants exhibit profound toxicity to human polymorphonuclear neutrophils.Jun 01, 2003

Pubmed Data : Anesthesiology. 2003 Jun;98(6):1356-62. PMID: 12766643
Article Published Date : Jun 01, 2003
Study Type : In Vitro Study
Additional Links
Problem Substances : Antidepressants, Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
Adverse Pharmacological Actions : Immunotoxic
[+]

Ayahuasca preparations and serotonin reuptake inhibitors: a potential combination for severe adverse interactions.Sep 30, 1998

Pubmed Data : J Psychoactive Drugs. 1998 Oct-Dec;30(4):367-9. PMID: 9924842
Article Published Date : Sep 30, 1998
Study Type : Commentary
Additional Links
Substances : Ayahuasca
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)

Selective Serotonin Reuptake Inhibitors (SSRIs) Related Articles

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We know that all drugs have side effects. That’s just part of the deal right? But is it really possible that an antidepressant can cause a sane person to act like a cold-blooded criminal?
Dangerous Placebos: The Depressing Thing About Antidepressants Is That They’re Placebos With Side Effects
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Disappointingly, suicide rates among people who take antidepressants are not statistically any different than suicide rates for people who take a placebo
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Millions believe depression is caused by 'serotonin deficiency,' but where is the science in support of this theory?
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A study just published in JAMA Jan 5, reported that SSRI antidepressants are no better than placebo for most cases of depression.
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